Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L18a

Gene

RPL18A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18a
Alternative name(s):
Large ribosomal subunit protein eL201 Publication
Gene namesi
Name:RPL18A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105640.12
HGNCiHGNC:10311 RPL18A
MIMi604178 gene
neXtProtiNX_Q02543

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6142
OpenTargetsiENSG00000105640
PharmGKBiPA34680

Polymorphism and mutation databases

BioMutaiRPL18A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139251 – 17660S ribosomal protein L18aAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei63PhosphotyrosineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei76N6-succinyllysineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ02543
MaxQBiQ02543
PaxDbiQ02543
PeptideAtlasiQ02543
PRIDEiQ02543
TopDownProteomicsiQ02543

2D gel databases

SWISS-2DPAGEQ02543

PTM databases

iPTMnetiQ02543
PhosphoSitePlusiQ02543
SwissPalmiQ02543

Expressioni

Gene expression databases

BgeeiENSG00000105640
CleanExiHS_RPL18A
ExpressionAtlasiQ02543 baseline and differential
GenevisibleiQ02543 HS

Organism-specific databases

HPAiHPA055259

Interactioni

Subunit structurei

Binds IPO9 with high affinity.

Protein-protein interaction databases

BioGridi112062, 239 interactors
CORUMiQ02543
IntActiQ02543, 40 interactors
MINTiQ02543
STRINGi9606.ENSP00000222247

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LS1-176[»]
4V6Xelectron microscopy5.00CS1-176[»]
5AJ0electron microscopy3.50AS1-176[»]
5LKSelectron microscopy3.60LS1-176[»]
5T2Celectron microscopy3.60M1-176[»]
6EK0electron microscopy2.90LS1-176[»]
ProteinModelPortaliQ02543
SMRiQ02543
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0829 Eukaryota
COG2157 LUCA
GeneTreeiENSGT00390000015797
HOGENOMiHOG000211377
HOVERGENiHBG066281
InParanoidiQ02543
KOiK02882
OMAiCRRPAIK
OrthoDBiEOG091G0LX4
PhylomeDBiQ02543
TreeFamiTF300086

Family and domain databases

HAMAPiMF_00273 Ribosomal_L18Ae, 1 hit
InterProiView protein in InterPro
IPR028877 50S_L18Ae/Ribosomal_L18a/L20
IPR023573 Ribosomal_L18a//L18Ae/LX
IPR021138 Ribosomal_L18a/L20_eukaryotes
PANTHERiPTHR10052 PTHR10052, 1 hit
PfamiView protein in Pfam
PF01775 Ribosomal_L18A, 1 hit
PIRSFiPIRSF002190 Ribosomal_L18a, 1 hit

Sequencei

Sequence statusi: Complete.

Q02543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ
60 70 80 90 100
LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL
110 120 130 140 150
TTAGAVTQCY RDMGARHRAR AHSIQIMKVE EIAASKCRRP AVKQFHDSKI
160 170
KFPLPHRVLR RQHKPRFTTK RPNTFF
Length:176
Mass (Da):20,762
Last modified:February 1, 1995 - v2
Checksum:i5E501C6D835BE580
GO

Sequence cautioni

The sequence CAA56788 differs from that shown. Reason: Frameshift at position 65.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83R → S in CAA56788 (Ref. 2) Curated1
Sequence conflicti134A → V in CAA56788 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05093 mRNA Translation: AAC18781.1
X80822 mRNA Translation: CAA56788.1 Frameshift.
AC005796 Genomic DNA Translation: AAC62828.1
BC007512 mRNA Translation: AAH07512.1
BC066319 mRNA Translation: AAH66319.1
BC071920 mRNA Translation: AAH71920.1
CCDSiCCDS12367.1
PIRiS47353
RefSeqiNP_000971.1, NM_000980.3
UniGeneiHs.337766

Genome annotation databases

EnsembliENST00000222247; ENSP00000222247; ENSG00000105640
GeneIDi6142
KEGGihsa:6142
UCSCiuc002nhp.4 human

Similar proteinsi

Entry informationi

Entry nameiRL18A_HUMAN
AccessioniPrimary (citable) accession number: Q02543
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health