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Q02603

- BGAL_LEULA

UniProt

Q02603 - BGAL_LEULA

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Protein

Beta-galactosidase large subunit

Gene
lacL
Organism
Leuconostoc lactis
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei318 – 3181Has an effect on thermostability Reviewed prediction
Active sitei466 – 4661Proton donor By similarity
Active sitei534 – 5341Nucleophile By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase large subunit (EC:3.2.1.23)
Short name:
Beta-gal large subunit
Alternative name(s):
Lactase large subunit
Gene namesi
Name:lacL
Encoded oniPlasmid pNZ630 Publication
OrganismiLeuconostoc lactis
Taxonomic identifieri1246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Beta-galactosidase large subunitPRO_0000057672Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Structurei

3D structure databases

ProteinModelPortaliQ02603.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02603-1 [UniParc]FASTAAdd to Basket

« Hide

MQANLQWLDD PEVFRVNQLP AHSDHHYYHD TAEFKTGSRF IKSLNGAWRF    50
NFAKTPAERP VDFYQPDFDA TDFDTIQVPG HIELAGYGQI QYINTLYPWE 100
GKIYRRPPYT LNQDQLTPGL FSDAADNTVG SYLKTFDLDD VFKGQRIIIQ 150
FQGVEEALYV WLNGHFIGYS EDSFTPSEFD LTPYIQDQGN VLAVRVYKHS 200
TAAFIEDQDM FRFSGIFRDV NILAEPASHI TDLDIRPVPN ANLKSGELNI 250
TTKVTGEPAT LALTVKDHDG RVLTSQTQTG SGSVTFDTML FDQLHLWSPQ 300
TPYLYQLTIE VYDADHQLLE VVPYQFGFRT VELRDDKVIY VNNKRLVING 350
VNRHEWNAHT GRVISMADMR ADIQTMLANN INADRTCHYP DQLPWYQLCD 400
EAGIYLMAET NLESHGSWQK MGAIEPSYNV PGDNPHWPAA VIDRARSNYE 450
WFKNHPSIIF WSLGNESYAG EDIAAMQAFY KEHDDSRLVH YEGVFYTPEL 500
KDRISDVESR MYEKPQNIVA YLEDNPTKPF LNCEYMHDMG NSLGGMQSYN 550
DLIDKYPMYQ GGFIWDFIDQ ALFVHDPITD QDVLRYGGDF DERHSDYAFS 600
GNGLMFADRT PKPAMQEVKY YYGLHK 626
Length:626
Mass (Da):72,113
Last modified:July 1, 1993 - v1
Checksum:iE9CEA154B992CF7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92281 Genomic DNA. Translation: AAA25267.1.
PIRiA42891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92281 Genomic DNA. Translation: AAA25267.1 .
PIRi A42891.

3D structure databases

ProteinModelPortali Q02603.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SUPFAMi SSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Leuconostoc lactis beta-galactosidase is encoded by two overlapping genes."
    David S., Stevens H., van Riel M., Simons G., de Vos W.M.
    J. Bacteriol. 174:4475-4481(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-6.
    Strain: NZ6009.

Entry informationi

Entry nameiBGAL_LEULA
AccessioniPrimary (citable) accession number: Q02603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Plasmid

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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