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Q02453

- ARM_MUSDO

UniProt

Q02453 - ARM_MUSDO

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Protein

Armadillo segment polarity protein

Gene

arm

Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. intracellular protein transport Source: InterPro
  3. segment polarity determination Source: UniProtKB-KW
  4. vesicle-mediated transport Source: InterPro
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:arm
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
Note: Inner surface of cell membrane and adherens junction.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. membrane coat Source: InterPro
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Development of anterior structures in the posterior part of the segment.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Armadillo segment polarity proteinPRO_0000064293Add
BLAST

Post-translational modificationi

Phosphorylated on Ser, Thr and Tyr residues. Level of phosphorylation varies both during embryonic development and from embryonic tissue to tissue. Sgg is required for phosphorylation and wg signal negatively regulates arm phosphorylation. Hypophosphorylated form of arm increases in steady-state levels By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ02453.

Interactioni

Subunit structurei

Interacts with Mer and Moe at the adherens junction.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ02453.
SMRiQ02453. Positions 125-684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati139 – 17840ARM 1Add
BLAST
Repeati180 – 22142ARM 2Add
BLAST
Repeati223 – 26240ARM 3Add
BLAST
Repeati265 – 30440ARM 4Add
BLAST
Repeati349 – 38739ARM 5Add
BLAST
Repeati388 – 42740ARM 6Add
BLAST
Repeati430 – 47142ARM 7Add
BLAST
Repeati477 – 51741ARM 8Add
BLAST
Repeati587 – 62640ARM 9Add
BLAST
Repeati628 – 66740ARM 10Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 148148Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 10 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02453-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LVDSGIHSGA VTQAPSLSGK
60 70 80 90 100
EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ RVRAAMFPET
110 120 130 140 150
LEEGIEIPST QFDPQQPTAV QRLAEPSQML KHAVVNLINY QDDAELATRA
160 170 180 190 200
IPELIKLLND EDQVVVSQAA MMVHQLSKKE ASRHAITNSP QMVAALVRAI
210 220 230 240 250
SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK LLSSPVESVL
260 270 280 290 300
FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK FLAIVTDCLQ
310 320 330 340 350
ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR VLKVLSVCSS
360 370 380 390 400
NKPAIVDAGG MQALAMHLSN PSPRLVQNCL WTLRNLSDAA TKVDGLEPLL
410 420 430 440 450
QSLVQVLAST DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG GVDALVRTII
460 470 480 490 500
NAGDREEITE PAVCALRHLT TRHADSEMAQ NAVRLNYGLS VIVKLLHPPS
510 520 530 540 550
RWPLIKAAIG LVRNLALCPA NAAPLREHGA IHHLVRLLMR AFQDTERQRS
560 570 580 590 600
SVATTGSQQP AAYADGVRME EIVEGTVGAL HILARESHNR ALIRQQSVIP
610 620 630 640 650
IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT GPLTDLLHSR
660 670 680 690 700
NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTTNSLLRED NNIWGNADLG
710 720 730 740 750
LGPDLQDMLG PEQAYEGLYG QGPPSVHSSH GGRAFQQGYD TLPIDSMQGL
760 770 780 790 800
EISSPVGGGG GGGAPPSAAP TSPYSMDMDV GEIDAGALNF DLDAMPTPPN
810
DNNNLAAWYD TDC
Length:813
Mass (Da):88,237
Last modified:July 1, 1993 - v1
Checksum:i73E61F59BDBFA580
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04874 mRNA. Translation: AAA29292.1.
RefSeqiNP_001273824.1. NM_001286895.1.

Genome annotation databases

GeneIDi101899911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04874 mRNA. Translation: AAA29292.1 .
RefSeqi NP_001273824.1. NM_001286895.1.

3D structure databases

ProteinModelPortali Q02453.
SMRi Q02453. Positions 125-684.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q02453.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101899911.

Organism-specific databases

CTDi 101899911.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica."
    Peifer M.A., Wieschaus E.
    J. Mol. Evol. 36:224-233(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiARM_MUSDO
AccessioniPrimary (citable) accession number: Q02453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3