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Protein

60S ribosomal protein L18a

Gene

RPL18A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-9010553. Regulation of expression of SLITs and ROBOs.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18a
Alternative name(s):
Large ribosomal subunit protein eL201 Publication
Gene namesi
Name:RPL18A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105640.12.
HGNCiHGNC:10311. RPL18A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6142.
OpenTargetsiENSG00000105640.
PharmGKBiPA34680.

Polymorphism and mutation databases

BioMutaiRPL18A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139251 – 17660S ribosomal protein L18aAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei63PhosphotyrosineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei76N6-succinyllysineBy similarity1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ02543.
MaxQBiQ02543.
PaxDbiQ02543.
PeptideAtlasiQ02543.
PRIDEiQ02543.
TopDownProteomicsiQ02543.

2D gel databases

SWISS-2DPAGEiQ02543.

PTM databases

iPTMnetiQ02543.
PhosphoSitePlusiQ02543.
SwissPalmiQ02543.

Expressioni

Gene expression databases

BgeeiENSG00000105640.
CleanExiHS_RPL18A.
ExpressionAtlasiQ02543. baseline and differential.
GenevisibleiQ02543. HS.

Organism-specific databases

HPAiHPA055259.

Interactioni

Subunit structurei

Binds IPO9 with high affinity.

Protein-protein interaction databases

BioGridi112062. 234 interactors.
CORUMiQ02543.
IntActiQ02543. 38 interactors.
MINTiMINT-5000271.
STRINGi9606.ENSP00000222247.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LS1-176[»]
4V6Xelectron microscopy5.00CS1-176[»]
5AJ0electron microscopy3.50AS1-176[»]
5LKSelectron microscopy3.60LS1-176[»]
5T2Celectron microscopy3.60M1-176[»]
ProteinModelPortaliQ02543.
SMRiQ02543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0829. Eukaryota.
COG2157. LUCA.
GeneTreeiENSGT00390000015797.
HOGENOMiHOG000211377.
HOVERGENiHBG066281.
InParanoidiQ02543.
KOiK02882.
OMAiCRRPAIK.
OrthoDBiEOG091G0LX4.
PhylomeDBiQ02543.
TreeFamiTF300086.

Family and domain databases

HAMAPiMF_00273. Ribosomal_L18Ae. 1 hit.
InterProiView protein in InterPro
IPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
IPR023573. Ribosomal_L18a//L18Ae/LX.
IPR021138. Ribosomal_L18a/L20_eukaryotes.
PfamiView protein in Pfam
PF01775. Ribosomal_L18A. 1 hit.
PIRSFiPIRSF002190. Ribosomal_L18a. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ
60 70 80 90 100
LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL
110 120 130 140 150
TTAGAVTQCY RDMGARHRAR AHSIQIMKVE EIAASKCRRP AVKQFHDSKI
160 170
KFPLPHRVLR RQHKPRFTTK RPNTFF
Length:176
Mass (Da):20,762
Last modified:February 1, 1995 - v2
Checksum:i5E501C6D835BE580
GO

Sequence cautioni

The sequence CAA56788 differs from that shown. Reason: Frameshift at position 65.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83R → S in CAA56788 (Ref. 2) Curated1
Sequence conflicti134A → V in CAA56788 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05093 mRNA. Translation: AAC18781.1.
X80822 mRNA. Translation: CAA56788.1. Frameshift.
AC005796 Genomic DNA. Translation: AAC62828.1.
BC007512 mRNA. Translation: AAH07512.1.
BC066319 mRNA. Translation: AAH66319.1.
BC071920 mRNA. Translation: AAH71920.1.
CCDSiCCDS12367.1.
PIRiS47353.
RefSeqiNP_000971.1. NM_000980.3.
UniGeneiHs.337766.

Genome annotation databases

EnsembliENST00000222247; ENSP00000222247; ENSG00000105640.
GeneIDi6142.
KEGGihsa:6142.
UCSCiuc002nhp.4. human.

Similar proteinsi

Entry informationi

Entry nameiRL18A_HUMAN
AccessioniPrimary (citable) accession number: Q02543
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families