Reviewed, UniProtKB/Swiss-Prot Q02418 (MTLD_STRMU)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	SMU_1182

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000170725
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity
Experimental info
	Sequence conflict	170	1	E → K in AAA26942. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q02418-1 [UniParc]. Last modified November 28, 2002. Version 2. Checksum: B2C1F81856A1CA9D	FASTA	382	42,972
	10 20 30 40 50 60 MKKAVHFGAG NIGRGFIGQI LFENGFAIDF VDVNDKIINA LNERHSYDIE IAEDGKRHIT 70 80 90 100 110 120 VSNVAGINNK ENPQAVIDAV AETELITTAI GPNILPFIAQ LIAKGIEKRR ESQNQTPLDI 130 140 150 160 170 180 IACENMIGGS AFLWQEVQKY LSADGLAFAK DYIGFPNAAV DRIVPAQVHE DPLFVVVEPF 190 200 210 220 230 240 SEWVVETAAM KNPDLKLSSV HYEENLEPFI ERKLFSVNSG HATTAYTGAY FGAKTVLEAL 250 260 270 280 290 300 KDQQVKEQVK AVLGEIRQLL MAKWQFKEND LKVYHDIIIS RFENPYIVDD VTRVARTPIR 310 320 330 340 350 360 KLGYDERFIR PIRELKDRGL SYEYLLQTVA YVFHYKDSND EQSVQLKLLL QEKSLKAVVK 370 380 EVTGLTDAAL IEEIVTSVES LD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system." Honeyman A.L., Curtiss R. III Infect. Immun. 60:3369-3375(1992) [PubMed: 1322373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 700611 / UA130 / Serotype c.
[2]	"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF210133 Genomic DNA. Translation: AAA26942.1. AE014133 Genomic DNA. Translation: AAN58872.1.
PIR	C44798.
RefSeq	NP_721566.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1028490.
GenomeReviews	Gene locus SMU_1182 in contig AE014133_GR.
KEGG	smu:SMU.1182.
NMPDR	fig|210007.1.peg.1079.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q02418.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-13098. SMUT210007:SMU_1182-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_STRMU

Accession

Primary (citable) accession number: Q02418

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	November 28, 2002
Last modified:	November 25, 2008
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)