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Q02453 (ARM_MUSDO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Armadillo segment polarity protein
Gene names
Name:arm
OrganismMusca domestica (House fly)
Taxonomic identifier7370 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Protein attributes

Sequence length813 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.

Subunit structure

Interacts with Mer and Moe at the adherens junction By similarity.

Subcellular location

Cytoplasm By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity. Note: Inner surface of cell membrane and adherens junction By similarity.

Post-translational modification

Phosphorylated on Ser, Thr and Tyr residues. Level of phosphorylation varies both during embryonic development and from embryonic tissue to tissue. Sgg is required for phosphorylation and wg signal negatively regulates arm phosphorylation. Hypophosphorylated form of arm increases in steady-state levels By similarity.

Disruption phenotype

Development of anterior structures in the posterior part of the segment. Ref.1

Sequence similarities

Belongs to the beta-catenin family.

Contains 10 ARM repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 813813Armadillo segment polarity protein
PRO_0000064293

Regions

Repeat139 – 17840ARM 1
Repeat180 – 22142ARM 2
Repeat223 – 26240ARM 3
Repeat265 – 30440ARM 4
Repeat349 – 38739ARM 5
Repeat388 – 42740ARM 6
Repeat430 – 47142ARM 7
Repeat477 – 51741ARM 8
Repeat587 – 62640ARM 9
Repeat628 – 66740ARM 10
Compositional bias1 – 148148Asp/Glu-rich (acidic)

Sequences

Sequence LengthMass (Da)Tools
Q02453 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 73E61F59BDBFA580

FASTA81388,237
        10         20         30         40         50         60 
MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LVDSGIHSGA VTQAPSLSGK EDEEMEGDPL 

        70         80         90        100        110        120 
MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ RVRAAMFPET LEEGIEIPST QFDPQQPTAV 

       130        140        150        160        170        180 
QRLAEPSQML KHAVVNLINY QDDAELATRA IPELIKLLND EDQVVVSQAA MMVHQLSKKE 

       190        200        210        220        230        240 
ASRHAITNSP QMVAALVRAI SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK 

       250        260        270        280        290        300 
LLSSPVESVL FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK FLAIVTDCLQ 

       310        320        330        340        350        360 
ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR VLKVLSVCSS NKPAIVDAGG 

       370        380        390        400        410        420 
MQALAMHLSN PSPRLVQNCL WTLRNLSDAA TKVDGLEPLL QSLVQVLAST DVNVVTCAAG 

       430        440        450        460        470        480 
ILSNLTCNNQ RNKATVCQVG GVDALVRTII NAGDREEITE PAVCALRHLT TRHADSEMAQ 

       490        500        510        520        530        540 
NAVRLNYGLS VIVKLLHPPS RWPLIKAAIG LVRNLALCPA NAAPLREHGA IHHLVRLLMR 

       550        560        570        580        590        600 
AFQDTERQRS SVATTGSQQP AAYADGVRME EIVEGTVGAL HILARESHNR ALIRQQSVIP 

       610        620        630        640        650        660 
IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT GPLTDLLHSR NEGVATYAAA 

       670        680        690        700        710        720 
VLFRMSEDKP QDYKKRLSIE LTTNSLLRED NNIWGNADLG LGPDLQDMLG PEQAYEGLYG 

       730        740        750        760        770        780 
QGPPSVHSSH GGRAFQQGYD TLPIDSMQGL EISSPVGGGG GGGAPPSAAP TSPYSMDMDV 

       790        800        810 
GEIDAGALNF DLDAMPTPPN DNNNLAAWYD TDC 

« Hide

References

[1]"The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica."
Peifer M.A., Wieschaus E.
J. Mol. Evol. 36:224-233(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04874 mRNA. Translation: AAA29292.1.
RefSeqNP_001273824.1. NM_001286895.1.

3D structure databases

ProteinModelPortalQ02453.
SMRQ02453. Positions 125-684.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ02453.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101899911.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSPR01869. BCATNINFAMLY.
SMARTSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARM_MUSDO
AccessionPrimary (citable) accession number: Q02453
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families