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Protein

Homeobox protein goosecoid

Gene

Gsc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi160 – 219HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • dorsal/ventral neural tube patterning Source: MGI
  • ear development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • forebrain development Source: MGI
  • middle ear morphogenesis Source: UniProtKB
  • muscle organ morphogenesis Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • negative regulation of Wnt signaling pathway Source: MGI
  • neural crest cell fate specification Source: UniProtKB
  • signal transduction involved in regulation of gene expression Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein goosecoid
Gene namesi
Name:Gsc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:95841 Gsc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488861 – 256Homeobox protein goosecoidAdd BLAST256

Proteomic databases

PaxDbiQ02591
PeptideAtlasiQ02591
PRIDEiQ02591

PTM databases

iPTMnetiQ02591
PhosphoSitePlusiQ02591

Expressioni

Tissue specificityi

In early gastrulation, expressed in the dorsal lip. In later stages of development found in head, limbs and body wall. In the embryo, expressed in the postotic cranial neural crest cells, the frontonasal prominence, the first branchial arch and cleft, and specific regions of large joints.1 Publication

Inductioni

By activin.

Gene expression databases

BgeeiENSMUSG00000021095
CleanExiMM_GSC
GenevisibleiQ02591 MM

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi200082, 6 interactors
IntActiQ02591, 9 interactors
MINTiQ02591
STRINGi10090.ENSMUSP00000021513

Structurei

3D structure databases

ProteinModelPortaliQ02591
SMRiQ02591
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140776
HOGENOMiHOG000112823
HOVERGENiHBG005921
InParanoidiQ02591
KOiK09324
OMAiPVGPSCC
OrthoDBiEOG091G0OQ6
PhylomeDBiQ02591
TreeFamiTF351613

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q02591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASMFSIDN ILAARPRCKD AVLPVAPSAA APVVFPALHG DSLYGAGGGT
60 70 80 90 100
SSDYGAFYPR PVAPGGAGLP AAVGSSRLGY NSYFYGQLHV QAAPVGPACC
110 120 130 140 150
GAVPPLGAQQ CSCVPTPPGY EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ
160 170 180 190 200
LLNQLHCRRK RRHRTIFTDE QLEALENLFQ ETKYPDVGTR EQLARKVHLR
210 220 230 240 250
EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSKAS PEKREEEGKS

DLDSDS
Length:256
Mass (Da):27,980
Last modified:February 1, 1994 - v1
Checksum:i3639FB059AC3DB9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85271 Genomic DNA Translation: AAA37826.1
Y13149 mRNA Translation: CAA73611.1
Y13150 mRNA Translation: CAA73612.1
CCDSiCCDS26153.1
PIRiA42768
RefSeqiNP_034481.1, NM_010351.1
UniGeneiMm.129

Genome annotation databases

EnsembliENSMUST00000021513; ENSMUSP00000021513; ENSMUSG00000021095
GeneIDi14836
KEGGimmu:14836
UCSCiuc007oxh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGSC_MOUSE
AccessioniPrimary (citable) accession number: Q02591
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health