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Protein

[Protein ADP-ribosylarginine] hydrolase

Gene

Adprh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reverse reaction of mono-ADP-ribosylation.

Catalytic activityi

Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine.
N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine.

Enzyme regulationi

Its activity is synergistically stimulated by magnesium and dithiothreitol (DTT) in vitro.

GO - Molecular functioni

  • ADP-ribosylarginine hydrolase activity Source: UniProtKB
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • cellular protein modification process Source: UniProtKB
  • protein de-ADP-ribosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
[Protein ADP-ribosylarginine] hydrolase (EC:3.2.2.19)
Short name:
ADP-ribosylarginine hydrolase
Alternative name(s):
ADP-ribose-L-arginine cleaving enzyme
Gene namesi
Name:Adprh
Synonyms:Arh1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi2052. Adprh.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362[Protein ADP-ribosylarginine] hydrolasePRO_0000157285Add
BLAST

Proteomic databases

PaxDbiQ02589.
PRIDEiQ02589.

PTM databases

iPTMnetiQ02589.

Expressioni

Gene expression databases

GenevisibleiQ02589. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034815.

Structurei

3D structure databases

ProteinModelPortaliQ02589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosylglycohydrolase family.Curated

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00530000063627.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiQ02589.
KOiK01245.
OMAiPPRQWGK.
OrthoDBiEOG7SFHWT.
PhylomeDBiQ02589.
TreeFamiTF329417.

Family and domain databases

InterProiIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamiPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGLIERYV AAMVLSAAGD TLGYFNGKWE FLRDGEKIHR QLAQMGDLEA
60 70 80 90 100
IDVAQWRVSD DTIMHLATAE ALMEAGSSPD LPQLYSLLAK HYRDCMGDMD
110 120 130 140 150
GRAPGGACMQ NAMQLDPDRA DGWRIPFNSH EGGCGAAMRA MCIGLRFPHP
160 170 180 190 200
SQLDTLIQVS IESGRMTHHH PTGYLGSLAS ALFTAYAVNG KSPRQWGKGL
210 220 230 240 250
MEVLPEAKAY VTQSGYFVKE NLQHWSYFEK EWEKYLELRG ILDGKSAPVF
260 270 280 290 300
PKPFGVKERD QFYIEVSYSG WGGSSGHDAP MIAYDALLAA GDSWKELAHR
310 320 330 340 350
AFFHGGDSDS TATIAGCWWG VMHGFKGVNP SNYEKLEYRQ RLEEAGRALY
360
SLGSKEDTIL GP
Length:362
Mass (Da):39,961
Last modified:May 29, 2007 - v2
Checksum:i6C941A940AEAE10E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521K → Q in AAA40691 (PubMed:1375222).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86341 mRNA. Translation: AAA40691.1.
BC082065 mRNA. Translation: AAH82065.1.
PIRiA38135.
RefSeqiNP_899154.2. NM_183325.2.
XP_006248422.1. XM_006248360.2.
UniGeneiRn.13315.

Genome annotation databases

EnsembliENSRNOT00000038439; ENSRNOP00000034815; ENSRNOG00000027260.
GeneIDi25371.
KEGGirno:25371.
UCSCiRGD:2052. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86341 mRNA. Translation: AAA40691.1.
BC082065 mRNA. Translation: AAH82065.1.
PIRiA38135.
RefSeqiNP_899154.2. NM_183325.2.
XP_006248422.1. XM_006248360.2.
UniGeneiRn.13315.

3D structure databases

ProteinModelPortaliQ02589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034815.

PTM databases

iPTMnetiQ02589.

Proteomic databases

PaxDbiQ02589.
PRIDEiQ02589.

Protocols and materials databases

DNASUi25371.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038439; ENSRNOP00000034815; ENSRNOG00000027260.
GeneIDi25371.
KEGGirno:25371.
UCSCiRGD:2052. rat.

Organism-specific databases

CTDi141.
RGDi2052. Adprh.

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00530000063627.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiQ02589.
KOiK01245.
OMAiPPRQWGK.
OrthoDBiEOG7SFHWT.
PhylomeDBiQ02589.
TreeFamiTF329417.

Miscellaneous databases

PROiQ02589.

Gene expression databases

GenevisibleiQ02589. RN.

Family and domain databases

InterProiIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamiPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and immunological characterization of ADP-ribosylarginine hydrolases."
    Moss J., Stanley S.J., Nightingale M.S., Murtagh J.J. Jr., Monaco L., Mishima K., Chen H.C., Williamson K.C., Tsai S.C.
    J. Biol. Chem. 267:10481-10488(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 147-165, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.

Entry informationi

Entry nameiADPRH_RAT
AccessioniPrimary (citable) accession number: Q02589
Secondary accession number(s): Q66H27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 29, 2007
Last modified: July 6, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.