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Protein

Homeobox protein goosecoid

Gene

Gsc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi160 – 21960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • dorsal/ventral neural tube patterning Source: MGI
  • ear development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • forebrain development Source: MGI
  • middle ear morphogenesis Source: UniProtKB
  • muscle organ morphogenesis Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • negative regulation of Wnt signaling pathway Source: MGI
  • neural crest cell fate specification Source: UniProtKB
  • signal transduction involved in regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein goosecoid
Gene namesi
Name:Gsc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:95841. Gsc.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Homeobox protein goosecoidPRO_0000048886Add
BLAST

Proteomic databases

PRIDEiQ02591.

PTM databases

PhosphoSiteiQ02591.

Expressioni

Tissue specificityi

In early gastrulation, expressed in the dorsal lip. In later stages of development found in head, limbs and body wall. In the embryo, expressed in the postotic cranial neural crest cells, the frontonasal prominence, the first branchial arch and cleft, and specific regions of large joints.1 Publication

Inductioni

By activin.

Gene expression databases

BgeeiQ02591.
CleanExiMM_GSC.
GenevisibleiQ02591. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Foxh1O886212EBI-7457485,EBI-7457430
Hdac1O091062EBI-7457485,EBI-301912

Protein-protein interaction databases

BioGridi200082. 6 interactions.
IntActiQ02591. 4 interactions.
MINTiMINT-4998459.
STRINGi10090.ENSMUSP00000021513.

Structurei

3D structure databases

ProteinModelPortaliQ02591.
SMRiQ02591. Positions 161-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG247162.
GeneTreeiENSGT00760000118908.
HOGENOMiHOG000112823.
HOVERGENiHBG005921.
InParanoidiQ02591.
KOiK09324.
OMAiPVGPSCC.
OrthoDBiEOG78SQKS.
PhylomeDBiQ02591.
TreeFamiTF351613.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASMFSIDN ILAARPRCKD AVLPVAPSAA APVVFPALHG DSLYGAGGGT
60 70 80 90 100
SSDYGAFYPR PVAPGGAGLP AAVGSSRLGY NSYFYGQLHV QAAPVGPACC
110 120 130 140 150
GAVPPLGAQQ CSCVPTPPGY EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ
160 170 180 190 200
LLNQLHCRRK RRHRTIFTDE QLEALENLFQ ETKYPDVGTR EQLARKVHLR
210 220 230 240 250
EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSKAS PEKREEEGKS

DLDSDS
Length:256
Mass (Da):27,980
Last modified:February 1, 1994 - v1
Checksum:i3639FB059AC3DB9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85271 Genomic DNA. Translation: AAA37826.1.
Y13149 mRNA. Translation: CAA73611.1.
Y13150 mRNA. Translation: CAA73612.1.
CCDSiCCDS26153.1.
PIRiA42768.
RefSeqiNP_034481.1. NM_010351.1.
UniGeneiMm.129.

Genome annotation databases

EnsembliENSMUST00000021513; ENSMUSP00000021513; ENSMUSG00000021095.
GeneIDi14836.
KEGGimmu:14836.
UCSCiuc007oxh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85271 Genomic DNA. Translation: AAA37826.1.
Y13149 mRNA. Translation: CAA73611.1.
Y13150 mRNA. Translation: CAA73612.1.
CCDSiCCDS26153.1.
PIRiA42768.
RefSeqiNP_034481.1. NM_010351.1.
UniGeneiMm.129.

3D structure databases

ProteinModelPortaliQ02591.
SMRiQ02591. Positions 161-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200082. 6 interactions.
IntActiQ02591. 4 interactions.
MINTiMINT-4998459.
STRINGi10090.ENSMUSP00000021513.

PTM databases

PhosphoSiteiQ02591.

Proteomic databases

PRIDEiQ02591.

Protocols and materials databases

DNASUi14836.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021513; ENSMUSP00000021513; ENSMUSG00000021095.
GeneIDi14836.
KEGGimmu:14836.
UCSCiuc007oxh.1. mouse.

Organism-specific databases

CTDi145258.
MGIiMGI:95841. Gsc.

Phylogenomic databases

eggNOGiNOG247162.
GeneTreeiENSGT00760000118908.
HOGENOMiHOG000112823.
HOVERGENiHBG005921.
InParanoidiQ02591.
KOiK09324.
OMAiPVGPSCC.
OrthoDBiEOG78SQKS.
PhylomeDBiQ02591.
TreeFamiTF351613.

Miscellaneous databases

NextBioi287051.
PROiQ02591.
SOURCEiSearch...

Gene expression databases

BgeeiQ02591.
CleanExiMM_GSC.
GenevisibleiQ02591. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gastrulation in the mouse: the role of the homeobox gene goosecoid."
    Blum M., Gaunt S.J., Cho K.W.Y., Steinbeisser H., Blumberg B., Bittner D.A., De Robertis E.M.
    Cell 69:1097-1106(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Negative autoregulation of the organizer-specific homeobox gene goosecoid."
    Danilov V., Blum M., Schweickert A., Campione M., Steinbeisser H.
    J. Biol. Chem. 273:627-635(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution."
    Tucker A.S., Watson R.P., Lettice L.A., Yamada G., Hill R.E.
    Development 131:1235-1245(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid."
    Parry D.A., Logan C.V., Stegmann A.P., Abdelhamed Z.A., Calder A., Khan S., Bonthron D.T., Clowes V., Sheridan E., Ghali N., Chudley A.E., Dobbie A., Stumpel C.T., Johnson C.A.
    Am. J. Hum. Genet. 93:1135-1142(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGSC_MOUSE
AccessioniPrimary (citable) accession number: Q02591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 24, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.