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Q02591

- GSC_MOUSE

UniProt

Q02591 - GSC_MOUSE

Protein

Homeobox protein goosecoid

Gene

Gsc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis By similarity. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi160 – 21960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II repressing transcription factor binding Source: BHF-UCL
    3. RNA polymerase II transcription factor binding Source: BHF-UCL
    4. sequence-specific DNA binding Source: InterPro
    5. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anatomical structure morphogenesis Source: MGI
    2. dorsal/ventral neural tube patterning Source: MGI
    3. ear development Source: MGI
    4. embryonic skeletal system morphogenesis Source: MGI
    5. forebrain development Source: MGI
    6. middle ear morphogenesis Source: UniProtKB
    7. muscle organ morphogenesis Source: MGI
    8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    9. negative regulation of Wnt signaling pathway Source: MGI
    10. neural crest cell fate specification Source: UniProtKB
    11. signal transduction involved in regulation of gene expression Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein goosecoid
    Gene namesi
    Name:Gsc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:95841. Gsc.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Homeobox protein goosecoidPRO_0000048886Add
    BLAST

    Proteomic databases

    PRIDEiQ02591.

    PTM databases

    PhosphoSiteiQ02591.

    Expressioni

    Tissue specificityi

    In early gastrulation, expressed in the dorsal lip. In later stages of development found in head, limbs and body wall. In the embryo, expressed in the postotic cranial neural crest cells, the frontonasal prominence, the first branchial arch and cleft, and specific regions of large joints.1 Publication

    Inductioni

    By activin.

    Gene expression databases

    BgeeiQ02591.
    CleanExiMM_GSC.
    GenevestigatoriQ02591.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Foxh1O886212EBI-7457485,EBI-7457430
    Hdac1O091062EBI-7457485,EBI-301912

    Protein-protein interaction databases

    BioGridi200082. 6 interactions.
    IntActiQ02591. 4 interactions.
    MINTiMINT-4998459.
    STRINGi10090.ENSMUSP00000021513.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02591.
    SMRiQ02591. Positions 161-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG247162.
    GeneTreeiENSGT00750000117284.
    HOGENOMiHOG000112823.
    HOVERGENiHBG005921.
    InParanoidiQ02591.
    KOiK09324.
    OMAiPVGPSCC.
    OrthoDBiEOG78SQKS.
    PhylomeDBiQ02591.
    TreeFamiTF351613.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02591-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPASMFSIDN ILAARPRCKD AVLPVAPSAA APVVFPALHG DSLYGAGGGT    50
    SSDYGAFYPR PVAPGGAGLP AAVGSSRLGY NSYFYGQLHV QAAPVGPACC 100
    GAVPPLGAQQ CSCVPTPPGY EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ 150
    LLNQLHCRRK RRHRTIFTDE QLEALENLFQ ETKYPDVGTR EQLARKVHLR 200
    EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSKAS PEKREEEGKS 250
    DLDSDS 256
    Length:256
    Mass (Da):27,980
    Last modified:February 1, 1994 - v1
    Checksum:i3639FB059AC3DB9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M85271 Genomic DNA. Translation: AAA37826.1.
    Y13149 mRNA. Translation: CAA73611.1.
    Y13150 mRNA. Translation: CAA73612.1.
    CCDSiCCDS26153.1.
    PIRiA42768.
    RefSeqiNP_034481.1. NM_010351.1.
    UniGeneiMm.129.

    Genome annotation databases

    EnsembliENSMUST00000021513; ENSMUSP00000021513; ENSMUSG00000021095.
    GeneIDi14836.
    KEGGimmu:14836.
    UCSCiuc007oxh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M85271 Genomic DNA. Translation: AAA37826.1 .
    Y13149 mRNA. Translation: CAA73611.1 .
    Y13150 mRNA. Translation: CAA73612.1 .
    CCDSi CCDS26153.1.
    PIRi A42768.
    RefSeqi NP_034481.1. NM_010351.1.
    UniGenei Mm.129.

    3D structure databases

    ProteinModelPortali Q02591.
    SMRi Q02591. Positions 161-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200082. 6 interactions.
    IntActi Q02591. 4 interactions.
    MINTi MINT-4998459.
    STRINGi 10090.ENSMUSP00000021513.

    PTM databases

    PhosphoSitei Q02591.

    Proteomic databases

    PRIDEi Q02591.

    Protocols and materials databases

    DNASUi 14836.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021513 ; ENSMUSP00000021513 ; ENSMUSG00000021095 .
    GeneIDi 14836.
    KEGGi mmu:14836.
    UCSCi uc007oxh.1. mouse.

    Organism-specific databases

    CTDi 145258.
    MGIi MGI:95841. Gsc.

    Phylogenomic databases

    eggNOGi NOG247162.
    GeneTreei ENSGT00750000117284.
    HOGENOMi HOG000112823.
    HOVERGENi HBG005921.
    InParanoidi Q02591.
    KOi K09324.
    OMAi PVGPSCC.
    OrthoDBi EOG78SQKS.
    PhylomeDBi Q02591.
    TreeFami TF351613.

    Miscellaneous databases

    NextBioi 287051.
    PROi Q02591.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02591.
    CleanExi MM_GSC.
    Genevestigatori Q02591.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gastrulation in the mouse: the role of the homeobox gene goosecoid."
      Blum M., Gaunt S.J., Cho K.W.Y., Steinbeisser H., Blumberg B., Bittner D.A., De Robertis E.M.
      Cell 69:1097-1106(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Negative autoregulation of the organizer-specific homeobox gene goosecoid."
      Danilov V., Blum M., Schweickert A., Campione M., Steinbeisser H.
      J. Biol. Chem. 273:627-635(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    3. "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution."
      Tucker A.S., Watson R.P., Lettice L.A., Yamada G., Hill R.E.
      Development 131:1235-1245(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid."
      Parry D.A., Logan C.V., Stegmann A.P., Abdelhamed Z.A., Calder A., Khan S., Bonthron D.T., Clowes V., Sheridan E., Ghali N., Chudley A.E., Dobbie A., Stumpel C.T., Johnson C.A.
      Am. J. Hum. Genet. 93:1135-1142(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGSC_MOUSE
    AccessioniPrimary (citable) accession number: Q02591
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3