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Q02505

- MUC3A_HUMAN

UniProt

Q02505 - MUC3A_HUMAN

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Protein

Mucin-3A

Gene

MUC3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.1 Publication

GO - Molecular functioni

  1. extracellular matrix constituent, lubricant activity Source: UniProtKB
  2. extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. O-glycan processing Source: Reactome
  3. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiS71.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-3A
Short name:
MUC-3A
Alternative name(s):
Intestinal mucin-3A
Gene namesi
Name:MUC3A
Synonyms:MUC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:7513. MUC3A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2445 – 246521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. Golgi lumen Source: Reactome
  3. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 25412520Mucin-3APRO_0000158955Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2198 ↔ 2204PROSITE-ProRule annotation
Disulfide bondi2217 ↔ 2226PROSITE-ProRule annotation

Post-translational modificationi

Highly O-glycosylated and probably also N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02505.
PRIDEiQ02505.

PTM databases

PhosphoSiteiQ02505.

Expressioni

Tissue specificityi

Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.1 Publication

Gene expression databases

BgeeiQ02505.
ExpressionAtlasiQ02505. baseline and differential.
GenevestigatoriQ02505.

Organism-specific databases

HPAiHPA010871.
HPA047868.

Interactioni

Protein-protein interaction databases

IntActiQ02505. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ02505.
SMRiQ02505. Positions 2170-2230, 2408-2442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1325 – 1341171Add
BLAST
Repeati1342 – 1358172Add
BLAST
Repeati1359 – 1375173Add
BLAST
Repeati1376 – 1392174Add
BLAST
Repeati1393 – 1409175Add
BLAST
Repeati1410 – 1426176Add
BLAST
Repeati1427 – 1443177Add
BLAST
Repeati1444 – 1460178Add
BLAST
Repeati1461 – 1477179Add
BLAST
Repeati1478 – 14941710Add
BLAST
Repeati1495 – 15111711Add
BLAST
Repeati1512 – 15281712Add
BLAST
Repeati1529 – 15451713Add
BLAST
Repeati1546 – 15621714Add
BLAST
Repeati1563 – 15791715Add
BLAST
Repeati1580 – 15961716Add
BLAST
Repeati1597 – 16131717Add
BLAST
Repeati1614 – 16301718Add
BLAST
Repeati1631 – 16471719Add
BLAST
Repeati1648 – 16641720Add
BLAST
Domaini2194 – 222734EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini2236 – 2361126SEAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1325 – 166434017 X approximate tandem repeats, Ser/Thr-richAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 21752099Thr-richAdd
BLAST
Compositional biasi496 – 19651470Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiQ02505.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q02505-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS
60 70 80 90 100
RDLAGWPLGV PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT
110 120 130 140 150
STTPTSKFAF KVETTPPTVL VYSATTECVY PTSFIITISH PTSICVTTTQ
160 170 180 190 200
VAFTSSYTST PVTQKPVTTV TSTYSMTTTE KGTSAMTSSP STTTARETPI
210 220 230 240 250
VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT SPTPVFTTLK
260 270 280 290 300
TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS
310 320 330 340 350
TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYPTSP XXXXXXXXXX
360 370 380 390 400
AMTSPPPVSS SITPTNTMTS MRTTTYWPTA TNTLSPLTSS ILSSTPVPST
410 420 430 440 450
EMITSHTTNT TPLSTLVTTL LTTITRSTPT SETTYPTSPT SIVSDSTTEI
460 470 480 490 500
TYSTSITGTL STATTLPPTS SSLPTTETAT MTPTTTLITT TPNTTSHSTP
510 520 530 540 550
SFTSSTIYST VSTSTTAISS ASPTSGTMVT STTMTPSSLS TDTPSTTPTT
560 570 580 590 600
ITYPSVGSTG FLTTATDLTS TFTVSSSSAM SKSVIPSSPS IQNTETSSLV
610 620 630 640 650
SMTSATTPSL RPTITSTDST LTSSLLTTFP STYSFSSSMS ASSAGTTHTE
660 670 680 690 700
TISSLPASTN TIHTTAESAL APTTTTSFTT SPTMEPPSTT VATTGTGQTT
710 720 730 740 750
FPSSTATFLE TTTLTPTTDF STESLTTAMT STPPITSSIT PTDTMTSMRT
760 770 780 790 800
TTSWPTATNT LSPLTSSILS STPVPSTEVT TSHTTNTNPV STLVTTLPIT
810 820 830 840 850
ITRSTLTSET AYPSSPTSTV TESTTEITYP TTMTETSSTA TSLPPTSSLV
860 870 880 890 900
STAETAKTPT TNLXXXXXXX XXXFTSSTSL LHSQHTTXLP SPSVPTTLGT
910 920 930 940 950
MVTSTSXIPS SLSTDIPTSQ PTTITPSSVG ITGSLPMMTD LTSVYTVSSM
960 970 980 990 1000
SARPTSVIPS SPTVQNTETS IFVSMMSATT PSGGSTFTST ENTPTRSLLT
1010 1020 1030 1040 1050
SFPVTHSFSS SMSASSVGTT HTQSISSPPA ITSTLHTTAE STPSPTTTMS
1060 1070 1080 1090 1100
FTTFTKMETP SSTVATTGTG QTTFTSSTAT SPKTTTLTPT SDISTGSFKT
1110 1120 1130 1140 1150
AVSSTPPITS SITSTYTVTS MTTTTPLGPT ATNTLPSFTS SVSSSTPVPS
1160 1170 1180 1190 1200
TEAITSGTTN TTPLSTLVTT FSNSDTSSTP TSETTYPTSL TSALTDSTTR
1210 1220 1230 1240 1250
TTYSTNMTGT LSTVTSLRPT SSSLLTTVTA TVPTTNLVTT TTKITSHSTP
1260 1270 1280 1290 1300
SFTSSIATTE TPSHSTPRFT SSITTTETPS HSTPRFTSSI TNTKTTSHSS
1310 1320 1330 1340 1350
PSFTSSITTT DSIVXXXXXX XXXXITITET TSHSTPSYTT SITTTETPSH
1360 1370 1380 1390 1400
STPSYTTSIT TTETPSHSTP SFTSSITTTE TTSHSTPSFT SSIRTTETTS
1410 1420 1430 1440 1450
YSTPSFTSSN TITETTSHST PSYITSITTT ETPSSSTPSF SSSITTTEIS
1460 1470 1480 1490 1500
SHSTPSFSSS TIYSTVTSHS TPRFTSSITT TETPSHSTPR FTSSFTNTKT
1510 1520 1530 1540 1550
TSHRSPSFTS LITTTETTSH STPSFTSSIT TTETTSHSAR SFTSSITTTE
1560 1570 1580 1590 1600
TTSHNTRSFT SSITTTETNS HSTTSFTSSI TTTETTSHST PSFSSSITTT
1610 1620 1630 1640 1650
ETPLHSTPGL TSWVTTTKTT SHITPGLTSS ITTTETTSHS TPGFTSSITT
1660 1670 1680 1690 1700
TETTSESTPS LSSSTIYSTV STSTTAITSH FTTSETAVTP TPVTPSSLST
1710 1720 1730 1740 1750
DIPTTSLRTL TPSSVGTSTS LTTTTDFPSI PTDISTLPTR THIISSSPSI
1760 1770 1780 1790 1800
QSTETSSLVG TTSPTMSTVR MTLRITENTP ISSFSTSIVV IPETPTQTPP
1810 1820 1830 1840 1850
VLTSATGTQT SPAPTTVTFG STDSSTSTLH TLTPSTALST IVSTSQVPIP
1860 1870 1880 1890 1900
STHSSTLQTT PSTPSLQTSL TSTSEFTTES FTRGSTSTNA ILTSFSTIIW
1910 1920 1930 1940 1950
SSTPTIIMSS SPSSASITPV FSTTIHSVPS SPYIFSTENV GSASITGFPS
1960 1970 1980 1990 2000
LSSSATTSTS STSSSLTTAL TEITPFSYIS LPSTTPCPGT ITITIVPASP
2010 2020 2030 2040 2050
TDPCVEMDPS TEATSPPTTP LTVFPFTTEM VTCPTSISIQ TTLTTYMDTS
2060 2070 2080 2090 2100
SMMPESESSI SPNASSSTGT GTVPTNTVFT STRLPTSETW LSNSSVIPLP
2110 2120 2130 2140 2150
LPGVSTIPLT MKPSSSLPTI LRTSSKSTHP SPPTTRTSET PVATTQTPTT
2160 2170 2180 2190 2200
LTSRRTTRIT SQMTTQSTLT TTAGTCDNGG TWEQGQCACL PGFSGDRCQL
2210 2220 2230 2240 2250
QTRCQNGGQW DGLKCQCPST FYGSSCEFAV EQVDLDVVET EVGMEVSVDQ
2260 2270 2280 2290 2300
QFSPDLNDNT SQAYRDFNKT FWNQMQKIFA DMQGFTFKGV EILSLRNGSI
2310 2320 2330 2340 2350
VVDYLVLLEM PFSPQLESEY EQVKTTLKEG LQNASQDANS CQDSQTLCFK
2360 2370 2380 2390 2400
PDSIKVNNNS KTELTPEAIC RRAAPTGYEE FYFPLVEATR LRCVTKCTSG
2410 2420 2430 2440 2450
VDNAIDCHQG QCVLETSGPA CRCYSTDTHW FSGPRCEVAV HWRALVGGLT
2460 2470 2480 2490 2500
AGAALLVLLL LALGVRAVRS GWWGGQRRGR SWDQDRKWFE TWDEEVVGTF
2510 2520 2530 2540
SNWGFEDDGT DKDTNFHVAL ENVDTTMKVH IKRPEMTSSS V
Length:2,541
Mass (Da):265,918
Last modified:February 20, 2007 - v2
Checksum:iF1BEB775F9507760
GO
Isoform 2 (identifier: Q02505-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2237-2284: VVETEVGMEV...MQKIFADMQG → AEDFCRHAGL...ALQPPAGERV
     2285-2541: Missing.

Show »
Length:2,281
Mass (Da):236,332
Checksum:i826DA98F3C19CFF9
GO
Isoform 3 (identifier: Q02505-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2275-2298: MQKIFADMQGFTFKGVEILSLRNG → EWQHRGGLPGPAGDALQPPAGERV
     2299-2541: Missing.

Show »
Length:2,298
Mass (Da):238,520
Checksum:i6C1AC87258B27389
GO
Isoform 4 (identifier: Q02505-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2299: RNGS → SPVF
     2300-2541: Missing.

Show »
Length:2,299
Mass (Da):238,859
Checksum:i7298CD3D7EBEDB44
GO
Isoform 5 (identifier: Q02505-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2422-2479: Missing.

Show »
Length:2,483
Mass (Da):259,631
Checksum:i3D15D516E62A5B82
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581P → S in AAQ73824. (PubMed:12958310)Curated
Sequence conflicti1238 – 12381V → L in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1238 – 12381V → L in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1239 – 12391T → I in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1239 – 12391T → I in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1242 – 12454TKIT → SETP in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1242 – 12454TKIT → SETP in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1257 – 12571A → T in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1257 – 12571A → T in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1261 – 12611T → A in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1261 – 12611T → A in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1264 – 12641H → S in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1264 – 12641H → S in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1268 – 12681R → S in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1268 – 12681R → S in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1277 – 12771E → D in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1277 – 12771E → D in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1278 – 128811Missing in AAA63772. (PubMed:2393399)CuratedAdd
BLAST
Sequence conflicti1278 – 128811Missing in AAA63773. (PubMed:2393399)CuratedAdd
BLAST
Sequence conflicti1291 – 12922TN → VT in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1291 – 12922TN → VT in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1294 – 12941K → E in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1294 – 12941K → E in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1297 – 12971S → Y in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1297 – 12971S → Y in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1300 – 13001S → T in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1300 – 13001S → T in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1306 – 132318Missing in AAA63772. (PubMed:2393399)CuratedAdd
BLAST
Sequence conflicti1306 – 132318Missing in AAA63773. (PubMed:2393399)CuratedAdd
BLAST
Sequence conflicti1344 – 13463TTE → STK in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1344 – 13463TTE → STK in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1364 – 13641T → I in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1364 – 13641T → I in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1377 – 13771T → I in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1377 – 13771T → I in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1393 – 13964IRTT → MFNS in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1393 – 13964IRTT → MFNS in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1397 – 1504108Missing in AAA63772. (PubMed:2393399)CuratedAdd
BLAST
Sequence conflicti1397 – 1504108Missing in AAA63773. (PubMed:2393399)CuratedAdd
BLAST
Sequence conflicti1449 – 14502IS → TT in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1449 – 14502IS → TT in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1456 – 14561S → G in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1456 – 14561S → G in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1458 – 14581S → T in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1458 – 14581S → T in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1461 – 14666TIYSTV → ITTTET in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1461 – 14666TIYSTV → ITTTET in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1473 – 14731R → S in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1473 – 14731R → S in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1484 – 14841P → T in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1484 – 14841P → T in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1487 – 14871S → D in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1487 – 14871S → D in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1490 – 14901R → S in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1490 – 14901R → S in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1495 – 14951F → I in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1495 – 14951F → I in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1497 – 14993NTK → TSE in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1497 – 14993NTK → TSE in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1501 – 15011T → P in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1501 – 15011T → P in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1504 – 15052RS → ST in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1504 – 15052RS → ST in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1505 – 15062SP → TA in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1505 – 15062SP → TA in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1508 – 15081F → S in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1508 – 15081F → S in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1511 – 15122LI → SM in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1511 – 15122LI → SM in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1516 – 15161E → K in AAC02272. (PubMed:9334251)Curated
Sequence conflicti1516 – 15161E → K in AAF13032. (PubMed:10512748)Curated
Sequence conflicti1525 – 15251F → L in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1525 – 15251F → L in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1529 – 15291I → M in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1529 – 15291I → M in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1531 – 15311T → A in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1531 – 15311T → A in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1539 – 15402AR → TP in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1539 – 15402AR → TP in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1554 – 15552HN → NS in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1554 – 15552HN → NS in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1557 – 15571R → A in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1557 – 15571R → A in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1559 – 15591F → L in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1559 – 15591F → L in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1569 – 15691N → T in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1569 – 15691N → T in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1571 – 15711H → N in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1571 – 15711H → N in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1574 – 15741T → A in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1574 – 15741T → A in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1576 – 15761F → L in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1576 – 15761F → L in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1580 – 15801I → M in AAA63772. (PubMed:2393399)Curated
Sequence conflicti1580 – 15801I → M in AAA63773. (PubMed:2393399)Curated
Sequence conflicti1611 – 16111T → P in AAC02272. (PubMed:9334251)Curated
Sequence conflicti2174 – 21741G → GC in BAB12116. (PubMed:11289722)Curated
Sequence conflicti2367 – 23671E → A in AAF13032. (PubMed:10512748)Curated
Sequence conflicti2367 – 23671E → A in BAB12116. (PubMed:11289722)Curated
Sequence conflicti2367 – 23671E → A in AAD45882. (PubMed:10405327)Curated
Sequence conflicti2367 – 23671E → A in AAD45883. (PubMed:10405327)Curated
Sequence conflicti2420 – 24201A → T in AAF13032. (PubMed:10512748)Curated
Sequence conflicti2420 – 24201A → T in BAB12116. (PubMed:11289722)Curated
Sequence conflicti2420 – 24201A → T in AAD45882. (PubMed:10405327)Curated
Sequence conflicti2420 – 24201A → T in AAD45883. (PubMed:10405327)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2338 – 23381A → V.4 Publications
VAR_030722
Natural varianti2517 – 25171H → N.2 Publications
VAR_030723
Natural varianti2517 – 25171H → Y Polymorphism; may be associated with Crohn disease. 4 Publications
VAR_030724

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2237 – 228448VVETE…ADMQG → AEDFCRHAGLHLQGCGDPVP EEWQHRGGLPGPAGDALQPP AGERV in isoform 2. 2 PublicationsVSP_023229Add
BLAST
Alternative sequencei2275 – 229824MQKIF…SLRNG → EWQHRGGLPGPAGDALQPPA GERV in isoform 3. CuratedVSP_023230Add
BLAST
Alternative sequencei2285 – 2541257Missing in isoform 2. 2 PublicationsVSP_023231Add
BLAST
Alternative sequencei2296 – 22994RNGS → SPVF in isoform 4. CuratedVSP_023232
Alternative sequencei2299 – 2541243Missing in isoform 3. CuratedVSP_023233Add
BLAST
Alternative sequencei2300 – 2541242Missing in isoform 4. CuratedVSP_023234Add
BLAST
Alternative sequencei2422 – 247958Missing in isoform 5. 1 PublicationVSP_023235Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1.
AF007190 mRNA. Translation: AAC02268.1.
AF007193 mRNA. Translation: AAC02271.1.
AF007194 mRNA. Translation: AAC02272.1.
AF113616 Genomic DNA. Translation: AAF13032.1.
M55405 mRNA. Translation: AAA63772.1.
M55406 mRNA. Translation: AAA63773.1.
AB038782 Genomic DNA. Translation: BAB12116.1.
AF143371 mRNA. Translation: AAD45882.1.
AF143372 mRNA. Translation: AAD45883.1.
AF143373 mRNA. Translation: AAD45884.1.
PIRiA35690.
B35690.
UniGeneiHs.744422.
Hs.744530.

Genome annotation databases

EnsembliENST00000414964; ENSP00000393306; ENSG00000169894.

Polymorphism databases

DMDMi126302571.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1 .
AF007190 mRNA. Translation: AAC02268.1 .
AF007193 mRNA. Translation: AAC02271.1 .
AF007194 mRNA. Translation: AAC02272.1 .
AF113616 Genomic DNA. Translation: AAF13032.1 .
M55405 mRNA. Translation: AAA63772.1 .
M55406 mRNA. Translation: AAA63773.1 .
AB038782 Genomic DNA. Translation: BAB12116.1 .
AF143371 mRNA. Translation: AAD45882.1 .
AF143372 mRNA. Translation: AAD45883.1 .
AF143373 mRNA. Translation: AAD45884.1 .
PIRi A35690.
B35690.
UniGenei Hs.744422.
Hs.744530.

3D structure databases

ProteinModelPortali Q02505.
SMRi Q02505. Positions 2170-2230, 2408-2442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q02505. 1 interaction.

Protein family/group databases

MEROPSi S71.002.

PTM databases

PhosphoSitei Q02505.

Polymorphism databases

DMDMi 126302571.

Proteomic databases

PaxDbi Q02505.
PRIDEi Q02505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000414964 ; ENSP00000393306 ; ENSG00000169894 .

Organism-specific databases

GeneCardsi GC07P100550.
HGNCi HGNC:7513. MUC3A.
HPAi HPA010871.
HPA047868.
MIMi 158371. gene.
neXtProti NX_Q02505.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi Q02505.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSi MUC3A. human.
PROi Q02505.
SOURCEi Search...

Gene expression databases

Bgeei Q02505.
ExpressionAtlasi Q02505. baseline and differential.
Genevestigatori Q02505.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view ]
Pfami PF01390. SEA. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus."
    Gum J.R. Jr., Hicks J.W., Crawley S.C., Dahl C.M., Yang S.C., Roberton A.M., Kim Y.S.
    J. Biol. Chem. 278:49600-49609(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-340 (ISOFORM 1).
  3. "MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region."
    Gum J.R. Jr., Ho J.J.L., Pratt W.S., Hicks J.W., Hill A.S., Vinall L.E., Roberton A.M., Swallow D.M., Kim Y.S.
    J. Biol. Chem. 272:26678-26686(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 351-863 AND 874-1314 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1325-2284 (ISOFORM 2).
  4. "Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin."
    Crawley S.C., Gum J.R. Jr., Hicks J.W., Pratt W.S., Aubert J.-P., Swallow D.M., Kim Y.S.
    Biochem. Biophys. Res. Commun. 263:728-736(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-2541 (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), VARIANTS VAL-2338; ASN-2517 AND TYR-2517.
    Tissue: Intestine.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1238-1587.
    Tissue: Small intestine.
  6. "Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B."
    Pratt W.S., Crawley S., Hicks J., Ho J., Nash M., Kim Y.S., Gum J.R., Swallow D.M.
    Biochem. Biophys. Res. Commun. 275:916-923(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1642-2541 (ISOFORM 1), VARIANTS VAL-2338; ASN-2517 AND TYR-2517.
  7. "Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease."
    Kyo K., Muto T., Nagawa H., Lathrop G.M., Nakamura Y.
    J. Hum. Genet. 46:5-20(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1665-2541 (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VAL-2338 AND TYR-2517.
  8. "The MUC3 gene encodes a transmembrane mucin and is alternatively spliced."
    Williams S.J., Munster D.J., Quin R.J., Gotley D.C., McGuckin M.A.
    Biochem. Biophys. Res. Commun. 261:83-89(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2176-2541 (ISOFORMS 1; 2 AND 5), FUNCTION, VARIANTS VAL-2338 AND TYR-2517.
    Tissue: Colon mucosa and Small intestine.

Entry informationi

Entry nameiMUC3A_HUMAN
AccessioniPrimary (citable) accession number: Q02505
Secondary accession number(s): O14650
, O14651, O43418, O43421, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3