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Protein

Tissue factor pathway inhibitor

Gene

Tfpi

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63 – 64Reactive bondBy similarity2
Sitei134 – 135Reactive bondBy similarity2
Sitei232 – 233Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • response to estradiol Source: RGD
  • response to lipopolysaccharide Source: RGD

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-RNO-140834. Extrinsic Pathway of Fibrin Clot Formation.

Protein family/group databases

MEROPSiI02.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitor
Short name:
TFPI
Alternative name(s):
Extrinsic pathway inhibitor
Short name:
EPI
Lipoprotein-associated coagulation inhibitor
Short name:
LACI
Gene namesi
Name:Tfpi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi61914. Tfpi.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000001687529 – 302Tissue factor pathway inhibitorAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 103PROSITE-ProRule annotation
Disulfide bondi62 ↔ 86PROSITE-ProRule annotation
Disulfide bondi78 ↔ 99PROSITE-ProRule annotation
Disulfide bondi124 ↔ 174PROSITE-ProRule annotation
Disulfide bondi133 ↔ 157PROSITE-ProRule annotation
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 170PROSITE-ProRule annotation
Disulfide bondi222 ↔ 272PROSITE-ProRule annotation
Disulfide bondi231 ↔ 255PROSITE-ProRule annotation
Disulfide bondi247 ↔ 268PROSITE-ProRule annotation
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02445.
PRIDEiQ02445.

Expressioni

Tissue specificityi

Most abundant in heart, lung, kidney, and aortic endothelial cells.

Gene expression databases

BgeeiENSRNOG00000005039.
ExpressionAtlasiQ02445. baseline and differential.
GenevisibleiQ02445. RN.

Interactioni

Protein-protein interaction databases

BioGridi248083. 1 interactor.
STRINGi10116.ENSRNOP00000006787.

Structurei

3D structure databases

ProteinModelPortaliQ02445.
SMRiQ02445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 103BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini124 – 174BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini222 – 272BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd BLAST51

Domaini

This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity).By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiQ02445.
KOiK03909.
OMAiFIQRISK.
OrthoDBiEOG091G14M8.
PhylomeDBiQ02445.
TreeFamiTF315349.

Family and domain databases

CDDicd00109. KU. 3 hits.
Gene3Di4.10.410.10. 3 hits.
InterProiView protein in InterPro
IPR002223. Kunitz_BPTI.
IPR036880. Kunitz_BPTI_sf.
IPR020901. Prtase_inh_Kunz-CS.
IPR008296. TFPI-like.
IPR029864. TFPI1.
PANTHERiPTHR10083:SF317. PTHR10083:SF317. 1 hit.
PfamiView protein in Pfam
PF00014. Kunitz_BPTI. 3 hits.
PIRSFiPIRSF001620. TFPI. 1 hit.
PRINTSiPR00759. BASICPTASE.
SMARTiView protein in SMART
SM00131. KU. 3 hits.
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiView protein in PROSITE
PS00280. BPTI_KUNITZ_1. 3 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKLKKDHA FWAAVCLLLS IVPELLNALP EEDDDTINTD SELRPMKPLH
60 70 80 90 100
TFCAMKAEDG PCKAMIRSYY FNMNSHQCEE FIYGGCRGNK NRFDTLEECR
110 120 130 140 150
KTCIPGYKKT TIKTTSGAEK PDFCFLEEDP GICRGFMTRY FYNNQSKQCE
160 170 180 190 200
QFKYGGCLGN SNNFETLEEC RNTCEDPVNE VQKGDYVTNQ ITVTDRTTVN
210 220 230 240 250
NVVIPQATKA PSQWDYDGPS WCLEPADSGL CKASEKRFYY NPAIGKCRQF
260 270 280 290 300
NYTGCGGNNN NFTTKQDCNR ACKKDSSKKS SKRAKTQRRR KSFVKVMYEN

IH
Length:302
Mass (Da):34,554
Last modified:July 1, 1993 - v1
Checksum:iF9AE82130A24A59F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10926 mRNA. Translation: BAA01724.1.
PIRiJX0213. TIRTGK.
RefSeqiNP_058896.1. NM_017200.1.
XP_006234502.1. XM_006234440.3.
XP_006234503.1. XM_006234441.2.
XP_006234506.1. XM_006234444.2.
UniGeneiRn.15795.

Genome annotation databases

EnsembliENSRNOT00000006787; ENSRNOP00000006787; ENSRNOG00000005039.
GeneIDi29436.
KEGGirno:29436.
UCSCiRGD:61914. rat.

Similar proteinsi

Entry informationi

Entry nameiTFPI1_RAT
AccessioniPrimary (citable) accession number: Q02445
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome