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Q02453

- ARM_MUSDO

UniProt

Q02453 - ARM_MUSDO

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Protein

Armadillo segment polarity protein

Gene
arm
Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. intracellular protein transport Source: InterPro
  3. segment polarity determination Source: UniProtKB-KW
  4. vesicle-mediated transport Source: InterPro
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:arm
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Subcellular locationi

Cytoplasm By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
Note: Inner surface of cell membrane and adherens junction By similarity.

GO - Cellular componenti

  1. adherens junction Source: UniProtKB-SubCell
  2. membrane coat Source: InterPro
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Development of anterior structures in the posterior part of the segment.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Armadillo segment polarity proteinPRO_0000064293Add
BLAST

Post-translational modificationi

Phosphorylated on Ser, Thr and Tyr residues. Level of phosphorylation varies both during embryonic development and from embryonic tissue to tissue. Sgg is required for phosphorylation and wg signal negatively regulates arm phosphorylation. Hypophosphorylated form of arm increases in steady-state levels By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ02453.

Interactioni

Subunit structurei

Interacts with Mer and Moe at the adherens junction By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ02453.
SMRiQ02453. Positions 125-684.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati139 – 17840ARM 1Add
BLAST
Repeati180 – 22142ARM 2Add
BLAST
Repeati223 – 26240ARM 3Add
BLAST
Repeati265 – 30440ARM 4Add
BLAST
Repeati349 – 38739ARM 5Add
BLAST
Repeati388 – 42740ARM 6Add
BLAST
Repeati430 – 47142ARM 7Add
BLAST
Repeati477 – 51741ARM 8Add
BLAST
Repeati587 – 62640ARM 9Add
BLAST
Repeati628 – 66740ARM 10Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 148148Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 10 ARM repeats.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02453-1 [UniParc]FASTAAdd to Basket

« Hide

MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LVDSGIHSGA VTQAPSLSGK    50
EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ RVRAAMFPET 100
LEEGIEIPST QFDPQQPTAV QRLAEPSQML KHAVVNLINY QDDAELATRA 150
IPELIKLLND EDQVVVSQAA MMVHQLSKKE ASRHAITNSP QMVAALVRAI 200
SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK LLSSPVESVL 250
FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK FLAIVTDCLQ 300
ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR VLKVLSVCSS 350
NKPAIVDAGG MQALAMHLSN PSPRLVQNCL WTLRNLSDAA TKVDGLEPLL 400
QSLVQVLAST DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG GVDALVRTII 450
NAGDREEITE PAVCALRHLT TRHADSEMAQ NAVRLNYGLS VIVKLLHPPS 500
RWPLIKAAIG LVRNLALCPA NAAPLREHGA IHHLVRLLMR AFQDTERQRS 550
SVATTGSQQP AAYADGVRME EIVEGTVGAL HILARESHNR ALIRQQSVIP 600
IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT GPLTDLLHSR 650
NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTTNSLLRED NNIWGNADLG 700
LGPDLQDMLG PEQAYEGLYG QGPPSVHSSH GGRAFQQGYD TLPIDSMQGL 750
EISSPVGGGG GGGAPPSAAP TSPYSMDMDV GEIDAGALNF DLDAMPTPPN 800
DNNNLAAWYD TDC 813
Length:813
Mass (Da):88,237
Last modified:July 1, 1993 - v1
Checksum:i73E61F59BDBFA580
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04874 mRNA. Translation: AAA29292.1.
RefSeqiNP_001273824.1. NM_001286895.1.

Genome annotation databases

GeneIDi101899911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04874 mRNA. Translation: AAA29292.1 .
RefSeqi NP_001273824.1. NM_001286895.1.

3D structure databases

ProteinModelPortali Q02453.
SMRi Q02453. Positions 125-684.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q02453.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101899911.

Organism-specific databases

CTDi 101899911.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica."
    Peifer M.A., Wieschaus E.
    J. Mol. Evol. 36:224-233(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiARM_MUSDO
AccessioniPrimary (citable) accession number: Q02453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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