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Protein

Armadillo segment polarity protein

Gene

arm

Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:arm
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Development of anterior structures in the posterior part of the segment.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642931 – 813Armadillo segment polarity proteinAdd BLAST813

Post-translational modificationi

Phosphorylated on Ser, Thr and Tyr residues. Level of phosphorylation varies both during embryonic development and from embryonic tissue to tissue. Sgg is required for phosphorylation and wg signal negatively regulates arm phosphorylation. Hypophosphorylated form of arm increases in steady-state levels (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ02453.

Interactioni

Subunit structurei

Interacts with Mer and Moe at the adherens junction.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ02453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati139 – 178ARM 1Add BLAST40
Repeati180 – 221ARM 2Add BLAST42
Repeati223 – 262ARM 3Add BLAST40
Repeati265 – 304ARM 4Add BLAST40
Repeati349 – 387ARM 5Add BLAST39
Repeati388 – 427ARM 6Add BLAST40
Repeati430 – 471ARM 7Add BLAST42
Repeati477 – 517ARM 8Add BLAST41
Repeati587 – 626ARM 9Add BLAST40
Repeati628 – 667ARM 10Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 148Asp/Glu-rich (acidic)Add BLAST148

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 10 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK02105.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LVDSGIHSGA VTQAPSLSGK
60 70 80 90 100
EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ RVRAAMFPET
110 120 130 140 150
LEEGIEIPST QFDPQQPTAV QRLAEPSQML KHAVVNLINY QDDAELATRA
160 170 180 190 200
IPELIKLLND EDQVVVSQAA MMVHQLSKKE ASRHAITNSP QMVAALVRAI
210 220 230 240 250
SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK LLSSPVESVL
260 270 280 290 300
FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK FLAIVTDCLQ
310 320 330 340 350
ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR VLKVLSVCSS
360 370 380 390 400
NKPAIVDAGG MQALAMHLSN PSPRLVQNCL WTLRNLSDAA TKVDGLEPLL
410 420 430 440 450
QSLVQVLAST DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG GVDALVRTII
460 470 480 490 500
NAGDREEITE PAVCALRHLT TRHADSEMAQ NAVRLNYGLS VIVKLLHPPS
510 520 530 540 550
RWPLIKAAIG LVRNLALCPA NAAPLREHGA IHHLVRLLMR AFQDTERQRS
560 570 580 590 600
SVATTGSQQP AAYADGVRME EIVEGTVGAL HILARESHNR ALIRQQSVIP
610 620 630 640 650
IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT GPLTDLLHSR
660 670 680 690 700
NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTTNSLLRED NNIWGNADLG
710 720 730 740 750
LGPDLQDMLG PEQAYEGLYG QGPPSVHSSH GGRAFQQGYD TLPIDSMQGL
760 770 780 790 800
EISSPVGGGG GGGAPPSAAP TSPYSMDMDV GEIDAGALNF DLDAMPTPPN
810
DNNNLAAWYD TDC
Length:813
Mass (Da):88,237
Last modified:July 1, 1993 - v1
Checksum:i73E61F59BDBFA580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04874 mRNA. Translation: AAA29292.1.
RefSeqiNP_001273824.1. NM_001286895.1.

Genome annotation databases

GeneIDi101899911.
KEGGimde:101899911.
VectorBaseiMDOA012332-RC; MDOA012332-PC; MDOA012332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04874 mRNA. Translation: AAA29292.1.
RefSeqiNP_001273824.1. NM_001286895.1.

3D structure databases

ProteinModelPortaliQ02453.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ02453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101899911.
KEGGimde:101899911.
VectorBaseiMDOA012332-RC; MDOA012332-PC; MDOA012332.

Organism-specific databases

CTDi101899911.

Phylogenomic databases

KOiK02105.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARM_MUSDO
AccessioniPrimary (citable) accession number: Q02453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.