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Q02575 (HEN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Helix-loop-helix protein 1

Short name=HEN-1
Alternative name(s):
Class A basic helix-loop-helix protein 35
Short name=bHLHa35
Nescient helix loop helix 1
Short name=NSCL-1
Gene names
Name:NHLH1
Synonyms:BHLHA35, HEN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

central nervous system development

Traceable author statement Ref.2. Source: ProtInc

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 133133Helix-loop-helix protein 1
PRO_0000127197

Regions

Domain75 – 12753bHLH
Compositional bias66 – 716Poly-Arg

Sequences

Sequence LengthMass (Da)Tools
Q02575 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: FE90B574BE16D2C6

FASTA13314,618
        10         20         30         40         50         60 
MMLNSDTMEL DLPPTHSETE SGFSDCGGGA GPDGAGPGGP GGGQARGPEP GEPGRKDLQH 

        70         80         90        100        110        120 
LSREERRRRR RATAKYRTAH ATRERIRVEA FNLAFAELRK LLPTLPPDKK LSKIEILRLA 

       130 
ICYISYLNHV LDV 

« Hide

References

« Hide 'large scale' references
[1]"HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma."
Brown L., Espinosa R. III, le Beau M.M., Siciliano M.J., Baer R.
Proc. Natl. Acad. Sci. U.S.A. 89:8492-8496(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[2]"A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system."
Lipkowitz S., Gobel V., Varterasian M.L., Nakahara K., Tchorz K., Kirsch I.R.
J. Biol. Chem. 267:21065-21071(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97507 Genomic DNA. Translation: AAA58634.1.
BC013789 mRNA. Translation: AAH13789.1.
CCDSCCDS1204.1.
PIRA45075. B46167.
RefSeqNP_005589.1. NM_005598.3.
UniGeneHs.30956.

3D structure databases

ProteinModelPortalQ02575.
SMRQ02575. Positions 82-132.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110872. 7 interactions.
IntActQ02575. 3 interactions.
STRING9606.ENSP00000302189.

PTM databases

PhosphoSiteQ02575.

Polymorphism databases

DMDM399885.

Proteomic databases

PRIDEQ02575.

Protocols and materials databases

DNASU4807.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302101; ENSP00000302189; ENSG00000171786.
GeneID4807.
KEGGhsa:4807.
UCSCuc001fwa.2. human.

Organism-specific databases

CTD4807.
GeneCardsGC01P160336.
HGNCHGNC:7817. NHLH1.
HPACAB004755.
CAB033854.
HPA017943.
MIM162360. gene.
neXtProtNX_Q02575.
PharmGKBPA31619.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG264916.
HOGENOMHOG000016617.
HOVERGENHBG016345.
InParanoidQ02575.
KOK09075.
OMAMMLNSDA.
OrthoDBEOG7G1V82.
PhylomeDBQ02575.

Enzyme and pathway databases

SignaLinkQ02575.

Gene expression databases

ArrayExpressQ02575.
BgeeQ02575.
CleanExHS_NHLH1.
GenevestigatorQ02575.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNHLH1.
GenomeRNAi4807.
NextBio18524.
PROQ02575.
SOURCESearch...

Entry information

Entry nameHEN1_HUMAN
AccessionPrimary (citable) accession number: Q02575
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM