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Q02486

- ABF2_YEAST

UniProt

Q02486 - ABF2_YEAST

Protein

ARS-binding factor 2, mitochondrial

Gene

ABF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Specific binding to the autonomously replicating sequence 1 (ARS1). Interaction with regulatory regions: probably involved in compacting the mitochondrial genome. It might play a positive role in gene expression and replication.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi43 – 11169HMG box 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi116 – 18368HMG box 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: SGD
    2. DNA binding, bending Source: SGD

    GO - Biological processi

    1. mitochondrial DNA packaging Source: SGD
    2. mitochondrial genome maintenance Source: SGD
    3. mitochondrion inheritance Source: SGD

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32774-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ARS-binding factor 2, mitochondrial
    Gene namesi
    Name:ABF2
    Synonyms:HIM1
    Ordered Locus Names:YMR072W
    ORF Names:YM9916.11
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR072w.
    SGDiS000004676. ABF2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial chromosome Source: SGD
    2. mitochondrial nucleoid Source: SGD
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626Mitochondrion1 PublicationAdd
    BLAST
    Chaini27 – 183157ARS-binding factor 2, mitochondrialPRO_0000013477Add
    BLAST

    Proteomic databases

    MaxQBiQ02486.
    PaxDbiQ02486.
    PeptideAtlasiQ02486.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02486.

    Interactioni

    Protein-protein interaction databases

    BioGridi35247. 74 interactions.
    DIPiDIP-5492N.
    IntActiQ02486. 30 interactions.
    MINTiMINT-505363.
    STRINGi4932.YMR072W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02486.
    SMRiQ02486. Positions 42-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiCOG5648.
    GeneTreeiENSGT00730000113246.
    KOiK11830.
    OMAiDHICASH.
    OrthoDBiEOG70KH25.

    Family and domain databases

    Gene3Di1.10.30.10. 2 hits.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 2 hits.
    [Graphical view]
    SMARTiSM00398. HMG. 2 hits.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 2 hits.
    PROSITEiPS50118. HMG_BOX_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02486-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSYSLLTRS FHESSKPLFN LASTLLKASK RTQLRNELIK QGPKRPTSAY    50
    FLYLQDHRSQ FVKENPTLRP AEISKIAGEK WQNLEADIKE KYISERKKLY 100
    SEYQKAKKEF DEKLPPKKPA GPFIKYANEV RSQVFAQHPD KSQLDLMKII 150
    GDKWQSLDQS IKDKYIQEYK KAIQEYNARY PLN 183
    Length:183
    Mass (Da):21,562
    Last modified:July 1, 1993 - v1
    Checksum:iD280A7D2B675B5B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73753 Genomic DNA. Translation: AAA73079.2. Sequence problems.
    AJ223169 mRNA. Translation: CAA11146.1.
    Z48952 Genomic DNA. Translation: CAA88797.1.
    AY557967 Genomic DNA. Translation: AAS56293.1.
    BK006946 Genomic DNA. Translation: DAA09970.1.
    PIRiA41302.
    RefSeqiNP_013788.1. NM_001182570.1.

    Genome annotation databases

    EnsemblFungiiYMR072W; YMR072W; YMR072W.
    GeneIDi855094.
    KEGGisce:YMR072W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73753 Genomic DNA. Translation: AAA73079.2 . Sequence problems.
    AJ223169 mRNA. Translation: CAA11146.1 .
    Z48952 Genomic DNA. Translation: CAA88797.1 .
    AY557967 Genomic DNA. Translation: AAS56293.1 .
    BK006946 Genomic DNA. Translation: DAA09970.1 .
    PIRi A41302.
    RefSeqi NP_013788.1. NM_001182570.1.

    3D structure databases

    ProteinModelPortali Q02486.
    SMRi Q02486. Positions 42-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35247. 74 interactions.
    DIPi DIP-5492N.
    IntActi Q02486. 30 interactions.
    MINTi MINT-505363.
    STRINGi 4932.YMR072W.

    Proteomic databases

    MaxQBi Q02486.
    PaxDbi Q02486.
    PeptideAtlasi Q02486.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR072W ; YMR072W ; YMR072W .
    GeneIDi 855094.
    KEGGi sce:YMR072W.

    Organism-specific databases

    CYGDi YMR072w.
    SGDi S000004676. ABF2.

    Phylogenomic databases

    eggNOGi COG5648.
    GeneTreei ENSGT00730000113246.
    KOi K11830.
    OMAi DHICASH.
    OrthoDBi EOG70KH25.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32774-MONOMER.

    Miscellaneous databases

    NextBioi 978405.
    PROi Q02486.

    Gene expression databases

    Genevestigatori Q02486.

    Family and domain databases

    Gene3Di 1.10.30.10. 2 hits.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 2 hits.
    [Graphical view ]
    SMARTi SM00398. HMG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 2 hits.
    PROSITEi PS50118. HMG_BOX_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria."
      Diffley J.F.X., Stillman B.
      Proc. Natl. Acad. Sci. U.S.A. 88:7864-7868(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 27-56.
    2. "Molecular cloning and characterization of yeast CDRP1: an HMG protein which recognizes cisplatin-damaged DNA and confers drug sensitivity."
      Sun C.L., Lee F.J., Lin-Chao S., Chao C.K.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiABF2_YEAST
    AccessioniPrimary (citable) accession number: Q02486
    Secondary accession number(s): D6VZP6, Q712M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3810 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3