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Protein

Protein MLP1

Gene

MLP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved together with the closely related MLP2 in the structural and functional organization of perinuclear chromatin. MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery. According to PubMed:11862215 some telomeres are tethered to the nuclear periphery through MLP1/MLP2, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing. According to PubMed:12490156 MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring. MLP1 also recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself.6 Publications

Miscellaneous

Present with 2710 molecules/cell in log phase SD medium.1 Publication

Caution

PubMed:8154186 misquoted the gene name as 'MPL1'.Curated

GO - Molecular functioni

  • ribonucleoprotein complex binding Source: SGD

GO - Biological processi

  • DNA repair Source: UniProtKB-KW
  • mitotic spindle assembly checkpoint Source: GO_Central
  • negative regulation of protein import into nucleus during spindle assembly checkpoint Source: SGD
  • nuclear retention of unspliced pre-mRNA at the site of transcription Source: SGD
  • poly(A)+ mRNA export from nucleus Source: SGD
  • protein import into nucleus Source: SGD
  • protein localization to nuclear pore Source: SGD
  • telomere tethering at nuclear periphery Source: SGD
  • transcriptional activation by promoter-terminator looping Source: SGD

Keywordsi

Biological processDNA damage, DNA repair, mRNA transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32058-MONOMER

Protein family/group databases

TCDBi1.I.1.1.1 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MLP1
Alternative name(s):
Myosin-like protein 1
Gene namesi
Name:MLP1
Ordered Locus Names:YKR095W
ORF Names:YKR415
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YKR095W
SGDiS000001803 MLP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000965012 – 1875Protein MLP1Add BLAST1874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei337PhosphothreonineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei1670PhosphoserineCombined sources1
Modified residuei1710PhosphoserineCombined sources1
Modified residuei1733PhosphoserineCombined sources1
Modified residuei1803PhosphoserineCombined sources1

Post-translational modificationi

May be phosphorylated by CDC28.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ02455
PaxDbiQ02455
PRIDEiQ02455

PTM databases

CarbonylDBiQ02455
iPTMnetiQ02455

Interactioni

Subunit structurei

Interacts with NAB2, a hnRNP required for mRNA export. Also interacts with MLP2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34226, 310 interactors
DIPiDIP-6675N
IntActiQ02455, 9 interactors
MINTiQ02455
STRINGi4932.YKR095W

Structurei

3D structure databases

ProteinModelPortaliQ02455
SMRiQ02455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 487Sequence analysisAdd BLAST419
Coiled coili531 – 1678Sequence analysisAdd BLAST1148
Coiled coili1834 – 1866Sequence analysisAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1496 – 1565Required for nuclear localizationAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1804 – 1865Glu-richAdd BLAST62

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00900000142930
HOGENOMiHOG000113604
InParanoidiQ02455
KOiK09291
OMAiSENTRFR
OrthoDBiEOG092C0471

