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Protein

Desmoglein-1

Gene

DSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • gamma-catenin binding Source: BHF-UCL
  • toxic substance binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13579. Apoptotic cleavage of cell adhesion proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-1
Alternative name(s):
Cadherin family member 4
Desmosomal glycoprotein 1
Short name:
DG1
Short name:
DGI
Pemphigus foliaceus antigen
Gene namesi
Name:DSG1
Synonyms:CDHF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:3048. DSG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini50 – 548499ExtracellularSequence AnalysisAdd
BLAST
Transmembranei549 – 56921HelicalSequence AnalysisAdd
BLAST
Topological domaini570 – 1049480CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • cytoplasmic side of plasma membrane Source: BHF-UCL
  • cytosol Source: Reactome
  • desmosome Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA dermatological disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.

See also OMIM:148700
Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by severe dermatitis, multiple allergies and metabolic wasting. Clinical features include erythroderma, yellowish papules and plaques arranged at the periphery of the palms, along the fingers and over weight-bearing areas of the feet, skin erosions and scaling, and hypotrichosis. Additionally, patients manifest severe food allergies, elevated immunoglobulin E (IgE) levels and recurrent infections with marked metabolic wasting.

See also OMIM:615508

Keywords - Diseasei

Hypotrichosis, Palmoplantar keratoderma

Organism-specific databases

MIMi148700. phenotype.
615508. phenotype.
Orphaneti369999. Diffuse palmoplantar keratoderma with painful fissures.
370002. Focal palmoplantar keratoderma with joint keratoses.
50942. Keratosis palmoplantaris striata.
369992. Severe dermatitis-multiple allergies-metabolic wasting syndrome.
PharmGKBiPA27501.

Polymorphism and mutation databases

BioMutaiDSG1.
DMDMi292495005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 4926Sequence AnalysisPRO_0000003837Add
BLAST
Chaini50 – 10491000Desmoglein-1PRO_0000003838Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Modified residuei579 – 5791Phosphoserine1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ02413.
PaxDbiQ02413.
PRIDEiQ02413.

PTM databases

PhosphoSiteiQ02413.

Miscellaneous databases

PMAP-CutDBQ02413.

Expressioni

Tissue specificityi

Epidermis, tongue, tonsil and esophagus.

Gene expression databases

BgeeiQ02413.
CleanExiHS_DSG1.
GenevisibleiQ02413. HS.

Organism-specific databases

HPAiCAB009394.
HPA022128.

Interactioni

Subunit structurei

Binds to JUP/plakoglobin.

Protein-protein interaction databases

BioGridi108162. 25 interactions.
IntActiQ02413. 12 interactions.
STRINGi9606.ENSP00000257192.

