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Q02410

- APBA1_HUMAN

UniProt

Q02410 - APBA1_HUMAN

Protein

Amyloid beta A4 precursor protein-binding family A member 1

Gene

APBA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.

    GO - Molecular functioni

    1. beta-amyloid binding Source: Ensembl
    2. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
    3. protein binding Source: IntAct

    GO - Biological processi

    1. axon cargo transport Source: ProtInc
    2. cell adhesion Source: ProtInc
    3. gamma-aminobutyric acid secretion Source: Ensembl
    4. glutamate secretion Source: Ensembl
    5. intracellular protein transport Source: ProtInc
    6. in utero embryonic development Source: Ensembl
    7. locomotory behavior Source: Ensembl
    8. multicellular organism growth Source: Ensembl
    9. nervous system development Source: ProtInc
    10. protein complex assembly Source: ProtInc
    11. regulation of gene expression Source: Ensembl
    12. synaptic transmission Source: ProtInc

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amyloid beta A4 precursor protein-binding family A member 1
    Alternative name(s):
    Adapter protein X11alpha
    Neuron-specific X11 protein
    Neuronal Munc18-1-interacting protein 1
    Short name:
    Mint-1
    Gene namesi
    Name:APBA1
    Synonyms:MINT1, X11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:578. APBA1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmperinuclear region 1 Publication. Nucleus 1 Publication
    Note: Only about 5% of the protein is located in the nucleus.
    Isoform 2 : Golgi apparatus 1 Publication

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    4. plasma membrane Source: Ensembl
    5. protein complex Source: Ensembl
    6. synaptic vesicle Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi608 – 6081F → V: Diminishes interaction with APP. 1 Publication

    Organism-specific databases

    PharmGKBiPA24869.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 837837Amyloid beta A4 precursor protein-binding family A member 1PRO_0000064614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei263 – 2631Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ02410.
    PRIDEiQ02410.

    PTM databases

    PhosphoSiteiQ02410.

    Expressioni

    Tissue specificityi

    Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.1 Publication

    Gene expression databases

    BgeeiQ02410.
    CleanExiHS_APBA1.
    GenevestigatoriQ02410.

    Organism-specific databases

    HPAiCAB009338.
    HPA019850.

    Interactioni

    Subunit structurei

    Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Both isoform 1 and isoform 2 bind to the cytoplasmic domain of amyloid protein (APP). Interacts (via PDZ 1 and 2 domains) with FSPB. Isoform 2, but not isoform 1, interacts (via its truncated PID domain) with active, GTP-bound RAB6A and RAB6B.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPP050673EBI-368690,EBI-77613
    PSEN1P497684EBI-368690,EBI-297277
    RAB6AP20340-14EBI-9247455,EBI-8851226
    RAB6BQ9NRW14EBI-9247455,EBI-1760079

    Protein-protein interaction databases

    BioGridi106817. 12 interactions.
    IntActiQ02410. 11 interactions.
    MINTiMINT-153502.
    STRINGi9606.ENSP00000265381.

    Structurei

    Secondary structure

    1
    837
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni455 – 4573
    Beta strandi459 – 47214
    Helixi479 – 49820
    Beta strandi516 – 5216
    Beta strandi523 – 5308
    Turni531 – 5333
    Beta strandi536 – 5416
    Helixi542 – 5443
    Beta strandi545 – 5517
    Beta strandi554 – 5596
    Beta strandi586 – 5938
    Helixi597 – 61620
    Beta strandi655 – 6606
    Beta strandi669 – 6724
    Beta strandi676 – 6794
    Beta strandi684 – 6885
    Beta strandi690 – 6923
    Helixi693 – 6975
    Beta strandi705 – 7095
    Helixi719 – 7279
    Beta strandi730 – 74011
    Beta strandi746 – 75611
    Beta strandi760 – 7645
    Beta strandi767 – 7715
    Helixi777 – 7804
    Beta strandi786 – 7883
    Helixi796 – 7983
    Helixi801 – 8099
    Beta strandi813 – 8219

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AQCX-ray2.30A/B453-623[»]
    1U37NMR-A655-741[»]
    1U38NMR-A655-741[»]
    1U39NMR-A743-822[»]
    1U3BNMR-A655-837[»]
    1X11X-ray2.50A/B453-623[»]
    1X45NMR-A656-740[»]
    1Y7NNMR-A745-823[»]
    ProteinModelPortaliQ02410.
    SMRiQ02410. Positions 453-837.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ02410.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini457 – 643187PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini656 – 74287PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini747 – 82276PDZ 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni226 – 31489Munc-18-1 bindingAdd
    BLAST
    Regioni373 – 43664LIN-2/CASK bindingAdd
    BLAST
    Regioni626 – 64116Autoinhibitory helix linkerBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi67 – 704Poly-Glu
    Compositional biasi294 – 32835Pro-richAdd
    BLAST
    Compositional biasi368 – 45285Pro-richAdd
    BLAST

    Domaini

    Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
    The autoinhibitory helix linker occludes the APP binding site.By similarity
    The PID domain, truncated by 11 amino acids, as observed in isoform 2, but not full-length, mediates the interaction with RAB6A and RAB6B.1 Publication

    Sequence similaritiesi

    Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation
    Contains 1 PID domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG283022.
    HOGENOMiHOG000033981.
    HOVERGENiHBG050523.
    InParanoidiQ02410.
    KOiK04531.
    OMAiLQEHVYE.
    OrthoDBiEOG78PV8H.
    PhylomeDBiQ02410.
    TreeFamiTF315245.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    2.30.42.10. 2 hits.
    InterProiIPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view]
    PfamiPF00595. PDZ. 2 hits.
    PF00640. PID. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 2 hits.
    SM00462. PTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 2 hits.
    PROSITEiPS50106. PDZ. 2 hits.
    PS01179. PID. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q02410-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR    50
    HQRGRALEDL RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA 100
    RDGYDAERAQ DPEDESAYAV QYRPEAEEYT EQAEAEHAEA THRRALPNHL 150
    HFHSLEHEEA MNAAYSGYVY THRLFHRGED EPYSEPYADY GGLQEHVYEE 200
    IGDAPELDAR DGLRLYEQER DEAAAYRQEA LGARLHHYDE RSDGESDSPE 250
    KEAEFAPYPR MDSYEQEEDI DQIVAEVKQS MSSQSLDKAA EDMPEAEQDL 300
    ERPPTPAGGR PDSPGLQAPA GQQRAVGPAG GGEAGQRYSK EKRDAISLAI 350
    KDIKEAIEEV KTRTIRSPYT PDEPKEPIWV MRQDISPTRD CDDQRPMDGD 400
    SPSPGSSSPL GAESSSTSLH PSDPVEASTN KESRKSLASF PTYVEVPGPC 450
    DPEDLIDGII FAANYLGSTQ LLSDKTPSKN VRMMQAQEAV SRIKMAQKLA 500
    KSRKKAPEGE SQPMTEVDLF ISTQRIKVLN ADTQETMMDH PLRTISYIAD 550
    IGNIVVLMAR RRMPRSNSQE NVEASHPSQD GKRQYKMICH VFESEDAQLI 600
    AQSIGQAFSV AYQEFLRANG INPEDLSQKE YSDLLNTQDM YNDDLIHFSK 650
    SENCKDVFIE KQKGEILGVV IVESGWGSIL PTVIIANMMH GGPAEKSGKL 700
    NIGDQIMSIN GTSLVGLPLS TCQSIIKGLK NQSRVKLNIV RCPPVTTVLI 750
    RRPDLRYQLG FSVQNGIICS LMRGGIAERG GVRVGHRIIE INGQSVVATP 800
    HEKIVHILSN AVGEIHMKTM PAAMYRLLTA QEQPVYI 837
    Length:837
    Mass (Da):92,865
    Last modified:October 17, 2006 - v3
    Checksum:i29C3620BBC89534B
    GO
    Isoform 2 (identifier: Q02410-2) [UniParc]FASTAAdd to Basket

    Also known as: Mint1_826

    The sequence of this isoform differs from the canonical sequence as follows:
         495-505: Missing.

    Note: This isoform interacts with RAB6 GTPases.

    Show »
    Length:826
    Mass (Da):91,594
    Checksum:iDD7B6C1C6D3D9FE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1641A → V in AAA61307. (PubMed:7678331)Curated
    Sequence conflicti208 – 2081D → H in AAC05304. (PubMed:9395480)Curated
    Sequence conflicti427 – 4293AST → VPI in AAC05304. (PubMed:9395480)Curated
    Sequence conflicti427 – 4293AST → VPI in AAA61307. (PubMed:7678331)Curated
    Sequence conflicti522 – 5221S → L in AAC05304. (PubMed:9395480)Curated
    Sequence conflicti522 – 5221S → L in AAA61307. (PubMed:7678331)Curated
    Sequence conflicti563 – 5631M → I in AAC05304. (PubMed:9395480)Curated
    Sequence conflicti563 – 5631M → I in AAA61307. (PubMed:7678331)Curated
    Sequence conflicti730 – 7301K → E in AAC05304. (PubMed:9395480)Curated
    Sequence conflicti730 – 7301K → E in AAA61307. (PubMed:7678331)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841S → A.
    Corresponds to variant rs34788368 [ dbSNP | Ensembl ].
    VAR_050664

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei495 – 50511Missing in isoform 2. CuratedVSP_053518Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029106 mRNA. Translation: AAC05304.1.
    AF047347 mRNA. Translation: AAC39766.1.
    AL353693, AL355140 Genomic DNA. Translation: CAH74104.1.
    AL355140, AL353693 Genomic DNA. Translation: CAI15443.1.
    L04953 mRNA. Translation: AAA61307.1.
    CCDSiCCDS6630.1. [Q02410-1]
    PIRiA47176.
    RefSeqiNP_001154.2. NM_001163.3. [Q02410-1]
    XP_005252024.1. XM_005251967.1. [Q02410-1]
    XP_005252025.1. XM_005251968.1. [Q02410-2]
    XP_006717156.1. XM_006717093.1. [Q02410-1]
    UniGeneiHs.171939.
    Hs.592974.

