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Protein

60S ribosomal protein L18a

Gene

RPL18A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18a
Gene namesi
Name:RPL18A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10311. RPL18A.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34680.

Polymorphism and mutation databases

BioMutaiRPL18A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17617660S ribosomal protein L18aPRO_0000213925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei63 – 631PhosphotyrosineCombined sources
Modified residuei71 – 711PhosphoserineCombined sources
Modified residuei76 – 761N6-succinyllysineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ02543.
MaxQBiQ02543.
PaxDbiQ02543.
PeptideAtlasiQ02543.
PRIDEiQ02543.
TopDownProteomicsiQ02543.

2D gel databases

SWISS-2DPAGEQ02543.

PTM databases

iPTMnetiQ02543.
PhosphoSiteiQ02543.
SwissPalmiQ02543.

Expressioni

Gene expression databases

BgeeiENSG00000105640.
CleanExiHS_RPL18A.
ExpressionAtlasiQ02543. baseline and differential.
GenevisibleiQ02543. HS.

Organism-specific databases

HPAiHPA055259.

Interactioni

Subunit structurei

Binds IPO9 with high affinity.

Protein-protein interaction databases

BioGridi112062. 216 interactions.
IntActiQ02543. 34 interactions.
MINTiMINT-5000271.
STRINGi9606.ENSP00000222247.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LS1-176[»]
4V6Xelectron microscopy5.00CS1-176[»]
5AJ0electron microscopy3.50AS1-176[»]
ProteinModelPortaliQ02543.
SMRiQ02543. Positions 2-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L18Ae family.Curated

Phylogenomic databases

eggNOGiKOG0829. Eukaryota.
COG2157. LUCA.
GeneTreeiENSGT00390000015797.
HOGENOMiHOG000211377.
HOVERGENiHBG066281.
InParanoidiQ02543.
KOiK02882.
OMAiCRRPAIK.
OrthoDBiEOG091G0LX4.
PhylomeDBiQ02543.
TreeFamiTF300086.

Family and domain databases

HAMAPiMF_00273. Ribosomal_L18Ae. 1 hit.
InterProiIPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
IPR023573. Ribosomal_L18a//L18Ae/LX.
IPR021138. Ribosomal_L18a/L20_eukaryotes.
[Graphical view]
PfamiPF01775. Ribosomal_L18A. 1 hit.
[Graphical view]
PIRSFiPIRSF002190. Ribosomal_L18a. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ
60 70 80 90 100
LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL
110 120 130 140 150
TTAGAVTQCY RDMGARHRAR AHSIQIMKVE EIAASKCRRP AVKQFHDSKI
160 170
KFPLPHRVLR RQHKPRFTTK RPNTFF
Length:176
Mass (Da):20,762
Last modified:February 1, 1995 - v2
Checksum:i5E501C6D835BE580
GO

Sequence cautioni

The sequence CAA56788 differs from that shown. Reason: Frameshift at position 65. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831R → S in CAA56788 (Ref. 2) Curated
Sequence conflicti134 – 1341A → V in CAA56788 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05093 mRNA. Translation: AAC18781.1.
X80822 mRNA. Translation: CAA56788.1. Frameshift.
AC005796 Genomic DNA. Translation: AAC62828.1.
BC007512 mRNA. Translation: AAH07512.1.
BC066319 mRNA. Translation: AAH66319.1.
BC071920 mRNA. Translation: AAH71920.1.
CCDSiCCDS12367.1.
PIRiS47353.
RefSeqiNP_000971.1. NM_000980.3.
UniGeneiHs.337766.

Genome annotation databases

EnsembliENST00000222247; ENSP00000222247; ENSG00000105640.
GeneIDi6142.
KEGGihsa:6142.
UCSCiuc002nhp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05093 mRNA. Translation: AAC18781.1.
X80822 mRNA. Translation: CAA56788.1. Frameshift.
AC005796 Genomic DNA. Translation: AAC62828.1.
BC007512 mRNA. Translation: AAH07512.1.
BC066319 mRNA. Translation: AAH66319.1.
BC071920 mRNA. Translation: AAH71920.1.
CCDSiCCDS12367.1.
PIRiS47353.
RefSeqiNP_000971.1. NM_000980.3.
UniGeneiHs.337766.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LS1-176[»]
4V6Xelectron microscopy5.00CS1-176[»]
5AJ0electron microscopy3.50AS1-176[»]
ProteinModelPortaliQ02543.
SMRiQ02543. Positions 2-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112062. 216 interactions.
IntActiQ02543. 34 interactions.
MINTiMINT-5000271.
STRINGi9606.ENSP00000222247.

PTM databases

iPTMnetiQ02543.
PhosphoSiteiQ02543.
SwissPalmiQ02543.

Polymorphism and mutation databases

BioMutaiRPL18A.

2D gel databases

SWISS-2DPAGEQ02543.

Proteomic databases

EPDiQ02543.
MaxQBiQ02543.
PaxDbiQ02543.
PeptideAtlasiQ02543.
PRIDEiQ02543.
TopDownProteomicsiQ02543.

Protocols and materials databases

DNASUi6142.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222247; ENSP00000222247; ENSG00000105640.
GeneIDi6142.
KEGGihsa:6142.
UCSCiuc002nhp.4. human.

Organism-specific databases

CTDi6142.
GeneCardsiRPL18A.
HGNCiHGNC:10311. RPL18A.
HPAiHPA055259.
MIMi604178. gene.
neXtProtiNX_Q02543.
PharmGKBiPA34680.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0829. Eukaryota.
COG2157. LUCA.
GeneTreeiENSGT00390000015797.
HOGENOMiHOG000211377.
HOVERGENiHBG066281.
InParanoidiQ02543.
KOiK02882.
OMAiCRRPAIK.
OrthoDBiEOG091G0LX4.
PhylomeDBiQ02543.
TreeFamiTF300086.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

GeneWikiiRPL18A.
GenomeRNAii6142.
PROiQ02543.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105640.
CleanExiHS_RPL18A.
ExpressionAtlasiQ02543. baseline and differential.
GenevisibleiQ02543. HS.

Family and domain databases

HAMAPiMF_00273. Ribosomal_L18Ae. 1 hit.
InterProiIPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
IPR023573. Ribosomal_L18a//L18Ae/LX.
IPR021138. Ribosomal_L18a/L20_eukaryotes.
[Graphical view]
PfamiPF01775. Ribosomal_L18A. 1 hit.
[Graphical view]
PIRSFiPIRSF002190. Ribosomal_L18a. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL18A_HUMAN
AccessioniPrimary (citable) accession number: Q02543
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.