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Protein

Zinc finger protein 45

Gene

ZNF45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1; degenerateAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2Add BLAST23
Zinc fingeri220 – 247C2H2-type 3Add BLAST28
Zinc fingeri248 – 275C2H2-type 4Add BLAST28
Zinc fingeri276 – 298C2H2-type 5Add BLAST23
Zinc fingeri304 – 326C2H2-type 6Add BLAST23
Zinc fingeri332 – 354C2H2-type 7Add BLAST23
Zinc fingeri360 – 382C2H2-type 8Add BLAST23
Zinc fingeri388 – 410C2H2-type 9Add BLAST23
Zinc fingeri416 – 438C2H2-type 10Add BLAST23
Zinc fingeri444 – 466C2H2-type 11Add BLAST23
Zinc fingeri472 – 494C2H2-type 12Add BLAST23
Zinc fingeri500 – 522C2H2-type 13Add BLAST23
Zinc fingeri528 – 550C2H2-type 14Add BLAST23
Zinc fingeri556 – 578C2H2-type 15Add BLAST23
Zinc fingeri584 – 606C2H2-type 16Add BLAST23
Zinc fingeri612 – 634C2H2-type 17Add BLAST23
Zinc fingeri640 – 662C2H2-type 18Add BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • regulation of transcription, DNA-templated Source: ProtInc
  • transcription initiation from RNA polymerase II promoter Source: Reactome

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 45
Alternative name(s):
BRC1744
Zinc finger protein 13
Zinc finger protein KOX5
Gene namesi
Name:ZNF45
Synonyms:KOX5, ZNF13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000124459.11.
HGNCiHGNC:13111. ZNF45.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7596.
OpenTargetsiENSG00000124459.
PharmGKBiPA37686.

Polymorphism and mutation databases

BioMutaiZNF45.
DMDMi2507555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473781 – 682Zinc finger protein 45Add BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ02386.
PaxDbiQ02386.
PeptideAtlasiQ02386.
PRIDEiQ02386.

PTM databases

iPTMnetiQ02386.
PhosphoSitePlusiQ02386.

Expressioni

Gene expression databases

BgeeiENSG00000124459.
CleanExiHS_ZNF45.
ExpressionAtlasiQ02386. baseline and differential.
GenevisibleiQ02386. HS.

Organism-specific databases

HPAiHPA038611.
HPA075124.

Interactioni

Protein-protein interaction databases

BioGridi113421. 3 interactors.
IntActiQ02386. 1 interactor.
STRINGi9606.ENSP00000269973.

Structurei

3D structure databases

ProteinModelPortaliQ02386.
SMRiQ02386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1; degenerateAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2Add BLAST23
Zinc fingeri220 – 247C2H2-type 3Add BLAST28
Zinc fingeri248 – 275C2H2-type 4Add BLAST28
Zinc fingeri276 – 298C2H2-type 5Add BLAST23
Zinc fingeri304 – 326C2H2-type 6Add BLAST23
Zinc fingeri332 – 354C2H2-type 7Add BLAST23
Zinc fingeri360 – 382C2H2-type 8Add BLAST23
Zinc fingeri388 – 410C2H2-type 9Add BLAST23
Zinc fingeri416 – 438C2H2-type 10Add BLAST23
Zinc fingeri444 – 466C2H2-type 11Add BLAST23
Zinc fingeri472 – 494C2H2-type 12Add BLAST23
Zinc fingeri500 – 522C2H2-type 13Add BLAST23
Zinc fingeri528 – 550C2H2-type 14Add BLAST23
Zinc fingeri556 – 578C2H2-type 15Add BLAST23
Zinc fingeri584 – 606C2H2-type 16Add BLAST23
Zinc fingeri612 – 634C2H2-type 17Add BLAST23
Zinc fingeri640 – 662C2H2-type 18Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000141618.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ02386.
KOiK09228.
OMAiDEGDKDF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ02386.
TreeFamiTF350845.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 10 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.

Sequencei

Sequence statusi: Complete.

Q02386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSKEAVTF KDVAVVFSEE ELQLLDLAQR KLYRDVMLEN FRNVVSVGHQ
60 70 80 90 100
STPDGLPQLE REEKLWMMKM ATQRDNSSGA KNLKEMETLQ EVGLRYLPHE
110 120 130 140 150
ELFCSQIWQQ ITRELIKYQD SVVNIQRTGC QLEKRDDLHY KDEGFSNQSS
160 170 180 190 200
HLQVHRVHTG EKPYKGEHCV KSFSWSSHLQ INQRAHAGEK PYKCEKCDNA
210 220 230 240 250
FRRFSSLQAH QRVHSRAKSY TNDASYRSFS QRSHLPHHQR VPTGENPYKY
260 270 280 290 300
EECGRNVGKS SHCQAPLIVH TGEKPYKCEE CGVGFSQRSY LQVHLKVHTG
310 320 330 340 350
KKPYKCEECG KSFSWRSRLQ AHERIHTGEK PYKCNACGKS FSYSSHLNIH
360 370 380 390 400
CRIHTGEKPY KCEECGKGFS VGSHLQAHQI SHTGEKPYKC EECGKGFCRA
410 420 430 440 450
SNLLDHQRGH TGEKPYQCDA CGKGFSRSSD FNIHFRVHTG EKPYKCEECG
460 470 480 490 500
KGFSQASNLL AHQRGHTGEK PYKCGTCGKG FSRSSDLNVH CRIHTGEKPY
510 520 530 540 550
KCERCGKAFS QFSSLQVHQR VHTGEKPYQC AECGKGFSVG SQLQAHQRCH
560 570 580 590 600
TGEKPYQCEE CGKGFCRASN FLAHRGVHTG EKPYRCDVCG KRFRQRSYLQ
610 620 630 640 650
AHQRVHTGER PYKCEECGKV FSWSSYLQAH QRVHTGEKPY KCEECGKGFS
660 670 680
WSSSLIIHQR VHADDEGDKD FPSSEDSHRK TR
Length:682
Mass (Da):78,242
Last modified:November 1, 1997 - v2
Checksum:i9C8E536EB00FCE8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455Q → R in CAA36562 (PubMed:2288909).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012019187A → T. Corresponds to variant dbSNP:rs1047452Ensembl.1
Natural variantiVAR_012020255R → K1 PublicationCorresponds to variant dbSNP:rs399098Ensembl.1
Natural variantiVAR_012021299T → A1 PublicationCorresponds to variant dbSNP:rs388706Ensembl.1
Natural variantiVAR_012022303P → R1 PublicationCorresponds to variant dbSNP:rs388685Ensembl.1
Natural variantiVAR_012023504R → K1 PublicationCorresponds to variant dbSNP:rs407731Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75847 mRNA. Translation: AAB05653.1.
AC035150 Genomic DNA. Translation: AAF63030.1.
BC037575 mRNA. Translation: AAH37575.1.
M67509 mRNA. Translation: AAA36133.1.
M67509 mRNA. Translation: AAA36134.1.
X52336 mRNA. Translation: CAA36562.1.
CCDSiCCDS12632.1.
PIRiA42177.
I37973.
RefSeqiNP_003416.1. NM_003425.3.
XP_011525569.1. XM_011527267.1.
XP_011525571.1. XM_011527269.1.
XP_011525573.1. XM_011527271.1.
XP_011525575.1. XM_011527273.1.
XP_016882706.1. XM_017027217.1.
XP_016882707.1. XM_017027218.1.
XP_016882708.1. XM_017027219.1.
XP_016882709.1. XM_017027220.1.
XP_016882710.1. XM_017027221.1.
XP_016882711.1. XM_017027222.1.
XP_016882712.1. XM_017027223.1.
XP_016882713.1. XM_017027224.1.
XP_016882714.1. XM_017027225.1.
XP_016882715.1. XM_017027226.1.
XP_016882716.1. XM_017027227.1.
UniGeneiHs.381285.

Genome annotation databases

EnsembliENST00000269973; ENSP00000269973; ENSG00000124459.
ENST00000589703; ENSP00000468579; ENSG00000124459.
ENST00000615985; ENSP00000481895; ENSG00000124459.
GeneIDi7596.
KEGGihsa:7596.
UCSCiuc002oxu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF45_HUMAN
AccessioniPrimary (citable) accession number: Q02386
Secondary accession number(s): P17016, P78472, Q9P1U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families