Family and domain databases

InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR012929 TPR/MLP1
PfamiView protein in Pfam
PF07926 TPR_MLP1_2, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDHDTPMES IQNGENSDER LNAIASFFGC SLEQVKSFDG DVVKHLNDKL
60 70 80 90 100
LQFNELKSEN LKVTVSFDEL KASSLKKIDG LKTEMENVIR ENDKIRKERN
110 120 130 140 150
DTFVKFESVE NEKMKLSSEL EFVKRKLDDL TEEKKETQSN QQRTLKILDE
160 170 180 190 200
RLKEIELVRV ENNRSNSECK KLRSTIMDLE TKQQGYITND LNSRTELERK
210 220 230 240 250
TQELTLLQSN NDWLEKELRS KNEQYLSYRQ KTDKVILDIR NELNRLRNDF
260 270 280 290 300
QMERTNNDVL KQKNNELSKS LQEKLLEIKG LSDSLNSEKQ EFSAEMSLKQ
310 320 330 340 350
RLVDLLESQL NAVKEELNSI RELNTAKVIA DDSKKQTPEN EDLLKELQLT
360 370 380 390 400
KEKLAQCEKE CLRLSSITDE ADEDNENLSA KSSSDFIFLK KQLIKERRTK
410 420 430 440 450
EHLQNQIETF IVELEHKVPI INSFKERTDM LENELNNAAL LLEHTSNEKN
460 470 480 490 500
AKVKELNAKN QKLVECENDL QTLTKQRLDL CRQIQYLLIT NSVSNDSKGP
510 520 530 540 550
LRKEEIQFIQ NIMQEDDSTI TESDSQKVVT ERLVEFKNII QLQEKNAELL
560 570 580 590 600
KVVRNLADKL ESKEKKSKQS LQKIESETVN EAKEAIITLK SEKMDLESRI
610 620 630 640 650
EELQKELEEL KTSVPNEDAS YSNVTIKQLT ETKRDLESQV QDLQTRISQI
660 670 680 690 700
TRESTENMSL LNKEIQDLYD SKSDISIKLG KEKSSRILAE ERFKLLSNTL
710 720 730 740 750
DLTKAENDQL RKRFDYLQNT ILKQDSKTHE TLNEYVSCKS KLSIVETELL
760 770 780 790 800
NLKEEQKLRV HLEKNLKQEL NKLSPEKDSL RIMVTQLQTL QKEREDLLEE
810 820 830 840 850
TRKSCQKKID ELEDALSELK KETSQKDHHI KQLEEDNNSN IEWYQNKIEA
860 870 880 890 900
LKKDYESVIT SVDSKQTDIE KLQYKVKSLE KEIEEDKIRL HTYNVMDETI
910 920 930 940 950
NDDSLRKELE KSKINLTDAY SQIKEYKDLY ETTSQSLQQT NSKLDESFKD
960 970 980 990 1000
FTNQIKNLTD EKTSLEDKIS LLKEQMFNLN NELDLQKKGM EKEKADFKKR
1010 1020 1030 1040 1050
ISILQNNNKE VEAVKSEYES KLSKIQNDLD QQTIYANTAQ NNYEQELQKH
1060 1070 1080 1090 1100
ADVSKTISEL REQLHTYKGQ VKTLNLSRDQ LENALKENEK SWSSQKESLL
1110 1120 1130 1140 1150
EQLDLSNSRI EDLSSQNKLL YDQIQIYTAA DKEVNNSTNG PGLNNILITL
1160 1170 1180 1190 1200
RRERDILDTK VTVAERDAKM LRQKISLMDV ELQDARTKLD NSRVEKENHS
1210 1220 1230 1240 1250
SIIQQHDDIM EKLNQLNLLR ESNITLRNEL ENNNNKKKEL QSELDKLKQN
1260 1270 1280 1290 1300
VAPIESELTA LKYSMQEKEQ ELKLAKEEVH RWKKRSQDIL EKHEQLSSSD
1310 1320 1330 1340 1350
YEKLESEIEN LKEELENKER QGAEAEEKFN RLRRQAQERL KTSKLSQDSL
1360 1370 1380 1390 1400
TEQVNSLRDA KNVLENSLSE ANARIEELQN AKVAQGNNQL EAIRKLQEDA
1410 1420 1430 1440 1450
EKASRELQAK LEESTTSYES TINGLNEEIT TLKEEIEKQR QIQQQLQATS
1460 1470 1480 1490 1500
ANEQNDLSNI VESMKKSFEE DKIKFIKEKT QEVNEKILEA QERLNQPSNI
1510 1520 1530 1540 1550
NMEEIKKKWE SEHEQEVSQK IREAEEALKK RIRLPTEEKI NKIIERKKEE
1560 1570 1580 1590 1600
LEKEFEEKVE ERIKSMEQSG EIDVVLRKQL EAKVQEKQKE LENEYNKKLQ
1610 1620 1630 1640 1650
EELKDVPHSS HISDDERDKL RAEIESRLRE EFNNELQAIK KKSFDEGKQQ
1660 1670 1680 1690 1700
AMMKTTLLER KLAKMESQLS ETKQSAESPP KSVNNVQNPL LGLPRKIEEN
1710 1720 1730 1740 1750
SNSPFNPLLS GEKLLKLNSK SSSGGFNPFT SPSPNKHLQN DNDKRESLAN
1760 1770 1780 1790 1800
KTDPPTHLEP SFNIPASRGL ISSSSTLSTD TNDEELTSNN PAQKDSSNRN
1810 1820 1830 1840 1850
VQSEEDTEKK KEGEPVKRGE AIEEQTKSNK RPIDEVGELK NDEDDTTENI
1860 1870
NESKKIKTED EEEKETDKVN DENSI
Length:1,875
Mass (Da):218,456
Last modified:June 1, 1994 - v2
Checksum:i683A0D34C9066867
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301R → A in AAA34783 (PubMed:8483450).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01992 Genomic DNA Translation: AAA34783.1
X73541 Genomic DNA Translation: CAA51948.1
Z28320 Genomic DNA Translation: CAA82174.1
BK006944 Genomic DNA Translation: DAA09245.1
PIRiS38173
RefSeqiNP_013021.1, NM_001179885.1

Genome annotation databases

EnsemblFungiiYKR095W; YKR095W; YKR095W
GeneIDi853970
KEGGisce:YKR095W

Entry informationi

Entry nameiMLP1_YEAST
AccessioniPrimary (citable) accession number: Q02455
Secondary accession number(s): D6VXF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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