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Q02446

- SP4_HUMAN

UniProt

Q02446 - SP4_HUMAN

Protein

Transcription factor Sp4

Gene

SP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri647 – 67125C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri677 – 70125C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri707 – 72923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: Ensembl
    4. transcription coactivator activity Source: ProtInc

    GO - Biological processi

    1. regulation of heart contraction Source: Ensembl
    2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ02446.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor Sp4
    Alternative name(s):
    SPR-1
    Gene namesi
    Name:SP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:11209. SP4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36046.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 784784Transcription factor Sp4PRO_0000047144Add
    BLAST

    Proteomic databases

    MaxQBiQ02446.
    PaxDbiQ02446.
    PRIDEiQ02446.

    PTM databases

    PhosphoSiteiQ02446.

    Expressioni

    Tissue specificityi

    Abundant in brain.

    Gene expression databases

    ArrayExpressiQ02446.
    BgeeiQ02446.
    CleanExiHS_SP4.
    GenevestigatoriQ02446.

    Organism-specific databases

    HPAiCAB010246.
    HPA040395.

    Interactioni

    Protein-protein interaction databases

    BioGridi112554. 6 interactions.
    STRINGi9606.ENSP00000222584.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02446.
    SMRiQ02446. Positions 597-733.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 115Poly-Glu
    Compositional biasi12 – 198Poly-Ala
    Compositional biasi122 – 1309Poly-Ser
    Compositional biasi185 – 1884Poly-Ser

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri647 – 67125C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri677 – 70125C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri707 – 72923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234295.
    HOVERGENiHBG008933.
    InParanoidiQ02446.
    KOiK09194.
    OMAiCNWIFCG.
    OrthoDBiEOG7JQBMX.
    PhylomeDBiQ02446.
    TreeFamiTF350150.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02446-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDQKKEEEE EAAAAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL    50
    LAATCSKIGT PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN 100
    AWQLVASTPP ASKENNVSQP ASSSSSSSSS NNGSASPTKT KSGNSSTPGQ 150
    FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ INPTSSSSLQ DLQGQIQLIS 200
    AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP LQLQTLPGTQ 250
    AQVVTTLPIN IGGVTLALPV INNVAAGGGT GQVGQPAATA DSGTSNGNQL 300
    VSTPTNTTTS ASTMPESPSS STTCTTTAST SLTSSDTLVS SADTGQYAST 350
    SASSSERTIE ESQTPAATES EAQSSSQLQP NGMQNAQDQS NSLQQVQIVG 400
    QPILQQIQIQ QPQQQIIQAI PPQSFQLQSG QTIQTIQQQP LQNVQLQAVN 450
    PTQVLIRAPT LTPSGQISWQ TVQVQNIQSL SNLQVQNAGL SQQLTITPVS 500
    SSGGTTLAQI APVAVAGAPI TLNTAQLASV PNLQTVSVAN LGAAGVQVQG 550
    VPVTITSVAG QQQGQDGVKV QQATIAPVTV AVGGIANATI GAVSPDQLTQ 600
    VHLQQGQQTS DQEVQPGKRL RRVACSCPNC REGEGRGSNE PGKKKQHICH 650
    IEGCGKVYGK TSHLRAHLRW HTGERPFICN WMFCGKRFTR SDELQRHRRT 700
    HTGEKRFECP ECSKRFMRSD HLSKHVKTHQ NKKGGGTALA IVTSGELDSS 750
    VTEVLGSPRI VTVAAISQDS NPATPNVSTN MEEF 784
    Length:784
    Mass (Da):81,985
    Last modified:December 16, 2008 - v2
    Checksum:i5B0B03EC03657993
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti379 – 3802QP → HA in CAA48563. (PubMed:1454515)Curated
    Sequence conflicti386 – 3861A → Q in CAA48563. (PubMed:1454515)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti197 – 1971Q → K.1 Publication
    Corresponds to variant rs1042848 [ dbSNP | Ensembl ].
    VAR_047975

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68561 mRNA. Translation: CAA48563.1.
    AK289728 mRNA. Translation: BAF82417.1.
    AC004595 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93733.1.
    BC109300 mRNA. Translation: AAI09301.1.
    CCDSiCCDS5373.1.
    PIRiS26638.
    RefSeqiNP_003103.2. NM_003112.3.
    UniGeneiHs.88013.

    Genome annotation databases

    EnsembliENST00000222584; ENSP00000222584; ENSG00000105866.
    GeneIDi6671.
    KEGGihsa:6671.
    UCSCiuc003sva.3. human.

    Polymorphism databases

    DMDMi218511800.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68561 mRNA. Translation: CAA48563.1 .
    AK289728 mRNA. Translation: BAF82417.1 .
    AC004595 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93733.1 .
    BC109300 mRNA. Translation: AAI09301.1 .
    CCDSi CCDS5373.1.
    PIRi S26638.
    RefSeqi NP_003103.2. NM_003112.3.
    UniGenei Hs.88013.

    3D structure databases

    ProteinModelPortali Q02446.
    SMRi Q02446. Positions 597-733.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112554. 6 interactions.
    STRINGi 9606.ENSP00000222584.

    PTM databases

    PhosphoSitei Q02446.

    Polymorphism databases

    DMDMi 218511800.

    Proteomic databases

    MaxQBi Q02446.
    PaxDbi Q02446.
    PRIDEi Q02446.

    Protocols and materials databases

    DNASUi 6671.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222584 ; ENSP00000222584 ; ENSG00000105866 .
    GeneIDi 6671.
    KEGGi hsa:6671.
    UCSCi uc003sva.3. human.

    Organism-specific databases

    CTDi 6671.
    GeneCardsi GC07P021434.
    H-InvDB HIX0033690.
    HGNCi HGNC:11209. SP4.
    HPAi CAB010246.
    HPA040395.
    MIMi 600540. gene.
    neXtProti NX_Q02446.
    PharmGKBi PA36046.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234295.
    HOVERGENi HBG008933.
    InParanoidi Q02446.
    KOi K09194.
    OMAi CNWIFCG.
    OrthoDBi EOG7JQBMX.
    PhylomeDBi Q02446.
    TreeFami TF350150.

    Enzyme and pathway databases

    SignaLinki Q02446.

    Miscellaneous databases

    GeneWikii Sp4_transcription_factor.
    GenomeRNAii 6671.
    NextBioi 26011.
    PROi Q02446.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02446.
    Bgeei Q02446.
    CleanExi HS_SP4.
    Genevestigatori Q02446.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes."
      Hagen G., Mueller S., Beato M., Suske G.
      Nucleic Acids Res. 20:5519-5525(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-197.
      Tissue: Uterus.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSP4_HUMAN
    AccessioniPrimary (citable) accession number: Q02446
    Secondary accession number(s): O60402, Q32M52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3