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Protein

Mucin-3A

Gene

MUC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.1 Publication

GO - Molecular functioni

  • extracellular matrix constituent, lubricant activity Source: UniProtKB
  • extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-3ACurated
Short name:
MUC-3ACurated
Alternative name(s):
Intestinal mucin-3A1 Publication
Gene namesi
Name:MUC3AImported
Synonyms:MUC31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:7513. MUC3A.

Subcellular locationi

Isoform 2 :
Isoform 3 :
Isoform 4 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3227 – 324721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • Golgi lumen Source: Reactome
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi126302571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 33233308Mucin-3APRO_0000158955Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2980 ↔ 2986PROSITE-ProRule annotation
Disulfide bondi2999 ↔ 3008PROSITE-ProRule annotation

Post-translational modificationi

Highly O-glycosylated and probably also N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02505.
PRIDEiQ02505.

PTM databases

iPTMnetiQ02505.
PhosphoSiteiQ02505.

Expressioni

Tissue specificityi

Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.1 Publication

Gene expression databases

BgeeiQ02505.
ExpressionAtlasiQ02505. baseline and differential.
GenevisibleiQ02505. HS.

Organism-specific databases

HPAiHPA010871.
HPA047868.

Interactioni

Protein-protein interaction databases

IntActiQ02505. 1 interaction.
STRINGi9606.ENSP00000324834.

Structurei

3D structure databases

ProteinModelPortaliQ02505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1893 – 1910181Add
BLAST
Repeati1911 – 1927172Add
BLAST
Repeati1928 – 1944173Add
BLAST
Repeati1945 – 1961174Add
BLAST
Repeati1962 – 1978175Add
BLAST
Repeati1979 – 1995176Add
BLAST
Repeati1996 – 2012177Add
BLAST
Repeati2013 – 2029178Add
BLAST
Repeati2030 – 2046179Add
BLAST
Repeati2047 – 20621610Add
BLAST
Repeati2063 – 20791711Add
BLAST
Repeati2080 – 20961712Add
BLAST
Repeati2097 – 21131713Add
BLAST
Repeati2114 – 21301714Add
BLAST
Repeati2131 – 21471715Add
BLAST
Repeati2148 – 21641716Add
BLAST
Repeati2165 – 21912717Add
BLAST
Repeati2192 – 22081718Add
BLAST
Repeati2209 – 22251719Add
BLAST
Repeati2226 – 22421720Add
BLAST
Repeati2243 – 22591721Add
BLAST
Repeati2260 – 22761722Add
BLAST
Repeati2277 – 22931723Add
BLAST
Repeati2294 – 23101724Add
BLAST
Repeati2311 – 23271725Add
BLAST
Repeati2328 – 23441726Add
BLAST
Repeati2345 – 23611727Add
BLAST
Repeati2362 – 23781728Add
BLAST
Repeati2379 – 23951729Add
BLAST
Repeati2396 – 24121730Add
BLAST
Repeati2413 – 24291731Add
BLAST
Repeati2430 – 24461732Add
BLAST
Domaini2976 – 300934EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini3018 – 3143126SEAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1893 – 244655432 X approximate tandem repeats, Ser/Thr-richAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 29572881Thr-richAdd
BLAST
Compositional biasi395 – 27472353Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVGW. Eukaryota.
ENOG410ZCSE. LUCA.
GeneTreeiENSGT00730000111040.
HOVERGENiHBG099390.
InParanoidiQ02505.
OMAiQYMANAD.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000082. SEA_dom.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q02505-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS
60 70 80 90 100
RDLAGWPLGV PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT
110 120 130 140 150
STTPTSKFAF KVETTPPTVL VYSATTECVY PTSFIITISH PTSICVTTTQ
160 170 180 190 200
VAFTSSYTST PVTQKPVTTV TSTYSMTTTE KGTSAMTSSP STTTARETPI
210 220 230 240 250
VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT SPTPVFTTLK
260 270 280 290 300
TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS
310 320 330 340 350
TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYTTSP TSTVTDSTTK
360 370 380 390 400
IAYSTSMTGT LSTETSLPPT SSSLPTTETA TTPMTNLVTT TTEISSHSTP
410 420 430 440 450
SFSSSTIYST VSTSTTAISS LPPTSGTMVT STTMTPSSLS TDIPFTTPTT
460 470 480 490 500
ITHHSVGSTG FLTTATDLTS TFTVSSSSAM STSVIPSSPS IQNTETSSLV
510 520 530 540 550
SMTSATTPNV RPTFVSTLST PTSSLLTTFP ATYSFSSSMS ASSAGTTHTE
560 570 580 590 600
SISSPPASTS TLHTTAESTL APTTTTSFTT STTMEPPSTT AATTGTGQTT
610 620 630 640 650
FTSSTATFPE TTTPTPTTDM STESLTTAMT SPPITSSVTS TNTVTSMTTT
660 670 680 690 700
TSPPTTTNSF TSLTSMPLSS TPVPSTEVVT SGTINTIPPS ILVTTLPTPN
710 720 730 740 750
ASSMTTSETT YPNSPTGPGT NSTTEITYPT TMTETSSTAT SLPPTSPLVS
760 770 780 790 800
TAKTAKTPTT NLVTTTTKTT SHSTTSFTSS TVYSTASTYT TAITSVPTTL
810 820 830 840 850
GTMVTSTSMI SSTVSTGIPT SQPTTITPSS VGISGSLPMM TDLTSVYTVS
860 870 880 890 900
NMSARPTTVI PSSPTVQNTE ISISVSMTSA TTPSGGPTFT STENTPTRSL
910 920 930 940 950
LTSFPMTHSF SSSMSESSAG TTHTESISSP RGTTSTLHTT VESTPSPTTT
960 970 980 990 1000
TSFTTSTMME PPSSTVSTTG RGQTTFPSST ATFPETTTLT PTTDISTVSL
1010 1020 1030 1040 1050
TTAMTSPPPV SSSITPTNTM TSMRTTTYWP TATNTLSPLT SSILSSTPVP
1060 1070 1080 1090 1100
STEMITSHTT NTTPLSTLVT TLLTTITRST PTSETTYPTS PTSIVSDSTT
1110 1120 1130 1140 1150
EITYSTSITG TLSTATTLPP TSSSLPTTET ATMTPTTTLI TTTPNTTSLS
1160 1170 1180 1190 1200
TPSFTSSTIY STVSTSTTAI SSASPTSGTM VTSTTMTPSS LSTDTPSTTP
1210 1220 1230 1240 1250
TTITYPSVGS TGFLTTATDL TSTFTVSSSS AMSTSVIPSS PSIQNTETSS
1260 1270 1280 1290 1300
LVSMTSATTP SLRPTITSTD STLTSSLLTT FPSTYSFSSS MSASSAGTTH
1310 1320 1330 1340 1350
TETISSLPAS TNTIHTTAES ALAPTTTTSF TTSPTMEPPS TTVATTGTGQ
1360 1370 1380 1390 1400
TTFPSSTATF LETTTLTPTT DFSTESLTTA MTSTPPITSS ITPTDTMTSM
1410 1420 1430 1440 1450
RTTTSWPTAT NTLSPLTSSI LSSTPVPSTE VTTSHTTNTN PVSTLVTTLP
1460 1470 1480 1490 1500
ITITRSTLTS ETAYPSSPTS TVTESTTEIT YPTTMTETSS TATSLPPTSS
1510 1520 1530 1540 1550
LVSTAETAKT PTTNLVTTTT KTTSHSTTSF TSSTIYSTAS TPTTAITSVP
1560 1570 1580 1590 1600
TTLGTMVTST SMIPSTVSTG IPTSQPTTIT PSSVGISGSL PMMTDLTSVY
1610 1620 1630 1640 1650
TVSSMSARPT SVIPSSPTVQ NTETSIFVSM MSATTPSGGP TFTSTENTPT
1660 1670 1680 1690 1700
RSLLTSFPVT HSFSSSMSAS SVGTTHTQSI SSPPAITSTL HTTAESTPSP
1710 1720 1730 1740 1750
TTTMSFTTFT KMETPSSTVA TTGTGQTTFT SSTATSPKTT TLTPTSDIST
1760 1770 1780 1790 1800
GSFKTAVSST PPITSSITST YTVTSMTTTT PLGPTATNTL PSFTSSVSSS
1810 1820 1830 1840 1850
TPVPSTEAIT SGTTNTTPLS TLVTTFSNSD TSSTPTSETT YPTSLTSALT
1860 1870 1880 1890 1900
DSTTRTTYST NMTGTLSTVT SLRPTSSSLL TTVTATVPTT NLVTTTTKIT
1910 1920 1930 1940 1950
SHSTPSFTSS IATTETPSHS TPRFTSSITT TETPSHSTPR FTSSITNTKT
1960 1970 1980 1990 2000
TSHSSPSFTS SITTTETTSH NTPSLTSSIT TTKTTSHSTP SYTSLITTTT
2010 2020 2030 2040 2050
TTSHSTPSFT SSITTTETTS HNTPSLTSSI TTTETTSHST PSFTSSITTE
2060 2070 2080 2090 2100
TTSHSTPSFT SLITITEITS HSTLSYTTSI TTTETPSHST LSFTSSITTT
2110 2120 2130 2140 2150
ETTSHSTPSF TSSITTSEMP SHSTPSFTSS ITTTENATHS TPNFTSSITT
2160 2170 2180 2190 2200
TETTSHSTPS FTSLITTTET TSHRWGTTET TSYSTPSFTS SNTITETTSH
2210 2220 2230 2240 2250
STPSYITSIT TTETPSSSTP SFSSSITTTE TTSHSTPGFT SSITTTETTS
2260 2270 2280 2290 2300
HSTPSFTSSI TTTETTSHDT PSFTSSITTS ETPSHSTPSS TSLITTTKTT
2310 2320 2330 2340 2350
SHSTPSFTSS ITTTETTSHS AHSFTSSITT TETTSHNTRS FTSSITTTET
2360 2370 2380 2390 2400
NSHSTTSFTS SITTTETTSH STPSFSSSIT TTETPLHSTP GLTSWVTTTK
2410 2420 2430 2440 2450
TTSHITPGLT SSITTTETTS HSTPGFTSSI TTTETTSEST PSLSSSTIYS
2460 2470 2480 2490 2500
TVSTSTTAIT SHFTTSETAV TPTPVTPSSL STDIPTTSLR TLTPSSVGTS
2510 2520 2530 2540 2550
TSLTTTTDFP SIPTDISTLP TRTHIISSSP SIQSTETSSL VGTTSPTMST
2560 2570 2580 2590 2600
VRMTLRITEN TPISSFSTSI VVIPETPTQT PPVLTSATGT QTSPAPTTVT
2610 2620 2630 2640 2650
FGSTDSSTST LHTLTPSTAL STIVSTSQVP IPSTHSSTLQ TTPSTPSLQT
2660 2670 2680 2690 2700
SLTSTSEFTT ESFTRGSTST NAILTSFSTI IWSSTPTIIM SSSPSSASIT
2710 2720 2730 2740 2750
PVFSTTIHSV PSSPYIFSTE NVGSASITGF PSLSSSATTS TSSTSSSLTT
2760 2770 2780 2790 2800
ALTEITPFSY ISLPSTTPCP GTITITIVPA SPTDPCVEMD PSTEATSPPT
2810 2820 2830 2840 2850
TPLTVFPFTT EMVTCPTSIS IQTTLTTYMD TSSMMPESES SISPNASSST
2860 2870 2880 2890 2900
GTGTVPTNTV FTSTRLPTSE TWLSNSSVIP LPLPGVSTIP LTMKPSSSLP
2910 2920 2930 2940 2950
TILRTSSKST HPSPPTTRTS ETPVATTQTP TTLTSRRTTR ITSQMTTQST
2960 2970 2980 2990 3000
LTTTAGTCDN GGTWEQGQCA CLPGFSGDRC QLQTRCQNGG QWDGLKCQCP
3010 3020 3030 3040 3050
STFYGSSCEF AVEQVDLDVV ETEVGMEVSV DQQFSPDLND NTSQAYRDFN
3060 3070 3080 3090 3100
KTFWNQMQKI FADMQGFTFK GVEILSLRNG SIVVDYLVLL EMPFSPQLES
3110 3120 3130 3140 3150
EYEQVKTTLK EGLQNASQDV NSCQDSQTLC FKPDSIKVNN NSKTELTPAA
3160 3170 3180 3190 3200
ICRRAAPTGY EEFYFPLVEA TRLRCVTKCT SGVDNAIDCH QGQCVLETSG
3210 3220 3230 3240 3250
PTCRCYSTDT HWFSGPRCEV AVHWRALVGG LTAGAALLVL LLLALGVRAV
3260 3270 3280 3290 3300
RSGWWGGQRR GRSWDQDRKW FETWDEEVVG TFSNWGFEDD GTDKDTNFYV
3310 3320
ALENVDTTMK VHIKRPEMTS SSV
Length:3,323
Mass (Da):345,127
Last modified:April 13, 2016 - v3
Checksum:i8C6E21ADD26637EF
GO
Isoform 2 (identifier: Q02505-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3019-3063: VVETEVGMEV...WNQMQKIFAD → AEDFCRHAGL...ALQPPAGERV
     3064-3323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:3,063
Mass (Da):315,514
Checksum:i5DDF446F97DAF6C3
GO
Isoform 3 (identifier: Q02505-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3057-3080: MQKIFADMQGFTFKGVEILSLRNG → EWQHRGGLPGPAGDALQPPAGERV
     3081-3323: Missing.

Show »
Length:3,080
Mass (Da):317,703
Checksum:i8EB5575D9A5144B1
GO
Isoform 4 (identifier: Q02505-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3078-3081: RNGS → SPVF
     3082-3323: Missing.

Show »
Length:3,081
Mass (Da):318,041
Checksum:i52FA62A2517C3873
GO
Isoform 5 (identifier: Q02505-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3204-3261: Missing.

Show »
Length:3,265
Mass (Da):338,839
Checksum:i16A557A14778C0CE
GO

Sequence cautioni

The sequence AAA63772.1 differs from that shown.This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.Curated
The sequence AAA63773.1 differs from that shown.This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.Curated
The sequence AAC02271.1 differs from that shown. Reason: Frameshift at positions 1535, 1542 and 1548. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581P → S in AAQ73824 (PubMed:12853948).Curated
Sequence conflicti337 – 3371T → P in AAQ73824 (PubMed:12853948).Curated
Sequence conflicti1149 – 11491L → H in AAC02268 (PubMed:9334251).Curated
Sequence conflicti1234 – 12341T → K in AAC02268 (PubMed:9334251).Curated
Sequence conflicti1542 – 15421P → L in AAC02271 (PubMed:9334251).Curated
Sequence conflicti1570 – 15701G → D in AAC02271 (PubMed:9334251).Curated
Sequence conflicti1587 – 15871S → T in AAC02271 (PubMed:9334251).Curated
Sequence conflicti1640 – 16401P → S in AAC02271 (PubMed:9334251).Curated
Sequence conflicti1966 – 19694ETTS → DSIV in AAC02271 (PubMed:9334251).Curated
Sequence conflicti2099 – 20991T → I in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2099 – 20991T → I in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2110 – 21101F → Y in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2110 – 21101F → Y in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2112 – 21121S → T in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2112 – 21121S → T in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2117 – 21171S → T in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2117 – 21171S → T in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2119 – 21191M → T in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2119 – 21191M → T in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2127 – 21271F → Y in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2127 – 21271F → Y in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2129 – 21291S → T in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2129 – 21291S → T in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2136 – 21383NAT → TPS in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2136 – 21383NAT → TPS in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2143 – 21431N → S in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2143 – 21431N → S in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2164 – 21663LIT → SIR in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2164 – 21663LIT → SIR in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2169 – 217810Missing in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2169 – 217810Missing in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2322 – 23221H → R in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2322 – 23221H → R in AAF13032 (PubMed:10512748).Curated
Sequence conflicti2393 – 23931T → P in AAC02272 (PubMed:9334251).Curated
Sequence conflicti2956 – 29561G → GC in BAB12116 (PubMed:11289722).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3120 – 31201V → A.1 Publication
VAR_030722
Natural varianti3299 – 32991Y → H Polymorphism; may be associated with Crohn disease. 1 Publication
VAR_030724
Natural varianti3299 – 32991Y → N.2 Publications
VAR_030723

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3019 – 306345VVETE…KIFAD → AEDFCRHAGLHLQGCGDPVP EEWQHRGGLPGPAGDALQPP AGERV in isoform 2. 2 PublicationsVSP_023229Add
BLAST
Alternative sequencei3057 – 308024MQKIF…SLRNG → EWQHRGGLPGPAGDALQPPA GERV in isoform 3. 1 PublicationVSP_023230Add
BLAST
Alternative sequencei3064 – 3323260Missing in isoform 2. 2 PublicationsVSP_023231Add
BLAST
Alternative sequencei3078 – 30814RNGS → SPVF in isoform 4. 1 PublicationVSP_023232
Alternative sequencei3081 – 3323243Missing in isoform 3. 1 PublicationVSP_023233Add
BLAST
Alternative sequencei3082 – 3323242Missing in isoform 4. 1 PublicationVSP_023234Add
BLAST
Alternative sequencei3204 – 326158Missing in isoform 5. 1 PublicationVSP_023235Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AC254629 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1.
AF007190 mRNA. Translation: AAC02268.1.
AF007193 mRNA. Translation: AAC02271.1. Frameshift.
AF007194 mRNA. Translation: AAC02272.1.
AF113616 Genomic DNA. Translation: AAF13032.1.
AB038782 Genomic DNA. Translation: BAB12116.1.
AF143371 mRNA. Translation: AAD45882.1.
AF143372 mRNA. Translation: AAD45883.1.
AF143373 mRNA. Translation: AAD45884.1.
M55405 mRNA. Translation: AAA63772.1. Sequence problems.
M55406 mRNA. Translation: AAA63773.1. Sequence problems.
PIRiA35690.
B35690.
RefSeqiNP_005951.1. NM_005960.1.
UniGeneiHs.703577.
Hs.723567.
Hs.744422.
Hs.744530.

Genome annotation databases

EnsembliENST00000379458; ENSP00000368771; ENSG00000169894. [Q02505-1]
ENST00000483366; ENSP00000483541; ENSG00000169894. [Q02505-5]
GeneIDi4584.
KEGGihsa:4584.
UCSCiuc064gjo.1. human. [Q02505-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AC254629 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1.
AF007190 mRNA. Translation: AAC02268.1.
AF007193 mRNA. Translation: AAC02271.1. Frameshift.
AF007194 mRNA. Translation: AAC02272.1.
AF113616 Genomic DNA. Translation: AAF13032.1.
AB038782 Genomic DNA. Translation: BAB12116.1.
AF143371 mRNA. Translation: AAD45882.1.
AF143372 mRNA. Translation: AAD45883.1.
AF143373 mRNA. Translation: AAD45884.1.
M55405 mRNA. Translation: AAA63772.1. Sequence problems.
M55406 mRNA. Translation: AAA63773.1. Sequence problems.
PIRiA35690.
B35690.
RefSeqiNP_005951.1. NM_005960.1.
UniGeneiHs.703577.
Hs.723567.
Hs.744422.
Hs.744530.

3D structure databases

ProteinModelPortaliQ02505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02505. 1 interaction.
STRINGi9606.ENSP00000324834.

PTM databases

iPTMnetiQ02505.
PhosphoSiteiQ02505.

Polymorphism and mutation databases

DMDMi126302571.

Proteomic databases

PaxDbiQ02505.
PRIDEiQ02505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379458; ENSP00000368771; ENSG00000169894. [Q02505-1]
ENST00000483366; ENSP00000483541; ENSG00000169894. [Q02505-5]
GeneIDi4584.
KEGGihsa:4584.
UCSCiuc064gjo.1. human. [Q02505-1]

Organism-specific databases

CTDi4584.
GeneCardsiMUC3A.
HGNCiHGNC:7513. MUC3A.
HPAiHPA010871.
HPA047868.
MIMi158371. gene.
neXtProtiNX_Q02505.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVGW. Eukaryota.
ENOG410ZCSE. LUCA.
GeneTreeiENSGT00730000111040.
HOVERGENiHBG099390.
InParanoidiQ02505.
OMAiQYMANAD.

Enzyme and pathway databases

ReactomeiR-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiMUC3A. human.
NextBioi35462721.
PROiQ02505.
SOURCEiSearch...

Gene expression databases

BgeeiQ02505.
ExpressionAtlasiQ02505. baseline and differential.
GenevisibleiQ02505. HS.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000082. SEA_dom.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus."
    Gum J.R. Jr., Hicks J.W., Crawley S.C., Dahl C.M., Yang S.C., Roberton A.M., Kim Y.S.
    J. Biol. Chem. 278:49600-49609(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-340 (ISOFORM 1).
  3. "MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region."
    Gum J.R. Jr., Ho J.J.L., Pratt W.S., Hicks J.W., Hill A.S., Vinall L.E., Roberton A.M., Swallow D.M., Kim Y.S.
    J. Biol. Chem. 272:26678-26686(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1003-1515 AND 1530-1969 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 2097-3323 (ISOFORM 2).
  4. "Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin."
    Crawley S.C., Gum J.R. Jr., Hicks J.W., Pratt W.S., Aubert J.-P., Swallow D.M., Kim Y.S.
    Biochem. Biophys. Res. Commun. 263:728-736(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2097-3323 (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), VARIANT ASN-3299, SUBCELLULAR LOCATION.
    Tissue: Intestine.
  5. "Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease."
    Kyo K., Muto T., Nagawa H., Lathrop G.M., Nakamura Y.
    J. Hum. Genet. 46:5-20(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2447-3323 (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS ALA-3120; ASN-3299 AND HIS-3299.
  6. "The MUC3 gene encodes a transmembrane mucin and is alternatively spliced."
    Williams S.J., Munster D.J., Quin R.J., Gotley D.C., McGuckin M.A.
    Biochem. Biophys. Res. Commun. 261:83-89(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2958-3323 (ISOFORMS 1; 2 AND 5), FUNCTION.
    Tissue: Colon mucosa and Small intestine.
  7. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMUC3A_HUMAN
AccessioniPrimary (citable) accession number: Q02505
Secondary accession number(s): A6NP22
, O14650, O14651, O43418, O43421, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 13, 2016
Last modified: May 11, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.