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Protein

Helix-loop-helix protein 1

Gene

Nhlh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Helix-loop-helix protein 1
Short name:
HEN-1
Alternative name(s):
Nescient helix loop helix 1
Short name:
NSCL-1
Gene namesi
Name:Nhlh1
Synonyms:Hen1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98481 Nhlh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271981 – 133Helix-loop-helix protein 1Add BLAST133

Proteomic databases

PaxDbiQ02576
PRIDEiQ02576

PTM databases

PhosphoSitePlusiQ02576

Expressioni

Gene expression databases

BgeeiENSMUSG00000051251
CleanExiMM_NHLH1
GenevisibleiQ02576 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057489

Structurei

3D structure databases

ProteinModelPortaliQ02576
SMRiQ02576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 127bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 71Poly-Arg6

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000016617
HOVERGENiHBG016345
InParanoidiQ02576
KOiK09075
OMAiMMLNSDA
PhylomeDBiQ02576

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q02576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLNSDTMEL DLPPTHSETE SGFSDCGGGP GPDGAGSGDP GVVQVRSSEL
60 70 80 90 100
GESGRKDLQH LSREERRRRR RATAKYRTAH ATRERIRVEA FNLAFAELRK
110 120 130
LLPTLPPDKK LSKIEILRLA ICYISYLNHV LDV
Length:133
Mass (Da):14,830
Last modified:July 1, 1993 - v1
Checksum:i49D4118F67ECAD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97506 Genomic DNA Translation: AAA37801.1
M82874 mRNA Translation: AAA39840.1
BC051018 mRNA Translation: AAH51018.1
CCDSiCCDS15506.1
PIRiA41788
RefSeqiNP_035046.1, NM_010916.2
UniGeneiMm.2474

Genome annotation databases

EnsembliENSMUST00000059794; ENSMUSP00000057489; ENSMUSG00000051251
GeneIDi18071
KEGGimmu:18071
UCSCiuc007dpj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHEN1_MOUSE
AccessioniPrimary (citable) accession number: Q02576
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health