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Q02413

- DSG1_HUMAN

UniProt

Q02413 - DSG1_HUMAN

Protein

Desmoglein-1

Gene

DSG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. gamma-catenin binding Source: BHF-UCL
    3. toxic substance binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: Reactome
    2. calcium-dependent cell-cell adhesion Source: UniProtKB
    3. cell-cell junction assembly Source: UniProtKB
    4. cellular component disassembly involved in execution phase of apoptosis Source: Reactome
    5. homophilic cell adhesion Source: InterPro
    6. maternal process involved in female pregnancy Source: Ensembl
    7. protein stabilization Source: BHF-UCL
    8. response to progesterone Source: Ensembl
    9. single organismal cell-cell adhesion Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13579. Apoptotic cleavage of cell adhesion proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmoglein-1
    Alternative name(s):
    Cadherin family member 4
    Desmosomal glycoprotein 1
    Short name:
    DG1
    Short name:
    DGI
    Pemphigus foliaceus antigen
    Gene namesi
    Name:DSG1
    Synonyms:CDHF4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:3048. DSG1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cytoplasmic side of plasma membrane Source: BHF-UCL
    3. cytosol Source: Reactome
    4. desmosome Source: UniProtKB
    5. extracellular vesicular exosome Source: UniProt
    6. integral component of membrane Source: UniProtKB-KW
    7. lateral plasma membrane Source: Ensembl
    8. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1) [MIM:148700]: A dermatological disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE) [MIM:615508]: A syndrome characterized by severe dermatitis, multiple allergies and metabolic wasting. Clinical features include erythroderma, yellowish papules and plaques arranged at the periphery of the palms, along the fingers and over weight-bearing areas of the feet, skin erosions and scaling, and hypotrichosis. Additionally, patients manifest severe food allergies, elevated immunoglobulin E (IgE) levels and recurrent infections with marked metabolic wasting.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Hypotrichosis, Palmoplantar keratoderma

    Organism-specific databases

    MIMi148700. phenotype.
    615508. phenotype.
    Orphaneti369999. Diffuse palmoplantar keratoderma with painful fissures.
    370002. Focal palmoplantar keratoderma with joint keratoses.
    50942. Keratosis palmoplantaris striata.
    369992. Severe dermatitis-multiple allergies-metabolic wasting syndrome.
    PharmGKBiPA27501.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 4926Sequence AnalysisPRO_0000003837Add
    BLAST
    Chaini50 – 10491000Desmoglein-1PRO_0000003838Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Modified residuei579 – 5791Phosphoserine1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ02413.
    PaxDbiQ02413.
    PRIDEiQ02413.

    PTM databases

    PhosphoSiteiQ02413.

    Miscellaneous databases

    PMAP-CutDBQ02413.

    Expressioni

    Tissue specificityi

    Epidermis, tongue, tonsil and esophagus.

    Gene expression databases

    ArrayExpressiQ02413.
    BgeeiQ02413.
    CleanExiHS_DSG1.
    GenevestigatoriQ02413.

    Organism-specific databases

    HPAiCAB009394.
    HPA022128.

    Interactioni

    Subunit structurei

    Binds to JUP/plakoglobin.

    Protein-protein interaction databases

    BioGridi108162. 20 interactions.
    IntActiQ02413. 12 interactions.
    STRINGi9606.ENSP00000257192.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02413.
    SMRiQ02413. Positions 47-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini50 – 548499ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini570 – 1049480CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei549 – 56921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 158109Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini159 – 270112Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini271 – 385115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini386 – 497112Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati813 – 83927Desmoglein repeat 1Add
    BLAST
    Repeati840 – 86930Desmoglein repeat 2Add
    BLAST
    Repeati870 – 89930Desmoglein repeat 3Add
    BLAST
    Repeati900 – 92728Desmoglein repeat 4Add
    BLAST
    Repeati928 – 95629Desmoglein repeat 5Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi969 – 101951Gly/Ser-richAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 4 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283402.
    HOGENOMiHOG000236266.
    HOVERGENiHBG005532.
    InParanoidiQ02413.
    KOiK07596.
    OMAiVRYVMGN.
    OrthoDBiEOG7VTDM9.
    PhylomeDBiQ02413.
    TreeFamiTF331809.

