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Protein

Filensin

Gene

Bfsp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • structural constituent of eye lens Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Filensin
Alternative name(s):
Beaded filament structural protein 1
Lens fiber cell beaded-filament structural protein CP 94
Short name:
CP94
Gene namesi
Name:Bfsp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2205. Bfsp1.

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmcytoskeleton By similarity
  • Cytoplasmcell cortex By similarity

  • Note: Detected adjacent to the cell membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Intermediate filament, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›617›617FilensinPRO_0000063848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51Phosphoserine; by PKASequence analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02435.
PRIDEiQ02435.

Expressioni

Tissue specificityi

Detected in eye lens.1 Publication

Interactioni

Subunit structurei

Associates with BFSP2 to form long fibrils (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007727.

Structurei

3D structure databases

ProteinModelPortaliQ02435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3333HeadAdd
BLAST
Regioni34 – 313280RodAdd
BLAST
Regioni34 – 6835Coil 1AAdd
BLAST
Regioni69 – 779Linker 1
Regioni78 – 177100Coil 1BAdd
BLAST
Regioni178 – 19417Linker 12Add
BLAST
Regioni195 – 313119Coil 2Add
BLAST
Regioni314 – ›617›304TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IHW9. Eukaryota.
ENOG410ZJHK. LUCA.
HOGENOMiHOG000095201.
HOVERGENiHBG050684.
InParanoidiQ02435.
KOiK10378.

Family and domain databases

InterProiIPR001664. IF.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q02435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRRSYVFQA RQERYERAQP AGPTAQPGGT APGLAALQAL GERVAAQVQR
60 70 80 90 100
ARALQQRHAG LRRQLYAFQR LGEQPGPEEA LARHVEANLQ RARDLAAEHA
110 120 130 140 150
RLERQEAEAQ RALDEFRSKY ENECECQLVL KEMLERLNKE ADEALLRNLH
160 170 180 190 200
LQLEAQFLQA DISVAKDRYK KNLLEIQTYI TILQQIIQTA PQVSLVTGGM
210 220 230 240 250
REEKLLTERE VAALRNQLDE GREAVTHLQA QKAELQAQTT ALEQAIKHAH
260 270 280 290 300
ECYDDEIQLY NGQIENLRKE IEEAERSLER SSYDCRQLAV AQQTLRNELD
310 320 330 340 350
RYHRIIEIEG NRLSSVFIET PISLITPSHG ASLSLGSNVK DLTRAVQDIT
360 370 380 390 400
AAKPRQKALP KSLPKRKEII AQDKVDETLE DAPLKTLQEP KAVQGELTGD
410 420 430 440 450
GDSQLGAGGG HEVSPTQEGG PEDVPDGSQI SKAFGKLCKV VKERVSGHKE
460 470 480 490 500
PVPEPPADLF TKGRHILVTG ESSFVDPEFY SSSIPARGGV VVSIEEDSMH
510 520 530 540 550
HDGHVEPSPG QPMPPVENGQ GVPQGREGAH SNHQQVTDKN GIRAKEPKDL
560 570 580 590 600
EEKDDDSRKD DEAGRRPCPV IIPGPDGPST THSQTSGSNQ GGPEGPGSKS
610
SSLLAKSPSK ALSFKKV
Length:617
Mass (Da):68,038
Last modified:July 1, 1997 - v2
Checksum:iEA9303D1B0911CFF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei617 – 6171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003104 mRNA. Translation: BAA19737.1.
RefSeqiNP_113743.1. NM_031555.1.
UniGeneiRn.9785.

Genome annotation databases

GeneIDi25394.
KEGGirno:25394.
UCSCiRGD:2205. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003104 mRNA. Translation: BAA19737.1.
RefSeqiNP_113743.1. NM_031555.1.
UniGeneiRn.9785.

3D structure databases

ProteinModelPortaliQ02435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007727.

Proteomic databases

PaxDbiQ02435.
PRIDEiQ02435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25394.
KEGGirno:25394.
UCSCiRGD:2205. rat.

Organism-specific databases

CTDi631.
RGDi2205. Bfsp1.

Phylogenomic databases

eggNOGiENOG410IHW9. Eukaryota.
ENOG410ZJHK. LUCA.
HOGENOMiHOG000095201.
HOVERGENiHBG050684.
InParanoidiQ02435.
KOiK10378.

Miscellaneous databases

NextBioi606475.

Family and domain databases

InterProiIPR001664. IF.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA sequence analysis of CP94: rat lens fiber cell beaded-filament structural protein shows homology to cytokeratins."
    Masaki S., Watanabe T.
    Biochem. Biophys. Res. Commun. 186:190-198(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Lens.
  2. Masaki S.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiBFSP1_RAT
AccessioniPrimary (citable) accession number: Q02435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.