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Protein

Unconventional myosin-Va

Gene

MYO5A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi163 – 1708ATPBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB
  • microfilament motor activity Source: UniProtKB
  • minus-end directed microfilament motor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Va
Alternative name(s):
Dilute myosin heavy chain, non-muscle
Myosin heavy chain p190
Myosin-V
Gene namesi
Name:MYO5A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • filamentous actin Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • insulin-responsive compartment Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1781866.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18291829Unconventional myosin-VaPRO_0000123459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1734 – 17341PhosphothreonineSequence analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02440.
PRIDEiQ02440.

Expressioni

Tissue specificityi

Neuronal and non-neuronal cells of the brain.

Interactioni

Subunit structurei

May be a homodimer, which associates with multiple calmodulin or myosin light chains.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MYL6BP146492EBI-1040586,EBI-358570From a different organism.

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ02440. 1 interaction.
MINTiMINT-365207.
STRINGi9031.ENSGALP00000007352.

Chemistry

BindingDBiQ02440.

Structurei

Secondary structure

1
1829
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63Combined sources
Beta strandi12 – 176Combined sources
Turni18 – 203Combined sources
Beta strandi21 – 299Combined sources
Beta strandi36 – 416Combined sources
Beta strandi43 – 519Combined sources
Turni54 – 574Combined sources
Helixi66 – 683Combined sources
Beta strandi72 – 743Combined sources
Helixi82 – 9615Combined sources
Beta strandi100 – 1034Combined sources
Beta strandi106 – 1105Combined sources
Beta strandi117 – 1204Combined sources
Helixi121 – 1277Combined sources
Helixi132 – 1343Combined sources
Helixi139 – 15315Combined sources
Beta strandi157 – 1626Combined sources
Helixi169 – 18315Combined sources
Beta strandi187 – 1904Combined sources
Helixi192 – 20716Combined sources
Beta strandi208 – 2114Combined sources
Beta strandi214 – 2185Combined sources
Beta strandi220 – 2289Combined sources
Beta strandi234 – 2429Combined sources
Helixi246 – 2494Combined sources
Helixi260 – 2678Combined sources
Turni268 – 2703Combined sources
Helixi272 – 2776Combined sources
Turni282 – 2843Combined sources
Helixi286 – 2894Combined sources
Helixi301 – 31414Combined sources
Helixi319 – 33618Combined sources
Beta strandi341 – 3444Combined sources
Beta strandi347 – 3493Combined sources
Helixi355 – 36410Combined sources
Helixi368 – 3758Combined sources
Beta strandi376 – 3816Combined sources
Beta strandi386 – 3905Combined sources
Helixi393 – 42331Combined sources
Beta strandi430 – 4378Combined sources
Beta strandi445 – 4473Combined sources
Helixi449 – 47931Combined sources
Helixi484 – 4863Combined sources
Helixi493 – 5008Combined sources
Helixi505 – 5139Combined sources
Beta strandi515 – 5173Combined sources
Helixi520 – 53112Combined sources
Turni532 – 5343Combined sources
Beta strandi545 – 5517Combined sources
Beta strandi556 – 5605Combined sources
Helixi564 – 5696Combined sources
Helixi574 – 5818Combined sources
Helixi588 – 5914Combined sources
Turni629 – 6335Combined sources
Helixi636 – 65217Combined sources
Beta strandi654 – 6629Combined sources
Helixi675 – 68410Combined sources
Helixi687 – 69610Combined sources
Beta strandi700 – 7034Combined sources
Helixi704 – 7118Combined sources
Helixi712 – 7143Combined sources
Helixi717 – 7193Combined sources
Helixi724 – 73512Combined sources
Helixi739 – 7413Combined sources
Beta strandi742 – 7443Combined sources
Beta strandi746 – 7516Combined sources
Helixi755 – 79137Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05A1-792[»]
1W7IX-ray3.00A1-792[»]
1W7JX-ray2.00A1-792[»]
1W8JX-ray2.70A/B/C/D1-766[»]
2DFSelectron microscopy24.00A/M1-1080[»]
ProteinModelPortaliQ02440.
SMRiQ02440. Positions 2-819.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02440.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 764696Myosin motorAdd
BLAST
Domaini767 – 78923IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini790 – 81425IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini815 – 83723IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini838 – 86225IQ 4PROSITE-ProRule annotationAdd
BLAST
Domaini863 – 88725IQ 5PROSITE-ProRule annotationAdd
BLAST
Domaini888 – 91528IQ 6PROSITE-ProRule annotationAdd
BLAST
Domaini1508 – 1784277DilutePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni644 – 66623Actin-bindingSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili916 – 1239324Sequence analysisAdd
BLAST
Coiled coili1315 – 1419105Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
KOG0161. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000171839.
HOVERGENiHBG052556.
InParanoidiQ02440.
KOiK10357.
PhylomeDBiQ02440.

Family and domain databases

InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 6 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 6 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASELYTKY ARVWIPDPEE VWKSAELLKD YKPGDKVLQL RLEEGKDLEY
60 70 80 90 100
CLDPKTKELP PLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFIDSKLIY
110 120 130 140 150
TYCGIVLVAI NPYEQLPIYG EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM
160 170 180 190 200
ARDERNQSII VSGESGAGKT VSAKYAMRYF ATVSGSASEA NVEEKVLASN
210 220 230 240 250
PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR TYLLEKSRVV
260 270 280 290 300
FQAEEERNYH IFYQLCASAA LPEFKTLRLG NANYFHYTKQ GGSPVIDGID
310 320 330 340 350
DAKEMVNTRQ ACTLLGISDS YQMGIFRILA GILHLGNVEF ASRDSDSCAI
360 370 380 390 400
PPKHDPLTIF CDLMGVDYEE MAHWLCHRKL ATATETYIKP ISKLHAINAR
410 420 430 440 450
DALAKHIYAN LFNWIVDHVN KALHSTVKQH SFIGVLDIYG FETFEINSFE
460 470 480 490 500
QFCINYANEK LQQQFNMHVF KLEQEEYMKE QIPWTLIDFY DNQPCINLIE
510 520 530 540 550
AKMGVLDLLD EECKMPKGSD DTWAQKLYNT HLNKCALFEK PRLSNKAFII
560 570 580 590 600
KHFADKVEYQ CEGFLEKNKD TVYEEQIKVL KSSKKFKLLP ELFQDEEKAI
610 620 630 640 650
SPTSATPSGR VPLSRTPVKP AKARPGQTSK EHKKTVGHQF RNSLHLLMET
660 670 680 690 700
LNATTPHYVR CIKPNDFKFP FTFDEKRAVQ QLRACGVLET IRISAAGFPS
710 720 730 740 750
RWTYQEFFSR YRVLMKQKDV LSDRKQTCKN VLEKLILDKD KYQFGKTKIF
760 770 780 790 800
FRAGQVAYLE KIRADKLRAA CIRIQKTIRG WLMRKKYMRM RRAAITIQRY
810 820 830 840 850
VRGHQARCYA TFLRRTRAAI IIQKFQRMYV VRKRYQCMRD ATIALQALLR
860 870 880 890 900
GYLVRNKYQM MLREHKSIII QKHVRGWLAR VHYHRTLKAI VYLQCCYRRM
910 920 930 940 950
MAKRELKKLK IEARSVERYK KLHIGLENKI MQLQRKIDEQ NKEYKSLLEK
960 970 980 990 1000
MNNLEITYST ETEKLRSDVE RLRMSEEEAK NATNRVLSLQ EEIAKLRKEL
1010 1020 1030 1040 1050
HQTQTEKKTI EEWADKYKHE TEQLVSELKE QNTLLKTEKE ELNRRIHDQA
1060 1070 1080 1090 1100
KEITETMEKK LVEETKQLEL DLNDERLRYQ NLLNEFSRLE ERYDDLKDEM
1110 1120 1130 1140 1150
NLMVSIPKPG HKRTDSTHSS NESEYTFSSE ITEAEDLPLR MEEPSEKKAP
1160 1170 1180 1190 1200
LDMSLFLKLQ KRVTELEQEK QSLQDELDRK EEQALRAKAK EEERPPIRGA
1210 1220 1230 1240 1250
ELEYESLKRQ ELESENKKLK NELNELQKAL TETRAPEVTA PGAPAYRVLL
1260 1270 1280 1290 1300
DQLTSVSEEL EVRKEEVLIL RSQLVSQKEA IQPKEDKNTM TDSTILLEDV
1310 1320 1330 1340 1350
QKMKDKGEIA QAYIGLKETN RLLESQLQSQ KKSHENELES LRGEIQSLKE
1360 1370 1380 1390 1400
ENNRQQQLLA QNLQLPPEAR IEASLQHEIT RLTNENLDLM EQLEKQDKTV
1410 1420 1430 1440 1450
RKLKKQLKVF AKKIGELEVG QMENISPGQI IDEPIRPVNI PRKEKDFQGM
1460 1470 1480 1490 1500
LEYKKEDEQK LVKNLILELK PRGVAVNLIP GLPAYILFMC VRHADYLNDD
1510 1520 1530 1540 1550
QKVRSLLTST INGIKKVLKK RGDDFETVSF WLSNTCRFLH CLKQYSGEEG
1560 1570 1580 1590 1600
FMKHNTPRQN EHCLTNFDLA EYRQVLSDLA IQIYQQLVRV LENILQPMIV
1610 1620 1630 1640 1650
SGMLEHETIQ GVSGVKPTGL RKRTSSIADE GTYTLDSIIR QLNSFHSVMC
1660 1670 1680 1690 1700
QHGMDPELIK QVVKQMFYII GAVTLNNLLL RKDMCSWSKG MQIRYNVSQL
1710 1720 1730 1740 1750
EEWLRDKNLM NSGAKETLEP LIQAAQLLQV KKKTDEDAEA ICSMCNALTT
1760 1770 1780 1790 1800
AQIVKVLNLY TPVNEFEERV LVSFIRTIQL RLRDRKDSPQ LLMDAKHIFP
1810 1820
VTFPFNPSSL ALETIQIPAS LGLGFISRV
Length:1,829
Mass (Da):212,383
Last modified:June 1, 1994 - v1
Checksum:i0538B278DFC09F6E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1142 – 11421E → EQ in CAA77782 (PubMed:1469047).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67251 mRNA. Translation: CAA47673.1.
Z11718 mRNA. Translation: CAA77782.1.
PIRiS19188.
RefSeqiNP_990631.1. NM_205300.1.
UniGeneiGga.3550.

Genome annotation databases

GeneIDi396237.
KEGGigga:396237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67251 mRNA. Translation: CAA47673.1.
Z11718 mRNA. Translation: CAA77782.1.
PIRiS19188.
RefSeqiNP_990631.1. NM_205300.1.
UniGeneiGga.3550.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05A1-792[»]
1W7IX-ray3.00A1-792[»]
1W7JX-ray2.00A1-792[»]
1W8JX-ray2.70A/B/C/D1-766[»]
2DFSelectron microscopy24.00A/M1-1080[»]
ProteinModelPortaliQ02440.
SMRiQ02440. Positions 2-819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02440. 1 interaction.
MINTiMINT-365207.
STRINGi9031.ENSGALP00000007352.

Chemistry

BindingDBiQ02440.
ChEMBLiCHEMBL1781866.

Proteomic databases

PaxDbiQ02440.
PRIDEiQ02440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396237.
KEGGigga:396237.

Organism-specific databases

CTDi4644.

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
KOG0161. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000171839.
HOVERGENiHBG052556.
InParanoidiQ02440.
KOiK10357.
PhylomeDBiQ02440.

Miscellaneous databases

EvolutionaryTraceiQ02440.
PROiQ02440.

Family and domain databases

InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 6 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 6 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO5A_CHICK
AccessioniPrimary (citable) accession number: Q02440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.