    Family and domain databases

    Gene3Di2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view]
    PANTHERiPTHR24025. PTHR24025. 1 hit.
    PfamiPF00028. Cadherin. 3 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTiSM00112. CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 4 hits.
    PROSITEiPS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q02413-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDWSFFRVVA MLFIFLVVVE VNSEFRIQVR DYNTKNGTIK WHSIRRQKRE     50
    WIKFAAACRE GEDNSKRNPI AKIHSDCAAN QQVTYRISGV GIDQPPYGIF 100
    VINQKTGEIN ITSIVDREVT PFFIIYCRAL NSMGQDLERP LELRVRVLDI 150
    NDNPPVFSMA TFAGQIEENS NANTLVMILN ATDADEPNNL NSKIAFKIIR 200
    QEPSDSPMFI INRNTGEIRT MNNFLDREQY GQYALAVRGS DRDGGADGMS 250
    AECECNIKIL DVNDNIPYME QSSYTIEIQE NTLNSNLLEI RVIDLDEEFS 300
    ANWMAVIFFI SGNEGNWFEI EMNERTNVGI LKVVKPLDYE AMQSLQLSIG 350
    VRNKAEFHHS IMSQYKLKAS AISVTVLNVI EGPVFRPGSK TYVVTGNMGS 400
    NDKVGDFVAT DLDTGRPSTT VRYVMGNNPA DLLAVDSRTG KLTLKNKVTK 450
    EQYNMLGGKY QGTILSIDDN LQRTCTGTIN INIQSFGNDD RTNTEPNTKI 500
    TTNTGRQEST SSTNYDTSTT STDSSQVYSS EPGNGAKDLL SDNVHFGPAG 550
    IGLLIMGFLV LGLVPFLMIC CDCGGAPRSA AGFEPVPECS DGAIHSWAVE 600
    GPQPEPRDIT TVIPQIPPDN ANIIECIDNS GVYTNEYGGR EMQDLGGGER 650
    MTGFELTEGV KTSGMPEICQ EYSGTLRRNS MRECREGGLN MNFMESYFCQ 700
    KAYAYADEDE GRPSNDCLLI YDIEGVGSPA GSVGCCSFIG EDLDDSFLDT 750
    LGPKFKKLAD ISLGKESYPD LDPSWPPQST EPVCLPQETE PVVSGHPPIS 800
    PHFGTTTVIS ESTYPSGPGV LHPKPILDPL GYGNVTVTES YTTSDTLKPS 850
    VHVHDNRPAS NVVVTERVVG PISGADLHGM LEMPDLRDGS NVIVTERVIA 900
    PSSSLPTSLT IHHPRESSNV VVTERVIQPT SGMIGSLSMH PELANAHNVI 950
    VTERVVSGAG VTGISGTTGI SGGIGSSGLV GTSMGAGSGA LSGAGISGGG 1000
    IGLSSLGGTA SIGHMRSSSD HHFNQTIGSA SPSTARSRIT KYSTVQYSK 1049
    Length:1,049
    Mass (Da):113,748
    Last modified:March 23, 2010 - v2
    Checksum:iFEA471244B9D67AE
    GO
    Isoform 2 (identifier: Q02413-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-641: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:408
    Mass (Da):42,619
    Checksum:iA910C8D97368B725
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111M → V.2 Publications
    Corresponds to variant rs1426310 [ dbSNP | Ensembl ].
    VAR_060248
    Natural varianti395 – 3951T → S.
    Corresponds to variant rs16961655 [ dbSNP | Ensembl ].
    VAR_055573
    Natural varianti493 – 4931N → T.
    Corresponds to variant rs8091003 [ dbSNP | Ensembl ].
    VAR_024385
    Natural varianti498 – 4981T → N.
    Corresponds to variant rs8091117 [ dbSNP | Ensembl ].
    VAR_024386
    Natural varianti528 – 5281Y → S.
    Corresponds to variant rs16961689 [ dbSNP | Ensembl ].
    VAR_055574
    Natural varianti538 – 5381D → N.
    Corresponds to variant rs34302455 [ dbSNP | Ensembl ].
    VAR_055575
    Natural varianti665 – 6651M → I.
    Corresponds to variant rs35360042 [ dbSNP | Ensembl ].
    VAR_055576
    Natural varianti821 – 8211L → Q.
    Corresponds to variant rs16961692 [ dbSNP | Ensembl ].
    VAR_055577
    Natural varianti828 – 8281D → N.
    Corresponds to variant rs3752094 [ dbSNP | Ensembl ].
    VAR_060249
    Natural varianti841 – 8411Y → F.
    Corresponds to variant rs3752095 [ dbSNP | Ensembl ].
    VAR_020364

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 641641Missing in isoform 2. 1 PublicationVSP_055930Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56654 mRNA. Translation: CAA39976.1.
    AF097935 mRNA. Translation: AAC83817.1.
    AK302888 mRNA. Translation: BAH13831.1.
    AC009717 Genomic DNA. No translation available.
    CCDSiCCDS11896.1.
    PIRiS16906. IJHUG1.
    RefSeqiNP_001933.2. NM_001942.2.
    UniGeneiHs.2633.

    Genome annotation databases

    EnsembliENST00000257192; ENSP00000257192; ENSG00000134760.
    ENST00000462981; ENSP00000462666; ENSG00000134760.
    GeneIDi1828.
    KEGGihsa:1828.
    UCSCiuc002kwp.3. human.

    Polymorphism databases

    DMDMi292495005.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56654 mRNA. Translation: CAA39976.1 .
    AF097935 mRNA. Translation: AAC83817.1 .
    AK302888 mRNA. Translation: BAH13831.1 .
    AC009717 Genomic DNA. No translation available.
    CCDSi CCDS11896.1.
    PIRi S16906. IJHUG1.
    RefSeqi NP_001933.2. NM_001942.2.
    UniGenei Hs.2633.

    3D structure databases

    ProteinModelPortali Q02413.
    SMRi Q02413. Positions 47-516.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108162. 20 interactions.
    IntActi Q02413. 12 interactions.
    STRINGi 9606.ENSP00000257192.

    PTM databases

    PhosphoSitei Q02413.

    Polymorphism databases

    DMDMi 292495005.

    Proteomic databases

    MaxQBi Q02413.
    PaxDbi Q02413.
    PRIDEi Q02413.

    Protocols and materials databases

    DNASUi 1828.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257192 ; ENSP00000257192 ; ENSG00000134760 .
    ENST00000462981 ; ENSP00000462666 ; ENSG00000134760 .
    GeneIDi 1828.
    KEGGi hsa:1828.
    UCSCi uc002kwp.3. human.

    Organism-specific databases

    CTDi 1828.
    GeneCardsi GC18P028921.
    H-InvDB HIX0039708.
    HGNCi HGNC:3048. DSG1.
    HPAi CAB009394.
    HPA022128.
    MIMi 125670. gene.
    148700. phenotype.
    615508. phenotype.
    neXtProti NX_Q02413.
    Orphaneti 369999. Diffuse palmoplantar keratoderma with painful fissures.
    370002. Focal palmoplantar keratoderma with joint keratoses.
    50942. Keratosis palmoplantaris striata.
    369992. Severe dermatitis-multiple allergies-metabolic wasting syndrome.
    PharmGKBi PA27501.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283402.
    HOGENOMi HOG000236266.
    HOVERGENi HBG005532.
    InParanoidi Q02413.
    KOi K07596.
    OMAi VRYVMGN.
    OrthoDBi EOG7VTDM9.
    PhylomeDBi Q02413.
    TreeFami TF331809.

    Enzyme and pathway databases

    Reactomei REACT_13579. Apoptotic cleavage of cell adhesion proteins.

    Miscellaneous databases

    GeneWikii Desmoglein_1.
    GenomeRNAii 1828.
    NextBioi 7461.
    PMAP-CutDB Q02413.
    PROi Q02413.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02413.
    Bgeei Q02413.
    CleanExi HS_DSG1.
    Genevestigatori Q02413.

    Family and domain databases

    Gene3Di 2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view ]
    PANTHERi PTHR24025. PTHR24025. 1 hit.
    Pfami PF00028. Cadherin. 3 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTi SM00112. CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 4 hits.
    PROSITEi PS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules."
      Wheeler G.N., Parker A.E., Thomas C.L., Ataliotis P., Poynter D., Arnemann J., Rutman A.J., Pidsley S.C., Watt F.M., Rees D.A., Buxton R.S., Magee A.I.
      Proc. Natl. Acad. Sci. U.S.A. 88:4796-4800(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-11.
      Tissue: Keratinocyte.
    2. "Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome."
      Nilles L.A., Parry D.A., Powers E.E., Angst B.D., Wagner R.M., Green K.J.
      J. Cell Sci. 99:809-821(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-11.
      Tissue: Foreskin.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma."
      Rickman L., Simrak D., Stevens H.P., Hunt D.M., King I.A., Bryant S.P., Eady R.A.J., Leigh I.M., Arnemann J., Magee A.I., Kelsell D.P., Buxton R.S.
      Hum. Mol. Genet. 8:971-976(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PPKS1.
    6. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
      Tissue: Saliva.
    7. "Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes."
      Choi H.J., Gross J.C., Pokutta S., Weis W.I.
      J. Biol. Chem. 284:31776-31788(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH JUP/PLAKOGLOBIN.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: INVOLVEMENT IN EPKHE.

    Entry informationi

    Entry nameiDSG1_HUMAN
    AccessioniPrimary (citable) accession number: Q02413
    Secondary accession number(s): B7Z845
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3