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Q02543

- RL18A_HUMAN

UniProt

Q02543 - RL18A_HUMAN

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Protein

60S ribosomal protein L18a

Gene
RPL18A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: ProtInc
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  5. RNA metabolic process Source: Reactome
  6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  7. translation Source: UniProtKB
  8. translational elongation Source: Reactome
  9. translational initiation Source: Reactome
  10. translational termination Source: Reactome
  11. viral life cycle Source: Reactome
  12. viral process Source: Reactome
  13. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18a
Gene namesi
Name:RPL18A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10311. RPL18A.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic large ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17617660S ribosomal protein L18aUniRule annotationPRO_0000213925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Phosphotyrosine1 Publication
Modified residuei71 – 711Phosphoserine3 Publications
Modified residuei76 – 761N6-succinyllysine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02543.
PaxDbiQ02543.
PeptideAtlasiQ02543.
PRIDEiQ02543.

2D gel databases

SWISS-2DPAGEQ02543.

PTM databases

PhosphoSiteiQ02543.

Expressioni

Gene expression databases

BgeeiQ02543.
CleanExiHS_RPL18A.
GenevestigatoriQ02543.

Organism-specific databases

HPAiHPA055259.

Interactioni

Subunit structurei

Binds IPO9 with high affinity.

Protein-protein interaction databases

BioGridi112062. 102 interactions.
IntActiQ02543. 19 interactions.
MINTiMINT-5000271.
STRINGi9606.ENSP00000222247.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00S1-176[»]
ProteinModelPortaliQ02543.
SMRiQ02543. Positions 2-176.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2157.
HOGENOMiHOG000211377.
HOVERGENiHBG066281.
InParanoidiQ02543.
KOiK02882.
OMAiCRRPAIK.
OrthoDBiEOG7TMZT2.
PhylomeDBiQ02543.
TreeFamiTF300086.

Family and domain databases

HAMAPiMF_00273. Ribosomal_L18Ae.
InterProiIPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
IPR021138. Ribosomal_L18a/L20_eukaryotes.
IPR023573. Ribosomal_L18a/LX.
[Graphical view]
PfamiPF01775. Ribosomal_L18ae. 1 hit.
[Graphical view]
PIRSFiPIRSF002190. Ribosomal_L18a. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02543-1 [UniParc]FASTAAdd to Basket

« Hide

MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ    50
LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL 100
TTAGAVTQCY RDMGARHRAR AHSIQIMKVE EIAASKCRRP AVKQFHDSKI 150
KFPLPHRVLR RQHKPRFTTK RPNTFF 176
Length:176
Mass (Da):20,762
Last modified:February 1, 1995 - v2
Checksum:i5E501C6D835BE580
GO

Sequence cautioni

The sequence CAA56788.1 differs from that shown. Reason: Frameshift at position 65.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831R → S in CAA56788. 1 Publication
Sequence conflicti134 – 1341A → V in CAA56788. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05093 mRNA. Translation: AAC18781.1.
X80822 mRNA. Translation: CAA56788.1. Frameshift.
AC005796 Genomic DNA. Translation: AAC62828.1.
BC007512 mRNA. Translation: AAH07512.1.
BC066319 mRNA. Translation: AAH66319.1.
BC071920 mRNA. Translation: AAH71920.1.
CCDSiCCDS12367.1.
PIRiS47353.
RefSeqiNP_000971.1. NM_000980.3.
UniGeneiHs.337766.

Genome annotation databases

EnsembliENST00000222247; ENSP00000222247; ENSG00000105640.
GeneIDi6142.
KEGGihsa:6142.
UCSCiuc002nhp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05093 mRNA. Translation: AAC18781.1 .
X80822 mRNA. Translation: CAA56788.1 . Frameshift.
AC005796 Genomic DNA. Translation: AAC62828.1 .
BC007512 mRNA. Translation: AAH07512.1 .
BC066319 mRNA. Translation: AAH66319.1 .
BC071920 mRNA. Translation: AAH71920.1 .
CCDSi CCDS12367.1.
PIRi S47353.
RefSeqi NP_000971.1. NM_000980.3.
UniGenei Hs.337766.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3B electron microscopy 5.00 S 1-176 [» ]
ProteinModelPortali Q02543.
SMRi Q02543. Positions 2-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112062. 102 interactions.
IntActi Q02543. 19 interactions.
MINTi MINT-5000271.
STRINGi 9606.ENSP00000222247.

PTM databases

PhosphoSitei Q02543.

2D gel databases

SWISS-2DPAGE Q02543.

Proteomic databases

MaxQBi Q02543.
PaxDbi Q02543.
PeptideAtlasi Q02543.
PRIDEi Q02543.

Protocols and materials databases

DNASUi 6142.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222247 ; ENSP00000222247 ; ENSG00000105640 .
GeneIDi 6142.
KEGGi hsa:6142.
UCSCi uc002nhp.3. human.

Organism-specific databases

CTDi 6142.
GeneCardsi GC19P017970.
HGNCi HGNC:10311. RPL18A.
HPAi HPA055259.
MIMi 604178. gene.
neXtProti NX_Q02543.
PharmGKBi PA34680.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2157.
HOGENOMi HOG000211377.
HOVERGENi HBG066281.
InParanoidi Q02543.
KOi K02882.
OMAi CRRPAIK.
OrthoDBi EOG7TMZT2.
PhylomeDBi Q02543.
TreeFami TF300086.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

GeneWikii RPL18A.
GenomeRNAii 6142.
NextBioi 23861.
PROi Q02543.
SOURCEi Search...

Gene expression databases

Bgeei Q02543.
CleanExi HS_RPL18A.
Genevestigatori Q02543.

Family and domain databases

HAMAPi MF_00273. Ribosomal_L18Ae.
InterProi IPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
IPR021138. Ribosomal_L18a/L20_eukaryotes.
IPR023573. Ribosomal_L18a/LX.
[Graphical view ]
Pfami PF01775. Ribosomal_L18ae. 1 hit.
[Graphical view ]
PIRSFi PIRSF002190. Ribosomal_L18a. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Bhat K.S.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Zenz K.I.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Muscle.
  5. "Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains."
    Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D.
    EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IPO9.
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-63, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRL18A_HUMAN
AccessioniPrimary (citable) accession number: Q02543
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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