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Protein

Synaptic vesicle glycoprotein 2A

Gene

Sv2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
Receptor for the botulinium neurotoxin type A/BOTA.

GO - Molecular functioni

  • receptor activity Source: Ensembl
  • transmembrane transporter activity Source: InterPro
  • transporter activity Source: RGD

GO - Biological processi

  • cellular calcium ion homeostasis Source: Ensembl
  • neurotransmitter transport Source: RGD
  • neurotransmitter uptake Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Neurotransmitter transport, Transport

Protein family/group databases

TCDBi2.A.1.22.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2A
Short name:
Synaptic vesicle protein 2
Short name:
Synaptic vesicle protein 2A
Gene namesi
Name:Sv2a
Synonyms:Sv2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619715. Sv2a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 169CytoplasmicSequence analysisAdd BLAST169
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 205ExtracellularSequence analysisAdd BLAST15
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 233CytoplasmicSequence analysis7
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 262ExtracellularSequence analysis8
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 294CytoplasmicSequence analysisAdd BLAST11
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 334ExtracellularSequence analysisAdd BLAST19
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 447CytoplasmicSequence analysisAdd BLAST92
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 598ExtracellularSequence analysisAdd BLAST130
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 626CytoplasmicSequence analysis7
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 651ExtracellularSequence analysis4
Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Topological domaini673 – 685CytoplasmicSequence analysisAdd BLAST13
Transmembranei686 – 708HelicalSequence analysisAdd BLAST23
Topological domaini709 – 712ExtracellularSequence analysis4
Transmembranei713 – 731HelicalSequence analysisAdd BLAST19
Topological domaini732 – 742CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • cell-cell junction Source: Ensembl
  • endoplasmic reticulum Source: Ensembl
  • integral component of membrane Source: RGD
  • neuromuscular junction Source: Ensembl
  • presynaptic active zone Source: Ensembl
  • synapse Source: MGI
  • synaptic vesicle membrane Source: RGD
  • terminal bouton Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4381.
GuidetoPHARMACOLOGYi2634.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848821 – 742Synaptic vesicle glycoprotein 2AAdd BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1
Modified residuei84PhosphothreonineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei480PhosphotyrosineBy similarity1
Glycosylationi498N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1
Glycosylationi573N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.1 Publication
N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ02563.
PRIDEiQ02563.

PTM databases

iPTMnetiQ02563.
PhosphoSitePlusiQ02563.
SwissPalmiQ02563.
UniCarbKBiQ02563.

Expressioni

Tissue specificityi

Widely expressed throughout the brain (at protein level). Expressed by neural and endocrine cells of brain and spinal cord.1 Publication

Gene expression databases

BgeeiENSRNOG00000021182.
GenevisibleiQ02563. RN.

Interactioni

Subunit structurei

Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
botAP108452EBI-466194,EBI-8178893From a different organism.
Syt1P217072EBI-466194,EBI-458098

Protein-protein interaction databases

BioGridi250772. 1 interactor.
IntActiQ02563. 6 interactors.
MINTiMINT-87493.
STRINGi10116.ENSRNOP00000028760.

Chemistry databases

BindingDBiQ02563.

Structurei

3D structure databases

ProteinModelPortaliQ02563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 57Interaction with SYT1Add BLAST57
Regioni543 – 580BOTA-bindingBy similarityAdd BLAST38

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRID. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ02563.
KOiK06258.
OMAiMSCISCF.
OrthoDBiEOG091G02NC.
PhylomeDBiQ02563.
TreeFamiTF324824.

Family and domain databases

CDDicd06174. MFS. 2 hits.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE
60 70 80 90 100
EEEDDDDFPA PADGYYRGEG AQDEEEGGAS SDATEGHDED DEIYEGEYQG
110 120 130 140 150
IPRAESGGKG ERMADGAPLA GVRGGLSDGE GPPGGRGEAQ RRKDREELAQ
160 170 180 190 200
QYETILRECG HGRFQWTLYF VLGLALMADG VEVFVVGFVL PSAEKDMCLS
210 220 230 240 250
DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS VNSVFAFFSS
260 270 280 290 300
FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW
310 320 330 340 350
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA
360 370 380 390 400
LTTQPESPRF FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI
410 420 430 440 450
HQEDELIEIQ SDTGTWYQRW GVRALSLGGQ VWGNFLSCFS PEYRRITLMM
460 470 480 490 500
MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY AARTKVFPGE RVEHVTFNFT
510 520 530 540 550
LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT SSNTFFRNCT
560 570 580 590 600
FINTVFYNTD LFEYKFVNSR LVNSTFLHNK EGCPLDVTGT GEGAYMVYFV
610 620 630 640 650
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVLSCVSCF FLSFGNSESA
660 670 680 690 700
MIALLCLFGG VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG
710 720 730 740
ISIFTSFVGI TKAAPILFAS AALALGSSLA LKLPETRGQV LQ
Length:742
Mass (Da):82,661
Last modified:June 13, 2006 - v2
Checksum:iE10FC62BEEFE316A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340C → F in AAA42188 (PubMed:1355409).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01788 Genomic RNA. No translation available.
L05435 mRNA. Translation: AAA42188.1.
BC092132 mRNA. Translation: AAH92132.1.
PIRiA43344.
RefSeqiNP_476558.2. NM_057210.2.
XP_006233014.1. XM_006232952.3.
UniGeneiRn.11264.

Genome annotation databases

EnsembliENSRNOT00000028760; ENSRNOP00000028760; ENSRNOG00000021182.
GeneIDi117559.
KEGGirno:117559.
UCSCiRGD:619715. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01788 Genomic RNA. No translation available.
L05435 mRNA. Translation: AAA42188.1.
BC092132 mRNA. Translation: AAH92132.1.
PIRiA43344.
RefSeqiNP_476558.2. NM_057210.2.
XP_006233014.1. XM_006232952.3.
UniGeneiRn.11264.

3D structure databases

ProteinModelPortaliQ02563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250772. 1 interactor.
IntActiQ02563. 6 interactors.
MINTiMINT-87493.
STRINGi10116.ENSRNOP00000028760.

Chemistry databases

BindingDBiQ02563.
ChEMBLiCHEMBL4381.
GuidetoPHARMACOLOGYi2634.

Protein family/group databases

TCDBi2.A.1.22.1. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ02563.
PhosphoSitePlusiQ02563.
SwissPalmiQ02563.
UniCarbKBiQ02563.

Proteomic databases

PaxDbiQ02563.
PRIDEiQ02563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028760; ENSRNOP00000028760; ENSRNOG00000021182.
GeneIDi117559.
KEGGirno:117559.
UCSCiRGD:619715. rat.

Organism-specific databases

CTDi9900.
RGDi619715. Sv2a.

Phylogenomic databases

eggNOGiENOG410IRID. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ02563.
KOiK06258.
OMAiMSCISCF.
OrthoDBiEOG091G02NC.
PhylomeDBiQ02563.
TreeFamiTF324824.

Miscellaneous databases

PROiQ02563.

Gene expression databases

BgeeiENSRNOG00000021182.
GenevisibleiQ02563. RN.

Family and domain databases

CDDicd06174. MFS. 2 hits.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSV2A_RAT
AccessioniPrimary (citable) accession number: Q02563
Secondary accession number(s): Q58DZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 13, 2006
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.