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Protein

Amyloid beta A4 precursor protein-binding family A member 1

Gene

APBA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.

GO - Molecular functioni

  1. beta-amyloid binding Source: Ensembl
  2. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl

GO - Biological processi

  1. axon cargo transport Source: ProtInc
  2. cell adhesion Source: ProtInc
  3. gamma-aminobutyric acid secretion Source: Ensembl
  4. glutamate secretion Source: Ensembl
  5. intracellular protein transport Source: ProtInc
  6. in utero embryonic development Source: Ensembl
  7. locomotory behavior Source: Ensembl
  8. multicellular organism growth Source: Ensembl
  9. nervous system development Source: ProtInc
  10. protein complex assembly Source: ProtInc
  11. regulation of gene expression Source: Ensembl
  12. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family A member 1
Alternative name(s):
Adapter protein X11alpha
Neuron-specific X11 protein
Neuronal Munc18-1-interacting protein 1
Short name:
Mint-1
Gene namesi
Name:APBA1
Synonyms:MINT1, X11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:578. APBA1.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmperinuclear region 1 Publication. Nucleus 1 Publication
Note: Only about 5% of the protein is located in the nucleus.
Isoform 2 : Golgi apparatus 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  4. plasma membrane Source: Ensembl
  5. protein complex Source: Ensembl
  6. synaptic vesicle Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi608 – 6081F → V: Diminishes interaction with APP. 1 Publication

Organism-specific databases

PharmGKBiPA24869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 837837Amyloid beta A4 precursor protein-binding family A member 1PRO_0000064614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481Phosphoserine1 Publication
Modified residuei263 – 2631Phosphoserine2 Publications
Modified residuei305 – 3051Phosphothreonine1 Publication
Modified residuei370 – 3701Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02410.
PRIDEiQ02410.

PTM databases

PhosphoSiteiQ02410.

Expressioni

Tissue specificityi

Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.1 Publication

Gene expression databases

BgeeiQ02410.
CleanExiHS_APBA1.
GenevestigatoriQ02410.

Organism-specific databases

HPAiCAB009338.
HPA019850.

Interactioni

Subunit structurei

Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Both isoform 1 and isoform 2 bind to the cytoplasmic domain of amyloid protein (APP). Interacts (via PDZ 1 and 2 domains) with FSPB. Isoform 2, but not isoform 1, interacts (via its truncated PID domain) with active, GTP-bound RAB6A and RAB6B.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APPP050673EBI-368690,EBI-77613
PSEN1P497684EBI-368690,EBI-297277
RAB6AP20340-14EBI-9247455,EBI-8851226
RAB6BQ9NRW14EBI-9247455,EBI-1760079

Protein-protein interaction databases

BioGridi106817. 13 interactions.
IntActiQ02410. 11 interactions.
MINTiMINT-153502.
STRINGi9606.ENSP00000265381.

Structurei

Secondary structure

1
837
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni455 – 4573Combined sources
Beta strandi459 – 47214Combined sources
Helixi479 – 49820Combined sources
Beta strandi516 – 5216Combined sources
Beta strandi523 – 5308Combined sources
Turni531 – 5333Combined sources
Beta strandi536 – 5416Combined sources
Helixi542 – 5443Combined sources
Beta strandi545 – 5517Combined sources
Beta strandi554 – 5596Combined sources
Beta strandi586 – 5938Combined sources
Helixi597 – 61620Combined sources
Beta strandi655 – 6606Combined sources
Beta strandi669 – 6724Combined sources
Beta strandi676 – 6794Combined sources
Beta strandi684 – 6885Combined sources
Beta strandi690 – 6923Combined sources
Helixi693 – 6975Combined sources
Beta strandi705 – 7095Combined sources
Helixi719 – 7279Combined sources
Beta strandi730 – 74011Combined sources
Beta strandi746 – 75611Combined sources
Beta strandi760 – 7645Combined sources
Beta strandi767 – 7715Combined sources
Helixi777 – 7804Combined sources
Beta strandi786 – 7883Combined sources
Helixi796 – 7983Combined sources
Helixi801 – 8099Combined sources
Beta strandi813 – 8219Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AQCX-ray2.30A/B453-623[»]
1U37NMR-A655-741[»]
1U38NMR-A655-741[»]
1U39NMR-A743-822[»]
1U3BNMR-A655-837[»]
1X11X-ray2.50A/B453-623[»]
1X45NMR-A656-740[»]
1Y7NNMR-A745-823[»]
ProteinModelPortaliQ02410.
SMRiQ02410. Positions 453-837.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02410.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini457 – 643187PIDPROSITE-ProRule annotationAdd
BLAST
Domaini656 – 74287PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini747 – 82276PDZ 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni226 – 31489Munc-18-1 bindingAdd
BLAST
Regioni373 – 43664LIN-2/CASK bindingAdd
BLAST
Regioni626 – 64116Autoinhibitory helix linkerBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 704Poly-Glu
Compositional biasi294 – 32835Pro-richAdd
BLAST
Compositional biasi368 – 45285Pro-richAdd
BLAST

