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Protein

Transcription factor Sp4

Gene

SP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri647 – 67125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri677 – 70125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri707 – 72923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ02446.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp4
Alternative name(s):
SPR-1
Gene namesi
Name:SP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11209. SP4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36046.

Polymorphism and mutation databases

BioMutaiSP4.
DMDMi218511800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 784784Transcription factor Sp4PRO_0000047144Add
BLAST

Proteomic databases

MaxQBiQ02446.
PaxDbiQ02446.
PRIDEiQ02446.

PTM databases

PhosphoSiteiQ02446.

Expressioni

Tissue specificityi

Abundant in brain.

Gene expression databases

BgeeiQ02446.
CleanExiHS_SP4.
ExpressionAtlasiQ02446. baseline and differential.
GenevisibleiQ02446. HS.

Organism-specific databases

HPAiCAB010246.
HPA040395.
HPA059881.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAM15Q134443EBI-10198587,EBI-77818
ATXN7L1Q9BTQ83EBI-10198587,EBI-10298510
CIB3Q96Q773EBI-10198587,EBI-10292696
COL8A1P276583EBI-10198587,EBI-747133
FOXP2Q75MZ53EBI-10198587,EBI-10255915
hCG_2003792A0A024R5S03EBI-10198587,EBI-10188461
LMO3Q8TAP43EBI-10198587,EBI-742259
LOC730441Q4G0S13EBI-10198587,EBI-10241801
NRF1Q166563EBI-10198587,EBI-2547810
POU2F1P148595EBI-10198587,EBI-624770
PRR20CP864795EBI-10198587,EBI-10172814

Protein-protein interaction databases

BioGridi112554. 17 interactions.
IntActiQ02446. 11 interactions.
STRINGi9606.ENSP00000222584.

Structurei

3D structure databases

ProteinModelPortaliQ02446.
SMRiQ02446. Positions 627-733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 115Poly-Glu
Compositional biasi12 – 198Poly-Ala
Compositional biasi122 – 1309Poly-Ser
Compositional biasi185 – 1884Poly-Ser

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri647 – 67125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri677 – 70125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri707 – 72923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
InParanoidiQ02446.
KOiK09194.
OMAiCNWIFCG.
OrthoDBiEOG7JQBMX.
PhylomeDBiQ02446.
TreeFamiTF350150.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR030453. SP4.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PTHR23235:SF5. PTHR23235:SF5. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQKKEEEE EAAAAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL
60 70 80 90 100
LAATCSKIGT PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN
110 120 130 140 150
AWQLVASTPP ASKENNVSQP ASSSSSSSSS NNGSASPTKT KSGNSSTPGQ
160 170 180 190 200
FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ INPTSSSSLQ DLQGQIQLIS
210 220 230 240 250
AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP LQLQTLPGTQ
260 270 280 290 300
AQVVTTLPIN IGGVTLALPV INNVAAGGGT GQVGQPAATA DSGTSNGNQL
310 320 330 340 350
VSTPTNTTTS ASTMPESPSS STTCTTTAST SLTSSDTLVS SADTGQYAST
360 370 380 390 400
SASSSERTIE ESQTPAATES EAQSSSQLQP NGMQNAQDQS NSLQQVQIVG
410 420 430 440 450
QPILQQIQIQ QPQQQIIQAI PPQSFQLQSG QTIQTIQQQP LQNVQLQAVN
460 470 480 490 500
PTQVLIRAPT LTPSGQISWQ TVQVQNIQSL SNLQVQNAGL SQQLTITPVS
510 520 530 540 550
SSGGTTLAQI APVAVAGAPI TLNTAQLASV PNLQTVSVAN LGAAGVQVQG
560 570 580 590 600
VPVTITSVAG QQQGQDGVKV QQATIAPVTV AVGGIANATI GAVSPDQLTQ
610 620 630 640 650
VHLQQGQQTS DQEVQPGKRL RRVACSCPNC REGEGRGSNE PGKKKQHICH
660 670 680 690 700
IEGCGKVYGK TSHLRAHLRW HTGERPFICN WMFCGKRFTR SDELQRHRRT
710 720 730 740 750
HTGEKRFECP ECSKRFMRSD HLSKHVKTHQ NKKGGGTALA IVTSGELDSS
760 770 780
VTEVLGSPRI VTVAAISQDS NPATPNVSTN MEEF
Length:784
Mass (Da):81,985
Last modified:December 16, 2008 - v2
Checksum:i5B0B03EC03657993
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti379 – 3802QP → HA in CAA48563 (PubMed:1454515).Curated
Sequence conflicti386 – 3861A → Q in CAA48563 (PubMed:1454515).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti197 – 1971Q → K.1 Publication
Corresponds to variant rs1042848 [ dbSNP | Ensembl ].
VAR_047975

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68561 mRNA. Translation: CAA48563.1.
AK289728 mRNA. Translation: BAF82417.1.
AC004595 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93733.1.
BC109300 mRNA. Translation: AAI09301.1.
CCDSiCCDS5373.1.
PIRiS26638.
RefSeqiNP_003103.2. NM_003112.3.
UniGeneiHs.88013.

Genome annotation databases

EnsembliENST00000222584; ENSP00000222584; ENSG00000105866.
GeneIDi6671.
KEGGihsa:6671.
UCSCiuc003sva.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68561 mRNA. Translation: CAA48563.1.
AK289728 mRNA. Translation: BAF82417.1.
AC004595 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93733.1.
BC109300 mRNA. Translation: AAI09301.1.
CCDSiCCDS5373.1.
PIRiS26638.
RefSeqiNP_003103.2. NM_003112.3.
UniGeneiHs.88013.

3D structure databases

ProteinModelPortaliQ02446.
SMRiQ02446. Positions 627-733.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112554. 17 interactions.
IntActiQ02446. 11 interactions.
STRINGi9606.ENSP00000222584.

PTM databases

PhosphoSiteiQ02446.

Polymorphism and mutation databases

BioMutaiSP4.
DMDMi218511800.

Proteomic databases

MaxQBiQ02446.
PaxDbiQ02446.
PRIDEiQ02446.

Protocols and materials databases

DNASUi6671.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222584; ENSP00000222584; ENSG00000105866.
GeneIDi6671.
KEGGihsa:6671.
UCSCiuc003sva.3. human.

Organism-specific databases

CTDi6671.
GeneCardsiGC07P021434.
H-InvDBHIX0033690.
HGNCiHGNC:11209. SP4.
HPAiCAB010246.
HPA040395.
HPA059881.
MIMi600540. gene.
neXtProtiNX_Q02446.
PharmGKBiPA36046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
InParanoidiQ02446.
KOiK09194.
OMAiCNWIFCG.
OrthoDBiEOG7JQBMX.
PhylomeDBiQ02446.
TreeFamiTF350150.

Enzyme and pathway databases

SignaLinkiQ02446.

Miscellaneous databases

GeneWikiiSp4_transcription_factor.
GenomeRNAii6671.
NextBioi26011.
PROiQ02446.
SOURCEiSearch...

Gene expression databases

BgeeiQ02446.
CleanExiHS_SP4.
ExpressionAtlasiQ02446. baseline and differential.
GenevisibleiQ02446. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR030453. SP4.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PTHR23235:SF5. PTHR23235:SF5. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes."
    Hagen G., Mueller S., Beato M., Suske G.
    Nucleic Acids Res. 20:5519-5525(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-197.
    Tissue: Uterus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSP4_HUMAN
AccessioniPrimary (citable) accession number: Q02446
Secondary accession number(s): O60402, Q32M52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 16, 2008
Last modified: June 24, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.