Structurei

3D structure databases

ProteinModelPortaliQ02413.
SMRiQ02413. Positions 25-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 158109Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini159 – 270112Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini271 – 385115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini386 – 497112Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Repeati813 – 83927Desmoglein repeat 1Add
BLAST
Repeati840 – 86930Desmoglein repeat 2Add
BLAST
Repeati870 – 89930Desmoglein repeat 3Add
BLAST
Repeati900 – 92728Desmoglein repeat 4Add
BLAST
Repeati928 – 95629Desmoglein repeat 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi969 – 101951Gly/Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283402.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiQ02413.
KOiK07596.
OMAiERTNVGI.
OrthoDBiEOG7VTDM9.
PhylomeDBiQ02413.
TreeFamiTF331809.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDWSFFRVVA MLFIFLVVVE VNSEFRIQVR DYNTKNGTIK WHSIRRQKRE
60 70 80 90 100
WIKFAAACRE GEDNSKRNPI AKIHSDCAAN QQVTYRISGV GIDQPPYGIF
110 120 130 140 150
VINQKTGEIN ITSIVDREVT PFFIIYCRAL NSMGQDLERP LELRVRVLDI
160 170 180 190 200
NDNPPVFSMA TFAGQIEENS NANTLVMILN ATDADEPNNL NSKIAFKIIR
210 220 230 240 250
QEPSDSPMFI INRNTGEIRT MNNFLDREQY GQYALAVRGS DRDGGADGMS
260 270 280 290 300
AECECNIKIL DVNDNIPYME QSSYTIEIQE NTLNSNLLEI RVIDLDEEFS
310 320 330 340 350
ANWMAVIFFI SGNEGNWFEI EMNERTNVGI LKVVKPLDYE AMQSLQLSIG
360 370 380 390 400
VRNKAEFHHS IMSQYKLKAS AISVTVLNVI EGPVFRPGSK TYVVTGNMGS
410 420 430 440 450
NDKVGDFVAT DLDTGRPSTT VRYVMGNNPA DLLAVDSRTG KLTLKNKVTK
460 470 480 490 500
EQYNMLGGKY QGTILSIDDN LQRTCTGTIN INIQSFGNDD RTNTEPNTKI
510 520 530 540 550
TTNTGRQEST SSTNYDTSTT STDSSQVYSS EPGNGAKDLL SDNVHFGPAG
560 570 580 590 600
IGLLIMGFLV LGLVPFLMIC CDCGGAPRSA AGFEPVPECS DGAIHSWAVE
610 620 630 640 650
GPQPEPRDIT TVIPQIPPDN ANIIECIDNS GVYTNEYGGR EMQDLGGGER
660 670 680 690 700
MTGFELTEGV KTSGMPEICQ EYSGTLRRNS MRECREGGLN MNFMESYFCQ
710 720 730 740 750
KAYAYADEDE GRPSNDCLLI YDIEGVGSPA GSVGCCSFIG EDLDDSFLDT
760 770 780 790 800
LGPKFKKLAD ISLGKESYPD LDPSWPPQST EPVCLPQETE PVVSGHPPIS
810 820 830 840 850
PHFGTTTVIS ESTYPSGPGV LHPKPILDPL GYGNVTVTES YTTSDTLKPS
860 870 880 890 900
VHVHDNRPAS NVVVTERVVG PISGADLHGM LEMPDLRDGS NVIVTERVIA
910 920 930 940 950
PSSSLPTSLT IHHPRESSNV VVTERVIQPT SGMIGSLSMH PELANAHNVI
960 970 980 990 1000
VTERVVSGAG VTGISGTTGI SGGIGSSGLV GTSMGAGSGA LSGAGISGGG
1010 1020 1030 1040
IGLSSLGGTA SIGHMRSSSD HHFNQTIGSA SPSTARSRIT KYSTVQYSK
Length:1,049
Mass (Da):113,748
Last modified:March 23, 2010 - v2
Checksum:iFEA471244B9D67AE
GO
Isoform 2 (identifier: Q02413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-641: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):42,619
Checksum:iA910C8D97368B725
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111M → V.2 Publications
Corresponds to variant rs1426310 [ dbSNP | Ensembl ].
VAR_060248
Natural varianti395 – 3951T → S.
Corresponds to variant rs16961655 [ dbSNP | Ensembl ].
VAR_055573
Natural varianti493 – 4931N → T.
Corresponds to variant rs8091003 [ dbSNP | Ensembl ].
VAR_024385
Natural varianti498 – 4981T → N.
Corresponds to variant rs8091117 [ dbSNP | Ensembl ].
VAR_024386
Natural varianti528 – 5281Y → S.
Corresponds to variant rs16961689 [ dbSNP | Ensembl ].
VAR_055574
Natural varianti538 – 5381D → N.
Corresponds to variant rs34302455 [ dbSNP | Ensembl ].
VAR_055575
Natural varianti665 – 6651M → I.
Corresponds to variant rs35360042 [ dbSNP | Ensembl ].
VAR_055576
Natural varianti821 – 8211L → Q.
Corresponds to variant rs16961692 [ dbSNP | Ensembl ].
VAR_055577
Natural varianti828 – 8281D → N.
Corresponds to variant rs3752094 [ dbSNP | Ensembl ].
VAR_060249
Natural varianti841 – 8411Y → F.
Corresponds to variant rs3752095 [ dbSNP | Ensembl ].
VAR_020364

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 641641Missing in isoform 2. 1 PublicationVSP_055930Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56654 mRNA. Translation: CAA39976.1.
AF097935 mRNA. Translation: AAC83817.1.
AK302888 mRNA. Translation: BAH13831.1.
AC009717 Genomic DNA. No translation available.
CCDSiCCDS11896.1. [Q02413-1]
PIRiS16906. IJHUG1.
RefSeqiNP_001933.2. NM_001942.3. [Q02413-1]
UniGeneiHs.2633.

Genome annotation databases

EnsembliENST00000257192; ENSP00000257192; ENSG00000134760.
ENST00000462981; ENSP00000462666; ENSG00000134760. [Q02413-2]
GeneIDi1828.
KEGGihsa:1828.
UCSCiuc002kwp.3. human. [Q02413-1]
uc010xbp.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56654 mRNA. Translation: CAA39976.1.
AF097935 mRNA. Translation: AAC83817.1.
AK302888 mRNA. Translation: BAH13831.1.
AC009717 Genomic DNA. No translation available.
CCDSiCCDS11896.1. [Q02413-1]
PIRiS16906. IJHUG1.
RefSeqiNP_001933.2. NM_001942.3. [Q02413-1]
UniGeneiHs.2633.

3D structure databases

ProteinModelPortaliQ02413.
SMRiQ02413. Positions 25-516.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108162. 25 interactions.
IntActiQ02413. 12 interactions.
STRINGi9606.ENSP00000257192.

PTM databases

PhosphoSiteiQ02413.

Polymorphism and mutation databases

BioMutaiDSG1.
DMDMi292495005.

Proteomic databases

MaxQBiQ02413.
PaxDbiQ02413.
PRIDEiQ02413.

Protocols and materials databases

DNASUi1828.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257192; ENSP00000257192; ENSG00000134760.
ENST00000462981; ENSP00000462666; ENSG00000134760. [Q02413-2]
GeneIDi1828.
KEGGihsa:1828.
UCSCiuc002kwp.3. human. [Q02413-1]
uc010xbp.2. human.

Organism-specific databases

CTDi1828.
GeneCardsiGC18P028921.
H-InvDBHIX0039708.
HGNCiHGNC:3048. DSG1.
HPAiCAB009394.
HPA022128.
MIMi125670. gene.
148700. phenotype.
615508. phenotype.
neXtProtiNX_Q02413.
Orphaneti369999. Diffuse palmoplantar keratoderma with painful fissures.
370002. Focal palmoplantar keratoderma with joint keratoses.
50942. Keratosis palmoplantaris striata.
369992. Severe dermatitis-multiple allergies-metabolic wasting syndrome.
PharmGKBiPA27501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG283402.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiQ02413.
KOiK07596.
OMAiERTNVGI.
OrthoDBiEOG7VTDM9.
PhylomeDBiQ02413.
TreeFamiTF331809.

Enzyme and pathway databases

ReactomeiREACT_13579. Apoptotic cleavage of cell adhesion proteins.

Miscellaneous databases

GeneWikiiDesmoglein_1.
GenomeRNAii1828.
NextBioi35480388.
PMAP-CutDBQ02413.
PROiQ02413.
SOURCEiSearch...

Gene expression databases

BgeeiQ02413.
CleanExiHS_DSG1.
GenevisibleiQ02413. HS.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules."
    Wheeler G.N., Parker A.E., Thomas C.L., Ataliotis P., Poynter D., Arnemann J., Rutman A.J., Pidsley S.C., Watt F.M., Rees D.A., Buxton R.S., Magee A.I.
    Proc. Natl. Acad. Sci. U.S.A. 88:4796-4800(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-11.
    Tissue: Keratinocyte.
  2. "Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome."
    Nilles L.A., Parry D.A., Powers E.E., Angst B.D., Wagner R.M., Green K.J.
    J. Cell Sci. 99:809-821(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-11.
    Tissue: Foreskin.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma."
    Rickman L., Simrak D., Stevens H.P., Hunt D.M., King I.A., Bryant S.P., Eady R.A.J., Leigh I.M., Arnemann J., Magee A.I., Kelsell D.P., Buxton R.S.
    Hum. Mol. Genet. 8:971-976(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PPKS1.
  6. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
    Tissue: Saliva.
  7. "Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes."
    Choi H.J., Gross J.C., Pokutta S., Weis W.I.
    J. Biol. Chem. 284:31776-31788(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JUP/PLAKOGLOBIN.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: INVOLVEMENT IN EPKHE.

Entry informationi

Entry nameiDSG1_HUMAN
AccessioniPrimary (citable) accession number: Q02413
Secondary accession number(s): B7Z845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 23, 2010
Last modified: July 22, 2015
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.