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Q02591

- GSC_MOUSE

UniProt

Q02591 - GSC_MOUSE

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Protein

Homeobox protein goosecoid

Gene

Gsc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi160 – 21960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  2. RNA polymerase II transcription factor binding Source: BHF-UCL
  3. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anatomical structure morphogenesis Source: MGI
  2. dorsal/ventral neural tube patterning Source: MGI
  3. ear development Source: MGI
  4. embryonic skeletal system morphogenesis Source: MGI
  5. forebrain development Source: MGI
  6. middle ear morphogenesis Source: UniProtKB
  7. muscle organ morphogenesis Source: MGI
  8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  9. negative regulation of Wnt signaling pathway Source: MGI
  10. neural crest cell fate specification Source: UniProtKB
  11. signal transduction involved in regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein goosecoid
Gene namesi
Name:Gsc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:95841. Gsc.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Homeobox protein goosecoidPRO_0000048886Add
BLAST

Proteomic databases

PRIDEiQ02591.

PTM databases

PhosphoSiteiQ02591.

Expressioni

Tissue specificityi

In early gastrulation, expressed in the dorsal lip. In later stages of development found in head, limbs and body wall. In the embryo, expressed in the postotic cranial neural crest cells, the frontonasal prominence, the first branchial arch and cleft, and specific regions of large joints.1 Publication

Inductioni

By activin.

Gene expression databases

BgeeiQ02591.
CleanExiMM_GSC.
GenevestigatoriQ02591.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Foxh1O886212EBI-7457485,EBI-7457430
Hdac1O091062EBI-7457485,EBI-301912

Protein-protein interaction databases

BioGridi200082. 6 interactions.
IntActiQ02591. 4 interactions.
MINTiMINT-4998459.
STRINGi10090.ENSMUSP00000021513.

Structurei

3D structure databases

ProteinModelPortaliQ02591.
SMRiQ02591. Positions 161-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG247162.
GeneTreeiENSGT00760000118908.
HOGENOMiHOG000112823.
HOVERGENiHBG005921.
InParanoidiQ02591.
KOiK09324.
OMAiPVGPSCC.
OrthoDBiEOG78SQKS.
PhylomeDBiQ02591.
TreeFamiTF351613.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02591-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPASMFSIDN ILAARPRCKD AVLPVAPSAA APVVFPALHG DSLYGAGGGT
60 70 80 90 100
SSDYGAFYPR PVAPGGAGLP AAVGSSRLGY NSYFYGQLHV QAAPVGPACC
110 120 130 140 150
GAVPPLGAQQ CSCVPTPPGY EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ
160 170 180 190 200
LLNQLHCRRK RRHRTIFTDE QLEALENLFQ ETKYPDVGTR EQLARKVHLR
210 220 230 240 250
EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSKAS PEKREEEGKS

DLDSDS
Length:256
Mass (Da):27,980
Last modified:February 1, 1994 - v1
Checksum:i3639FB059AC3DB9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M85271 Genomic DNA. Translation: AAA37826.1.
Y13149 mRNA. Translation: CAA73611.1.
Y13150 mRNA. Translation: CAA73612.1.
CCDSiCCDS26153.1.
PIRiA42768.
RefSeqiNP_034481.1. NM_010351.1.
UniGeneiMm.129.

Genome annotation databases

EnsembliENSMUST00000021513; ENSMUSP00000021513; ENSMUSG00000021095.
GeneIDi14836.
KEGGimmu:14836.
UCSCiuc007oxh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M85271 Genomic DNA. Translation: AAA37826.1 .
Y13149 mRNA. Translation: CAA73611.1 .
Y13150 mRNA. Translation: CAA73612.1 .
CCDSi CCDS26153.1.
PIRi A42768.
RefSeqi NP_034481.1. NM_010351.1.
UniGenei Mm.129.

3D structure databases

ProteinModelPortali Q02591.
SMRi Q02591. Positions 161-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200082. 6 interactions.
IntActi Q02591. 4 interactions.
MINTi MINT-4998459.
STRINGi 10090.ENSMUSP00000021513.

PTM databases

PhosphoSitei Q02591.

Proteomic databases

PRIDEi Q02591.

Protocols and materials databases

DNASUi 14836.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021513 ; ENSMUSP00000021513 ; ENSMUSG00000021095 .
GeneIDi 14836.
KEGGi mmu:14836.
UCSCi uc007oxh.1. mouse.

Organism-specific databases

CTDi 145258.
MGIi MGI:95841. Gsc.

Phylogenomic databases

eggNOGi NOG247162.
GeneTreei ENSGT00760000118908.
HOGENOMi HOG000112823.
HOVERGENi HBG005921.
InParanoidi Q02591.
KOi K09324.
OMAi PVGPSCC.
OrthoDBi EOG78SQKS.
PhylomeDBi Q02591.
TreeFami TF351613.

Miscellaneous databases

NextBioi 287051.
PROi Q02591.
SOURCEi Search...

Gene expression databases

Bgeei Q02591.
CleanExi MM_GSC.
Genevestigatori Q02591.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gastrulation in the mouse: the role of the homeobox gene goosecoid."
    Blum M., Gaunt S.J., Cho K.W.Y., Steinbeisser H., Blumberg B., Bittner D.A., De Robertis E.M.
    Cell 69:1097-1106(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Negative autoregulation of the organizer-specific homeobox gene goosecoid."
    Danilov V., Blum M., Schweickert A., Campione M., Steinbeisser H.
    J. Biol. Chem. 273:627-635(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution."
    Tucker A.S., Watson R.P., Lettice L.A., Yamada G., Hill R.E.
    Development 131:1235-1245(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid."
    Parry D.A., Logan C.V., Stegmann A.P., Abdelhamed Z.A., Calder A., Khan S., Bonthron D.T., Clowes V., Sheridan E., Ghali N., Chudley A.E., Dobbie A., Stumpel C.T., Johnson C.A.
    Am. J. Hum. Genet. 93:1135-1142(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGSC_MOUSE
AccessioniPrimary (citable) accession number: Q02591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3