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Q02505 (MUC3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-3A

Short name=MUC-3A
Alternative name(s):
Intestinal mucin-3A
Gene names
Name:MUC3A
Synonyms:MUC3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2541 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. Ref.8

Subcellular location

Isoform 1: Membrane; Single-pass membrane protein.

Isoform 2: Secreted.

Isoform 3: Secreted.

Isoform 4: Secreted.

Isoform 5: Secreted.

Tissue specificity

Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder. Ref.7

Post-translational modification

Highly O-glycosylated and probably also N-glycosylated.

Sequence similarities

Contains 1 EGF-like domain.

Contains 1 SEA domain.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q02505-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q02505-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2237-2284: VVETEVGMEV...MQKIFADMQG → AEDFCRHAGL...ALQPPAGERV
     2285-2541: Missing.
Isoform 3 (identifier: Q02505-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2275-2298: MQKIFADMQGFTFKGVEILSLRNG → EWQHRGGLPGPAGDALQPPAGERV
     2299-2541: Missing.
Isoform 4 (identifier: Q02505-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2299: RNGS → SPVF
     2300-2541: Missing.
Isoform 5 (identifier: Q02505-5)

The sequence of this isoform differs from the canonical sequence as follows:
     2422-2479: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 25412520Mucin-3A
PRO_0000158955

Regions

Transmembrane2445 – 246521Helical; Potential
Repeat1325 – 1341171
Repeat1342 – 1358172
Repeat1359 – 1375173
Repeat1376 – 1392174
Repeat1393 – 1409175
Repeat1410 – 1426176
Repeat1427 – 1443177
Repeat1444 – 1460178
Repeat1461 – 1477179
Repeat1478 – 14941710
Repeat1495 – 15111711
Repeat1512 – 15281712
Repeat1529 – 15451713
Repeat1546 – 15621714
Repeat1563 – 15791715
Repeat1580 – 15961716
Repeat1597 – 16131717
Repeat1614 – 16301718
Repeat1631 – 16471719
Repeat1648 – 16641720
Domain2194 – 222734EGF-like
Domain2236 – 2361126SEA
Region1325 – 166434017 X approximate tandem repeats, Ser/Thr-rich
Compositional bias77 – 21752099Thr-rich
Compositional bias496 – 19651470Ser-rich

Amino acid modifications

Disulfide bond2198 ↔ 2204 By similarity
Disulfide bond2217 ↔ 2226 By similarity

Natural variations

Alternative sequence2237 – 228448VVETE…ADMQG → AEDFCRHAGLHLQGCGDPVP EEWQHRGGLPGPAGDALQPP AGERV in isoform 2.
VSP_023229
Alternative sequence2275 – 229824MQKIF…SLRNG → EWQHRGGLPGPAGDALQPPA GERV in isoform 3.
VSP_023230
Alternative sequence2285 – 2541257Missing in isoform 2.
VSP_023231
Alternative sequence2296 – 22994RNGS → SPVF in isoform 4.
VSP_023232
Alternative sequence2299 – 2541243Missing in isoform 3.
VSP_023233
Alternative sequence2300 – 2541242Missing in isoform 4.
VSP_023234
Alternative sequence2422 – 247958Missing in isoform 5.
VSP_023235
Natural variant23381A → V. Ref.4 Ref.6 Ref.7 Ref.8
VAR_030722
Natural variant25171H → N. Ref.4 Ref.6
VAR_030723
Natural variant25171H → Y Polymorphism; may be associated with Crohn disease. Ref.4 Ref.6 Ref.7 Ref.8
VAR_030724

Experimental info

Sequence conflict2581P → S in AAQ73824. Ref.2
Sequence conflict12381V → L in AAA63772. Ref.5
Sequence conflict12381V → L in AAA63773. Ref.5
Sequence conflict12391T → I in AAA63772. Ref.5
Sequence conflict12391T → I in AAA63773. Ref.5
Sequence conflict1242 – 12454TKIT → SETP in AAA63772. Ref.5
Sequence conflict1242 – 12454TKIT → SETP in AAA63773. Ref.5
Sequence conflict12571A → T in AAA63772. Ref.5
Sequence conflict12571A → T in AAA63773. Ref.5
Sequence conflict12611T → A in AAA63772. Ref.5
Sequence conflict12611T → A in AAA63773. Ref.5
Sequence conflict12641H → S in AAA63772. Ref.5
Sequence conflict12641H → S in AAA63773. Ref.5
Sequence conflict12681R → S in AAA63772. Ref.5
Sequence conflict12681R → S in AAA63773. Ref.5
Sequence conflict12771E → D in AAA63772. Ref.5
Sequence conflict12771E → D in AAA63773. Ref.5
Sequence conflict1278 – 128811Missing in AAA63772. Ref.5
Sequence conflict1278 – 128811Missing in AAA63773. Ref.5
Sequence conflict1291 – 12922TN → VT in AAA63772. Ref.5
Sequence conflict1291 – 12922TN → VT in AAA63773. Ref.5
Sequence conflict12941K → E in AAA63772. Ref.5
Sequence conflict12941K → E in AAA63773. Ref.5
Sequence conflict12971S → Y in AAA63772. Ref.5
Sequence conflict12971S → Y in AAA63773. Ref.5
Sequence conflict13001S → T in AAA63772. Ref.5
Sequence conflict13001S → T in AAA63773. Ref.5
Sequence conflict1306 – 132318Missing in AAA63772. Ref.5
Sequence conflict1306 – 132318Missing in AAA63773. Ref.5
Sequence conflict1344 – 13463TTE → STK in AAA63772. Ref.5
Sequence conflict1344 – 13463TTE → STK in AAA63773. Ref.5
Sequence conflict13641T → I in AAA63772. Ref.5
Sequence conflict13641T → I in AAA63773. Ref.5
Sequence conflict13771T → I in AAA63772. Ref.5
Sequence conflict13771T → I in AAA63773. Ref.5
Sequence conflict1393 – 13964IRTT → MFNS in AAA63772. Ref.5
Sequence conflict1393 – 13964IRTT → MFNS in AAA63773. Ref.5
Sequence conflict1397 – 1504108Missing in AAA63772. Ref.5
Sequence conflict1397 – 1504108Missing in AAA63773. Ref.5
Sequence conflict1449 – 14502IS → TT in AAC02272. Ref.3
Sequence conflict1449 – 14502IS → TT in AAF13032. Ref.4
Sequence conflict14561S → G in AAC02272. Ref.3
Sequence conflict14561S → G in AAF13032. Ref.4
Sequence conflict14581S → T in AAC02272. Ref.3
Sequence conflict14581S → T in AAF13032. Ref.4
Sequence conflict1461 – 14666TIYSTV → ITTTET in AAC02272. Ref.3
Sequence conflict1461 – 14666TIYSTV → ITTTET in AAF13032. Ref.4
Sequence conflict14731R → S in AAC02272. Ref.3
Sequence conflict14731R → S in AAF13032. Ref.4
Sequence conflict14841P → T in AAC02272. Ref.3
Sequence conflict14841P → T in AAF13032. Ref.4
Sequence conflict14871S → D in AAC02272. Ref.3
Sequence conflict14871S → D in AAF13032. Ref.4
Sequence conflict14901R → S in AAC02272. Ref.3
Sequence conflict14901R → S in AAF13032. Ref.4
Sequence conflict14951F → I in AAC02272. Ref.3
Sequence conflict14951F → I in AAF13032. Ref.4
Sequence conflict1497 – 14993NTK → TSE in AAC02272. Ref.3
Sequence conflict1497 – 14993NTK → TSE in AAF13032. Ref.4
Sequence conflict15011T → P in AAC02272. Ref.3
Sequence conflict15011T → P in AAF13032. Ref.4
Sequence conflict1504 – 15052RS → ST in AAC02272. Ref.3
Sequence conflict1504 – 15052RS → ST in AAF13032. Ref.4
Sequence conflict1505 – 15062SP → TA in AAA63772. Ref.5
Sequence conflict1505 – 15062SP → TA in AAA63773. Ref.5
Sequence conflict15081F → S in AAC02272. Ref.3
Sequence conflict15081F → S in AAF13032. Ref.4
Sequence conflict1511 – 15122LI → SM in AAA63772. Ref.5
Sequence conflict1511 – 15122LI → SM in AAA63773. Ref.5
Sequence conflict15161E → K in AAC02272. Ref.3
Sequence conflict15161E → K in AAF13032. Ref.4
Sequence conflict15251F → L in AAA63772. Ref.5
Sequence conflict15251F → L in AAA63773. Ref.5
Sequence conflict15291I → M in AAA63772. Ref.5
Sequence conflict15291I → M in AAA63773. Ref.5
Sequence conflict15311T → A in AAA63772. Ref.5
Sequence conflict15311T → A in AAA63773. Ref.5
Sequence conflict1539 – 15402AR → TP in AAA63772. Ref.5
Sequence conflict1539 – 15402AR → TP in AAA63773. Ref.5
Sequence conflict1554 – 15552HN → NS in AAA63772. Ref.5
Sequence conflict1554 – 15552HN → NS in AAA63773. Ref.5
Sequence conflict15571R → A in AAA63772. Ref.5
Sequence conflict15571R → A in AAA63773. Ref.5
Sequence conflict15591F → L in AAA63772. Ref.5
Sequence conflict15591F → L in AAA63773. Ref.5
Sequence conflict15691N → T in AAA63772. Ref.5
Sequence conflict15691N → T in AAA63773. Ref.5
Sequence conflict15711H → N in AAA63772. Ref.5
Sequence conflict15711H → N in AAA63773. Ref.5
Sequence conflict15741T → A in AAA63772. Ref.5
Sequence conflict15741T → A in AAA63773. Ref.5
Sequence conflict15761F → L in AAA63772. Ref.5
Sequence conflict15761F → L in AAA63773. Ref.5
Sequence conflict15801I → M in AAA63772. Ref.5
Sequence conflict15801I → M in AAA63773. Ref.5
Sequence conflict16111T → P in AAC02272. Ref.3
Sequence conflict21741G → GC in BAB12116. Ref.7
Sequence conflict23671E → A in AAF13032. Ref.4
Sequence conflict23671E → A in BAB12116. Ref.7
Sequence conflict23671E → A in AAD45882. Ref.8
Sequence conflict23671E → A in AAD45883. Ref.8
Sequence conflict24201A → T in AAF13032. Ref.4
Sequence conflict24201A → T in BAB12116. Ref.7
Sequence conflict24201A → T in AAD45882. Ref.8
Sequence conflict24201A → T in AAD45883. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: F1BEB775F9507760

FASTA2,541265,918
        10         20         30         40         50         60 
MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS RDLAGWPLGV 

        70         80         90        100        110        120 
PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT STTPTSKFAF KVETTPPTVL 

       130        140        150        160        170        180 
VYSATTECVY PTSFIITISH PTSICVTTTQ VAFTSSYTST PVTQKPVTTV TSTYSMTTTE 

       190        200        210        220        230        240 
KGTSAMTSSP STTTARETPI VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT 

       250        260        270        280        290        300 
SPTPVFTTLK TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS 

       310        320        330        340        350        360 
TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYPTSP XXXXXXXXXX AMTSPPPVSS 

       370        380        390        400        410        420 
SITPTNTMTS MRTTTYWPTA TNTLSPLTSS ILSSTPVPST EMITSHTTNT TPLSTLVTTL 

       430        440        450        460        470        480 
LTTITRSTPT SETTYPTSPT SIVSDSTTEI TYSTSITGTL STATTLPPTS SSLPTTETAT 

       490        500        510        520        530        540 
MTPTTTLITT TPNTTSHSTP SFTSSTIYST VSTSTTAISS ASPTSGTMVT STTMTPSSLS 

       550        560        570        580        590        600 
TDTPSTTPTT ITYPSVGSTG FLTTATDLTS TFTVSSSSAM SKSVIPSSPS IQNTETSSLV 

       610        620        630        640        650        660 
SMTSATTPSL RPTITSTDST LTSSLLTTFP STYSFSSSMS ASSAGTTHTE TISSLPASTN 

       670        680        690        700        710        720 
TIHTTAESAL APTTTTSFTT SPTMEPPSTT VATTGTGQTT FPSSTATFLE TTTLTPTTDF 

       730        740        750        760        770        780 
STESLTTAMT STPPITSSIT PTDTMTSMRT TTSWPTATNT LSPLTSSILS STPVPSTEVT 

       790        800        810        820        830        840 
TSHTTNTNPV STLVTTLPIT ITRSTLTSET AYPSSPTSTV TESTTEITYP TTMTETSSTA 

       850        860        870        880        890        900 
TSLPPTSSLV STAETAKTPT TNLXXXXXXX XXXFTSSTSL LHSQHTTXLP SPSVPTTLGT 

       910        920        930        940        950        960 
MVTSTSXIPS SLSTDIPTSQ PTTITPSSVG ITGSLPMMTD LTSVYTVSSM SARPTSVIPS 

       970        980        990       1000       1010       1020 
SPTVQNTETS IFVSMMSATT PSGGSTFTST ENTPTRSLLT SFPVTHSFSS SMSASSVGTT 

      1030       1040       1050       1060       1070       1080 
HTQSISSPPA ITSTLHTTAE STPSPTTTMS FTTFTKMETP SSTVATTGTG QTTFTSSTAT 

      1090       1100       1110       1120       1130       1140 
SPKTTTLTPT SDISTGSFKT AVSSTPPITS SITSTYTVTS MTTTTPLGPT ATNTLPSFTS 

      1150       1160       1170       1180       1190       1200 
SVSSSTPVPS TEAITSGTTN TTPLSTLVTT FSNSDTSSTP TSETTYPTSL TSALTDSTTR 

      1210       1220       1230       1240       1250       1260 
TTYSTNMTGT LSTVTSLRPT SSSLLTTVTA TVPTTNLVTT TTKITSHSTP SFTSSIATTE 

      1270       1280       1290       1300       1310       1320 
TPSHSTPRFT SSITTTETPS HSTPRFTSSI TNTKTTSHSS PSFTSSITTT DSIVXXXXXX 

      1330       1340       1350       1360       1370       1380 
XXXXITITET TSHSTPSYTT SITTTETPSH STPSYTTSIT TTETPSHSTP SFTSSITTTE 

      1390       1400       1410       1420       1430       1440 
TTSHSTPSFT SSIRTTETTS YSTPSFTSSN TITETTSHST PSYITSITTT ETPSSSTPSF 

      1450       1460       1470       1480       1490       1500 
SSSITTTEIS SHSTPSFSSS TIYSTVTSHS TPRFTSSITT TETPSHSTPR FTSSFTNTKT 

      1510       1520       1530       1540       1550       1560 
TSHRSPSFTS LITTTETTSH STPSFTSSIT TTETTSHSAR SFTSSITTTE TTSHNTRSFT 

      1570       1580       1590       1600       1610       1620 
SSITTTETNS HSTTSFTSSI TTTETTSHST PSFSSSITTT ETPLHSTPGL TSWVTTTKTT 

      1630       1640       1650       1660       1670       1680 
SHITPGLTSS ITTTETTSHS TPGFTSSITT TETTSESTPS LSSSTIYSTV STSTTAITSH 

      1690       1700       1710       1720       1730       1740 
FTTSETAVTP TPVTPSSLST DIPTTSLRTL TPSSVGTSTS LTTTTDFPSI PTDISTLPTR 

      1750       1760       1770       1780       1790       1800 
THIISSSPSI QSTETSSLVG TTSPTMSTVR MTLRITENTP ISSFSTSIVV IPETPTQTPP 

      1810       1820       1830       1840       1850       1860 
VLTSATGTQT SPAPTTVTFG STDSSTSTLH TLTPSTALST IVSTSQVPIP STHSSTLQTT 

      1870       1880       1890       1900       1910       1920 
PSTPSLQTSL TSTSEFTTES FTRGSTSTNA ILTSFSTIIW SSTPTIIMSS SPSSASITPV 

      1930       1940       1950       1960       1970       1980 
FSTTIHSVPS SPYIFSTENV GSASITGFPS LSSSATTSTS STSSSLTTAL TEITPFSYIS 

      1990       2000       2010       2020       2030       2040 
LPSTTPCPGT ITITIVPASP TDPCVEMDPS TEATSPPTTP LTVFPFTTEM VTCPTSISIQ 

      2050       2060       2070       2080       2090       2100 
TTLTTYMDTS SMMPESESSI SPNASSSTGT GTVPTNTVFT STRLPTSETW LSNSSVIPLP 

      2110       2120       2130       2140       2150       2160 
LPGVSTIPLT MKPSSSLPTI LRTSSKSTHP SPPTTRTSET PVATTQTPTT LTSRRTTRIT 

      2170       2180       2190       2200       2210       2220 
SQMTTQSTLT TTAGTCDNGG TWEQGQCACL PGFSGDRCQL QTRCQNGGQW DGLKCQCPST 

      2230       2240       2250       2260       2270       2280 
FYGSSCEFAV EQVDLDVVET EVGMEVSVDQ QFSPDLNDNT SQAYRDFNKT FWNQMQKIFA 

      2290       2300       2310       2320       2330       2340 
DMQGFTFKGV EILSLRNGSI VVDYLVLLEM PFSPQLESEY EQVKTTLKEG LQNASQDANS 

      2350       2360       2370       2380       2390       2400 
CQDSQTLCFK PDSIKVNNNS KTELTPEAIC RRAAPTGYEE FYFPLVEATR LRCVTKCTSG 

      2410       2420       2430       2440       2450       2460 
VDNAIDCHQG QCVLETSGPA CRCYSTDTHW FSGPRCEVAV HWRALVGGLT AGAALLVLLL 

      2470       2480       2490       2500       2510       2520 
LALGVRAVRS GWWGGQRRGR SWDQDRKWFE TWDEEVVGTF SNWGFEDDGT DKDTNFHVAL 

      2530       2540 
ENVDTTMKVH IKRPEMTSSS V 

« Hide

Isoform 2 [UniParc].

Checksum: 826DA98F3C19CFF9
Show »

FASTA2,281236,332
Isoform 3 [UniParc].

Checksum: 6C1AC87258B27389
Show »

FASTA2,298238,520
Isoform 4 [UniParc].

Checksum: 7298CD3D7EBEDB44
Show »

FASTA2,299238,859
Isoform 5 [UniParc].

Checksum: 3D15D516E62A5B82
Show »

FASTA2,483259,631

References

« Hide 'large scale' references
[1]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus."
Gum J.R. Jr., Hicks J.W., Crawley S.C., Dahl C.M., Yang S.C., Roberton A.M., Kim Y.S.
J. Biol. Chem. 278:49600-49609(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-340 (ISOFORM 1).
[3]"MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region."
Gum J.R. Jr., Ho J.J.L., Pratt W.S., Hicks J.W., Hill A.S., Vinall L.E., Roberton A.M., Swallow D.M., Kim Y.S.
J. Biol. Chem. 272:26678-26686(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 351-863 AND 874-1314 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1325-2284 (ISOFORM 2).
[4]"Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin."
Crawley S.C., Gum J.R. Jr., Hicks J.W., Pratt W.S., Aubert J.-P., Swallow D.M., Kim Y.S.
Biochem. Biophys. Res. Commun. 263:728-736(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-2541 (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), VARIANTS VAL-2338; ASN-2517 AND TYR-2517.
Tissue: Intestine.
[5]"Molecular cloning of cDNAs derived from a novel human intestinal mucin gene."
Gum J.R. Jr., Hicks J.W., Swallow D.M., Lagace R.L., Byrd J.C., Lamport D.T.A., Siddiki B., Kim Y.S.
Biochem. Biophys. Res. Commun. 171:407-415(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1238-1587.
Tissue: Small intestine.
[6]"Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B."
Pratt W.S., Crawley S., Hicks J., Ho J., Nash M., Kim Y.S., Gum J.R., Swallow D.M.
Biochem. Biophys. Res. Commun. 275:916-923(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1642-2541 (ISOFORM 1), VARIANTS VAL-2338; ASN-2517 AND TYR-2517.
[7]"Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease."
Kyo K., Muto T., Nagawa H., Lathrop G.M., Nakamura Y.
J. Hum. Genet. 46:5-20(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1665-2541 (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VAL-2338 AND TYR-2517.
[8]"The MUC3 gene encodes a transmembrane mucin and is alternatively spliced."
Williams S.J., Munster D.J., Quin R.J., Gotley D.C., McGuckin M.A.
Biochem. Biophys. Res. Commun. 261:83-89(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2176-2541 (ISOFORMS 1; 2 AND 5), FUNCTION, VARIANTS VAL-2338 AND TYR-2517.
Tissue: Colon mucosa and Small intestine.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1.
AF007190 mRNA. Translation: AAC02268.1.
AF007193 mRNA. Translation: AAC02271.1.
AF007194 mRNA. Translation: AAC02272.1.
AF113616 Genomic DNA. Translation: AAF13032.1.
M55405 mRNA. Translation: AAA63772.1.
M55406 mRNA. Translation: AAA63773.1.
AB038782 Genomic DNA. Translation: BAB12116.1.
AF143371 mRNA. Translation: AAD45882.1.
AF143372 mRNA. Translation: AAD45883.1.
AF143373 mRNA. Translation: AAD45884.1.
PIRA35690.
B35690.
UniGeneHs.744422.
Hs.744530.

3D structure databases

ProteinModelPortalQ02505.
SMRQ02505. Positions 2171-2229, 2407-2443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ02505. 1 interaction.

Protein family/group databases

MEROPSS71.002.

PTM databases

PhosphoSiteQ02505.

Polymorphism databases

DMDM126302571.

Proteomic databases

PaxDbQ02505.
PRIDEQ02505.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000414964; ENSP00000393306; ENSG00000169894.

Organism-specific databases

GeneCardsGC07P100550.
HGNCHGNC:7513. MUC3A.
HPAHPA010871.
HPA047868.
MIM158371. gene.
neXtProtNX_Q02505.
Orphanet771. Ulcerative colitis.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
InParanoidQ02505.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ02505.
BgeeQ02505.
GenevestigatorQ02505.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view]
PfamPF01390. SEA. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMSSF82671. SSF82671. 1 hit.
PROSITEPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMUC3A. human.
PROQ02505.
SOURCESearch...

Entry information

Entry nameMUC3A_HUMAN
AccessionPrimary (citable) accession number: Q02505
Secondary accession number(s): O14650 expand/collapse secondary AC list , O14651, O43418, O43421, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM