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Q02487

- DSC2_HUMAN

UniProt

Q02487 - DSC2_HUMAN

Protein

Desmocollin-2

Gene

DSC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. bundle of His cell to Purkinje myocyte communication Source: BHF-UCL
    2. cardiac muscle cell-cardiac muscle cell adhesion Source: UniProt
    3. cell adhesion Source: ProtInc
    4. homophilic cell adhesion Source: InterPro
    5. regulation of heart rate by cardiac conduction Source: BHF-UCL
    6. ventricular cardiac muscle cell action potential Source: BHF-UCL

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmocollin-2
    Alternative name(s):
    Cadherin family member 2
    Desmocollin-3
    Desmosomal glycoprotein II
    Desmosomal glycoprotein III
    Gene namesi
    Name:DSC2
    Synonyms:CDHF2, DSC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:3036. DSC2.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell junctiondesmosome 1 Publication

    GO - Cellular componenti

    1. cell-cell adherens junction Source: Ensembl
    2. cytoplasmic vesicle Source: UniProt
    3. desmosome Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. integral component of membrane Source: UniProtKB-KW
    6. intercalated disc Source: UniProt
    7. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11) [MIM:610476]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti203 – 2031R → C in ARVD11; fails to undergo complete processing into a mature form; fails to localize at the desmosomes. 1 Publication
    VAR_065687
    Natural varianti231 – 2311I → T in ARVD11. 1 Publication
    VAR_065688
    Natural varianti275 – 2751T → M in ARVD11; can be processed into a mature form but shows a higher pro-protein to mature protein ratio; only a proportion of the partly functional mutant is incorporated into the desmosomes. 1 Publication
    VAR_065689
    Natural varianti340 – 3401T → A in ARVD11. 1 Publication
    VAR_065690

    Keywords - Diseasei

    Cardiomyopathy, Disease mutation

    Organism-specific databases

    MIMi610476. phenotype.
    Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
    293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
    293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
    PharmGKBiPA27489.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Propeptidei28 – 135108Sequence AnalysisPRO_0000003869Add
    BLAST
    Chaini136 – 901766Desmocollin-2PRO_0000003870Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...) (complex)2 Publications
    Glycosylationi546 – 5461N-linked (GlcNAc...)1 Publication
    Glycosylationi629 – 6291N-linked (GlcNAc...)1 Publication
    Modified residuei864 – 8641PhosphoserineSequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ02487.
    PaxDbiQ02487.
    PRIDEiQ02487.

    PTM databases

    PhosphoSiteiQ02487.

    Expressioni

    Tissue specificityi

    Expressed in epithelia, myocardium and lymph nodes.

    Gene expression databases

    ArrayExpressiQ02487.
    BgeeiQ02487.
    CleanExiHS_DSC2.
    HS_DSC3.
    GenevestigatoriQ02487.

    Organism-specific databases

    HPAiHPA011911.
    HPA012615.

    Interactioni

    Subunit structurei

    Interacts with DSP, PKP2 and JUP.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    F1M7L92EBI-6900677,EBI-6900770From a different organism.
    GJA1P173022EBI-6900677,EBI-1103439
    GJA1Q6TYA93EBI-6900677,EBI-6901331From a different organism.

    Protein-protein interaction databases

    BioGridi108158. 8 interactions.
    IntActiQ02487. 7 interactions.
    STRINGi9606.ENSP00000280904.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02487.
    SMRiQ02487. Positions 137-669.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini136 – 694559ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini716 – 901186CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei695 – 71521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 243108Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 355112Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini356 – 471116Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 579108Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini580 – 694115Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Calcium may be bound by the cadherin-like repeats.Curated
    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG304955.
    HOGENOMiHOG000231253.
    HOVERGENiHBG102801.
    InParanoidiQ02487.
    KOiK07601.
    OMAiPLNYEER.
    OrthoDBiEOG74BJR7.
    PhylomeDBiQ02487.
    TreeFamiTF316817.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR009124. Cadherin/Desmocollin.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR014868. Cadherin_pro_dom.
    IPR027397. Catenin_binding_dom.
    IPR009122. Desmosomal_cadherin.
    [Graphical view]
    PANTHERiPTHR24025. PTHR24025. 1 hit.
    PfamiPF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    PF08758. Cadherin_pro. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01820. DESMOCOLLIN.
    SMARTiSM00112. CA. 5 hits.
    SM01055. Cadherin_pro. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2A (identifier: Q02487-1) [UniParc]FASTAAdd to Basket

    Also known as: DGII

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAARPSGSW NGALCRLLLL TLAILIFASD ACKNVTLHVP SKLDAEKLVG    50
    RVNLKECFTA ANLIHSSDPD FQILEDGSVY TTNTILLSSE KRSFTILLSN 100
    TENQEKKKIF VFLEHQTKVL KKRHTKEKVL RRAKRRWAPI PCSMLENSLG 150
    PFPLFLQQVQ SDTAQNYTIY YSIRGPGVDQ EPRNLFYVER DTGNLYCTRP 200
    VDREQYESFE IIAFATTPDG YTPELPLPLI IKIEDENDNY PIFTEETYTF 250
    TIFENCRVGT TVGQVCATDK DEPDTMHTRL KYSIIGQVPP SPTLFSMHPT 300
    TGVITTTSSQ LDRELIDKYQ LKIKVQDMDG QYFGLQTTST CIINIDDVND 350
    HLPTFTRTSY VTSVEENTVD VEILRVTVED KDLVNTANWR ANYTILKGNE 400
    NGNFKIVTDA KTNEGVLCVV KPLNYEEKQQ MILQIGVVNE APFSREASPR 450
    SAMSTATVTV NVEDQDEGPE CNPPIQTVRM KENAEVGTTS NGYKAYDPET 500
    RSSSGIRYKK LTDPTGWVTI DENTGSIKVF RSLDREAETI KNGIYNITVL 550
    ASDQGGRTCT GTLGIILQDV NDNSPFIPKK TVIICKPTMS SAEIVAVDPD 600
    EPIHGPPFDF SLESSTSEVQ RMWRLKAIND TAARLSYQND PPFGSYVVPI 650
    TVRDRLGMSS VTSLDVTLCD CITENDCTHR VDPRIGGGGV QLGKWAILAI 700
    LLGIALLFCI LFTLVCGASG TSKQPKVIPD DLAQQNLIVS NTEAPGDDKV 750
    YSANGFTTQT VGASAQGVCG TVGSGIKNGG QETIEMVKGG HQTSESCRGA 800
    GHHHTLDSCR GGHTEVDNCR YTYSEWHSFT QPRLGEKVYL CNQDENHKHA 850
    QDYVLTYNYE GRGSVAGSVG CCSERQEEDG LEFLDNLEPK FRTLAEACMK 900
    R 901
    Length:901
    Mass (Da):99,962
    Last modified:February 1, 1994 - v1
    Checksum:i30F7E3D33ECA67CC
    GO
    Isoform 2B (identifier: Q02487-2) [UniParc]FASTAAdd to Basket

    Also known as: DGIII

    The sequence of this isoform differs from the canonical sequence as follows:
         837-847: KVYLCNQDENH → ESIRGHTLIKN
         848-901: Missing.

    Show »
    Length:847
    Mass (Da):93,769
    Checksum:iA53588B1D490CD8F
    GO

    Sequence cautioni

    The sequence CAA40141.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA40142.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111N → S.1 Publication
    Corresponds to variant rs868333 [ dbSNP | Ensembl ].
    VAR_029480
    Natural varianti203 – 2031R → C in ARVD11; fails to undergo complete processing into a mature form; fails to localize at the desmosomes. 1 Publication
    VAR_065687
    Natural varianti231 – 2311I → T in ARVD11. 1 Publication
    VAR_065688
    Natural varianti275 – 2751T → M in ARVD11; can be processed into a mature form but shows a higher pro-protein to mature protein ratio; only a proportion of the partly functional mutant is incorporated into the desmosomes. 1 Publication
    VAR_065689
    Natural varianti340 – 3401T → A in ARVD11. 1 Publication
    VAR_065690
    Natural varianti358 – 3581T → I.1 Publication
    Corresponds to variant rs139399951 [ dbSNP | Ensembl ].
    VAR_062391
    Natural varianti596 – 5961A → V.1 Publication
    Corresponds to variant rs148185335 [ dbSNP | Ensembl ].
    VAR_065691
    Natural varianti638 – 6381Q → H.1 Publication
    VAR_065692
    Natural varianti776 – 7761I → V.2 Publications
    Corresponds to variant rs1893963 [ dbSNP | Ensembl ].
    VAR_024388
    Natural varianti798 – 7981R → Q.3 Publications
    Corresponds to variant rs61731921 [ dbSNP | Ensembl ].
    VAR_062392

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei837 – 84711KVYLCNQDENH → ESIRGHTLIKN in isoform 2B. 1 PublicationVSP_000657Add
    BLAST
    Alternative sequencei848 – 90154Missing in isoform 2B. 1 PublicationVSP_000658Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56807 mRNA. Translation: CAA40141.1. Different initiation.
    X56807 mRNA. Translation: CAA40142.1. Different initiation.
    BC063291 mRNA. Translation: AAH63291.1.
    CCDSiCCDS11892.1. [Q02487-1]
    CCDS11893.1. [Q02487-2]
    PIRiA40390. IJHUDB.
    B40390. IJHUDA.
    RefSeqiNP_004940.1. NM_004949.3. [Q02487-2]
    NP_077740.1. NM_024422.3. [Q02487-1]
    UniGeneiHs.95612.

    Genome annotation databases

    EnsembliENST00000251081; ENSP00000251081; ENSG00000134755. [Q02487-2]
    ENST00000280904; ENSP00000280904; ENSG00000134755. [Q02487-1]
    GeneIDi1824.
    KEGGihsa:1824.
    UCSCiuc002kwk.4. human. [Q02487-2]
    uc002kwl.4. human. [Q02487-1]

    Polymorphism databases

    DMDMi461968.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56807 mRNA. Translation: CAA40141.1 . Different initiation.
    X56807 mRNA. Translation: CAA40142.1 . Different initiation.
    BC063291 mRNA. Translation: AAH63291.1 .
    CCDSi CCDS11892.1. [Q02487-1 ]
    CCDS11893.1. [Q02487-2 ]
    PIRi A40390. IJHUDB.
    B40390. IJHUDA.
    RefSeqi NP_004940.1. NM_004949.3. [Q02487-2 ]
    NP_077740.1. NM_024422.3. [Q02487-1 ]
    UniGenei Hs.95612.

    3D structure databases

    ProteinModelPortali Q02487.
    SMRi Q02487. Positions 137-669.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108158. 8 interactions.
    IntActi Q02487. 7 interactions.
    STRINGi 9606.ENSP00000280904.

    PTM databases

    PhosphoSitei Q02487.

    Polymorphism databases

    DMDMi 461968.

    Proteomic databases

    MaxQBi Q02487.
    PaxDbi Q02487.
    PRIDEi Q02487.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000251081 ; ENSP00000251081 ; ENSG00000134755 . [Q02487-2 ]
    ENST00000280904 ; ENSP00000280904 ; ENSG00000134755 . [Q02487-1 ]
    GeneIDi 1824.
    KEGGi hsa:1824.
    UCSCi uc002kwk.4. human. [Q02487-2 ]
    uc002kwl.4. human. [Q02487-1 ]

    Organism-specific databases

    CTDi 1824.
    GeneCardsi GC18M028670.
    GeneReviewsi DSC2.
    HGNCi HGNC:3036. DSC2.
    HPAi HPA011911.
    HPA012615.
    MIMi 125645. gene.
    610476. phenotype.
    neXtProti NX_Q02487.
    Orphaneti 293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
    293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
    293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
    PharmGKBi PA27489.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304955.
    HOGENOMi HOG000231253.
    HOVERGENi HBG102801.
    InParanoidi Q02487.
    KOi K07601.
    OMAi PLNYEER.
    OrthoDBi EOG74BJR7.
    PhylomeDBi Q02487.
    TreeFami TF316817.

    Miscellaneous databases

    ChiTaRSi DSC2. human.
    GeneWikii DSC2.
    GenomeRNAii 1824.
    NextBioi 7437.
    PROi Q02487.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02487.
    Bgeei Q02487.
    CleanExi HS_DSC2.
    HS_DSC3.
    Genevestigatori Q02487.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR009124. Cadherin/Desmocollin.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR014868. Cadherin_pro_dom.
    IPR027397. Catenin_binding_dom.
    IPR009122. Desmosomal_cadherin.
    [Graphical view ]
    PANTHERi PTHR24025. PTHR24025. 1 hit.
    Pfami PF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    PF08758. Cadherin_pro. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01820. DESMOCOLLIN.
    SMARTi SM00112. CA. 5 hits.
    SM01055. Cadherin_pro. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing."
      Parker A.E., Wheeler G.N., Arnemann J., Pidsley S.C., Ataliotis P., Thomas C.L., Rees D.A., Magee A.I., Buxton R.S.
      J. Biol. Chem. 266:10438-10445(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2A AND 2B).
      Tissue: Keratinocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A).
      Tissue: Placenta.
    3. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-546.
      Tissue: Plasma.
    4. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-392 AND ASN-629.
      Tissue: Saliva.
    5. "Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2."
      Syrris P., Ward D., Evans A., Asimaki A., Gandjbakhch E., Sen-Chowdhry S., McKenna W.J.
      Am. J. Hum. Genet. 79:978-984(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN ARVD11.
    6. Cited for: GLYCOSYLATION AT ASN-392.
    7. "Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."
      Gehmlich K., Syrris P., Peskett E., Evans A., Ehler E., Asimaki A., Anastasakis A., Tsatsopoulou A., Vouliotis A.I., Stefanadis C., Saffitz J.E., Protonotarios N., McKenna W.J.
      Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH DSP; PKP2 AND JUP, VARIANTS ARVD11 CYS-203 AND MET-275, CHARACTERIZATION OF VARIANTS ARVD11 CYS-203 AND MET-275.
    8. Cited for: VARIANTS ILE-358; VAL-776 AND GLN-798.
    9. "Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."
      den Haan A.D., Tan B.Y., Zikusoka M.N., Llado L.I., Jain R., Daly A., Tichnell C., James C., Amat-Alarcon N., Abraham T., Russell S.D., Bluemke D.A., Calkins H., Dalal D., Judge D.P.
      Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-11; VAL-596; HIS-638; VAL-776 AND GLN-798.
    10. "Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."
      Barahona-Dussault C., Benito B., Campuzano O., Iglesias A., Leung T.L., Robb L., Talajic M., Brugada R.
      Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARVD11 THR-231 AND ALA-340, VARIANT GLN-798.

    Entry informationi

    Entry nameiDSC2_HUMAN
    AccessioniPrimary (citable) accession number: Q02487
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3