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Protein

Zinc finger protein 41

Gene

Zfp41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 41
Short name:
Zfp-41
Alternative name(s):
CtFIN92
Gene namesi
Name:Zfp41
Synonyms:Zfp-41
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:99186. Zfp41.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Zinc finger protein 41PRO_0000047299Add
BLAST

Proteomic databases

EPDiQ02526.
MaxQBiQ02526.
PaxDbiQ02526.
PeptideAtlasiQ02526.
PRIDEiQ02526.

PTM databases

iPTMnetiQ02526.

Expressioni

Tissue specificityi

Predominantly in the spermatocytes and spermatids of testes. It is also expressed in the fetus and embryonic stem cells at lower levels.1 Publication

Developmental stagei

Detected in the newborn testis and peaks at 3 weeks during the first cycle of spermatogenesis. Expressed in the fetus and embryo.1 Publication

Gene expression databases

BgeeiQ02526.
CleanExiMM_ZFP41.
ExpressionAtlasiQ02526. baseline and differential.
GenevisibleiQ02526. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056510.

Structurei

3D structure databases

ProteinModelPortaliQ02526.
SMRiQ02526. Positions 84-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127140.
HOGENOMiHOG000234617.
HOVERGENiHBG098192.
InParanoidiQ02526.
OMAiMEKPATR.
OrthoDBiEOG7B05D3.
PhylomeDBiQ02526.
TreeFamiTF337091.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPATRKKK SQAPKEEAGA QKATVKGEKT SKGKKATKKP RKPRRPRKEP
60 70 80 90 100
VLSPEDEAHI FDAFDASFKD DFEGVPVFVP FQRKKPYECG ECGRIFKHKT
110 120 130 140 150
DHIRHQRVHT GEKPFKCDQC GKTFRHSSDV TKHQRIHTGE KPFKCGECGK
160 170 180 190
AFNCGSNLLK HQKTHTGEKP YGCEECGKSF AYSSCLIRHR KRHPRKKH
Length:198
Mass (Da):22,724
Last modified:July 24, 2007 - v2
Checksum:iBD9ACDF28A97E01F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030420 mRNA. Translation: BAC26955.1.
BC053927 mRNA. Translation: AAH53927.1.
D10631 mRNA. Translation: BAA01481.1.
CCDSiCCDS37108.1.
PIRiB48827.
RefSeqiNP_001038183.1. NM_001044718.2.
NP_035889.1. NM_011759.3.
XP_006520957.1. XM_006520894.2.
XP_006520958.1. XM_006520895.2.
XP_006520959.1. XM_006520896.2.
UniGeneiMm.87210.

Genome annotation databases

EnsembliENSMUST00000054555; ENSMUSP00000056510; ENSMUSG00000047003.
ENSMUST00000161785; ENSMUSP00000124626; ENSMUSG00000047003.
GeneIDi22701.
KEGGimmu:22701.
UCSCiuc007wgx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030420 mRNA. Translation: BAC26955.1.
BC053927 mRNA. Translation: AAH53927.1.
D10631 mRNA. Translation: BAA01481.1.
CCDSiCCDS37108.1.
PIRiB48827.
RefSeqiNP_001038183.1. NM_001044718.2.
NP_035889.1. NM_011759.3.
XP_006520957.1. XM_006520894.2.
XP_006520958.1. XM_006520895.2.
XP_006520959.1. XM_006520896.2.
UniGeneiMm.87210.

3D structure databases

ProteinModelPortaliQ02526.
SMRiQ02526. Positions 84-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056510.

PTM databases

iPTMnetiQ02526.

Proteomic databases

EPDiQ02526.
MaxQBiQ02526.
PaxDbiQ02526.
PeptideAtlasiQ02526.
PRIDEiQ02526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054555; ENSMUSP00000056510; ENSMUSG00000047003.
ENSMUST00000161785; ENSMUSP00000124626; ENSMUSG00000047003.
GeneIDi22701.
KEGGimmu:22701.
UCSCiuc007wgx.2. mouse.

Organism-specific databases

CTDi286128.
MGIiMGI:99186. Zfp41.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127140.
HOGENOMiHOG000234617.
HOVERGENiHBG098192.
InParanoidiQ02526.
OMAiMEKPATR.
OrthoDBiEOG7B05D3.
PhylomeDBiQ02526.
TreeFamiTF337091.

Miscellaneous databases

PROiQ02526.
SOURCEiSearch...

Gene expression databases

BgeeiQ02526.
CleanExiMM_ZFP41.
ExpressionAtlasiQ02526. baseline and differential.
GenevisibleiQ02526. MM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  3. "Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis."
    Noce T., Fujiwara Y., Sezaki M., Fujimoto H., Higashinakagawa T.
    Dev. Biol. 153:356-367(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 89-193, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BTBRTF.
    Tissue: Spermatocyte.

Entry informationi

Entry nameiZFP41_MOUSE
AccessioniPrimary (citable) accession number: Q02526
Secondary accession number(s): Q8BSV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 24, 2007
Last modified: July 6, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.