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Q02591 (GSC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein goosecoid
Gene names
Name:Gsc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis By similarity. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Ref.3

Subcellular location

Nucleus.

Tissue specificity

In early gastrulation, expressed in the dorsal lip. In later stages of development found in head, limbs and body wall.

Induction

By activin.

Sequence similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanatomical structure morphogenesis

Inferred from genetic interaction PubMed 9226455. Source: MGI

dorsal/ventral neural tube patterning

Inferred from genetic interaction PubMed 9226455. Source: MGI

ear development

Inferred from mutant phenotype PubMed 7555718. Source: MGI

embryonic skeletal system morphogenesis

Inferred from mutant phenotype PubMed 7555718PubMed 7555726. Source: MGI

forebrain development

Inferred from genetic interaction PubMed 17127040. Source: MGI

middle ear morphogenesis

Inferred from mutant phenotype Ref.3. Source: UniProtKB

muscle organ morphogenesis

Inferred from mutant phenotype PubMed 7555718. Source: MGI

negative regulation of Wnt signaling pathway

Inferred from mutant phenotype PubMed 17127040. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 17568773. Source: MGI

signal transduction involved in regulation of gene expression

Inferred from direct assay PubMed 18462699. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from direct assay PubMed 17568773. Source: MGI

   Molecular_functionRNA polymerase II repressing transcription factor binding

Inferred from physical interaction PubMed 22164283. Source: BHF-UCL

RNA polymerase II transcription factor binding

Inferred from physical interaction PubMed 22164283. Source: BHF-UCL

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Homeobox protein goosecoid
PRO_0000048886

Regions

DNA binding160 – 21960Homeobox

Sequences

Sequence LengthMass (Da)Tools
Q02591 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 3639FB059AC3DB9E

FASTA25627,980
        10         20         30         40         50         60 
MPASMFSIDN ILAARPRCKD AVLPVAPSAA APVVFPALHG DSLYGAGGGT SSDYGAFYPR 

        70         80         90        100        110        120 
PVAPGGAGLP AAVGSSRLGY NSYFYGQLHV QAAPVGPACC GAVPPLGAQQ CSCVPTPPGY 

       130        140        150        160        170        180 
EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ LLNQLHCRRK RRHRTIFTDE QLEALENLFQ 

       190        200        210        220        230        240 
ETKYPDVGTR EQLARKVHLR EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSKAS 

       250 
PEKREEEGKS DLDSDS 

« Hide

References

[1]"Gastrulation in the mouse: the role of the homeobox gene goosecoid."
Blum M., Gaunt S.J., Cho K.W.Y., Steinbeisser H., Blumberg B., Bittner D.A., De Robertis E.M.
Cell 69:1097-1106(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Negative autoregulation of the organizer-specific homeobox gene goosecoid."
Danilov V., Blum M., Schweickert A., Campione M., Steinbeisser H.
J. Biol. Chem. 273:627-635(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[3]"Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution."
Tucker A.S., Watson R.P., Lettice L.A., Yamada G., Hill R.E.
Development 131:1235-1245(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M85271 Genomic DNA. Translation: AAA37826.1.
Y13149 mRNA. Translation: CAA73611.1.
Y13150 mRNA. Translation: CAA73612.1.
PIRA42768.
RefSeqNP_034481.1. NM_010351.1.
UniGeneMm.129.

3D structure databases

ProteinModelPortalQ02591.
SMRQ02591. Positions 161-222.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200082. 6 interactions.
IntActQ02591. 4 interactions.
MINTMINT-4998459.
STRING10090.ENSMUSP00000021513.

PTM databases

PhosphoSiteQ02591.

Proteomic databases

PRIDEQ02591.

Protocols and materials databases

DNASU14836.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021513; ENSMUSP00000021513; ENSMUSG00000021095.
GeneID14836.
KEGGmmu:14836.
UCSCuc007oxh.1. mouse.

Organism-specific databases

CTD145258.
MGIMGI:95841. Gsc.

Phylogenomic databases

eggNOGNOG247162.
GeneTreeENSGT00750000117284.
HOGENOMHOG000112823.
HOVERGENHBG005921.
InParanoidQ02591.
KOK09324.
OMAPVGPSCC.
OrthoDBEOG78SQKS.
PhylomeDBQ02591.
TreeFamTF351613.

Gene expression databases

BgeeQ02591.
CleanExMM_GSC.
GenevestigatorQ02591.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287051.
PROQ02591.
SOURCESearch...

Entry information

Entry nameGSC_MOUSE
AccessionPrimary (citable) accession number: Q02591
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot