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Q02505

- MUC3A_HUMAN

UniProt

Q02505 - MUC3A_HUMAN

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Protein

Mucin-3A

Gene
MUC3A, MUC3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.1 Publication

GO - Molecular functioni

  1. extracellular matrix constituent, lubricant activity Source: UniProtKB
  2. extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. O-glycan processing Source: Reactome
  3. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiS71.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-3A
Short name:
MUC-3A
Alternative name(s):
Intestinal mucin-3A
Gene namesi
Name:MUC3A
Synonyms:MUC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:7513. MUC3A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2445 – 246521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. Golgi lumen Source: Reactome
  3. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti771. Ulcerative colitis.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 25412520Mucin-3APRO_0000158955Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2198 ↔ 2204 By similarity
Disulfide bondi2217 ↔ 2226 By similarity

Post-translational modificationi

Highly O-glycosylated and probably also N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02505.
PRIDEiQ02505.

PTM databases

PhosphoSiteiQ02505.

Expressioni

Tissue specificityi

Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.1 Publication

Gene expression databases

ArrayExpressiQ02505.
BgeeiQ02505.
GenevestigatoriQ02505.

Organism-specific databases

HPAiHPA010871.
HPA047868.

Interactioni

Protein-protein interaction databases

IntActiQ02505. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ02505.
SMRiQ02505. Positions 2183-2228, 2409-2441.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1325 – 1341171Add
BLAST
Repeati1342 – 1358172Add
BLAST
Repeati1359 – 1375173Add
BLAST
Repeati1376 – 1392174Add
BLAST
Repeati1393 – 1409175Add
BLAST
Repeati1410 – 1426176Add
BLAST
Repeati1427 – 1443177Add
BLAST
Repeati1444 – 1460178Add
BLAST
Repeati1461 – 1477179Add
BLAST
Repeati1478 – 14941710Add
BLAST
Repeati1495 – 15111711Add
BLAST
Repeati1512 – 15281712Add
BLAST
Repeati1529 – 15451713Add
BLAST
Repeati1546 – 15621714Add
BLAST
Repeati1563 – 15791715Add
BLAST
Repeati1580 – 15961716Add
BLAST
Repeati1597 – 16131717Add
BLAST
Repeati1614 – 16301718Add
BLAST
Repeati1631 – 16471719Add
BLAST
Repeati1648 – 16641720Add
BLAST
Domaini2194 – 222734EGF-likeAdd
BLAST
Domaini2236 – 2361126SEAAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1325 – 166434017 X approximate tandem repeats, Ser/Thr-richAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 21752099Thr-richAdd
BLAST
Compositional biasi496 – 19651470Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.
Contains 1 SEA domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiQ02505.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q02505-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS     50
RDLAGWPLGV PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT 100
STTPTSKFAF KVETTPPTVL VYSATTECVY PTSFIITISH PTSICVTTTQ 150
VAFTSSYTST PVTQKPVTTV TSTYSMTTTE KGTSAMTSSP STTTARETPI 200
VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT SPTPVFTTLK 250
TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS 300
TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYPTSP XXXXXXXXXX 350
AMTSPPPVSS SITPTNTMTS MRTTTYWPTA TNTLSPLTSS ILSSTPVPST 400
EMITSHTTNT TPLSTLVTTL LTTITRSTPT SETTYPTSPT SIVSDSTTEI 450
TYSTSITGTL STATTLPPTS SSLPTTETAT MTPTTTLITT TPNTTSHSTP 500
SFTSSTIYST VSTSTTAISS ASPTSGTMVT STTMTPSSLS TDTPSTTPTT 550
ITYPSVGSTG FLTTATDLTS TFTVSSSSAM SKSVIPSSPS IQNTETSSLV 600
SMTSATTPSL RPTITSTDST LTSSLLTTFP STYSFSSSMS ASSAGTTHTE 650
TISSLPASTN TIHTTAESAL APTTTTSFTT SPTMEPPSTT VATTGTGQTT 700
FPSSTATFLE TTTLTPTTDF STESLTTAMT STPPITSSIT PTDTMTSMRT 750
TTSWPTATNT LSPLTSSILS STPVPSTEVT TSHTTNTNPV STLVTTLPIT 800
ITRSTLTSET AYPSSPTSTV TESTTEITYP TTMTETSSTA TSLPPTSSLV 850
STAETAKTPT TNLXXXXXXX XXXFTSSTSL LHSQHTTXLP SPSVPTTLGT 900
MVTSTSXIPS SLSTDIPTSQ PTTITPSSVG ITGSLPMMTD LTSVYTVSSM 950
SARPTSVIPS SPTVQNTETS IFVSMMSATT PSGGSTFTST ENTPTRSLLT 1000
SFPVTHSFSS SMSASSVGTT HTQSISSPPA ITSTLHTTAE STPSPTTTMS 1050
FTTFTKMETP SSTVATTGTG QTTFTSSTAT SPKTTTLTPT SDISTGSFKT 1100
AVSSTPPITS SITSTYTVTS MTTTTPLGPT ATNTLPSFTS SVSSSTPVPS 1150
TEAITSGTTN TTPLSTLVTT FSNSDTSSTP TSETTYPTSL TSALTDSTTR 1200
TTYSTNMTGT LSTVTSLRPT SSSLLTTVTA TVPTTNLVTT TTKITSHSTP 1250
SFTSSIATTE TPSHSTPRFT SSITTTETPS HSTPRFTSSI TNTKTTSHSS 1300
PSFTSSITTT DSIVXXXXXX XXXXITITET TSHSTPSYTT SITTTETPSH 1350
STPSYTTSIT TTETPSHSTP SFTSSITTTE TTSHSTPSFT SSIRTTETTS 1400
YSTPSFTSSN TITETTSHST PSYITSITTT ETPSSSTPSF SSSITTTEIS 1450
SHSTPSFSSS TIYSTVTSHS TPRFTSSITT TETPSHSTPR FTSSFTNTKT 1500
TSHRSPSFTS LITTTETTSH STPSFTSSIT TTETTSHSAR SFTSSITTTE 1550
TTSHNTRSFT SSITTTETNS HSTTSFTSSI TTTETTSHST PSFSSSITTT 1600
ETPLHSTPGL TSWVTTTKTT SHITPGLTSS ITTTETTSHS TPGFTSSITT 1650
TETTSESTPS LSSSTIYSTV STSTTAITSH FTTSETAVTP TPVTPSSLST 1700
DIPTTSLRTL TPSSVGTSTS LTTTTDFPSI PTDISTLPTR THIISSSPSI 1750
QSTETSSLVG TTSPTMSTVR MTLRITENTP ISSFSTSIVV IPETPTQTPP 1800
VLTSATGTQT SPAPTTVTFG STDSSTSTLH TLTPSTALST IVSTSQVPIP 1850
STHSSTLQTT PSTPSLQTSL TSTSEFTTES FTRGSTSTNA ILTSFSTIIW 1900
SSTPTIIMSS SPSSASITPV FSTTIHSVPS SPYIFSTENV GSASITGFPS 1950
LSSSATTSTS STSSSLTTAL TEITPFSYIS LPSTTPCPGT ITITIVPASP 2000
TDPCVEMDPS TEATSPPTTP LTVFPFTTEM VTCPTSISIQ TTLTTYMDTS 2050
SMMPESESSI SPNASSSTGT GTVPTNTVFT STRLPTSETW LSNSSVIPLP 2100
LPGVSTIPLT MKPSSSLPTI LRTSSKSTHP SPPTTRTSET PVATTQTPTT 2150
LTSRRTTRIT SQMTTQSTLT TTAGTCDNGG TWEQGQCACL PGFSGDRCQL 2200
QTRCQNGGQW DGLKCQCPST FYGSSCEFAV EQVDLDVVET EVGMEVSVDQ 2250
QFSPDLNDNT SQAYRDFNKT FWNQMQKIFA DMQGFTFKGV EILSLRNGSI 2300
VVDYLVLLEM PFSPQLESEY EQVKTTLKEG LQNASQDANS CQDSQTLCFK 2350
PDSIKVNNNS KTELTPEAIC RRAAPTGYEE FYFPLVEATR LRCVTKCTSG 2400
VDNAIDCHQG QCVLETSGPA CRCYSTDTHW FSGPRCEVAV HWRALVGGLT 2450
AGAALLVLLL LALGVRAVRS GWWGGQRRGR SWDQDRKWFE TWDEEVVGTF 2500
SNWGFEDDGT DKDTNFHVAL ENVDTTMKVH IKRPEMTSSS V 2541
Length:2,541
Mass (Da):265,918
Last modified:February 20, 2007 - v2
Checksum:iF1BEB775F9507760
GO
Isoform 2 (identifier: Q02505-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2237-2284: VVETEVGMEV...MQKIFADMQG → AEDFCRHAGL...ALQPPAGERV
     2285-2541: Missing.

Show »
Length:2,281
Mass (Da):236,332
Checksum:i826DA98F3C19CFF9
GO
Isoform 3 (identifier: Q02505-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2275-2298: MQKIFADMQGFTFKGVEILSLRNG → EWQHRGGLPGPAGDALQPPAGERV
     2299-2541: Missing.

Show »
Length:2,298
Mass (Da):238,520
Checksum:i6C1AC87258B27389
GO
Isoform 4 (identifier: Q02505-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2299: RNGS → SPVF
     2300-2541: Missing.

Show »
Length:2,299
Mass (Da):238,859
Checksum:i7298CD3D7EBEDB44
GO
Isoform 5 (identifier: Q02505-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2422-2479: Missing.

Show »
Length:2,483
Mass (Da):259,631
Checksum:i3D15D516E62A5B82
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2338 – 23381A → V.4 Publications
VAR_030722
Natural varianti2517 – 25171H → N.2 Publications
VAR_030723
Natural varianti2517 – 25171H → Y Polymorphism; may be associated with Crohn disease. 4 Publications
VAR_030724

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2237 – 228448VVETE…ADMQG → AEDFCRHAGLHLQGCGDPVP EEWQHRGGLPGPAGDALQPP AGERV in isoform 2. VSP_023229Add
BLAST
Alternative sequencei2275 – 229824MQKIF…SLRNG → EWQHRGGLPGPAGDALQPPA GERV in isoform 3. VSP_023230Add
BLAST
Alternative sequencei2285 – 2541257Missing in isoform 2. VSP_023231Add
BLAST
Alternative sequencei2296 – 22994RNGS → SPVF in isoform 4. VSP_023232
Alternative sequencei2299 – 2541243Missing in isoform 3. VSP_023233Add
BLAST
Alternative sequencei2300 – 2541242Missing in isoform 4. VSP_023234Add
BLAST
Alternative sequencei2422 – 247958Missing in isoform 5. VSP_023235Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581P → S in AAQ73824. 1 Publication
Sequence conflicti1238 – 12381V → L in AAA63772. 1 Publication
Sequence conflicti1238 – 12381V → L in AAA63773. 1 Publication
Sequence conflicti1239 – 12391T → I in AAA63772. 1 Publication
Sequence conflicti1239 – 12391T → I in AAA63773. 1 Publication
Sequence conflicti1242 – 12454TKIT → SETP in AAA63772. 1 Publication
Sequence conflicti1242 – 12454TKIT → SETP in AAA63773. 1 Publication
Sequence conflicti1257 – 12571A → T in AAA63772. 1 Publication
Sequence conflicti1257 – 12571A → T in AAA63773. 1 Publication
Sequence conflicti1261 – 12611T → A in AAA63772. 1 Publication
Sequence conflicti1261 – 12611T → A in AAA63773. 1 Publication
Sequence conflicti1264 – 12641H → S in AAA63772. 1 Publication
Sequence conflicti1264 – 12641H → S in AAA63773. 1 Publication
Sequence conflicti1268 – 12681R → S in AAA63772. 1 Publication
Sequence conflicti1268 – 12681R → S in AAA63773. 1 Publication
Sequence conflicti1277 – 12771E → D in AAA63772. 1 Publication
Sequence conflicti1277 – 12771E → D in AAA63773. 1 Publication
Sequence conflicti1278 – 128811Missing in AAA63772. 1 PublicationAdd
BLAST
Sequence conflicti1278 – 128811Missing in AAA63773. 1 PublicationAdd
BLAST
Sequence conflicti1291 – 12922TN → VT in AAA63772. 1 Publication
Sequence conflicti1291 – 12922TN → VT in AAA63773. 1 Publication
Sequence conflicti1294 – 12941K → E in AAA63772. 1 Publication
Sequence conflicti1294 – 12941K → E in AAA63773. 1 Publication
Sequence conflicti1297 – 12971S → Y in AAA63772. 1 Publication
Sequence conflicti1297 – 12971S → Y in AAA63773. 1 Publication
Sequence conflicti1300 – 13001S → T in AAA63772. 1 Publication
Sequence conflicti1300 – 13001S → T in AAA63773. 1 Publication
Sequence conflicti1306 – 132318Missing in AAA63772. 1 PublicationAdd
BLAST
Sequence conflicti1306 – 132318Missing in AAA63773. 1 PublicationAdd
BLAST
Sequence conflicti1344 – 13463TTE → STK in AAA63772. 1 Publication
Sequence conflicti1344 – 13463TTE → STK in AAA63773. 1 Publication
Sequence conflicti1364 – 13641T → I in AAA63772. 1 Publication
Sequence conflicti1364 – 13641T → I in AAA63773. 1 Publication
Sequence conflicti1377 – 13771T → I in AAA63772. 1 Publication
Sequence conflicti1377 – 13771T → I in AAA63773. 1 Publication
Sequence conflicti1393 – 13964IRTT → MFNS in AAA63772. 1 Publication
Sequence conflicti1393 – 13964IRTT → MFNS in AAA63773. 1 Publication
Sequence conflicti1397 – 1504108Missing in AAA63772. 1 PublicationAdd
BLAST
Sequence conflicti1397 – 1504108Missing in AAA63773. 1 PublicationAdd
BLAST
Sequence conflicti1449 – 14502IS → TT in AAC02272. 1 Publication
Sequence conflicti1449 – 14502IS → TT in AAF13032. 1 Publication
Sequence conflicti1456 – 14561S → G in AAC02272. 1 Publication
Sequence conflicti1456 – 14561S → G in AAF13032. 1 Publication
Sequence conflicti1458 – 14581S → T in AAC02272. 1 Publication
Sequence conflicti1458 – 14581S → T in AAF13032. 1 Publication
Sequence conflicti1461 – 14666TIYSTV → ITTTET in AAC02272. 1 Publication
Sequence conflicti1461 – 14666TIYSTV → ITTTET in AAF13032. 1 Publication
Sequence conflicti1473 – 14731R → S in AAC02272. 1 Publication
Sequence conflicti1473 – 14731R → S in AAF13032. 1 Publication
Sequence conflicti1484 – 14841P → T in AAC02272. 1 Publication
Sequence conflicti1484 – 14841P → T in AAF13032. 1 Publication
Sequence conflicti1487 – 14871S → D in AAC02272. 1 Publication
Sequence conflicti1487 – 14871S → D in AAF13032. 1 Publication
Sequence conflicti1490 – 14901R → S in AAC02272. 1 Publication
Sequence conflicti1490 – 14901R → S in AAF13032. 1 Publication
Sequence conflicti1495 – 14951F → I in AAC02272. 1 Publication
Sequence conflicti1495 – 14951F → I in AAF13032. 1 Publication
Sequence conflicti1497 – 14993NTK → TSE in AAC02272. 1 Publication
Sequence conflicti1497 – 14993NTK → TSE in AAF13032. 1 Publication
Sequence conflicti1501 – 15011T → P in AAC02272. 1 Publication
Sequence conflicti1501 – 15011T → P in AAF13032. 1 Publication
Sequence conflicti1504 – 15052RS → ST in AAC02272. 1 Publication
Sequence conflicti1504 – 15052RS → ST in AAF13032. 1 Publication
Sequence conflicti1505 – 15062SP → TA in AAA63772. 1 Publication
Sequence conflicti1505 – 15062SP → TA in AAA63773. 1 Publication
Sequence conflicti1508 – 15081F → S in AAC02272. 1 Publication
