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Q02486

- ABF2_YEAST

UniProt

Q02486 - ABF2_YEAST

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Protein

ARS-binding factor 2, mitochondrial

Gene
ABF2, HIM1, YMR072W, YM9916.11
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Specific binding to the autonomously replicating sequence 1 (ARS1). Interaction with regulatory regions: probably involved in compacting the mitochondrial genome. It might play a positive role in gene expression and replication.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi43 – 11169HMG box 1Add
BLAST
DNA bindingi116 – 18368HMG box 2Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: SGD
  2. DNA binding, bending Source: SGD

GO - Biological processi

  1. mitochondrial DNA packaging Source: SGD
  2. mitochondrial genome maintenance Source: SGD
  3. mitochondrion inheritance Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32774-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ARS-binding factor 2, mitochondrial
Gene namesi
Name:ABF2
Synonyms:HIM1
Ordered Locus Names:YMR072W
ORF Names:YM9916.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR072w.
SGDiS000004676. ABF2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial chromosome Source: SGD
  2. mitochondrial nucleoid Source: SGD
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626Mitochondrion1 PublicationAdd
BLAST
Chaini27 – 183157ARS-binding factor 2, mitochondrialPRO_0000013477Add
BLAST

Proteomic databases

MaxQBiQ02486.
PaxDbiQ02486.
PeptideAtlasiQ02486.

Expressioni

Gene expression databases

GenevestigatoriQ02486.

Interactioni

Protein-protein interaction databases

BioGridi35247. 74 interactions.
DIPiDIP-5492N.
IntActiQ02486. 30 interactions.
MINTiMINT-505363.
STRINGi4932.YMR072W.

Structurei

3D structure databases

ProteinModelPortaliQ02486.
SMRiQ02486. Positions 42-179.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiCOG5648.
GeneTreeiENSGT00730000113246.
KOiK11830.
OMAiDHICASH.
OrthoDBiEOG70KH25.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 2 hits.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS50118. HMG_BOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02486-1 [UniParc]FASTAAdd to Basket

« Hide

MNSYSLLTRS FHESSKPLFN LASTLLKASK RTQLRNELIK QGPKRPTSAY    50
FLYLQDHRSQ FVKENPTLRP AEISKIAGEK WQNLEADIKE KYISERKKLY 100
SEYQKAKKEF DEKLPPKKPA GPFIKYANEV RSQVFAQHPD KSQLDLMKII 150
GDKWQSLDQS IKDKYIQEYK KAIQEYNARY PLN 183
Length:183
Mass (Da):21,562
Last modified:July 1, 1993 - v1
Checksum:iD280A7D2B675B5B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73753 Genomic DNA. Translation: AAA73079.2. Sequence problems.
AJ223169 mRNA. Translation: CAA11146.1.
Z48952 Genomic DNA. Translation: CAA88797.1.
AY557967 Genomic DNA. Translation: AAS56293.1.
BK006946 Genomic DNA. Translation: DAA09970.1.
PIRiA41302.
RefSeqiNP_013788.1. NM_001182570.1.

Genome annotation databases

EnsemblFungiiYMR072W; YMR072W; YMR072W.
GeneIDi855094.
KEGGisce:YMR072W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73753 Genomic DNA. Translation: AAA73079.2 . Sequence problems.
AJ223169 mRNA. Translation: CAA11146.1 .
Z48952 Genomic DNA. Translation: CAA88797.1 .
AY557967 Genomic DNA. Translation: AAS56293.1 .
BK006946 Genomic DNA. Translation: DAA09970.1 .
PIRi A41302.
RefSeqi NP_013788.1. NM_001182570.1.

3D structure databases

ProteinModelPortali Q02486.
SMRi Q02486. Positions 42-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35247. 74 interactions.
DIPi DIP-5492N.
IntActi Q02486. 30 interactions.
MINTi MINT-505363.
STRINGi 4932.YMR072W.

Proteomic databases

MaxQBi Q02486.
PaxDbi Q02486.
PeptideAtlasi Q02486.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR072W ; YMR072W ; YMR072W .
GeneIDi 855094.
KEGGi sce:YMR072W.

Organism-specific databases

CYGDi YMR072w.
SGDi S000004676. ABF2.

Phylogenomic databases

eggNOGi COG5648.
GeneTreei ENSGT00730000113246.
KOi K11830.
OMAi DHICASH.
OrthoDBi EOG70KH25.

Enzyme and pathway databases

BioCyci YEAST:G3O-32774-MONOMER.

Miscellaneous databases

NextBioi 978405.
PROi Q02486.

Gene expression databases

Genevestigatori Q02486.

Family and domain databases

Gene3Di 1.10.30.10. 2 hits.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 2 hits.
[Graphical view ]
SMARTi SM00398. HMG. 2 hits.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 2 hits.
PROSITEi PS50118. HMG_BOX_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria."
    Diffley J.F.X., Stillman B.
    Proc. Natl. Acad. Sci. U.S.A. 88:7864-7868(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 27-56.
  2. "Molecular cloning and characterization of yeast CDRP1: an HMG protein which recognizes cisplatin-damaged DNA and confers drug sensitivity."
    Sun C.L., Lee F.J., Lin-Chao S., Chao C.K.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiABF2_YEAST
AccessioniPrimary (citable) accession number: Q02486
Secondary accession number(s): D6VZP6, Q712M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 14, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3810 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi