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Protein

Filensin

Gene

Bfsp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • structural constituent of eye lens Source: RGD

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Filensin
Alternative name(s):
Beaded filament structural protein 1
Lens fiber cell beaded-filament structural protein CP 94
Short name:
CP94
Gene namesi
Name:Bfsp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2205 Bfsp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Intermediate filament, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000638481 – ›617FilensinAdd BLAST›617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02435
PRIDEiQ02435

PTM databases

iPTMnetiQ02435
PhosphoSitePlusiQ02435

Expressioni

Tissue specificityi

Detected in eye lens.1 Publication

Interactioni

Subunit structurei

Associates with BFSP2 to form long fibrils (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007727

Structurei

3D structure databases

ProteinModelPortaliQ02435
SMRiQ02435
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 313IF rodPROSITE-ProRule annotationAdd BLAST281

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 33HeadAdd BLAST33
Regioni34 – 68Coil 1AAdd BLAST35
Regioni69 – 77Linker 19
Regioni78 – 177Coil 1BAdd BLAST100
Regioni178 – 194Linker 12Add BLAST17
Regioni195 – 313Coil 2Add BLAST119
Regioni314 – ›617TailAdd BLAST›304

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IHW9 Eukaryota
ENOG410ZJHK LUCA
HOGENOMiHOG000095201
HOVERGENiHBG050684
InParanoidiQ02435
KOiK10378

Family and domain databases

InterProiView protein in InterPro
IPR039008 IF_rod_dom
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q02435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRRSYVFQA RQERYERAQP AGPTAQPGGT APGLAALQAL GERVAAQVQR
60 70 80 90 100
ARALQQRHAG LRRQLYAFQR LGEQPGPEEA LARHVEANLQ RARDLAAEHA
110 120 130 140 150
RLERQEAEAQ RALDEFRSKY ENECECQLVL KEMLERLNKE ADEALLRNLH
160 170 180 190 200
LQLEAQFLQA DISVAKDRYK KNLLEIQTYI TILQQIIQTA PQVSLVTGGM
210 220 230 240 250
REEKLLTERE VAALRNQLDE GREAVTHLQA QKAELQAQTT ALEQAIKHAH
260 270 280 290 300
ECYDDEIQLY NGQIENLRKE IEEAERSLER SSYDCRQLAV AQQTLRNELD
310 320 330 340 350
RYHRIIEIEG NRLSSVFIET PISLITPSHG ASLSLGSNVK DLTRAVQDIT
360 370 380 390 400
AAKPRQKALP KSLPKRKEII AQDKVDETLE DAPLKTLQEP KAVQGELTGD
410 420 430 440 450
GDSQLGAGGG HEVSPTQEGG PEDVPDGSQI SKAFGKLCKV VKERVSGHKE
460 470 480 490 500
PVPEPPADLF TKGRHILVTG ESSFVDPEFY SSSIPARGGV VVSIEEDSMH
510 520 530 540 550
HDGHVEPSPG QPMPPVENGQ GVPQGREGAH SNHQQVTDKN GIRAKEPKDL
560 570 580 590 600
EEKDDDSRKD DEAGRRPCPV IIPGPDGPST THSQTSGSNQ GGPEGPGSKS
610
SSLLAKSPSK ALSFKKV
Length:617
Mass (Da):68,038
Last modified:July 1, 1997 - v2
Checksum:iEA9303D1B0911CFF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei6171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003104 mRNA Translation: BAA19737.1
RefSeqiNP_113743.1, NM_031555.1
UniGeneiRn.9785

Genome annotation databases

GeneIDi25394
KEGGirno:25394
UCSCiRGD:2205 rat

Similar proteinsi

Entry informationi

Entry nameiBFSP1_RAT
AccessioniPrimary (citable) accession number: Q02435
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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