Reviewed, UniProtKB/Swiss-Prot Q02539 (H11_HUMAN)

Names and origin

Protein names

Recommended name:
    Histone H1.1

Gene names

Name:	HIST1H1A
Synonyms:	H1F1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the histone H1/H5 family.

Ontologies

Keywords
Cellular component	Chromosomal protein Nucleus
Ligand	DNA-binding
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	nucleosome assembly Inferred from electronic annotation. Source: InterPro spermatogenesis Traceable author statement. Source: ProtInc
Cellular component	nucleosome Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 215	214	Histone H1.1		PRO_0000195905
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	162	1	Phosphothreonine

Sequences

	Sequence		Length	Mass (Da)
	Q02539-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 854B03622D78774A	FASTA	215	21,842
	10 20 30 40 50 60 MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA ASSSKERGGV 70 80 90 100 110 120 SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK GTGASGSFKL NKKASSVETK 130 140 150 160 170 180 PGASKVATKT KATGASKKLK KATGASKKSV KTPKKAKKPA ATRKSSKNPK KPKTVKPKKV 190 200 210 AKSPAKAKAV KPKAAKARVT KPKTAKPKKA APKKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human H1 histones: conserved and varied sequence elements in two H1 subtype genes." Eick S., Nicolai M., Mumberg D., Doenecke D. Eur. J. Cell Biol. 49:110-115(1989) [PubMed: 2759094] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[2]	"The human and mouse replication-dependent histone genes." Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J. Genomics 80:487-498(2002) [PubMed: 12408966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-162, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X57130 Genomic DNA. Translation: CAA40409.1. AF531299 Genomic DNA. Translation: AAN06699.1. BC069492 mRNA. Translation: AAH69492.1. BC101593 mRNA. Translation: AAI01594.1. BC112140 mRNA. Translation: AAI12141.1.
PIR	S26363.
RefSeq	NP_005316.1.
UniGene	Hs.150206
3D structure databases
HSSP	HSSP built from PDB template 1GHC based on UniProtKB P08287.
SMR	Q02539. Positions 39-112.
ModBase	Search...
PTM databases
PhosphoSite	Q02539.
Genome annotation databases
Ensembl	ENSG00000124610. Homo sapiens. [Contig view]
GeneID	3024.
KEGG	hsa:3024.
Organism-specific databases
H-InvDB	HIX0032935.
HGNC	HGNC:4715. HIST1H1A.
MIM	142709. gene.
PharmGKB	PA29093.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q02539.
HOVERGEN	Q02539.
Gene expression databases
ArrayExpress	Q02539.
CleanEx	HS_HIST1H1A.
GermOnline	ENSG00000124610. Homo sapiens.
Family and domain databases
InterPro	IPR005818. Histone_H1/H5. IPR005819. Histone_H5. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00538. Linker_histone. 1 hit. [Graphical view]
PRINTS	PR00624. HISTONEH5.
SMART	SM00526. H15. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	11976.
SOURCE	Search...

Entry information

Entry name

H11_HUMAN

Accession

Primary (citable) accession number: Q02539
Secondary accession number(s): Q3MJ34

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 61 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)