Q02420 (PTMA_STRMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-specific phosphotransferase enzyme IIA component
EC=2.7.1.-

Alternative name(s):
EIIA-Mtl
EIII-Mtl
PTS system mannitol-specific EIIA component

Gene names

Name:	mtlF
Synonyms:	mtlA2
Ordered Locus Names:	SMU_1183

Organism

Streptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]

Taxonomic identifier

210007 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus mutans

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport By similarity.
Catalytic activity	Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Subunit structure	Homotrimer.
Subcellular location	Cytoplasm Potential.
Domain	The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Sequence similarities	Contains 1 PTS EIIA type-2 domain.

Ontologies

Keywords
Biological process	Phosphotransferase system Sugar transport Transport
Cellular component	Cytoplasm
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	kinase activity Inferred from electronic annotation. Source: UniProtKB-KW sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Mannitol-specific phosphotransferase enzyme IIA component		PRO_0000186644
Regions
	Domain	1 – 144	144	PTS EIIA type-2
Sites
	Active site	61	1	Tele-phosphohistidine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02420 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 684973EEE46409C3	FASTA	145	15,878
	10 20 30 40 50 60 MEFQKDLIKL NQHFPDKEAA IRFCGQLLAD GGYVEPAYID AMIQRDKELS VYMGNFIAIP 70 80 90 100 110 120 HGTDDAKKDV LKSGITVVQV PDGVNFGTED DPQVATVLFG IAGIGDEHLQ IIQNISIFCA 130 140 DVDNVVKLAD AQTEDEVVKL LSQVN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system." Honeyman A.L., Curtiss R. III Infect. Immun. 60:3369-3375(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 700611 / UA130 / Serotype c.
[2]	"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF210133 Genomic DNA. Translation: AAA26941.1. AE014133 Genomic DNA. Translation: AAN58873.1.
PIR	B44798.
RefSeq	NP_721567.1. NC_004350.2.
3D structure databases
ProteinModelPortal	Q02420.
ModBase	Search...
Protein-protein interaction databases
STRING	210007.SMU.1183.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN58873; AAN58873; SMU_1183.
GeneID	1028483.
KEGG	smu:SMU_1183.
PATRIC	19664457. VBIStrMut61772_1061.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4668.
KO	K02798.
OMA	INQNFSN.
ProtClustDB	CLSK696971.
Family and domain databases
Gene3D	3.40.930.10. 1 hit.
InterPro	IPR016152. PTrfase/Anion_transptr. IPR002178. PTS_EIIA_2. [Graphical view]
Pfam	PF00359. PTS_EIIA_2. 1 hit. [Graphical view]
SUPFAM	SSF55804. PTrfase/Anion_transptr. 1 hit.
PROSITE	PS51094. PTS_EIIA_TYPE_2. 1 hit. PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTMA_STRMU

Accession

Primary (citable) accession number: Q02420

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program