Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mucin-3A

Gene

MUC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.1 Publication

GO - Molecular functioni

  • extracellular matrix constituent, lubricant activity Source: UniProtKB
  • extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-3ACurated
Short name:
MUC-3ACurated
Alternative name(s):
Intestinal mucin-3A1 Publication
Gene namesi
Name:MUC3AImported
Synonyms:MUC31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:7513. MUC3A.

Subcellular locationi

Isoform 2 :
Isoform 3 :
Isoform 4 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3227 – 3247HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • apical plasma membrane Source: GO_Central
  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
  • Golgi lumen Source: Reactome
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4584.
OpenTargetsiENSG00000169894.

Polymorphism and mutation databases

DMDMi126302571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000015895516 – 3323Mucin-3AAdd BLAST3308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2980 ↔ 2986PROSITE-ProRule annotation
Disulfide bondi2999 ↔ 3008PROSITE-ProRule annotation

Post-translational modificationi

Highly O-glycosylated and probably also N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02505.
PRIDEiQ02505.

PTM databases

iPTMnetiQ02505.
PhosphoSitePlusiQ02505.

Expressioni

Tissue specificityi

Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.1 Publication

Gene expression databases

BgeeiENSG00000169894.
ExpressionAtlasiQ02505. baseline and differential.
GenevisibleiQ02505. HS.

Organism-specific databases

HPAiHPA010871.

Interactioni

Protein-protein interaction databases

IntActiQ02505. 1 interactor.
STRINGi9606.ENSP00000324834.

Structurei

3D structure databases

ProteinModelPortaliQ02505.
SMRiQ02505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1893 – 19101Add BLAST18
Repeati1911 – 19272Add BLAST17
Repeati1928 – 19443Add BLAST17
Repeati1945 – 19614Add BLAST17
Repeati1962 – 19785Add BLAST17
Repeati1979 – 19956Add BLAST17
Repeati1996 – 20127Add BLAST17
Repeati2013 – 20298Add BLAST17
Repeati2030 – 20469Add BLAST17
Repeati2047 – 206210Add BLAST16
Repeati2063 – 207911Add BLAST17
Repeati2080 – 209612Add BLAST17
Repeati2097 – 211313Add BLAST17
Repeati2114 – 213014Add BLAST17
Repeati2131 – 214715Add BLAST17
Repeati2148 – 216416Add BLAST17
Repeati2165 – 219117Add BLAST27
Repeati2192 – 220818Add BLAST17
Repeati2209 – 222519Add BLAST17
Repeati2226 – 224220Add BLAST17
Repeati2243 – 225921Add BLAST17
Repeati2260 – 227622Add BLAST17
Repeati2277 – 229323Add BLAST17
Repeati2294 – 231024Add BLAST17
Repeati2311 – 232725Add BLAST17
Repeati2328 – 234426Add BLAST17
Repeati2345 – 236127Add BLAST17
Repeati2362 – 237828Add BLAST17
Repeati2379 – 239529Add BLAST17
Repeati2396 – 241230Add BLAST17
Repeati2413 – 242931Add BLAST17
Repeati2430 – 244632Add BLAST17
Domaini2976 – 3009EGF-likePROSITE-ProRule annotationAdd BLAST34
Domaini3018 – 3143SEAPROSITE-ProRule annotationAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1893 – 244632 X approximate tandem repeats, Ser/Thr-richAdd BLAST554

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 2957Thr-richAdd BLAST2881
Compositional biasi395 – 2747Ser-richAdd BLAST2353

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVGW. Eukaryota.
ENOG410ZCSE. LUCA.
GeneTreeiENSGT00730000111040.
HOVERGENiHBG099390.
InParanoidiQ02505.
OMAiVNSEATS.
OrthoDBiEOG091G02EJ.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000082. SEA_dom.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q02505-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS
60 70 80 90 100
RDLAGWPLGV PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT
110 120 130 140 150
STTPTSKFAF KVETTPPTVL VYSATTECVY PTSFIITISH PTSICVTTTQ
160 170 180 190 200
VAFTSSYTST PVTQKPVTTV TSTYSMTTTE KGTSAMTSSP STTTARETPI
210 220 230 240 250
VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT SPTPVFTTLK
260 270 280 290 300
TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS
310 320 330 340 350
TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYTTSP TSTVTDSTTK
360 370 380 390 400
IAYSTSMTGT LSTETSLPPT SSSLPTTETA TTPMTNLVTT TTEISSHSTP
410 420 430 440 450
SFSSSTIYST VSTSTTAISS LPPTSGTMVT STTMTPSSLS TDIPFTTPTT
460 470 480 490 500
ITHHSVGSTG FLTTATDLTS TFTVSSSSAM STSVIPSSPS IQNTETSSLV
510 520 530 540 550
SMTSATTPNV RPTFVSTLST PTSSLLTTFP ATYSFSSSMS ASSAGTTHTE
560 570 580 590 600
SISSPPASTS TLHTTAESTL APTTTTSFTT STTMEPPSTT AATTGTGQTT
610 620 630 640 650
FTSSTATFPE TTTPTPTTDM STESLTTAMT SPPITSSVTS TNTVTSMTTT
660 670 680 690 700
TSPPTTTNSF TSLTSMPLSS TPVPSTEVVT SGTINTIPPS ILVTTLPTPN
710 720 730 740 750
ASSMTTSETT YPNSPTGPGT NSTTEITYPT TMTETSSTAT SLPPTSPLVS
760 770 780 790 800
TAKTAKTPTT NLVTTTTKTT SHSTTSFTSS TVYSTASTYT TAITSVPTTL
810 820 830 840 850
GTMVTSTSMI SSTVSTGIPT SQPTTITPSS VGISGSLPMM TDLTSVYTVS
860 870 880 890 900
NMSARPTTVI PSSPTVQNTE ISISVSMTSA TTPSGGPTFT STENTPTRSL
910 920 930 940 950
LTSFPMTHSF SSSMSESSAG TTHTESISSP RGTTSTLHTT VESTPSPTTT
960 970 980 990 1000
TSFTTSTMME PPSSTVSTTG RGQTTFPSST ATFPETTTLT PTTDISTVSL
1010 1020 1030 1040 1050
TTAMTSPPPV SSSITPTNTM TSMRTTTYWP TATNTLSPLT SSILSSTPVP
1060 1070 1080 1090 1100
STEMITSHTT NTTPLSTLVT TLLTTITRST PTSETTYPTS PTSIVSDSTT
1110 1120 1130 1140 1150
EITYSTSITG TLSTATTLPP TSSSLPTTET ATMTPTTTLI TTTPNTTSLS
1160 1170 1180 1190 1200
TPSFTSSTIY STVSTSTTAI SSASPTSGTM VTSTTMTPSS LSTDTPSTTP
1210 1220 1230 1240 1250
TTITYPSVGS TGFLTTATDL TSTFTVSSSS AMSTSVIPSS PSIQNTETSS
1260 1270 1280 1290 1300
LVSMTSATTP SLRPTITSTD STLTSSLLTT FPSTYSFSSS MSASSAGTTH
1310 1320 1330 1340 1350
TETISSLPAS TNTIHTTAES ALAPTTTTSF TTSPTMEPPS TTVATTGTGQ
1360 1370 1380 1390 1400
TTFPSSTATF LETTTLTPTT DFSTESLTTA MTSTPPITSS ITPTDTMTSM
1410 1420 1430 1440 1450
RTTTSWPTAT NTLSPLTSSI LSSTPVPSTE VTTSHTTNTN PVSTLVTTLP
1460 1470 1480 1490 1500
ITITRSTLTS ETAYPSSPTS TVTESTTEIT YPTTMTETSS TATSLPPTSS
1510 1520 1530 1540 1550
LVSTAETAKT PTTNLVTTTT KTTSHSTTSF TSSTIYSTAS TPTTAITSVP
1560 1570 1580 1590 1600
TTLGTMVTST SMIPSTVSTG IPTSQPTTIT PSSVGISGSL PMMTDLTSVY
1610 1620 1630 1640 1650
TVSSMSARPT SVIPSSPTVQ NTETSIFVSM MSATTPSGGP TFTSTENTPT
1660 1670 1680 1690 1700
RSLLTSFPVT HSFSSSMSAS SVGTTHTQSI SSPPAITSTL HTTAESTPSP
1710 1720 1730 1740 1750
TTTMSFTTFT KMETPSSTVA TTGTGQTTFT SSTATSPKTT TLTPTSDIST
1760 1770 1780 1790 1800
GSFKTAVSST PPITSSITST YTVTSMTTTT PLGPTATNTL PSFTSSVSSS
1810 1820 1830 1840 1850
TPVPSTEAIT SGTTNTTPLS TLVTTFSNSD TSSTPTSETT YPTSLTSALT
1860 1870 1880 1890 1900
DSTTRTTYST NMTGTLSTVT SLRPTSSSLL TTVTATVPTT NLVTTTTKIT
1910 1920 1930 1940 1950
SHSTPSFTSS IATTETPSHS TPRFTSSITT TETPSHSTPR FTSSITNTKT
1960 1970 1980 1990 2000
TSHSSPSFTS SITTTETTSH NTPSLTSSIT TTKTTSHSTP SYTSLITTTT
2010 2020 2030 2040 2050
TTSHSTPSFT SSITTTETTS HNTPSLTSSI TTTETTSHST PSFTSSITTE
2060 2070 2080 2090 2100
TTSHSTPSFT SLITITEITS HSTLSYTTSI TTTETPSHST LSFTSSITTT
2110 2120 2130 2140 2150
ETTSHSTPSF TSSITTSEMP SHSTPSFTSS ITTTENATHS TPNFTSSITT
2160 2170 2180 2190 2200
TETTSHSTPS FTSLITTTET TSHRWGTTET TSYSTPSFTS SNTITETTSH
2210 2220 2230 2240 2250
STPSYITSIT TTETPSSSTP SFSSSITTTE TTSHSTPGFT SSITTTETTS
2260 2270 2280 2290 2300
HSTPSFTSSI TTTETTSHDT PSFTSSITTS ETPSHSTPSS TSLITTTKTT
2310 2320 2330 2340 2350
SHSTPSFTSS ITTTETTSHS AHSFTSSITT TETTSHNTRS FTSSITTTET
2360 2370 2380 2390 2400
NSHSTTSFTS SITTTETTSH STPSFSSSIT TTETPLHSTP GLTSWVTTTK
2410 2420 2430 2440 2450
TTSHITPGLT SSITTTETTS HSTPGFTSSI TTTETTSEST PSLSSSTIYS
2460 2470 2480 2490 2500
TVSTSTTAIT SHFTTSETAV TPTPVTPSSL STDIPTTSLR TLTPSSVGTS
2510 2520 2530 2540 2550
TSLTTTTDFP SIPTDISTLP TRTHIISSSP SIQSTETSSL VGTTSPTMST
2560 2570 2580 2590 2600
VRMTLRITEN TPISSFSTSI VVIPETPTQT PPVLTSATGT QTSPAPTTVT
2610 2620 2630 2640 2650
FGSTDSSTST LHTLTPSTAL STIVSTSQVP IPSTHSSTLQ TTPSTPSLQT
2660 2670 2680 2690 2700
SLTSTSEFTT ESFTRGSTST NAILTSFSTI IWSSTPTIIM SSSPSSASIT
2710 2720 2730 2740 2750
PVFSTTIHSV PSSPYIFSTE NVGSASITGF PSLSSSATTS TSSTSSSLTT
2760 2770 2780 2790 2800
ALTEITPFSY ISLPSTTPCP GTITITIVPA SPTDPCVEMD PSTEATSPPT
2810 2820 2830 2840 2850
TPLTVFPFTT EMVTCPTSIS IQTTLTTYMD TSSMMPESES SISPNASSST
2860 2870 2880 2890 2900
GTGTVPTNTV FTSTRLPTSE TWLSNSSVIP LPLPGVSTIP LTMKPSSSLP
2910 2920 2930 2940 2950
TILRTSSKST HPSPPTTRTS ETPVATTQTP TTLTSRRTTR ITSQMTTQST
2960 2970 2980 2990 3000
LTTTAGTCDN GGTWEQGQCA CLPGFSGDRC QLQTRCQNGG QWDGLKCQCP
3010 3020 3030 3040 3050
STFYGSSCEF AVEQVDLDVV ETEVGMEVSV DQQFSPDLND NTSQAYRDFN
3060 3070 3080 3090 3100
KTFWNQMQKI FADMQGFTFK GVEILSLRNG SIVVDYLVLL EMPFSPQLES
3110 3120 3130 3140 3150
EYEQVKTTLK EGLQNASQDV NSCQDSQTLC FKPDSIKVNN NSKTELTPAA
3160 3170 3180 3190 3200
ICRRAAPTGY EEFYFPLVEA TRLRCVTKCT SGVDNAIDCH QGQCVLETSG
3210 3220 3230 3240 3250
PTCRCYSTDT HWFSGPRCEV AVHWRALVGG LTAGAALLVL LLLALGVRAV
3260 3270 3280 3290 3300
RSGWWGGQRR GRSWDQDRKW FETWDEEVVG TFSNWGFEDD GTDKDTNFYV
3310 3320
ALENVDTTMK VHIKRPEMTS SSV
Length:3,323
Mass (Da):345,127
Last modified:April 13, 2016 - v3
Checksum:i8C6E21ADD26637EF
GO
Isoform 2 (identifier: Q02505-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3019-3063: VVETEVGMEV...WNQMQKIFAD → AEDFCRHAGL...ALQPPAGERV
     3064-3323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:3,063
Mass (Da):315,514
Checksum:i5DDF446F97DAF6C3
GO
Isoform 3 (identifier: Q02505-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3057-3080: MQKIFADMQGFTFKGVEILSLRNG → EWQHRGGLPGPAGDALQPPAGERV
     3081-3323: Missing.

Show »
Length:3,080
Mass (Da):317,703
Checksum:i8EB5575D9A5144B1
GO
Isoform 4 (identifier: Q02505-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3078-3081: RNGS → SPVF
     3082-3323: Missing.

Show »
Length:3,081
Mass (Da):318,041
Checksum:i52FA62A2517C3873
GO
Isoform 5 (identifier: Q02505-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3204-3261: Missing.

Show »
Length:3,265
Mass (Da):338,839
Checksum:i16A557A14778C0CE
GO

Sequence cautioni

The sequence AAA63772 differs from that shown. This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.Curated
The sequence AAA63773 differs from that shown. This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.Curated
The sequence AAC02271 differs from that shown. Reason: Frameshift at positions 1535, 1542 and 1548.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti258P → S in AAQ73824 (PubMed:12853948).Curated1
Sequence conflicti337T → P in AAQ73824 (PubMed:12853948).Curated1
Sequence conflicti1149L → H in AAC02268 (PubMed:9334251).Curated1
Sequence conflicti1234T → K in AAC02268 (PubMed:9334251).Curated1
Sequence conflicti1542P → L in AAC02271 (PubMed:9334251).Curated1
Sequence conflicti1570G → D in AAC02271 (PubMed:9334251).Curated1
Sequence conflicti1587S → T in AAC02271 (PubMed:9334251).Curated1
Sequence conflicti1640P → S in AAC02271 (PubMed:9334251).Curated1
Sequence conflicti1966 – 1969ETTS → DSIV in AAC02271 (PubMed:9334251).Curated4
Sequence conflicti2099T → I in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2099T → I in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2110F → Y in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2110F → Y in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2112S → T in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2112S → T in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2117S → T in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2117S → T in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2119M → T in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2119M → T in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2127F → Y in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2127F → Y in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2129S → T in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2129S → T in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2136 – 2138NAT → TPS in AAC02272 (PubMed:9334251).Curated3
Sequence conflicti2136 – 2138NAT → TPS in AAF13032 (PubMed:10512748).Curated3
Sequence conflicti2143N → S in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2143N → S in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2164 – 2166LIT → SIR in AAC02272 (PubMed:9334251).Curated3
Sequence conflicti2164 – 2166LIT → SIR in AAF13032 (PubMed:10512748).Curated3
Sequence conflicti2169 – 2178Missing in AAC02272 (PubMed:9334251).Curated10
Sequence conflicti2169 – 2178Missing in AAF13032 (PubMed:10512748).Curated10
Sequence conflicti2322H → R in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2322H → R in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2393T → P in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2956G → GC in BAB12116 (PubMed:11289722).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0307223120V → A.1 PublicationCorresponds to variant rs6960868dbSNPEnsembl.1
Natural variantiVAR_0307243299Y → H Polymorphism; may be associated with Crohn disease. 1 PublicationCorresponds to variant rs10258821dbSNPEnsembl.1
Natural variantiVAR_0307233299Y → N.2 PublicationsCorresponds to variant rs10258821dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0232293019 – 3063VVETE…KIFAD → AEDFCRHAGLHLQGCGDPVP EEWQHRGGLPGPAGDALQPP AGERV in isoform 2. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_0232303057 – 3080MQKIF…SLRNG → EWQHRGGLPGPAGDALQPPA GERV in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0232313064 – 3323Missing in isoform 2. 2 PublicationsAdd BLAST260
Alternative sequenceiVSP_0232323078 – 3081RNGS → SPVF in isoform 4. 1 Publication4
Alternative sequenceiVSP_0232333081 – 3323Missing in isoform 3. 1 PublicationAdd BLAST243
Alternative sequenceiVSP_0232343082 – 3323Missing in isoform 4. 1 PublicationAdd BLAST242
Alternative sequenceiVSP_0232353204 – 3261Missing in isoform 5. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AC254629 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1.
AF007190 mRNA. Translation: AAC02268.1.
AF007193 mRNA. Translation: AAC02271.1. Frameshift.
AF007194 mRNA. Translation: AAC02272.1.
AF113616 Genomic DNA. Translation: AAF13032.1.
AB038782 Genomic DNA. Translation: BAB12116.1.
AF143371 mRNA. Translation: AAD45882.1.
AF143372 mRNA. Translation: AAD45883.1.
AF143373 mRNA. Translation: AAD45884.1.
M55405 mRNA. Translation: AAA63772.1. Sequence problems.
M55406 mRNA. Translation: AAA63773.1. Sequence problems.
CCDSiCCDS78262.1. [Q02505-1]
PIRiA35690.
B35690.
RefSeqiNP_005951.1. NM_005960.1. [Q02505-1]
UniGeneiHs.703577.
Hs.723567.
Hs.744422.
Hs.744530.

Genome annotation databases

EnsembliENST00000379458; ENSP00000368771; ENSG00000169894. [Q02505-1]
ENST00000483366; ENSP00000483541; ENSG00000169894. [Q02505-5]
GeneIDi4584.
KEGGihsa:4584.
UCSCiuc033aad.2. human.
uc064gjo.1. human. [Q02505-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105446 Genomic DNA. No translation available.
AC118759 Genomic DNA. No translation available.
AC254629 Genomic DNA. No translation available.
AY307930 Genomic DNA. Translation: AAQ73824.1.
AF007190 mRNA. Translation: AAC02268.1.
AF007193 mRNA. Translation: AAC02271.1. Frameshift.
AF007194 mRNA. Translation: AAC02272.1.
AF113616 Genomic DNA. Translation: AAF13032.1.
AB038782 Genomic DNA. Translation: BAB12116.1.
AF143371 mRNA. Translation: AAD45882.1.
AF143372 mRNA. Translation: AAD45883.1.
AF143373 mRNA. Translation: AAD45884.1.
M55405 mRNA. Translation: AAA63772.1. Sequence problems.
M55406 mRNA. Translation: AAA63773.1. Sequence problems.
CCDSiCCDS78262.1. [Q02505-1]
PIRiA35690.
B35690.
RefSeqiNP_005951.1. NM_005960.1. [Q02505-1]
UniGeneiHs.703577.
Hs.723567.
Hs.744422.
Hs.744530.

3D structure databases

ProteinModelPortaliQ02505.
SMRiQ02505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02505. 1 interactor.
STRINGi9606.ENSP00000324834.

PTM databases

iPTMnetiQ02505.
PhosphoSitePlusiQ02505.

Polymorphism and mutation databases

DMDMi126302571.

Proteomic databases

PaxDbiQ02505.
PRIDEiQ02505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379458; ENSP00000368771; ENSG00000169894. [Q02505-1]
ENST00000483366; ENSP00000483541; ENSG00000169894. [Q02505-5]
GeneIDi4584.
KEGGihsa:4584.
UCSCiuc033aad.2. human.
uc064gjo.1. human. [Q02505-1]

Organism-specific databases

CTDi4584.
DisGeNETi4584.
GeneCardsiMUC3A.
HGNCiHGNC:7513. MUC3A.
HPAiHPA010871.
MIMi158371. gene.
neXtProtiNX_Q02505.
OpenTargetsiENSG00000169894.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVGW. Eukaryota.
ENOG410ZCSE. LUCA.
GeneTreeiENSGT00730000111040.
HOVERGENiHBG099390.
InParanoidiQ02505.
OMAiVNSEATS.
OrthoDBiEOG091G02EJ.

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiMUC3A. human.
GenomeRNAii4584.
PROiQ02505.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169894.
ExpressionAtlasiQ02505. baseline and differential.
GenevisibleiQ02505. HS.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000082. SEA_dom.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUC3A_HUMAN
AccessioniPrimary (citable) accession number: Q02505
Secondary accession number(s): A6NP22
, O14650, O14651, O43418, O43421, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 13, 2016
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.