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Protein

Tissue factor pathway inhibitor

Gene

Tfpi

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63 – 64Reactive bondBy similarity2
Sitei134 – 135Reactive bondBy similarity2
Sitei232 – 233Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • response to estradiol Source: RGD
  • response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-RNO-140834. Extrinsic Pathway of Fibrin Clot Formation.

Protein family/group databases

MEROPSiI02.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitor
Short name:
TFPI
Alternative name(s):
Extrinsic pathway inhibitor
Short name:
EPI
Lipoprotein-associated coagulation inhibitor
Short name:
LACI
Gene namesi
Name:Tfpi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi61914. Tfpi.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: Ensembl
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000001687529 – 302Tissue factor pathway inhibitorAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 103PROSITE-ProRule annotation
Disulfide bondi62 ↔ 86PROSITE-ProRule annotation
Disulfide bondi78 ↔ 99PROSITE-ProRule annotation
Disulfide bondi124 ↔ 174PROSITE-ProRule annotation
Disulfide bondi133 ↔ 157PROSITE-ProRule annotation
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 170PROSITE-ProRule annotation
Disulfide bondi222 ↔ 272PROSITE-ProRule annotation
Disulfide bondi231 ↔ 255PROSITE-ProRule annotation
Disulfide bondi247 ↔ 268PROSITE-ProRule annotation
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02445.
PRIDEiQ02445.

Expressioni

Tissue specificityi

Most abundant in heart, lung, kidney, and aortic endothelial cells.

Gene expression databases

BgeeiENSRNOG00000005039.
ExpressionAtlasiQ02445. baseline and differential.
GenevisibleiQ02445. RN.

Interactioni

Protein-protein interaction databases

BioGridi248083. 1 interactor.
STRINGi10116.ENSRNOP00000006787.

Structurei

3D structure databases

ProteinModelPortaliQ02445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 103BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini124 – 174BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini222 – 272BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd BLAST51

Domaini

This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity).By similarity

Sequence similaritiesi

Contains 3 BPTI/Kunitz inhibitor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiQ02445.
KOiK03909.
OMAiFIQRISK.
OrthoDBiEOG091G14M8.
PhylomeDBiQ02445.
TreeFamiTF315349.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR029864. TFPI1.
[Graphical view]
PANTHERiPTHR10083:SF238. PTHR10083:SF238. 1 hit.
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 3 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKLKKDHA FWAAVCLLLS IVPELLNALP EEDDDTINTD SELRPMKPLH
60 70 80 90 100
TFCAMKAEDG PCKAMIRSYY FNMNSHQCEE FIYGGCRGNK NRFDTLEECR
110 120 130 140 150
KTCIPGYKKT TIKTTSGAEK PDFCFLEEDP GICRGFMTRY FYNNQSKQCE
160 170 180 190 200
QFKYGGCLGN SNNFETLEEC RNTCEDPVNE VQKGDYVTNQ ITVTDRTTVN
210 220 230 240 250
NVVIPQATKA PSQWDYDGPS WCLEPADSGL CKASEKRFYY NPAIGKCRQF
260 270 280 290 300
NYTGCGGNNN NFTTKQDCNR ACKKDSSKKS SKRAKTQRRR KSFVKVMYEN

IH
Length:302
Mass (Da):34,554
Last modified:July 1, 1993 - v1
Checksum:iF9AE82130A24A59F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10926 mRNA. Translation: BAA01724.1.
PIRiJX0213. TIRTGK.
RefSeqiNP_058896.1. NM_017200.1.
XP_006234502.1. XM_006234440.3.
XP_006234503.1. XM_006234441.2.
XP_006234506.1. XM_006234444.2.
UniGeneiRn.15795.

Genome annotation databases

EnsembliENSRNOT00000006787; ENSRNOP00000006787; ENSRNOG00000005039.
GeneIDi29436.
KEGGirno:29436.
UCSCiRGD:61914. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10926 mRNA. Translation: BAA01724.1.
PIRiJX0213. TIRTGK.
RefSeqiNP_058896.1. NM_017200.1.
XP_006234502.1. XM_006234440.3.
XP_006234503.1. XM_006234441.2.
XP_006234506.1. XM_006234444.2.
UniGeneiRn.15795.

3D structure databases

ProteinModelPortaliQ02445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248083. 1 interactor.
STRINGi10116.ENSRNOP00000006787.

Protein family/group databases

MEROPSiI02.011.

Proteomic databases

PaxDbiQ02445.
PRIDEiQ02445.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006787; ENSRNOP00000006787; ENSRNOG00000005039.
GeneIDi29436.
KEGGirno:29436.
UCSCiRGD:61914. rat.

Organism-specific databases

CTDi7035.
RGDi61914. Tfpi.

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiQ02445.
KOiK03909.
OMAiFIQRISK.
OrthoDBiEOG091G14M8.
PhylomeDBiQ02445.
TreeFamiTF315349.

Enzyme and pathway databases

ReactomeiR-RNO-140834. Extrinsic Pathway of Fibrin Clot Formation.

Miscellaneous databases

PROiQ02445.

Gene expression databases

BgeeiENSRNOG00000005039.
ExpressionAtlasiQ02445. baseline and differential.
GenevisibleiQ02445. RN.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR029864. TFPI1.
[Graphical view]
PANTHERiPTHR10083:SF238. PTHR10083:SF238. 1 hit.
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 3 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFPI1_RAT
AccessioniPrimary (citable) accession number: Q02445
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.