Sequence conflicti1508 – 15081F → S in AAF13032. 1 Publication
Sequence conflicti1511 – 15122LI → SM in AAA63772. 1 Publication
Sequence conflicti1511 – 15122LI → SM in AAA63773. 1 Publication
Sequence conflicti1516 – 15161E → K in AAC02272. 1 Publication
Sequence conflicti1516 – 15161E → K in AAF13032. 1 Publication
Sequence conflicti1525 – 15251F → L in AAA63772. 1 Publication
Sequence conflicti1525 – 15251F → L in AAA63773. 1 Publication
Sequence conflicti1529 – 15291I → M in AAA63772. 1 Publication
Sequence conflicti1529 – 15291I → M in AAA63773. 1 Publication
Sequence conflicti1531 – 15311T → A in AAA63772. 1 Publication
Sequence conflicti1531 – 15311T → A in AAA63773. 1 Publication
Sequence conflicti1539 – 15402AR → TP in AAA63772. 1 Publication
Sequence conflicti1539 – 15402AR → TP in AAA63773. 1 Publication
Sequence conflicti1554 – 15552HN → NS in AAA63772. 1 Publication
Sequence conflicti1554 – 15552HN → NS in AAA63773. 1 Publication
Sequence conflicti1557 – 15571R → A in AAA63772. 1 Publication
Sequence conflicti1557 – 15571R → A in AAA63773. 1 Publication
Sequence conflicti1559 – 15591F → L in AAA63772. 1 Publication
Sequence conflicti1559 – 15591F → L in AAA63773. 1 Publication
Sequence conflicti1569 – 15691N → T in AAA63772. 1 Publication
Sequence conflicti1569 – 15691N → T in AAA63773. 1 Publication
Sequence conflicti1571 – 15711H → N in AAA63772. 1 Publication
Sequence conflicti1571 – 15711H → N in AAA63773. 1 Publication
Sequence conflicti1574 – 15741T → A in AAA63772. 1 Publication
Sequence conflicti1574 – 15741T → A in AAA63773. 1 Publication
Sequence conflicti1576 – 15761F → L in AAA63772. 1 Publication
Sequence conflicti1576 – 15761F → L in AAA63773. 1 Publication
Sequence conflicti1580 – 15801I → M in AAA63772. 1 Publication
Sequence conflicti1580 – 15801I → M in AAA63773. 1 Publication
Sequence conflicti1611 – 16111T → P in AAC02272. 1 Publication
Sequence conflicti2174 – 21741G → GC in BAB12116. 1 Publication
Sequence conflicti2367 – 23671E → A in AAF13032. 1 Publication
Sequence conflicti2367 – 23671E → A in BAB12116. 1 Publication
Sequence conflicti2367 – 23671E → A in AAD45882. 1 Publication
Sequence conflicti2367 – 23671E → A in AAD45883. 1 Publication
Sequence conflicti2420 – 24201A → T in AAF13032. 1 Publication
Sequence conflicti2420 – 24201A → T in BAB12116. 1 Publication
Sequence conflicti2420 – 24201A → T in AAD45882. 1 Publication
Sequence conflicti2420 – 24201A → T in AAD45883. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1.
AF007190 mRNA. Translation: AAC02268.1.
AF007193 mRNA. Translation: AAC02271.1.
AF007194 mRNA. Translation: AAC02272.1.
AF113616 Genomic DNA. Translation: AAF13032.1.
M55405 mRNA. Translation: AAA63772.1.
M55406 mRNA. Translation: AAA63773.1.
AB038782 Genomic DNA. Translation: BAB12116.1.
AF143371 mRNA. Translation: AAD45882.1.
AF143372 mRNA. Translation: AAD45883.1.
AF143373 mRNA. Translation: AAD45884.1.
PIRiA35690.
B35690.
UniGeneiHs.744422.
Hs.744530.