Domaini

Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
The autoinhibitory helix linker occludes the APP binding site.By similarity
The PID domain, truncated by 11 amino acids, as observed in isoform 2, but not full-length, mediates the interaction with RAB6A and RAB6B.1 Publication

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 PID domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG283022.
GeneTreeiENSGT00390000013578.
HOGENOMiHOG000033981.
HOVERGENiHBG050523.
InParanoidiQ02410.
KOiK04531.
OMAiPNHLHFH.
OrthoDBiEOG78PV8H.
PhylomeDBiQ02410.
TreeFamiTF315245.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00595. PDZ. 2 hits.
PF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
SM00462. PTB. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
PS01179. PID. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02410-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR
60 70 80 90 100
HQRGRALEDL RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA
110 120 130 140 150
RDGYDAERAQ DPEDESAYAV QYRPEAEEYT EQAEAEHAEA THRRALPNHL
160 170 180 190 200
HFHSLEHEEA MNAAYSGYVY THRLFHRGED EPYSEPYADY GGLQEHVYEE
210 220 230 240 250
IGDAPELDAR DGLRLYEQER DEAAAYRQEA LGARLHHYDE RSDGESDSPE
260 270 280 290 300
KEAEFAPYPR MDSYEQEEDI DQIVAEVKQS MSSQSLDKAA EDMPEAEQDL
310 320 330 340 350
ERPPTPAGGR PDSPGLQAPA GQQRAVGPAG GGEAGQRYSK EKRDAISLAI
360 370 380 390 400
KDIKEAIEEV KTRTIRSPYT PDEPKEPIWV MRQDISPTRD CDDQRPMDGD
410 420 430 440 450
SPSPGSSSPL GAESSSTSLH PSDPVEASTN KESRKSLASF PTYVEVPGPC
460 470 480 490 500
DPEDLIDGII FAANYLGSTQ LLSDKTPSKN VRMMQAQEAV SRIKMAQKLA
510 520 530 540 550
KSRKKAPEGE SQPMTEVDLF ISTQRIKVLN ADTQETMMDH PLRTISYIAD
560 570 580 590 600
IGNIVVLMAR RRMPRSNSQE NVEASHPSQD GKRQYKMICH VFESEDAQLI
610 620 630 640 650
AQSIGQAFSV AYQEFLRANG INPEDLSQKE YSDLLNTQDM YNDDLIHFSK
660 670 680 690 700
SENCKDVFIE KQKGEILGVV IVESGWGSIL PTVIIANMMH GGPAEKSGKL
710 720 730 740 750
NIGDQIMSIN GTSLVGLPLS TCQSIIKGLK NQSRVKLNIV RCPPVTTVLI
760 770 780 790 800
RRPDLRYQLG FSVQNGIICS LMRGGIAERG GVRVGHRIIE INGQSVVATP
810 820 830
HEKIVHILSN AVGEIHMKTM PAAMYRLLTA QEQPVYI
Length:837
Mass (Da):92,865
Last modified:October 17, 2006 - v3
Checksum:i29C3620BBC89534B
GO
Isoform 2 (identifier: Q02410-2) [UniParc]FASTAAdd to basket

Also known as: Mint1_826

The sequence of this isoform differs from the canonical sequence as follows:
     495-505: Missing.

Note: This isoform interacts with RAB6 GTPases.

Show »
Length:826
Mass (Da):91,594
Checksum:iDD7B6C1C6D3D9FE7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641A → V in AAA61307 (PubMed:7678331).Curated
Sequence conflicti208 – 2081D → H in AAC05304 (PubMed:9395480).Curated
Sequence conflicti427 – 4293AST → VPI in AAC05304 (PubMed:9395480).Curated
Sequence conflicti427 – 4293AST → VPI in AAA61307 (PubMed:7678331).Curated
Sequence conflicti522 – 5221S → L in AAC05304 (PubMed:9395480).Curated
Sequence conflicti522 – 5221S → L in AAA61307 (PubMed:7678331).Curated
Sequence conflicti563 – 5631M → I in AAC05304 (PubMed:9395480).Curated
Sequence conflicti563 – 5631M → I in AAA61307 (PubMed:7678331).Curated
Sequence conflicti730 – 7301K → E in AAC05304 (PubMed:9395480).Curated
Sequence conflicti730 – 7301K → E in AAA61307 (PubMed:7678331).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841S → A.
Corresponds to variant rs34788368 [ dbSNP | Ensembl ].
VAR_050664

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei495 – 50511Missing in isoform 2. CuratedVSP_053518Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029106 mRNA. Translation: AAC05304.1.
AF047347 mRNA. Translation: AAC39766.1.
AL353693, AL355140 Genomic DNA. Translation: CAH74104.1.
AL355140, AL353693 Genomic DNA. Translation: CAI15443.1.
L04953 mRNA. Translation: AAA61307.1.
CCDSiCCDS6630.1. [Q02410-1]
PIRiA47176.
RefSeqiNP_001154.2. NM_001163.3. [Q02410-1]
XP_005252024.1. XM_005251967.1. [Q02410-1]
XP_005252025.1. XM_005251968.1. [Q02410-2]
XP_006717156.1. XM_006717093.1. [Q02410-1]
UniGeneiHs.171939.
Hs.592974.

