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Protein

Zinc finger protein 45

Gene

ZNF45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 18623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 24728C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27528C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri584 – 60623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri612 – 63423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri640 – 66223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • regulation of transcription, DNA-templated Source: ProtInc
  • transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 45
Alternative name(s):
BRC1744
Zinc finger protein 13
Zinc finger protein KOX5
Gene namesi
Name:ZNF45
Synonyms:KOX5, ZNF13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13111. ZNF45.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37686.

Polymorphism and mutation databases

BioMutaiZNF45.
DMDMi2507555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682Zinc finger protein 45PRO_0000047378Add
BLAST

Proteomic databases

EPDiQ02386.
PaxDbiQ02386.
PeptideAtlasiQ02386.
PRIDEiQ02386.

PTM databases

iPTMnetiQ02386.
PhosphoSiteiQ02386.

Expressioni

Gene expression databases

BgeeiENSG00000124459.
CleanExiHS_ZNF45.
ExpressionAtlasiQ02386. baseline and differential.
GenevisibleiQ02386. HS.

Organism-specific databases

HPAiHPA038611.

Interactioni

Protein-protein interaction databases

BioGridi113421. 3 interactions.
IntActiQ02386. 1 interaction.
STRINGi9606.ENSP00000269973.

Structurei

3D structure databases

ProteinModelPortaliQ02386.
SMRiQ02386. Positions 147-662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7871KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 18623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 24728C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27528C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri584 – 60623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri612 – 63423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri640 – 66223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ02386.
KOiK09228.
OMAiDEGDKDF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ02386.
TreeFamiTF350845.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSKEAVTF KDVAVVFSEE ELQLLDLAQR KLYRDVMLEN FRNVVSVGHQ
60 70 80 90 100
STPDGLPQLE REEKLWMMKM ATQRDNSSGA KNLKEMETLQ EVGLRYLPHE
110 120 130 140 150
ELFCSQIWQQ ITRELIKYQD SVVNIQRTGC QLEKRDDLHY KDEGFSNQSS
160 170 180 190 200
HLQVHRVHTG EKPYKGEHCV KSFSWSSHLQ INQRAHAGEK PYKCEKCDNA
210 220 230 240 250
FRRFSSLQAH QRVHSRAKSY TNDASYRSFS QRSHLPHHQR VPTGENPYKY
260 270 280 290 300
EECGRNVGKS SHCQAPLIVH TGEKPYKCEE CGVGFSQRSY LQVHLKVHTG
310 320 330 340 350
KKPYKCEECG KSFSWRSRLQ AHERIHTGEK PYKCNACGKS FSYSSHLNIH
360 370 380 390 400
CRIHTGEKPY KCEECGKGFS VGSHLQAHQI SHTGEKPYKC EECGKGFCRA
410 420 430 440 450
SNLLDHQRGH TGEKPYQCDA CGKGFSRSSD FNIHFRVHTG EKPYKCEECG
460 470 480 490 500
KGFSQASNLL AHQRGHTGEK PYKCGTCGKG FSRSSDLNVH CRIHTGEKPY
510 520 530 540 550
KCERCGKAFS QFSSLQVHQR VHTGEKPYQC AECGKGFSVG SQLQAHQRCH
560 570 580 590 600
TGEKPYQCEE CGKGFCRASN FLAHRGVHTG EKPYRCDVCG KRFRQRSYLQ
610 620 630 640 650
AHQRVHTGER PYKCEECGKV FSWSSYLQAH QRVHTGEKPY KCEECGKGFS
660 670 680
WSSSLIIHQR VHADDEGDKD FPSSEDSHRK TR
Length:682
Mass (Da):78,242
Last modified:November 1, 1997 - v2
Checksum:i9C8E536EB00FCE8B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti455 – 4551Q → R in CAA36562 (PubMed:2288909).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871A → T.
Corresponds to variant rs1047452 [ dbSNP | Ensembl ].
VAR_012019
Natural varianti255 – 2551R → K.1 Publication
Corresponds to variant rs399098 [ dbSNP | Ensembl ].
VAR_012020
Natural varianti299 – 2991T → A.1 Publication
Corresponds to variant rs388706 [ dbSNP | Ensembl ].
VAR_012021
Natural varianti303 – 3031P → R.1 Publication
Corresponds to variant rs388685 [ dbSNP | Ensembl ].
VAR_012022
Natural varianti504 – 5041R → K.1 Publication
Corresponds to variant rs407731 [ dbSNP | Ensembl ].
VAR_012023