Genome annotation databases

EnsembliENST00000414964; ENSP00000393306; ENSG00000169894.

Polymorphism databases

DMDMi126302571.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1 .
AF007190 mRNA. Translation: AAC02268.1 .
AF007193 mRNA. Translation: AAC02271.1 .
AF007194 mRNA. Translation: AAC02272.1 .
AF113616 Genomic DNA. Translation: AAF13032.1 .
M55405 mRNA. Translation: AAA63772.1 .
M55406 mRNA. Translation: AAA63773.1 .
AB038782 Genomic DNA. Translation: BAB12116.1 .
AF143371 mRNA. Translation: AAD45882.1 .
AF143372 mRNA. Translation: AAD45883.1 .
AF143373 mRNA. Translation: AAD45884.1 .
PIRi A35690.
B35690.
UniGenei Hs.744422.
Hs.744530.

3D structure databases

ProteinModelPortali Q02505.
SMRi Q02505. Positions 2183-2228, 2409-2441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q02505. 1 interaction.

Protein family/group databases

MEROPSi S71.002.

PTM databases

PhosphoSitei Q02505.

Polymorphism databases

DMDMi 126302571.

Proteomic databases

PaxDbi Q02505.
PRIDEi Q02505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000414964 ; ENSP00000393306 ; ENSG00000169894 .

Organism-specific databases

GeneCardsi GC07P100550.
HGNCi HGNC:7513. MUC3A.
HPAi HPA010871.
HPA047868.
MIMi 158371. gene.
neXtProti NX_Q02505.
Orphaneti 771. Ulcerative colitis.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi Q02505.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSi MUC3A. human.
PROi Q02505.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q02505.
Bgeei Q02505.
Genevestigatori Q02505.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view ]
Pfami PF01390. SEA. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view ]
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Publicationsi

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  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus."
    Gum J.R. Jr., Hicks J.W., Crawley S.C., Dahl C.M., Yang S.C., Roberton A.M., Kim Y.S.
    J. Biol. Chem. 278:49600-49609(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-340 (ISOFORM 1).
  3. "MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region."
    Gum J.R. Jr., Ho J.J.L., Pratt W.S., Hicks J.W., Hill A.S., Vinall L.E., Roberton A.M., Swallow D.M., Kim Y.S.
    J. Biol. Chem. 272:26678-26686(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 351-863 AND 874-1314 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1325-2284 (ISOFORM 2).
  4. "Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin."
    Crawley S.C., Gum J.R. Jr., Hicks J.W., Pratt W.S., Aubert J.-P., Swallow D.M., Kim Y.S.
    Biochem. Biophys. Res. Commun. 263:728-736(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-2541 (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), VARIANTS VAL-2338; ASN-2517 AND TYR-2517.
    Tissue: Intestine.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1238-1587.
    Tissue: Small intestine.
  6. "Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B."
    Pratt W.S., Crawley S., Hicks J., Ho J., Nash M., Kim Y.S., Gum J.R., Swallow D.M.
    Biochem. Biophys. Res. Commun. 275:916-923(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1642-2541 (ISOFORM 1), VARIANTS VAL-2338; ASN-2517 AND TYR-2517.
  7. "Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease."
    Kyo K., Muto T., Nagawa H., Lathrop G.M., Nakamura Y.
    J. Hum. Genet. 46:5-20(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1665-2541 (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VAL-2338 AND TYR-2517.
  8. "The MUC3 gene encodes a transmembrane mucin and is alternatively spliced."
    Williams S.J., Munster D.J., Quin R.J., Gotley D.C., McGuckin M.A.
    Biochem. Biophys. Res. Commun. 261:83-89(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2176-2541 (ISOFORMS 1; 2 AND 5), FUNCTION, VARIANTS VAL-2338 AND TYR-2517.
    Tissue: Colon mucosa and Small intestine.

Entry informationi

Entry nameiMUC3A_HUMAN
AccessioniPrimary (citable) accession number: Q02505
Secondary accession number(s): O14650
, O14651, O43418, O43421, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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