Genome annotation databases

EnsembliENST00000265381; ENSP00000265381; ENSG00000107282. [Q02410-1]
GeneIDi320.
KEGGihsa:320.
UCSCiuc004ahh.2. human. [Q02410-1]

Polymorphism databases

DMDMi116241250.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029106 mRNA. Translation: AAC05304.1.
AF047347 mRNA. Translation: AAC39766.1.
AL353693, AL355140 Genomic DNA. Translation: CAH74104.1.
AL355140, AL353693 Genomic DNA. Translation: CAI15443.1.
L04953 mRNA. Translation: AAA61307.1.
CCDSiCCDS6630.1. [Q02410-1]
PIRiA47176.
RefSeqiNP_001154.2. NM_001163.3. [Q02410-1]
XP_005252024.1. XM_005251967.1. [Q02410-1]
XP_005252025.1. XM_005251968.1. [Q02410-2]
XP_006717156.1. XM_006717093.1. [Q02410-1]
UniGeneiHs.171939.
Hs.592974.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AQCX-ray2.30A/B453-623[»]
1U37NMR-A655-741[»]
1U38NMR-A655-741[»]
1U39NMR-A743-822[»]
1U3BNMR-A655-837[»]
1X11X-ray2.50A/B453-623[»]
1X45NMR-A656-740[»]
1Y7NNMR-A745-823[»]
ProteinModelPortaliQ02410.
SMRiQ02410. Positions 453-837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106817. 13 interactions.
IntActiQ02410. 11 interactions.
MINTiMINT-153502.
STRINGi9606.ENSP00000265381.

Chemistry

ChEMBLiCHEMBL2097170.

PTM databases

PhosphoSiteiQ02410.

Polymorphism databases

DMDMi116241250.

Proteomic databases

PaxDbiQ02410.
PRIDEiQ02410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265381; ENSP00000265381; ENSG00000107282. [Q02410-1]
GeneIDi320.
KEGGihsa:320.
UCSCiuc004ahh.2. human. [Q02410-1]

Organism-specific databases

CTDi320.
GeneCardsiGC09M072042.
HGNCiHGNC:578. APBA1.
HPAiCAB009338.
HPA019850.
MIMi602414. gene.
neXtProtiNX_Q02410.
PharmGKBiPA24869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG283022.
GeneTreeiENSGT00390000013578.
HOGENOMiHOG000033981.
HOVERGENiHBG050523.
InParanoidiQ02410.
KOiK04531.
OMAiPNHLHFH.
OrthoDBiEOG78PV8H.
PhylomeDBiQ02410.
TreeFamiTF315245.

Miscellaneous databases

ChiTaRSiAPBA1. human.
EvolutionaryTraceiQ02410.
GeneWikiiAPBA1.
GenomeRNAii320.
NextBioi1311.
PROiQ02410.
SOURCEiSearch...

Gene expression databases

BgeeiQ02410.
CleanExiHS_APBA1.
GenevestigatoriQ02410.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00595. PDZ. 2 hits.
PF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
SM00462. PTB. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
PS01179. PID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis."
    Okamoto M., Suedhof T.C.
    J. Biol. Chem. 272:31459-31464(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion."
    Borg J.-P., Yang Y., De Taddeo-Borg M., Margolis B., Turner R.S.
    J. Biol. Chem. 273:14761-14766(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system."
    Duclos F., Koenig M., Boschert U., Sirugo G., Hen R., Mandel J.-L.
    Proc. Natl. Acad. Sci. U.S.A. 90:109-113(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-837 (ISOFORM 1).
    Tissue: Fetal brain.
  5. "The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein."
    Borg J.-P., Ooi J., Levy E., Margolis B.
    Mol. Cell. Biol. 16:6229-6241(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF PHE-608.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."
    Lau K.F., Perkinton M.S., Rodriguez L., McLoughlin D.M., Miller C.C.
    NeuroReport 21:761-766(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH FSBP.
  8. Cited for: ALTERNATIVE SPLICING (ISOFORM 2), INTERACTION WITH APP; RAB6A AND RAB6B, SUBCELLULAR LOCATION (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248; SER-263; THR-305 AND THR-370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain."
    Zhang Z., Lee C.-H., Mandiyan V., Borg J.-P., Margolis B., Schlessinger J., Kuriyan J.
    EMBO J. 16:6141-6150(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 452-617.
  11. "Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 656-740.

Entry informationi

Entry nameiAPBA1_HUMAN
AccessioniPrimary (citable) accession number: Q02410
Secondary accession number(s): O14914, O60570, Q5VYR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 17, 2006
Last modified: March 4, 2015
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.