Q02509 (OC90_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Otoconin-90
Short name=Oc90

Alternative name(s):
Phospholipase A2 homolog

Gene names

Name:	OC90
Synonyms:	PLA2L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	It is unlikely that this protein has phospholipase A2 activity.
Subunit structure	Interacts with OTOL1 By similarity.
Subcellular location	Secreted By similarity.
Domain	Consists of 3 PA2-type domains.
Sequence similarities	Belongs to the phospholipase A2 family.
Sequence caution	The sequence CAA78662.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: InterPro phospholipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phospholipase A2 activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q02509-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q02509-2)

The sequence of this isoform differs from the canonical sequence as follows:
     227-243: VAAETEADRLITLSKKK → E

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 493	476	Otoconin-90		PRO_0000022993
Regions
	Region	76 – 190	115	Phospholipase A2-like 1
	Region	321 – 377	57	Phospholipase A2-like 2
	Region	389 – 441	53	Phospholipase A2-like 3
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Glycosylation	423	1	N-linked (GlcNAc...) Potential
	Disulfide bond	85 ↔ 145		By similarity
	Disulfide bond	99 ↔ 190		By similarity
	Disulfide bond	101 ↔ 117		By similarity
	Disulfide bond	116 ↔ 172		By similarity
	Disulfide bond	123 ↔ 165		By similarity
	Disulfide bond	132 ↔ 158		By similarity
	Disulfide bond	152 ↔ 163		By similarity
Natural variations
	Alternative sequence	227 – 243	17	VAAET…LSKKK → E in isoform 2.		VSP_040320
Experimental info
	Sequence conflict	61	1	P → A in CAA78662. Ref.1
	Sequence conflict	124	1	Y → C in CAA78662. Ref.1
	Sequence conflict	144	1	N → D in CAA78662. Ref.1
	Sequence conflict	144	1	N → D in BAG60230. Ref.2
	Sequence conflict	147	1	S → G in CAA78662. Ref.1
	Sequence conflict	147	1	S → G in BAG60230. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 44202DAE5851AEEC	FASTA	493	53,454
	10 20 30 40 50 60 MIAFLLTSVL MIPHAGGHPL DTPHLPQELP PGLPNNINIT FFSGMFKNVE SVAEIFDCLG 70 80 90 100 110 120 PHFTWLQAVF TNFPVLIQFV NGMKCVAGLC PRDFEDYGCT CRFEMEGLPV DESDSCCFQH 130 140 150 160 170 180 RRCYEEAAEM DCLQDPAKLS TEVNCVSKKI ICESKDNCEH LLCTCDKAAI ECLARSSLNS 190 200 210 220 230 240 SLNLLDTSFC LAQTPETTIK EDLTTLLPRV VPVEPTDTSL TALSGEVAAE TEADRLITLS 250 260 270 280 290 300 KKKAGHDQEG VGAARATSPP GSAEIVATRV TAKIVTLVPA GIKSLGLAVS SVENDPEETT 310 320 330 340 350 360 EKACDRFTFL HLGSGDNMQV MPQLGEMLFC LTSRCPEEFE SYGCYCGQEG RGEPRDDLDR 370 380 390 400 410 420 CCLSHHCCLE QVRRLGCLLE RLPWSPVVCV DHTPKCGGQS LCEKLLCACD QTAAECMTSA 430 440 450 460 470 480 SFNQSLKSPS RLGCPGQPAA CEDSLHPVPA APTLGSSSEE DSEEDPPQED LGRAKRFLRK 490 SLGPLGIGPL HGR
	Isoform 2 [UniParc]. Checksum: 14F1A3ED1F813842	FASTA	477	51,728
	10 20 30 40 50 60 MIAFLLTSVL MIPHAGGHPL DTPHLPQELP PGLPNNINIT FFSGMFKNVE SVAEIFDCLG 70 80 90 100 110 120 PHFTWLQAVF TNFPVLIQFV NGMKCVAGLC PRDFEDYGCT CRFEMEGLPV DESDSCCFQH 130 140 150 160 170 180 RRCYEEAAEM DCLQDPAKLS TEVNCVSKKI ICESKDNCEH LLCTCDKAAI ECLARSSLNS 190 200 210 220 230 240 SLNLLDTSFC LAQTPETTIK EDLTTLLPRV VPVEPTDTSL TALSGEEAGH DQEGVGAARA 250 260 270 280 290 300 TSPPGSAEIV ATRVTAKIVT LVPAGIKSLG LAVSSVENDP EETTEKACDR FTFLHLGSGD 310 320 330 340 350 360 NMQVMPQLGE MLFCLTSRCP EEFESYGCYC GQEGRGEPRD DLDRCCLSHH CCLEQVRRLG 370 380 390 400 410 420 CLLERLPWSP VVCVDHTPKC GGQSLCEKLL CACDQTAAEC MTSASFNQSL KSPSRLGCPG 430 440 450 460 470 QPAACEDSLH PVPAAPTLGS SSEEDSEEDP PQEDLGRAKR FLRKSLGPLG IGPLHGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene." Feuchter-Murthy A.E., Freeman J.D., Mager D.L. Nucleic Acids Res. 21:135-143(1993) [PubMed: 8382789] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo.
[3]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z14310 mRNA. Translation: CAA78662.1. Different initiation. AK297911 mRNA. Translation: BAG60230.1. AC092817 Genomic DNA. No translation available. AC100868 Genomic DNA. No translation available.
IPI	IPI00938069. IPI01024950.
PIR	S30392.
RefSeq	NP_001073868.2. NM_001080399.2.
UniGene	Hs.653174.
3D structure databases
ProteinModelPortal	Q02509.
SMR	Q02509. Positions 74-190, 320-441.
ModBase	Search...
Protein-protein interaction databases
STRING	Q02509.
Polymorphism databases
DMDM	215274202.
Proteomic databases
PRIDE	Q02509.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254627; ENSP00000254627; ENSG00000132297. ENST00000262283; ENSP00000262283; ENSG00000132297.
GeneID	729330.
KEGG	hsa:729330.
UCSC	uc003ytg.1. human.
Organism-specific databases
CTD	729330.
GeneCards	GC08M133105.
HGNC	HGNC:8100. OC90.
MIM	601658. gene.
neXtProt	NX_Q02509.
PharmGKB	PA31889.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18289.
GeneTree	ENSGT00550000074218.
HOVERGEN	HBG007862.
InParanoid	Q02509.
OrthoDB	EOG4FJ89C.
PhylomeDB	Q02509.
Gene expression databases
ArrayExpress	Q02509.
Bgee	Q02509.
CleanEx	HS_OC90.
Genevestigator	Q02509.
Family and domain databases
InterPro	IPR016090. PLipase_A2. IPR013090. PLipase_A2_AS. IPR001211. PLipase_A2_euk. [Graphical view]
Gene3D	G3DSA:1.20.90.10. Phospholipase_A2. 2 hits.
PANTHER	PTHR11716. Phospholipase_A2. 1 hit.
Pfam	PF00068. Phospholip_A2_1. 2 hits. [Graphical view]
PRINTS	PR00389. PHPHLIPASEA2.
SMART	SM00085. PA2c. 2 hits. [Graphical view]
SUPFAM	SSF48619. PhospholipaseA2. 2 hits.
PROSITE	PS00119. PA2_ASP. 1 hit. PS00118. PA2_HIS. 2 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

OC90_HUMAN

Accession

Primary (citable) accession number: Q02509
Secondary accession number(s): B4DNG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.