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Protein

Transcription factor Sp4

Gene

SP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri647 – 671C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri677 – 701C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri707 – 729C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: NTNU_SB
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ02446
SIGNORiQ02446

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp4
Alternative name(s):
SPR-1
Gene namesi
Name:SP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105866.13
HGNCiHGNC:11209 SP4
MIMi600540 gene
neXtProtiNX_Q02446

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6671
OpenTargetsiENSG00000105866
PharmGKBiPA36046

Polymorphism and mutation databases

BioMutaiSP4
DMDMi218511800

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471441 – 784Transcription factor Sp4Add BLAST784

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ02446
MaxQBiQ02446
PaxDbiQ02446
PeptideAtlasiQ02446
PRIDEiQ02446

PTM databases

iPTMnetiQ02446
PhosphoSitePlusiQ02446

Expressioni

Tissue specificityi

Abundant in brain.

Gene expression databases

BgeeiENSG00000105866
CleanExiHS_SP4
ExpressionAtlasiQ02446 baseline and differential
GenevisibleiQ02446 HS

Organism-specific databases

HPAiCAB010246
HPA040395

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112554, 19 interactors
IntActiQ02446, 28 interactors
STRINGi9606.ENSP00000222584

Structurei

3D structure databases

ProteinModelPortaliQ02446
SMRiQ02446
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 11Poly-Glu5
Compositional biasi12 – 19Poly-Ala8
Compositional biasi122 – 130Poly-Ser9
Compositional biasi185 – 188Poly-Ser4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri647 – 671C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri677 – 701C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri707 – 729C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000234295
HOVERGENiHBG008933
InParanoidiQ02446
KOiK09194
OMAiSCPNCRD
OrthoDBiEOG091G0HX6
PhylomeDBiQ02446
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR030453 SP4
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR23235:SF17 PTHR23235:SF17, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q02446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQKKEEEE EAAAAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL
60 70 80 90 100
LAATCSKIGT PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN
110 120 130 140 150
AWQLVASTPP ASKENNVSQP ASSSSSSSSS NNGSASPTKT KSGNSSTPGQ
160 170 180 190 200
FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ INPTSSSSLQ DLQGQIQLIS
210 220 230 240 250
AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP LQLQTLPGTQ
260 270 280 290 300
AQVVTTLPIN IGGVTLALPV INNVAAGGGT GQVGQPAATA DSGTSNGNQL
310 320 330 340 350
VSTPTNTTTS ASTMPESPSS STTCTTTAST SLTSSDTLVS SADTGQYAST
360 370 380 390 400
SASSSERTIE ESQTPAATES EAQSSSQLQP NGMQNAQDQS NSLQQVQIVG
410 420 430 440 450
QPILQQIQIQ QPQQQIIQAI PPQSFQLQSG QTIQTIQQQP LQNVQLQAVN
460 470 480 490 500
PTQVLIRAPT LTPSGQISWQ TVQVQNIQSL SNLQVQNAGL SQQLTITPVS
510 520 530 540 550
SSGGTTLAQI APVAVAGAPI TLNTAQLASV PNLQTVSVAN LGAAGVQVQG
560 570 580 590 600
VPVTITSVAG QQQGQDGVKV QQATIAPVTV AVGGIANATI GAVSPDQLTQ
610 620 630 640 650
VHLQQGQQTS DQEVQPGKRL RRVACSCPNC REGEGRGSNE PGKKKQHICH
660 670 680 690 700
IEGCGKVYGK TSHLRAHLRW HTGERPFICN WMFCGKRFTR SDELQRHRRT
710 720 730 740 750
HTGEKRFECP ECSKRFMRSD HLSKHVKTHQ NKKGGGTALA IVTSGELDSS
760 770 780
VTEVLGSPRI VTVAAISQDS NPATPNVSTN MEEF
Length:784
Mass (Da):81,985
Last modified:December 16, 2008 - v2
Checksum:i5B0B03EC03657993
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti379 – 380QP → HA in CAA48563 (PubMed:1454515).Curated2
Sequence conflicti386A → Q in CAA48563 (PubMed:1454515).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047975197Q → K1 PublicationCorresponds to variant dbSNP:rs1042848Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68561 mRNA Translation: CAA48563.1
AK289728 mRNA Translation: BAF82417.1
AC004595 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93733.1
BC109300 mRNA Translation: AAI09301.1
CCDSiCCDS5373.1
PIRiS26638
RefSeqiNP_001313472.1, NM_001326543.1
NP_003103.2, NM_003112.4
UniGeneiHs.88013

Genome annotation databases

EnsembliENST00000222584; ENSP00000222584; ENSG00000105866
GeneIDi6671
KEGGihsa:6671
UCSCiuc003sva.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSP4_HUMAN
AccessioniPrimary (citable) accession number: Q02446
Secondary accession number(s): O60402, Q32M52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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