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Q02543

- RL18A_HUMAN

UniProt

Q02543 - RL18A_HUMAN

Protein

60S ribosomal protein L18a

Gene

RPL18A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA binding Source: ProtInc
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L18a
    Gene namesi
    Name:RPL18A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10311. RPL18A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic large ribosomal subunit Source: UniProtKB
    3. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34680.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17617660S ribosomal protein L18aPRO_0000213925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei63 – 631Phosphotyrosine1 Publication
    Modified residuei71 – 711Phosphoserine3 Publications
    Modified residuei76 – 761N6-succinyllysineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ02543.
    PaxDbiQ02543.
    PeptideAtlasiQ02543.
    PRIDEiQ02543.

    2D gel databases

    SWISS-2DPAGEQ02543.

    PTM databases

    PhosphoSiteiQ02543.

    Expressioni

    Gene expression databases

    BgeeiQ02543.
    CleanExiHS_RPL18A.
    GenevestigatoriQ02543.

    Organism-specific databases

    HPAiHPA055259.

    Interactioni

    Subunit structurei

    Binds IPO9 with high affinity.

    Protein-protein interaction databases

    BioGridi112062. 102 interactions.
    IntActiQ02543. 19 interactions.
    MINTiMINT-5000271.
    STRINGi9606.ENSP00000222247.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00S1-176[»]
    ProteinModelPortaliQ02543.
    SMRiQ02543. Positions 2-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L18Ae family.Curated

    Phylogenomic databases

    eggNOGiCOG2157.
    HOGENOMiHOG000211377.
    HOVERGENiHBG066281.
    InParanoidiQ02543.
    KOiK02882.
    OMAiCRRPAIK.
    OrthoDBiEOG7TMZT2.
    PhylomeDBiQ02543.
    TreeFamiTF300086.

    Family and domain databases

    HAMAPiMF_00273. Ribosomal_L18Ae.
    InterProiIPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
    IPR021138. Ribosomal_L18a/L20_eukaryotes.
    IPR023573. Ribosomal_L18a/LX.
    [Graphical view]
    PfamiPF01775. Ribosomal_L18ae. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002190. Ribosomal_L18a. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q02543-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ    50
    LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL 100
    TTAGAVTQCY RDMGARHRAR AHSIQIMKVE EIAASKCRRP AVKQFHDSKI 150
    KFPLPHRVLR RQHKPRFTTK RPNTFF 176
    Length:176
    Mass (Da):20,762
    Last modified:February 1, 1995 - v2
    Checksum:i5E501C6D835BE580
    GO

    Sequence cautioni

    The sequence CAA56788.1 differs from that shown. Reason: Frameshift at position 65.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831R → S in CAA56788. 1 PublicationCurated
    Sequence conflicti134 – 1341A → V in CAA56788. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05093 mRNA. Translation: AAC18781.1.
    X80822 mRNA. Translation: CAA56788.1. Frameshift.
    AC005796 Genomic DNA. Translation: AAC62828.1.
    BC007512 mRNA. Translation: AAH07512.1.
    BC066319 mRNA. Translation: AAH66319.1.
    BC071920 mRNA. Translation: AAH71920.1.
    CCDSiCCDS12367.1.
    PIRiS47353.
    RefSeqiNP_000971.1. NM_000980.3.
    UniGeneiHs.337766.

    Genome annotation databases

    EnsembliENST00000222247; ENSP00000222247; ENSG00000105640.
    GeneIDi6142.
    KEGGihsa:6142.
    UCSCiuc002nhp.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05093 mRNA. Translation: AAC18781.1 .
    X80822 mRNA. Translation: CAA56788.1 . Frameshift.
    AC005796 Genomic DNA. Translation: AAC62828.1 .
    BC007512 mRNA. Translation: AAH07512.1 .
    BC066319 mRNA. Translation: AAH66319.1 .
    BC071920 mRNA. Translation: AAH71920.1 .
    CCDSi CCDS12367.1.
    PIRi S47353.
    RefSeqi NP_000971.1. NM_000980.3.
    UniGenei Hs.337766.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 S 1-176 [» ]
    ProteinModelPortali Q02543.
    SMRi Q02543. Positions 2-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112062. 102 interactions.
    IntActi Q02543. 19 interactions.
    MINTi MINT-5000271.
    STRINGi 9606.ENSP00000222247.

    PTM databases

    PhosphoSitei Q02543.

    2D gel databases

    SWISS-2DPAGE Q02543.

    Proteomic databases

    MaxQBi Q02543.
    PaxDbi Q02543.
    PeptideAtlasi Q02543.
    PRIDEi Q02543.

    Protocols and materials databases

    DNASUi 6142.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222247 ; ENSP00000222247 ; ENSG00000105640 .
    GeneIDi 6142.
    KEGGi hsa:6142.
    UCSCi uc002nhp.3. human.

    Organism-specific databases

    CTDi 6142.
    GeneCardsi GC19P017970.
    HGNCi HGNC:10311. RPL18A.
    HPAi HPA055259.
    MIMi 604178. gene.
    neXtProti NX_Q02543.
    PharmGKBi PA34680.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2157.
    HOGENOMi HOG000211377.
    HOVERGENi HBG066281.
    InParanoidi Q02543.
    KOi K02882.
    OMAi CRRPAIK.
    OrthoDBi EOG7TMZT2.
    PhylomeDBi Q02543.
    TreeFami TF300086.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    GeneWikii RPL18A.
    GenomeRNAii 6142.
    NextBioi 23861.
    PROi Q02543.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02543.
    CleanExi HS_RPL18A.
    Genevestigatori Q02543.

    Family and domain databases

    HAMAPi MF_00273. Ribosomal_L18Ae.
    InterProi IPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
    IPR021138. Ribosomal_L18a/L20_eukaryotes.
    IPR023573. Ribosomal_L18a/LX.
    [Graphical view ]
    Pfami PF01775. Ribosomal_L18ae. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002190. Ribosomal_L18a. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Bhat K.S.
      Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Zenz K.I.
      Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Muscle.
    5. "Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains."
      Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D.
      EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IPO9.
    6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-63, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL18A_HUMAN
    AccessioniPrimary (citable) accession number: Q02543
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3