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Protein

Helix-loop-helix protein 1

Gene

Nhlh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helix-loop-helix protein 1
Short name:
HEN-1
Alternative name(s):
Nescient helix loop helix 1
Short name:
NSCL-1
Gene namesi
Name:Nhlh1
Synonyms:Hen1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98481. Nhlh1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133Helix-loop-helix protein 1PRO_0000127198Add
BLAST

Proteomic databases

PaxDbiQ02576.
PRIDEiQ02576.

PTM databases

PhosphoSiteiQ02576.

Expressioni

Gene expression databases

BgeeiQ02576.
CleanExiMM_NHLH1.
GenevisibleiQ02576. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057489.

Structurei

3D structure databases

ProteinModelPortaliQ02576.
SMRiQ02576. Positions 82-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 12753bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 716Poly-Arg

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000016617.
HOVERGENiHBG016345.
InParanoidiQ02576.
KOiK09075.
OMAiMMLNSDA.
OrthoDBiEOG7G1V82.
PhylomeDBiQ02576.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLNSDTMEL DLPPTHSETE SGFSDCGGGP GPDGAGSGDP GVVQVRSSEL
60 70 80 90 100
GESGRKDLQH LSREERRRRR RATAKYRTAH ATRERIRVEA FNLAFAELRK
110 120 130
LLPTLPPDKK LSKIEILRLA ICYISYLNHV LDV
Length:133
Mass (Da):14,830
Last modified:July 1, 1993 - v1
Checksum:i49D4118F67ECAD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97506 Genomic DNA. Translation: AAA37801.1.
M82874 mRNA. Translation: AAA39840.1.
BC051018 mRNA. Translation: AAH51018.1.
CCDSiCCDS15506.1.
PIRiA41788.
RefSeqiNP_035046.1. NM_010916.2.
UniGeneiMm.2474.

Genome annotation databases

EnsembliENSMUST00000059794; ENSMUSP00000057489; ENSMUSG00000051251.
GeneIDi18071.
KEGGimmu:18071.
UCSCiuc007dpj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97506 Genomic DNA. Translation: AAA37801.1.
M82874 mRNA. Translation: AAA39840.1.
BC051018 mRNA. Translation: AAH51018.1.
CCDSiCCDS15506.1.
PIRiA41788.
RefSeqiNP_035046.1. NM_010916.2.
UniGeneiMm.2474.

3D structure databases

ProteinModelPortaliQ02576.
SMRiQ02576. Positions 82-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057489.

PTM databases

PhosphoSiteiQ02576.

Proteomic databases

PaxDbiQ02576.
PRIDEiQ02576.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059794; ENSMUSP00000057489; ENSMUSG00000051251.
GeneIDi18071.
KEGGimmu:18071.
UCSCiuc007dpj.2. mouse.

Organism-specific databases

CTDi4807.
MGIiMGI:98481. Nhlh1.

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000016617.
HOVERGENiHBG016345.
InParanoidiQ02576.
KOiK09075.
OMAiMMLNSDA.
OrthoDBiEOG7G1V82.
PhylomeDBiQ02576.

Miscellaneous databases

PROiQ02576.
SOURCEiSearch...

Gene expression databases

BgeeiQ02576.
CleanExiMM_NHLH1.
GenevisibleiQ02576. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma."
    Brown L., Espinosa R. III, le Beau M.M., Siciliano M.J., Baer R.
    Proc. Natl. Acad. Sci. U.S.A. 89:8492-8496(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system."
    Begley C.G., Lipkowitz S., Gobel V., Mahon K.A., Bertness V., Green A.R., Gough N.M., Kirsch I.R.
    Proc. Natl. Acad. Sci. U.S.A. 89:38-42(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiHEN1_MOUSE
AccessioniPrimary (citable) accession number: Q02576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 6, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.