Reviewed, UniProtKB/Swiss-Prot Q02597 (POLG_TUMVQ)

Names and origin

Protein names	Recommended name:     Genome polyprotein Cleaved into the following 10 chains:     1- Recommended name:             P1 proteinase         Alternative name(s):             N-terminal protein     2- Recommended name:             Helper component proteinase                 Short name=HC-pro               EC=3.4.22.45     3- Recommended name:             Protein P3     4- Recommended name:             6 kDa protein 1                 Short name=6K1     5- Recommended name:             Cytoplasmic inclusion protein                 Short name=CI               EC=3.6.1.-     6- Recommended name:             6 kDa protein 2                 Short name=6K2     7- Recommended name:             Viral genome-linked protein         Alternative name(s):             VPg     8- Recommended name:             Nuclear inclusion protein A                 Short name=NI-a                 Short name=NIa               EC=3.4.22.44         Alternative name(s):             NIa-pro             49 kDa proteinase               Short name=49 kDa-Pro     9- Recommended name:             Nuclear inclusion protein B                 Short name=NI-b                 Short name=NIb               EC=2.7.7.48         Alternative name(s):             RNA-directed RNA polymerase     10- Recommended name:             Coat protein                 Short name=CP
Organism	Turnip mosaic virus (strain Quebec) (TuMV) [Complete proteome]
Taxonomic identifier	36396 [NCBI]
Taxonomic lineage	Viruses › ssRNA positive-strand viruses, no DNA stage › Potyviridae › Potyvirus
Virus host	Brassica [TaxID: 3705] Capsella bursa-pastoris (Shepherd's purse) [TaxID: 3719] Stellaria media (Common chickweed) [TaxID: 13274] Calanthe [TaxID: 38206] Trifolium hybridum (Alsike clover) [TaxID: 74517] Alliaria [TaxID: 126269] Hesperis matronalis [TaxID: 264418]

Protein attributes

Sequence length	3163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Coat protein is involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification. Nuclear inclusion protein B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Helper component proteinase is required for aphid transmission and also has proteolytic activity. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity By similarity. Cytoplasmic inclusion protein has helicase activity. It may be involved in replication By similarity. Both 6K peptides are indispensable for virus replication By similarity. Nuclear inclusion protein A has RNA-binding and proteolytic activities.
Catalytic activity	Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
Subcellular location	Coat protein: Virion Potential.
Domain	The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.
Post-translational modification	VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase By similarity. The viral RNA of potyviruses is expressed as a single polyprotein which undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI By similarity.
Sequence similarities	Belongs to the potyviruses polyprotein family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 peptidase C4 domain. Contains 1 peptidase C6 domain. Contains 1 peptidase S30 domain. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Biological process	RNA replication
Cellular component	Capsid protein Virion
Coding sequence diversity	Ribosomal frameshifting
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase Nucleotidyltransferase Protease RNA-directed RNA polymerase Suppressor of RNA silencing Thiol protease Transferase
PTM	Covalent protein-RNA linkage Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	RNA-protein covalent cross-linking Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro transcription, RNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Cellular component	viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]

Note: Knockout of PIPO ORF is lethal for the virus. Because of a common N-terminus, some results depicted for the genome polyprotein might belong to the PIPO isoform.

Isoform Genome polyprotein (identifier: Q02597-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Produced by conventional translation.

Isoform PIPO (identifier: Q02597-2)

Also known as: Pretty interesting potyviridae ORF;

The sequence of this isoform differs from the canonical sequence as follows:
     982-1051: LEKSYLQILD...WSKQQAKGVK → GKKLSSADLG...EQTASKRSER
     1052-3163: Missing.

Note: Produced by ribosomal frameshifting.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	P1 proteinase Potential		PRO_0000040473
	Chain	363 – 820	458	Helper component proteinase Potential		PRO_0000040474
	Chain	821 – 1175	355	Protein P3 By similarity		PRO_0000040475
	Chain	1176 – 1227	52	6 kDa protein 1 By similarity		PRO_0000040476
	Chain	1228 – 1870	643	Cytoplasmic inclusion protein By similarity		PRO_0000040477
	Chain	1871 – 1923	53	6 kDa protein 2 By similarity		PRO_0000040478
	Chain	1924 – 2115	192	Viral genome-linked protein By similarity		PRO_0000040479
	Chain	2116 – 2358	243	Nuclear inclusion protein A By similarity		PRO_0000040480
	Chain	2359 – 2875	517	Nuclear inclusion protein B By similarity		PRO_0000040481
	Chain	2876 – 3163	288	Coat protein By similarity		PRO_0000040482
Regions
	Domain	1300 – 1452	153	Helicase ATP-binding
	Domain	1471 – 1630	160	Helicase C-terminal
	Domain	2600 – 2724	125	RdRp catalytic
	Nucleotide binding	1313 – 1320	8	ATP Potential
	Motif	414 – 417	4	Involved in interaction with stylet and aphid transmission By similarity
	Motif	672 – 674	3	Involved in virions binding and aphid transmission By similarity
	Motif	1402 – 1405	4	DECH box
	Motif	1964 – 1971	8	Nuclear localization signal Potential
Sites
	Active site	270	1	For P1 proteinase activity By similarity
	Active site	279	1	For P1 proteinase activity Potential
	Active site	313	1	For P1 proteinase activity By similarity
	Active site	706	1	For helper component proteinase activity By similarity
	Active site	779	1	For helper component proteinase activity By similarity
	Active site	2161	1	For nuclear inclusion protein A activity By similarity
	Active site	2196	1	For nuclear inclusion protein A activity By similarity
	Active site	2266	1	For nuclear inclusion protein A activity By similarity
	Site	362 – 363	2	Cleavage; by P1 proteinase Potential
	Site	820 – 821	2	Cleavage; by HC-pro Potential
	Site	1175 – 1176	2	Cleavage; by NIa-pro By similarity
	Site	1227 – 1228	2	Cleavage; by NIa-pro By similarity
	Site	1870 – 1871	2	Cleavage; by NIa-pro By similarity
	Site	2115 – 2116	2	Cleavage; by NIa-pro By similarity
	Site	2358 – 2359	2	Cleavage; by NIa-pro By similarity
	Site	2875 – 2876	2	Cleavage; by NIa-pro By similarity
Amino acid modifications
	Modified residue	1986	1	O-(5'-phospho-RNA)-tyrosine By similarity
Natural variations
	Alternative sequence	982 – 1051	70	LEKSY…AKGVK → GKKLSSADLGRGMERVKLVG ALCYKILPVKASNLYTERFA NAKRSRFRRQIQRVGHILLR VEQTASKRSER in isoform PIPO.		VSP_034776
	Alternative sequence	1052 – 3163	2112	Missing in isoform PIPO.		VSP_034777
Experimental info
	Sequence conflict	2862	1	E → G in BAA01452. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform Genome polyprotein [UniParc]. Last modified June 1, 1994. Version 2. Checksum: 61B0F73B58DF6D59	FASTA	3,163	357,822
	10 20 30 40 50 60 MAAVTFASAI TNAITNKTTS TGMVQFGSFP PMPLRSTTVT TVATPVGQPK LYTVRFGSLD 70 80 90 100 110 120 PVIVKGGAGS LAKATRQQPS VEIDVSLSEA AALEVAKPKS SAVLRMHEEA NKERALFLDW 130 140 150 160 170 180 EASLKRRSYG IAENEKVVMT TRGVSKIVPR SSRAMKQKRA RERRRAQQPI ILKWEPKLSG 190 200 210 220 230 240 FSIGGGFSAS AIEAEEVRTK WPLHKTPSMK KRMVHKTCKM SDQGVDMLIR SLVKIFKAKS 250 260 270 280 290 300 ANIEYIGKKP IKVDFIRKER TKFARIQVAH LLGKRAQRDL LAGMEENHFI DILSEYSGNG 310 320 330 340 350 360 TTINPGVVCA GWSGIVVRNE TLTQKRSRSP SKAFVIRGEH EDKLYDARIK ITKTMSLKIV 370 380 390 400 410 420 HFSARGANFW KGFDRCFLAY RSDNREHTCY SGLDVTECGE VAALMCLAMF PCGKITCPDC 430 440 450 460 470 480 VIDSELSQGQ ASGPSMKHRL TQLRDVIKSS YPRFKHAVQI LDRYEQSLSS ANENYQDFAE 490 500 510 520 530 540 IQSISDGVEK AAFPHVNKLN AILIKGATAT GEEFSQATKH LLEIARYLKN RTENIEKGSL 550 560 570 580 590 600 KSFRNKVSQK AHINPTLMCD NQLDKNGNFI WGERGYHAKR FFSNYFEIID PKKGYTQYET 610 620 630 640 650 660 RVVPNGSRKL AIGKLIVPTN FEVLREQMRG EPVEPYPVTV ECVSKSQGDF VHACCCVTTE 670 680 690 700 710 720 SGDPVLSEIK MPTKHHLVIG NSGDPKYIDL PEIEENKMYI AKEGYCYINI FLAMLVNVKE 730 740 750 760 770 780 SQAKEFTKVV RDKLVSELGK WPTLLDVATA CYFLKVFYPD VANAELPRML VDHKTKIIHV 790 800 810 820 830 840 VDSYGSLSTG YHVLKTNTVE QLIKFTRCNL ESSLKHYRVG GTEWENAHGA DNIDNPQWCI 850 860 870 880 890 900 KRLVKGVYRP KQLKEDMLAN PFLPLYALLS PGVILAFYNS GSLEHLMNHY ISADSNVAVL 910 920 930 940 950 960 LVVLKSLAKK VSTSQSVLAQ LQIIERSLPE LIEAKANING PDDAATRACN RFMGMLLHMA 970 980 990 1000 1010 1020 EPNYELANGG YTFLRDHSIS ILEKSYLQIL DEAWNELSWS ERCVIRYYPS KQAIFTQKDL 1030 1040 1050 1060 1070 1080 PMQSEADLGG RYSESVISSY EWSKQQAKGV KDSVVNKLRS SMSWTSSKVS NSVCRTINYL 1090 1100 1110 1120 1130 1140 VPDVFKFMNV LVCISLLIKM TAEANHIITT QRRLKLDIEE TERKKIEWEL AFHHNILTHS 1150 1160 1170 1180 1190 1200 ASQHPTLDEF TAYIAEKAPH LSEHIEPEEK EVVHQAKRQS EQELERVIAF VALVLMMFDA 1210 1220 1230 1240 1250 1260 ERSDCVTKIL NKLKGLVATV EPTVYHQTLN EIEDDLNERN LFVDFELSSD SEMLQQLPAE 1270 1280 1290 1300 1310 1320 KTFASWWSHQ LSRGFTIPHY RTEGKFMTFT RATATEVAGK IAHESDKDIL LMGAVGSGKS 1330 1340 1350 1360 1370 1380 TGLPYHLSRK GNVLLLEPTR PLAENVHKQL SQAPFHQNTT LRMRGLTAFG SAPISVMTSG 1390 1400 1410 1420 1430 1440 FALNYFANNR SRIEEFDFVI FDECHVHDAN AMAMRCLIHE CDYSGKIIKV SATPPGREVE 1450 1460 1470 1480 1490 1500 FSTQYPVSIS TEDTLSFQDF VNAQGSGSNC DVISKGDNIL VYVASYNEVD TLSKLLIERD 1510 1520 1530 1540 1550 1560 FKVTKVDGRT MKVGNIEITT SGTPSRKHFI VATNIIENGV TLDIDVVADF GTKVLPYLDT 1570 1580 1590 1600 1610 1620 DNRMLSTTKT SINYGERIQR LGRVGRHKPG HALRIGHTER GLSEVPSCIA TEAALKCFTY 1630 1640 1650 1660 1670 1680 GLPVITNNVS TSILGNVTVK QARTMSVFEI TPFYTSQVVR YDGSMHPQVH ALLKRFKLRD 1690 1700 1710 1720 1730 1740 SEIVLTKLAI PNRGVNAGSQ PVSMHDSVQM LKIGVTLRIP FMCRDIPEKL HLDMWDVVVK 1750 1760 1770 1780 1790 1800 FKGDAGFGRL SSSASKVAYT LQTDVNSIQR TVTIIDTLIA EERRKQEYFK TVTSNCVSSS 1810 1820 1830 1840 1850 1860 NFSLQSITNA IKSRMMKDHP CENISVLEGA KSQLLEFRNL NSDHSFVTKT DGISRSFMRD 1870 1880 1890 1900 1910 1920 YGALEAVNHQ STNEMSKFLQ LKGKWNKTLI TRDVLVICGV LGGGVWMVVQ HFRSKVSEPV 1930 1940 1950 1960 1970 1980 THEAKGKKQR QKLKFRNARD NKMGREVYGD DDTIEHFFGD AYTKKGKSKG RTRGIGHKNR 1990 2000 2010 2020 2030 2040 KFINMYGFDP EDFSAVRFVD PLTGATLDDN PFTDITLVQK HFGDIRMDLL GEDELDSNEI 2050 2060 2070 2080 2090 2100 RMNKTIQAYY MNNKTGKALK VDLTPHIPLK VCDLHATIAG FPERENELRQ TGKAQPINID 2110 2120 2130 2140 2150 2160 EVPRANNELV PVDHESNSMF RGLRDYNPIS NNICHLTNVS DGASNSLYGV GFGPLILTNR 2170 2180 2190 2200 2210 2220 HLFERNNGEL IIKSRHGEFV IKNTTQLHLL PIPDRDLLLI RLPKDVPPFP QKLGFRQPEK 2230 2240 2250 2260 2270 2280 GERICMVGSN FQTKSITSIV SETSTIMPVE NSQFWKHWIS TKDGQCGSPM VSTKDGKILG 2290 2300 2310 2320 2330 2340 LHSLANFQNS INYFAAFPDD FTEKYLHTIE AHEWVKHWKY NTSAISWGSL NIQASQPVSL 2350 2360 2370 2380 2390 2400 FKVSKLISDL DSTAVYAQTQ QNRWMFEQLT GNLKAIAHCP SQLVTKHTVK GKCQMFDLYL 2410 2420 2430 2440 2450 2460 KLHDEAREYF QPMLGQYQKS KLNREAYAKD LLKYATPIEA GNIDCDLFEK TVEIVISDLR 2470 2480 2490 2500 2510 2520 GYGFETCNYV TDENDIFEAL NMKSAVGALY KGKKKDYFAE FTPEVKEEIL KQSCERLFLG 2530 2540 2550 2560 2570 2580 KMGVWNGSLK AELRPLEKVE ANKTRTFTAA PLDTLLGGKV CVDDFNNQFY DHNLRAPWDV 2590 2600 2610 2620 2630 2640 GMTKFYCGWD RLLESLPDGW VYCDADGSQF DSSLSPYLIN AVLNIRLGFM EEWDVGEVML 2650 2660 2670 2680 2690 2700 RNLYTEIVYT PISTPDGTLV KKFKGNNSGQ PSTVVDNTLM VILAVNYSLK KGGIPSELRD 2710 2720 2730 2740 2750 2760 SIIRFFVNGD DLLLSVHPEY EYILDTMADN FRELGLKYTF DSRTREKGDL WFMSHQGHRR 2770 2780 2790 2800 2810 2820 EGIWIPKLEP ERIVSILEWD RSKEPCHRLE AICAAMIESW GYDKLTHEIR KFYAWMIEQA 2830 2840 2850 2860 2870 2880 PFSSLAQEGK APYIAETALR KLYLDKEPAQ EDLTQYLQAI FEDYEDGVEA CVYHQAGETL 2890 2900 2910 2920 2930 2940 DADLTEEQKQ AEKEKKEREK AEKERERQKQ LAFKKGKDVA QEEGKRDKEV NAGTSGTFSV 2950 2960 2970 2980 2990 3000 PRLKSLTSKM RVPRYEKRVA LNLDHLILYT PEQTDLSNTR STRKQFDTWF EGVMADYELT 3010 3020 3030 3040 3050 3060 EDKMQIILNG LRVWCIENGT SPNINGMWVM MDGDDQVEFP IKPLIDHAKP TFRQIMAHFS 3070 3080 3090 3100 3110 3120 DVAEAYIEKR NQDRPYMPRY GLQRNLTDMS LARYAFDFYE MTSRTPIRAR EAHIQMKAAA 3130 3140 3150 3160 LRGANNNLFG LDGNVGTTVE NTERHTTEDV NRNMHNLLGV QGL
	Isoform PIPO (Pretty interesting potyviridae ORF). Checksum: 4C31B83756B4CB58	FASTA	1,052	117,858
	10 20 30 40 50 60 MAAVTFASAI TNAITNKTTS TGMVQFGSFP PMPLRSTTVT TVATPVGQPK LYTVRFGSLD 70 80 90 100 110 120 PVIVKGGAGS LAKATRQQPS VEIDVSLSEA AALEVAKPKS SAVLRMHEEA NKERALFLDW 130 140 150 160 170 180 EASLKRRSYG IAENEKVVMT TRGVSKIVPR SSRAMKQKRA RERRRAQQPI ILKWEPKLSG 190 200 210 220 230 240 FSIGGGFSAS AIEAEEVRTK WPLHKTPSMK KRMVHKTCKM SDQGVDMLIR SLVKIFKAKS 250 260 270 280 290 300 ANIEYIGKKP IKVDFIRKER TKFARIQVAH LLGKRAQRDL LAGMEENHFI DILSEYSGNG 310 320 330 340 350 360 TTINPGVVCA GWSGIVVRNE TLTQKRSRSP SKAFVIRGEH EDKLYDARIK ITKTMSLKIV 370 380 390 400 410 420 HFSARGANFW KGFDRCFLAY RSDNREHTCY SGLDVTECGE VAALMCLAMF PCGKITCPDC 430 440 450 460 470 480 VIDSELSQGQ ASGPSMKHRL TQLRDVIKSS YPRFKHAVQI LDRYEQSLSS ANENYQDFAE 490 500 510 520 530 540 IQSISDGVEK AAFPHVNKLN AILIKGATAT GEEFSQATKH LLEIARYLKN RTENIEKGSL 550 560 570 580 590 600 KSFRNKVSQK AHINPTLMCD NQLDKNGNFI WGERGYHAKR FFSNYFEIID PKKGYTQYET 610 620 630 640 650 660 RVVPNGSRKL AIGKLIVPTN FEVLREQMRG EPVEPYPVTV ECVSKSQGDF VHACCCVTTE 670 680 690 700 710 720 SGDPVLSEIK MPTKHHLVIG NSGDPKYIDL PEIEENKMYI AKEGYCYINI FLAMLVNVKE 730 740 750 760 770 780 SQAKEFTKVV RDKLVSELGK WPTLLDVATA CYFLKVFYPD VANAELPRML VDHKTKIIHV 790 800 810 820 830 840 VDSYGSLSTG YHVLKTNTVE QLIKFTRCNL ESSLKHYRVG GTEWENAHGA DNIDNPQWCI 850 860 870 880 890 900 KRLVKGVYRP KQLKEDMLAN PFLPLYALLS PGVILAFYNS GSLEHLMNHY ISADSNVAVL 910 920 930 940 950 960 LVVLKSLAKK VSTSQSVLAQ LQIIERSLPE LIEAKANING PDDAATRACN RFMGMLLHMA 970 980 990 1000 1010 1020 EPNYELANGG YTFLRDHSIS IGKKLSSADL GRGMERVKLV GALCYKILPV KASNLYTERF 1030 1040 1050 ANAKRSRFRR QIQRVGHILL RVEQTASKRS ER

References

[1]	"The complete nucleotide sequence of turnip mosaic potyvirus RNA." Nicolas O., Laliberte J.F. J. Gen. Virol. 73:2785-2793(1992) [PubMed: 1431807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] (ISOFORM GENOME POLYPROTEIN).
[2]	"Sequence of the 3'-terminal region of turnip mosaic virus RNA and the capsid protein gene." Tremblay M.F., Nicolas O., Sinha R., Lazure C., Laliberte J.F. J. Gen. Virol. 71:2769-2772(1990) [PubMed: 2254757] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1534-3163 (ISOFORM GENOME POLYPROTEIN), PARTIAL PROTEIN SEQUENCE.
[3]	"An overlapping essential gene in the Potyviridae." Chung B.Y.-W., Miller W.A., Atkins J.F., Firth A.E. Proc. Natl. Acad. Sci. U.S.A. 105:5897-5902(2008) [PubMed: 18408156] [Abstract] Cited for: RIBOSOMAL FRAMESHIFT (ISOFORM PIPO).
[4]	"Potyvirus proteins: a wealth of functions." Urcuqui-Inchima S., Haenni A.L., Bernardi F. Virus Res. 74:157-175(2001) [PubMed: 11226583] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10927 Genomic RNA. Translation: BAA01725.1. D10601 Genomic RNA. Translation: BAA01452.1.
PIR	JQ1895.
3D structure databases
SMR	Q02597. Positions 1305-1596, 1313-1673, 2124-2337.
ModBase	Search...
Protein family/group databases
MEROPS	C04.001.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR002540. Pept_S30_P1_potyvir. IPR001730. Peptidase_C4. IPR001456. Peptidase_C6. IPR001592. Poty_coat. IPR013648. PP_Potyviridae. IPR001205. RNA-dir_pol_picornavirus. IPR007094. RNA-dir_pol_PSvirus. IPR009003. Ser/Cys_Pept_Trypsin-like. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. PF00863. Peptidase_C4. 1 hit. PF00851. Peptidase_C6. 1 hit. PF01577. Peptidase_S30. 1 hit. PF00767. Poty_coat. 1 hit. PF08440. Poty_PP. 1 hit. PF00680. RdRP_1. 1 hit. [Graphical view]
PRINTS	PR00966. NIAPOTYPTASE.
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50507. RDRP_SSRNA_POS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POLG_TUMVQ

Accession

Primary (citable) accession number: Q02597

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	June 1, 1994
Last modified:	January 19, 2010
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)