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Protein

Otoconin-90

Gene

OC90

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

It is unlikely that this protein has phospholipase A2 activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Otoconin-90
Short name:
Oc90
Alternative name(s):
Phospholipase A2 homolog
Gene namesi
Name:OC90
Synonyms:PLA2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:8100. OC90.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31889.

Polymorphism and mutation databases

BioMutaiOC90.
DMDMi215274202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 493476Otoconin-90PRO_0000022993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi85 ↔ 145By similarity
Disulfide bondi99 ↔ 190By similarity
Disulfide bondi101 ↔ 117By similarity
Disulfide bondi116 ↔ 172By similarity
Disulfide bondi123 ↔ 165By similarity
Disulfide bondi132 ↔ 158By similarity
Disulfide bondi152 ↔ 163By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02509.
PRIDEiQ02509.

PTM databases

iPTMnetiQ02509.
PhosphoSiteiQ02509.

Expressioni

Gene expression databases

BgeeiQ02509.
CleanExiHS_OC90.

Interactioni

Subunit structurei

Interacts with OTOL1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000262283.

Structurei

3D structure databases

ProteinModelPortaliQ02509.
SMRiQ02509. Positions 94-173, 342-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 190115Phospholipase A2-like 1Add
BLAST
Regioni321 – 37757Phospholipase A2-like 2Add
BLAST
Regioni389 – 44153Phospholipase A2-like 3Add
BLAST

Domaini

Consists of 3 PA2-type domains.

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000293375.
HOVERGENiHBG007862.
InParanoidiQ02509.
PhylomeDBiQ02509.
TreeFamiTF353106.

Family and domain databases

Gene3Di1.20.90.10. 2 hits.
InterProiIPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 2 hits.
PfamiPF00068. Phospholip_A2_1. 2 hits.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 2 hits.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 2 hits.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02509-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIAFLLTSVL MIPHAGGHPL DTPHLPQELP PGLPNNINIT FFSGMFKNVE
60 70 80 90 100
SVAEIFDCLG PHFTWLQAVF TNFPVLIQFV NGMKCVAGLC PRDFEDYGCT
110 120 130 140 150
CRFEMEGLPV DESDSCCFQH RRCYEEAAEM DCLQDPAKLS TEVNCVSKKI
160 170 180 190 200
ICESKDNCEH LLCTCDKAAI ECLARSSLNS SLNLLDTSFC LAQTPETTIK
210 220 230 240 250
EDLTTLLPRV VPVEPTDTSL TALSGEVAAE TEADRLITLS KKKAGHDQEG
260 270 280 290 300
VGAARATSPP GSAEIVATRV TAKIVTLVPA GIKSLGLAVS SVENDPEETT
310 320 330 340 350
EKACDRFTFL HLGSGDNMQV MPQLGEMLFC LTSRCPEEFE SYGCYCGQEG
360 370 380 390 400
RGEPRDDLDR CCLSHHCCLE QVRRLGCLLE RLPWSPVVCV DHTPKCGGQS
410 420 430 440 450
LCEKLLCACD QTAAECMTSA SFNQSLKSPS RLGCPGQPAA CEDSLHPVPA
460 470 480 490
APTLGSSSEE DSEEDPPQED LGRAKRFLRK SLGPLGIGPL HGR
Length:493
Mass (Da):53,454
Last modified:November 25, 2008 - v3
Checksum:i44202DAE5851AEEC
GO
Isoform 2 (identifier: Q02509-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-243: VAAETEADRLITLSKKK → E

Show »
Length:477
Mass (Da):51,728
Checksum:i14F1A3ED1F813842
GO

Sequence cautioni

The sequence CAA78662.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611P → A in CAA78662 (PubMed:8382789).Curated
Sequence conflicti124 – 1241Y → C in CAA78662 (PubMed:8382789).Curated
Sequence conflicti144 – 1441N → D in CAA78662 (PubMed:8382789).Curated
Sequence conflicti144 – 1441N → D in BAG60230 (PubMed:14702039).Curated
Sequence conflicti147 – 1471S → G in CAA78662 (PubMed:8382789).Curated
Sequence conflicti147 – 1471S → G in BAG60230 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei227 – 24317VAAET…LSKKK → E in isoform 2. 1 PublicationVSP_040320Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14310 mRNA. Translation: CAA78662.1. Different initiation.
AK297911 mRNA. Translation: BAG60230.1.
AC092817 Genomic DNA. No translation available.
AC100868 Genomic DNA. No translation available.
CCDSiCCDS47919.1. [Q02509-2]
PIRiS30392.
RefSeqiNP_001073868.2. NM_001080399.2. [Q02509-2]
UniGeneiHs.653174.

Genome annotation databases

EnsembliENST00000254627; ENSP00000254627; ENSG00000253117. [Q02509-2]
GeneIDi729330.
KEGGihsa:729330.
UCSCiuc011lix.1. human. [Q02509-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14310 mRNA. Translation: CAA78662.1. Different initiation.
AK297911 mRNA. Translation: BAG60230.1.
AC092817 Genomic DNA. No translation available.
AC100868 Genomic DNA. No translation available.
CCDSiCCDS47919.1. [Q02509-2]
PIRiS30392.
RefSeqiNP_001073868.2. NM_001080399.2. [Q02509-2]
UniGeneiHs.653174.

3D structure databases

ProteinModelPortaliQ02509.
SMRiQ02509. Positions 94-173, 342-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262283.

PTM databases

iPTMnetiQ02509.
PhosphoSiteiQ02509.

Polymorphism and mutation databases

BioMutaiOC90.
DMDMi215274202.

Proteomic databases

PaxDbiQ02509.
PRIDEiQ02509.

Protocols and materials databases

DNASUi729330.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254627; ENSP00000254627; ENSG00000253117. [Q02509-2]
GeneIDi729330.
KEGGihsa:729330.
UCSCiuc011lix.1. human. [Q02509-1]

Organism-specific databases

CTDi729330.
GeneCardsiOC90.
HGNCiHGNC:8100. OC90.
MIMi601658. gene.
neXtProtiNX_Q02509.
PharmGKBiPA31889.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000293375.
HOVERGENiHBG007862.
InParanoidiQ02509.
PhylomeDBiQ02509.
TreeFamiTF353106.

Miscellaneous databases

GenomeRNAii729330.
PROiQ02509.
SOURCEiSearch...

Gene expression databases

BgeeiQ02509.
CleanExiHS_OC90.

Family and domain databases

Gene3Di1.20.90.10. 2 hits.
InterProiIPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 2 hits.
PfamiPF00068. Phospholip_A2_1. 2 hits.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 2 hits.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 2 hits.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene."
    Feuchter-Murthy A.E., Freeman J.D., Mager D.L.
    Nucleic Acids Res. 21:135-143(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOC90_HUMAN
AccessioniPrimary (citable) accession number: Q02509
Secondary accession number(s): B4DNG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: June 8, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.