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75847 mRNA. Translation: AAB05653.1.
AC035150 Genomic DNA. Translation: AAF63030.1.
BC037575 mRNA. Translation: AAH37575.1.
M67509 mRNA. Translation: AAA36133.1.
M67509 mRNA. Translation: AAA36134.1.
X52336 mRNA. Translation: CAA36562.1.
CCDSiCCDS12632.1.
PIRiA42177.
I37973.
RefSeqiNP_003416.1. NM_003425.3.
XP_011525569.1. XM_011527267.1.
XP_011525571.1. XM_011527269.1.
XP_011525573.1. XM_011527271.1.
XP_011525575.1. XM_011527273.1.
UniGeneiHs.381285.

Genome annotation databases

EnsembliENST00000269973; ENSP00000269973; ENSG00000124459.
ENST00000589703; ENSP00000468579; ENSG00000124459.
ENST00000615985; ENSP00000481895; ENSG00000124459.
GeneIDi7596.
KEGGihsa:7596.
UCSCiuc002oxu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75847 mRNA. Translation: AAB05653.1.
AC035150 Genomic DNA. Translation: AAF63030.1.
BC037575 mRNA. Translation: AAH37575.1.
M67509 mRNA. Translation: AAA36133.1.
M67509 mRNA. Translation: AAA36134.1.
X52336 mRNA. Translation: CAA36562.1.
CCDSiCCDS12632.1.
PIRiA42177.
I37973.
RefSeqiNP_003416.1. NM_003425.3.
XP_011525569.1. XM_011527267.1.
XP_011525571.1. XM_011527269.1.
XP_011525573.1. XM_011527271.1.
XP_011525575.1. XM_011527273.1.
UniGeneiHs.381285.

3D structure databases

ProteinModelPortaliQ02386.
SMRiQ02386. Positions 147-662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113421. 3 interactions.
IntActiQ02386. 1 interaction.
STRINGi9606.ENSP00000269973.

PTM databases

iPTMnetiQ02386.
PhosphoSiteiQ02386.

Polymorphism and mutation databases

BioMutaiZNF45.
DMDMi2507555.

Proteomic databases

EPDiQ02386.
PaxDbiQ02386.
PeptideAtlasiQ02386.
PRIDEiQ02386.

Protocols and materials databases

DNASUi7596.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269973; ENSP00000269973; ENSG00000124459.
ENST00000589703; ENSP00000468579; ENSG00000124459.
ENST00000615985; ENSP00000481895; ENSG00000124459.
GeneIDi7596.
KEGGihsa:7596.
UCSCiuc002oxu.3. human.

Organism-specific databases

CTDi7596.
GeneCardsiZNF45.
HGNCiHGNC:13111. ZNF45.
HPAiHPA038611.
MIMi194554. gene.
neXtProtiNX_Q02386.
PharmGKBiPA37686.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ02386.
KOiK09228.
OMAiDEGDKDF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ02386.
TreeFamiTF350845.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7596.
PROiQ02386.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124459.
CleanExiHS_ZNF45.
ExpressionAtlasiQ02386. baseline and differential.
GenevisibleiQ02386. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF45_HUMAN
AccessioniPrimary (citable) accession number: Q02386
Secondary accession number(s): P17016, P78472, Q9P1U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.