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Protein

Glycosylation-dependent cell adhesion molecule 1

Gene

Glycam1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L-selectin.

GO - Molecular functioni

  • cell adhesion molecule binding Source: MGI
  • sulfate binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosylation-dependent cell adhesion molecule 1
Short name:
GlyCAM-1
Alternative name(s):
Endothelial ligand FOR L-selectin
MC26
SGP50
Sulfated 50 kDa glycoprotein
Gene namesi
Name:Glycam1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:95759. Glycam1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 151132Glycosylation-dependent cell adhesion molecule 1PRO_0000025406Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei59 – 591PhosphoserineBy similarity
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei71 – 711PhosphoserineBy similarity
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ02596.
PaxDbiQ02596.
PRIDEiQ02596.

PTM databases

PhosphoSiteiQ02596.

Expressioni

Tissue specificityi

Lymph nodes. Associated with the lumenal surface of the high endothelial venules of peripheral lymph nodes.

Gene expression databases

BgeeiENSMUSG00000022491.
CleanExiMM_GLYCAM1.
GenevisibleiQ02596. MM.

Interactioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023134.

Structurei

3D structure databases

ProteinModelPortaliQ02596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 6322Ser/Thr-richAdd
BLAST
Compositional biasi93 – 12230Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the PP3/GlyCAM-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFZZ. Eukaryota.
ENOG41117RE. LUCA.
GeneTreeiENSGT00520000060242.
HOGENOMiHOG000290655.
HOVERGENiHBG106667.
InParanoidiQ02596.
KOiK06815.
OrthoDBiEOG091G180P.
PhylomeDBiQ02596.
TreeFamiTF339780.

Family and domain databases

InterProiIPR007906. GLYCAM-1.
[Graphical view]
PfamiPF05242. GLYCAM-1. 1 hit.
[Graphical view]
ProDomiPD012695. PD012695. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFTVLLFV SLAATSLALL PGSKDELQMK TQPTDAIPAA QSTPTSYTSE
60 70 80 90 100
ESTSSKDLSK EPSIFREELI SKDNVVIEST KPENQEAQDG LRSGSSQLEE
110 120 130 140 150
TTRPTTSAAT TSEENLTKSS QTVEEELGKI IEGFVTGAED IISGASRITK

S
Length:151
Mass (Da):16,209
Last modified:July 1, 1993 - v1
Checksum:i274E66AA05534A77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08101 Genomic DNA. Translation: AAA79887.1.
M93428 mRNA. Translation: AAA37710.1.
D16108 Genomic DNA. Translation: BAA03682.1.
AK021358 mRNA. Translation: BAB32385.1.
BC145832 mRNA. Translation: AAI45833.1.
BC145858 mRNA. Translation: AAI45859.1.
CCDSiCCDS27905.1.
PIRiA41908.
RefSeqiNP_032160.1. NM_008134.3.
UniGeneiMm.219621.

Genome annotation databases

EnsembliENSMUST00000023134; ENSMUSP00000023134; ENSMUSG00000022491.
GeneIDi14663.
KEGGimmu:14663.
UCSCiuc007xyk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08101 Genomic DNA. Translation: AAA79887.1.
M93428 mRNA. Translation: AAA37710.1.
D16108 Genomic DNA. Translation: BAA03682.1.
AK021358 mRNA. Translation: BAB32385.1.
BC145832 mRNA. Translation: AAI45833.1.
BC145858 mRNA. Translation: AAI45859.1.
CCDSiCCDS27905.1.
PIRiA41908.
RefSeqiNP_032160.1. NM_008134.3.
UniGeneiMm.219621.

3D structure databases

ProteinModelPortaliQ02596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023134.

PTM databases

PhosphoSiteiQ02596.

Proteomic databases

MaxQBiQ02596.
PaxDbiQ02596.
PRIDEiQ02596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023134; ENSMUSP00000023134; ENSMUSG00000022491.
GeneIDi14663.
KEGGimmu:14663.
UCSCiuc007xyk.2. mouse.

Organism-specific databases

CTDi644076.
MGIiMGI:95759. Glycam1.

Phylogenomic databases

eggNOGiENOG410JFZZ. Eukaryota.
ENOG41117RE. LUCA.
GeneTreeiENSGT00520000060242.
HOGENOMiHOG000290655.
HOVERGENiHBG106667.
InParanoidiQ02596.
KOiK06815.
OrthoDBiEOG091G180P.
PhylomeDBiQ02596.
TreeFamiTF339780.

Miscellaneous databases

ChiTaRSiGlycam1. mouse.
PROiQ02596.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022491.
CleanExiMM_GLYCAM1.
GenevisibleiQ02596. MM.

Family and domain databases

InterProiIPR007906. GLYCAM-1.
[Graphical view]
PfamiPF05242. GLYCAM-1. 1 hit.
[Graphical view]
ProDomiPD012695. PD012695. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiGLCM1_MOUSE
AccessioniPrimary (citable) accession number: Q02596
Secondary accession number(s): A6H6D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.