    Genome annotation databases

    EnsembliENST00000265381; ENSP00000265381; ENSG00000107282. [Q02410-1]
    GeneIDi320.
    KEGGihsa:320.
    UCSCiuc004ahh.2. human. [Q02410-1]

    Polymorphism databases

    DMDMi116241250.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029106 mRNA. Translation: AAC05304.1 .
    AF047347 mRNA. Translation: AAC39766.1 .
    AL353693 , AL355140 Genomic DNA. Translation: CAH74104.1 .
    AL355140 , AL353693 Genomic DNA. Translation: CAI15443.1 .
    L04953 mRNA. Translation: AAA61307.1 .
    CCDSi CCDS6630.1. [Q02410-1 ]
    PIRi A47176.
    RefSeqi NP_001154.2. NM_001163.3. [Q02410-1 ]
    XP_005252024.1. XM_005251967.1. [Q02410-1 ]
    XP_005252025.1. XM_005251968.1. [Q02410-2 ]
    XP_006717156.1. XM_006717093.1. [Q02410-1 ]
    UniGenei Hs.171939.
    Hs.592974.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AQC X-ray 2.30 A/B 453-623 [» ]
    1U37 NMR - A 655-741 [» ]
    1U38 NMR - A 655-741 [» ]
    1U39 NMR - A 743-822 [» ]
    1U3B NMR - A 655-837 [» ]
    1X11 X-ray 2.50 A/B 453-623 [» ]
    1X45 NMR - A 656-740 [» ]
    1Y7N NMR - A 745-823 [» ]
    ProteinModelPortali Q02410.
    SMRi Q02410. Positions 453-837.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106817. 12 interactions.
    IntActi Q02410. 11 interactions.
    MINTi MINT-153502.
    STRINGi 9606.ENSP00000265381.

    Chemistry

    ChEMBLi CHEMBL2097170.

    PTM databases

    PhosphoSitei Q02410.

    Polymorphism databases

    DMDMi 116241250.

    Proteomic databases

    PaxDbi Q02410.
    PRIDEi Q02410.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265381 ; ENSP00000265381 ; ENSG00000107282 . [Q02410-1 ]
    GeneIDi 320.
    KEGGi hsa:320.
    UCSCi uc004ahh.2. human. [Q02410-1 ]

    Organism-specific databases

    CTDi 320.
    GeneCardsi GC09M072042.
    HGNCi HGNC:578. APBA1.
    HPAi CAB009338.
    HPA019850.
    MIMi 602414. gene.
    neXtProti NX_Q02410.
    PharmGKBi PA24869.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283022.
    HOGENOMi HOG000033981.
    HOVERGENi HBG050523.
    InParanoidi Q02410.
    KOi K04531.
    OMAi LQEHVYE.
    OrthoDBi EOG78PV8H.
    PhylomeDBi Q02410.
    TreeFami TF315245.

    Miscellaneous databases

    EvolutionaryTracei Q02410.
    GeneWikii APBA1.
    GenomeRNAii 320.
    NextBioi 1311.
    PROi Q02410.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02410.
    CleanExi HS_APBA1.
    Genevestigatori Q02410.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    2.30.42.10. 2 hits.
    InterProi IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view ]
    Pfami PF00595. PDZ. 2 hits.
    PF00640. PID. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 2 hits.
    SM00462. PTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 2 hits.
    PROSITEi PS50106. PDZ. 2 hits.
    PS01179. PID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis."
      Okamoto M., Suedhof T.C.
      J. Biol. Chem. 272:31459-31464(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion."
      Borg J.-P., Yang Y., De Taddeo-Borg M., Margolis B., Turner R.S.
      J. Biol. Chem. 273:14761-14766(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system."
      Duclos F., Koenig M., Boschert U., Sirugo G., Hen R., Mandel J.-L.
      Proc. Natl. Acad. Sci. U.S.A. 90:109-113(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-837 (ISOFORM 1).
      Tissue: Fetal brain.
    5. "The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein."
      Borg J.-P., Ooi J., Levy E., Margolis B.
      Mol. Cell. Biol. 16:6229-6241(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF PHE-608.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."
      Lau K.F., Perkinton M.S., Rodriguez L., McLoughlin D.M., Miller C.C.
      NeuroReport 21:761-766(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH FSBP.
    8. Cited for: ALTERNATIVE SPLICING (ISOFORM 2), INTERACTION WITH APP; RAB6A AND RAB6B, SUBCELLULAR LOCATION (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    9. "Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain."
      Zhang Z., Lee C.-H., Mandiyan V., Borg J.-P., Margolis B., Schlessinger J., Kuriyan J.
      EMBO J. 16:6141-6150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 452-617.
    10. "Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 656-740.

    Entry informationi

    Entry nameiAPBA1_HUMAN
    AccessioniPrimary (citable) accession number: Q02410
    Secondary accession number(s): O14914, O60570, Q5VYR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3