Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myosin-6

Gene

Myh6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Muscle contraction.

Miscellaneous

The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-6 (MYO6).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 185ATP8

GO - Molecular functioni

GO - Biological processi

  • actin filament-based movement Source: MGI
  • adult heart development Source: MGI
  • ATP metabolic process Source: MGI
  • atrial cardiac muscle tissue morphogenesis Source: MGI
  • BMP signaling pathway Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cardiac muscle contraction Source: BHF-UCL
  • cardiac muscle fiber development Source: MGI
  • cardiac muscle hypertrophy in response to stress Source: MGI
  • in utero embryonic development Source: MGI
  • microtubule-based movement Source: InterPro
  • muscle contraction Source: MGI
  • muscle filament sliding Source: MGI
  • myofibril assembly Source: MGI
  • regulation of ATPase activity Source: MGI
  • regulation of blood pressure Source: MGI
  • regulation of heart contraction Source: MGI
  • regulation of heart growth Source: MGI
  • regulation of heart rate Source: MGI
  • regulation of the force of heart contraction Source: MGI
  • sarcomere organization Source: MGI
  • striated muscle contraction Source: MGI
  • ventricular cardiac muscle tissue morphogenesis Source: MGI
  • visceral muscle development Source: MGI

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-6
Alternative name(s):
Myosin heavy chain 6
Myosin heavy chain, cardiac muscle alpha isoform
Short name:
MyHC-alpha
Gene namesi
Name:Myh6
Synonyms:Myhca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:97255 Myh6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234031 – 1938Myosin-6Add BLAST1938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei129N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei379PhosphothreonineBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei1090PhosphoserineBy similarity1
Modified residuei1139PhosphoserineBy similarity1
Modified residuei1261PhosphotyrosineBy similarity1
Modified residuei1271PhosphoserineCombined sources1
Modified residuei1277PhosphothreonineBy similarity1
Modified residuei1284PhosphothreonineBy similarity1
Modified residuei1309PhosphoserineBy similarity1
Modified residuei1310PhosphotyrosineBy similarity1
Modified residuei1311PhosphothreonineBy similarity1
Modified residuei1512PhosphoserineCombined sources1
Modified residuei1515PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ02566
MaxQBiQ02566
PaxDbiQ02566
PRIDEiQ02566

2D gel databases

SWISS-2DPAGEiQ02566

PTM databases

iPTMnetiQ02566
PhosphoSitePlusiQ02566

Expressioni

Gene expression databases

BgeeiENSMUSG00000040752
ExpressionAtlasiQ02566 baseline and differential
GenevisibleiQ02566 MM

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Binary interactionsi

WithEntry#Exp.IntActNotes
Mybpc3O704685EBI-299157,EBI-8347074

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201651, 2 interactors
DIPiDIP-31385N
IntActiQ02566, 4 interactors
MINTiQ02566
STRINGi10090.ENSMUSP00000080538

Structurei

3D structure databases

ProteinModelPortaliQ02566
SMRiQ02566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 81Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST50
Domaini85 – 780Myosin motorPROSITE-ProRule annotationAdd BLAST696
Domaini783 – 812IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni657 – 679Actin-bindingAdd BLAST23
Regioni759 – 773Actin-bindingAdd BLAST15
Regioni790 – 807Calmodulin-bindingBy similarityAdd BLAST18
Regioni816 – 833Calmodulin-bindingBy similarityAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili842 – 1938Sequence analysisAdd BLAST1097

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOGENOMiHOG000173959
HOVERGENiHBG004704
InParanoidiQ02566
KOiK17751
OMAiSRQMEER
OrthoDBiEOG091G07UM
PhylomeDBiQ02566
TreeFamiTF314375

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q02566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAQMADFG AAAQYLRKSE KERLEAQTRP FDIRTECFVP DDKEEYVKAK
60 70 80 90 100
VVSREGGKVT AETENGKTVT IKEDQVMQQN PPKFDKIEDM AMLTFLHEPA
110 120 130 140 150
VLYNLKERYA AWMIYTYSGL FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA
160 170 180 190 200
PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFASIAA
210 220 230 240 250
IGDRSKKENP NANKGTLEDQ IIQANPALEA FGNAKTVRND NSSRFGKFIR
260 270 280 290 300
IHFGATGKLA SADIETYLLE KSRVIFQLKA ERNYHIFYQI LSNKKPELLD
310 320 330 340 350
MLLVTNNPYD YAFVSQGEVS VASIDDSEEL LATDSAFDVL SFTAEEKAGV
360 370 380 390 400
YKLTGAIMHY GNMKFKQKQR EEQAEPDGTE DADKSAYLMG LNSADLLKGL
410 420 430 440 450
CHPRVKVGNE YVTKGQSVQQ VYYSIGALAK SVYEKMFNWM VTRINATLET
460 470 480 490 500
KQPRQYFIGV LDIAGFEIFD FNSFEQLCIN FTNEKLQQFF NHHMFVLEQE
510 520 530 540 550
EYKKEGIEWE FIDFGMDLQA CIDLIEKPMG IMSILEEECM FPKASDMTFK
560 570 580 590 600
AKLYDNHLGK SNNFQKPRNV KGKQEAHFSL VHYAGTVDYN IMGWLEKNKD
610 620 630 640 650
PLNETVVGLY QKSSLKLMAT LFSTYASADT GDSGKGKGGK KKGSSFQTVS
660 670 680 690 700
ALHRENLNKL MTNLKTTHPH FVRCIIPNER KAPGVMDNPL VMHQLRCNGV
710 720 730 740 750
LEGIRICRKG FPNRILYGDF RQRYRILNPA AIPEGQFIDS RKGAEKLLGS
760 770 780 790 800
LDIDHNQYKF GHTKVFFKAG LLGLLEEMRD ERLSRIITRI QAQARGQLMR
810 820 830 840 850
IEFKKIVERR DALLVIQWNI RAFMGVKNWP WMKLYFKIKP LLKSAETEKE
860 870 880 890 900
MANMKEEFGR VKDALEKSEA RRKELEEKMV SLLQEKNDLQ LQVQAEQDNL
910 920 930 940 950
NDAEERCDQL IKNKIQLEAK VKEMTERLED EEEMNAELTA KKRKLEDECS
960 970 980 990 1000
ELKKDIDDLE LTLAKVEKEK HATENKVKNL TEEMAGLDEI IAKLTKEKKA
1010 1020 1030 1040 1050
LQEAHQQALD DLQAEEDKVN TLTKSKVKLE QQVDDLEGSL EQEKKVRMDL
1060 1070 1080 1090 1100
ERAKRKLEGD LKLTQESIMD LENDKLQLEE KLKKKEFDIS QQNSKIEDEQ
1110 1120 1130 1140 1150
ALALQLQKKL KENQARIEEL EEELEAERTA RAKVEKLRSD LSRELEEISE
1160 1170 1180 1190 1200
RLEEAGGATS VQIEMNKKRE AEFQKMRRDL EEATLQHEAT AAALRKKHAD
1210 1220 1230 1240 1250
SVAELGEQID NLQRVKQKLE KEKSEFKLEL DDVTSNMEQI IKAKANLEKV
1260 1270 1280 1290 1300
SRTLEDQANE YRVKLEEAQR SLNDFTTQRA KLQTENGELA RQLEEKEALI
1310 1320 1330 1340 1350
SQLTRGKLSY TQQMEDLKRQ LEEEGKAKNA LAHALQSSRH DCDLLREQYE
1360 1370 1380 1390 1400
EEMEAKAELQ RVLSKANSEV AQWRTKYETD AIQRTEELEE AKKKLAQRLQ
1410 1420 1430 1440 1450
DAEEAVEAVN AKCSSLEKTK HRLQNEIEDL MVDVERSNAA AAALDKKQRN
1460 1470 1480 1490 1500
FDKILAEWKQ KYEESQSELE SSQKEARSLS TELFKLKNAY EESLEHLETF
1510 1520 1530 1540 1550
KRENKNLQEE ISDLTEQLGE GGKNVHELEK IRKQLEVEKL ELQSALEEAE
1560 1570 1580 1590 1600
ASLEHEEGKI LRAQLEFNQI KAEIERKLAE KDEEMEQAKR NHLRMVDSLQ
1610 1620 1630 1640 1650
TSLDAETRSR NEALRVKKKM EGDLNEMEIQ LSQANRIASE AQKHLKNSQA
1660 1670 1680 1690 1700
HLKDTQLQLD DAVHANDDLK ENIAIVERRN NLLQAELEEL RAVVEQTERS
1710 1720 1730 1740 1750
RKLAEQELIE TSERVQLLHS QNTSLINQKK KMESDLTQLQ TEVEEAVQEC
1760 1770 1780 1790 1800
RNAEEKAKKA ITDAAMMAEE LKKEQDTSAH LERMKKNMEQ TIKDLQHRLD
1810 1820 1830 1840 1850
EAEQIALKGG KKQLQKLEAR VRELENELEA EQKRNAESVK GMRKSERRIK
1860 1870 1880 1890 1900
ELTYQTEEDK KNLMRLQDLV DKLQLKVKAY KRQAEEAEEQ ANTNLSKFRK
1910 1920 1930
VQHELDEAEE RADIAESQVN KLRAKSRDIG AKKMHDEE
Length:1,938
Mass (Da):223,565
Last modified:July 15, 1998 - v2
Checksum:iEAD789ADA68818FB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti194Y → D. 1
Natural varianti545S → A. 1
Natural varianti838I → S. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76598 mRNA Translation: AAA37159.1
M76599 mRNA Translation: AAA37160.1
M76600 mRNA Translation: AAA37161.1
M76601 mRNA Translation: AAA37162.1
M62404 Genomic DNA Translation: AAA37424.1
CCDSiCCDS36927.1
PIRiI49464
RefSeqiNP_001157643.1, NM_001164171.1
NP_034986.1, NM_010856.4
UniGeneiMm.290003

Genome annotation databases

EnsembliENSMUST00000081857; ENSMUSP00000080538; ENSMUSG00000040752
ENSMUST00000226297; ENSMUSP00000154634; ENSMUSG00000040752
GeneIDi17888
KEGGimmu:17888
UCSCiuc007txr.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYH6_MOUSE
AccessioniPrimary (citable) accession number: Q02566
Secondary accession number(s): Q64258, Q64738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health