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Q02453

- ARM_MUSDO

UniProt

Q02453 - ARM_MUSDO

Protein

Armadillo segment polarity protein

Gene

arm

Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. intracellular protein transport Source: InterPro
    3. segment polarity determination Source: UniProtKB-KW
    4. vesicle-mediated transport Source: InterPro
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Segmentation polarity protein

    Keywords - Biological processi

    Cell adhesion, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo segment polarity protein
    Gene namesi
    Name:arm
    OrganismiMusca domestica (House fly)
    Taxonomic identifieri7370 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
    Note: Inner surface of cell membrane and adherens junction.By similarity

    GO - Cellular componenti

    1. adherens junction Source: UniProtKB-SubCell
    2. membrane coat Source: InterPro
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Development of anterior structures in the posterior part of the segment.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 813813Armadillo segment polarity proteinPRO_0000064293Add
    BLAST

    Post-translational modificationi

    Phosphorylated on Ser, Thr and Tyr residues. Level of phosphorylation varies both during embryonic development and from embryonic tissue to tissue. Sgg is required for phosphorylation and wg signal negatively regulates arm phosphorylation. Hypophosphorylated form of arm increases in steady-state levels By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ02453.

    Interactioni

    Subunit structurei

    Interacts with Mer and Moe at the adherens junction.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ02453.
    SMRiQ02453. Positions 125-684.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati139 – 17840ARM 1Add
    BLAST
    Repeati180 – 22142ARM 2Add
    BLAST
    Repeati223 – 26240ARM 3Add
    BLAST
    Repeati265 – 30440ARM 4Add
    BLAST
    Repeati349 – 38739ARM 5Add
    BLAST
    Repeati388 – 42740ARM 6Add
    BLAST
    Repeati430 – 47142ARM 7Add
    BLAST
    Repeati477 – 51741ARM 8Add
    BLAST
    Repeati587 – 62640ARM 9Add
    BLAST
    Repeati628 – 66740ARM 10Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 148148Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 10 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF00514. Arm. 3 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 12 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02453-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LVDSGIHSGA VTQAPSLSGK    50
    EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ RVRAAMFPET 100
    LEEGIEIPST QFDPQQPTAV QRLAEPSQML KHAVVNLINY QDDAELATRA 150
    IPELIKLLND EDQVVVSQAA MMVHQLSKKE ASRHAITNSP QMVAALVRAI 200
    SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK LLSSPVESVL 250
    FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK FLAIVTDCLQ 300
    ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR VLKVLSVCSS 350
    NKPAIVDAGG MQALAMHLSN PSPRLVQNCL WTLRNLSDAA TKVDGLEPLL 400
    QSLVQVLAST DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG GVDALVRTII 450
    NAGDREEITE PAVCALRHLT TRHADSEMAQ NAVRLNYGLS VIVKLLHPPS 500
    RWPLIKAAIG LVRNLALCPA NAAPLREHGA IHHLVRLLMR AFQDTERQRS 550
    SVATTGSQQP AAYADGVRME EIVEGTVGAL HILARESHNR ALIRQQSVIP 600
    IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT GPLTDLLHSR 650
    NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTTNSLLRED NNIWGNADLG 700
    LGPDLQDMLG PEQAYEGLYG QGPPSVHSSH GGRAFQQGYD TLPIDSMQGL 750
    EISSPVGGGG GGGAPPSAAP TSPYSMDMDV GEIDAGALNF DLDAMPTPPN 800
    DNNNLAAWYD TDC 813
    Length:813
    Mass (Da):88,237
    Last modified:July 1, 1993 - v1
    Checksum:i73E61F59BDBFA580
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04874 mRNA. Translation: AAA29292.1.
    RefSeqiNP_001273824.1. NM_001286895.1.

    Genome annotation databases

    GeneIDi101899911.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04874 mRNA. Translation: AAA29292.1 .
    RefSeqi NP_001273824.1. NM_001286895.1.

    3D structure databases

    ProteinModelPortali Q02453.
    SMRi Q02453. Positions 125-684.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q02453.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101899911.

    Organism-specific databases

    CTDi 101899911.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF00514. Arm. 3 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 12 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica."
      Peifer M.A., Wieschaus E.
      J. Mol. Evol. 36:224-233(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiARM_MUSDO
    AccessioniPrimary (citable) accession number: Q02453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3