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Protein

Son of sevenless homolog 2

Gene

Sos2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ras-bound GDP by GTP.By similarity

GO - Molecular functioni

  • DNA binding Source: InterPro
  • guanyl-nucleotide exchange factor activity Source: MGI
  • Ras guanyl-nucleotide exchange factor activity Source: MGI
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  • B cell homeostasis Source: MGI
  • lymphocyte homeostasis Source: MGI
  • regulation of pro-B cell differentiation Source: MGI
  • regulation of Rho protein signal transduction Source: InterPro
  • regulation of T cell differentiation in thymus Source: MGI
  • regulation of T cell proliferation Source: MGI
  • small GTPase mediated signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Son of sevenless homolog 2
Short name:
SOS-2
Short name:
mSOS-2
Gene namesi
Name:Sos2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:98355. Sos2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688971 – 1333Son of sevenless homolog 2Add BLAST1333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1322Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ02384.
PaxDbiQ02384.
PeptideAtlasiQ02384.
PRIDEiQ02384.

PTM databases

iPTMnetiQ02384.
PhosphoSitePlusiQ02384.

Expressioni

Tissue specificityi

Expressed in most embryonic and adult tissues.

Gene expression databases

BgeeiENSMUSG00000034801.
CleanExiMM_SOS2.
ExpressionAtlasiQ02384. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Abi1Q8CBW32EBI-395573,EBI-375511
Grb2Q606315EBI-395573,EBI-1688

Protein-protein interaction databases

IntActiQ02384. 5 interactors.
MINTiMINT-1348606.
STRINGi10090.ENSMUSP00000044866.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GBRNMR-B1300-1314[»]
ProteinModelPortaliQ02384.
SMRiQ02384.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02384.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 389DHPROSITE-ProRule annotationAdd BLAST191
Domaini443 – 546PHPROSITE-ProRule annotationAdd BLAST104
Domaini596 – 740N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST145
Domaini779 – 1018Ras-GEFPROSITE-ProRule annotationAdd BLAST240

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1181 – 1184Poly-Pro4
Compositional biasi1200 – 1209Poly-Pro10

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3417. Eukaryota.
ENOG410XR96. LUCA.
GeneTreeiENSGT00860000133664.
HOGENOMiHOG000013040.
HOVERGENiHBG017831.
InParanoidiQ02384.
OMAiVAICADQ.
OrthoDBiEOG091G04UL.
PhylomeDBiQ02384.
TreeFamiTF317296.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQAPQPYEF FSEENSPKWR GLLVPALRKV QEQVHPTLSA NEESLYYIEE
60 70 80 90 100
LIFQLLNKLC MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR
110 120 130 140 150
NPLLLPVDKI HPSLKEVLGY KVDYHVSLYI VAVLEYISAD ILKLAGNYVF
160 170 180 190 200
NIRHYEISQQ DIKVSMCADK VLMDMFDQDD DIGLVSLCED EPCSSGELNY
210 220 230 240 250
YDLVRTEIAE ERQYLRELNM IIKVFREAFL LDRKLFKPSE IEKIFSNISD
260 270 280 290 300
IHELTVKLLG LIEDTVEMTD ESSPHPLAGS CFEDLAEEQA FDPYETLSQD
310 320 330 340 350
ILAPEFNDHF SKLMARPAVA LHFQSIADGF KEAVRYVLPR LMLVPVYHCW
360 370 380 390 400
HYFELLKQLK ACSEEQEDKE CLNQAITALM NLQGSMDRIY KQHSPRRRPG
410 420 430 440 450
DPVCLFYNRQ LRSKHLAIKK MNEIQKNIDG WEGKDIGQCC NEFIMEGPLT
460 470 480 490 500
RIGAKHERHI FLFDGLMISC KPNHGQTRLP GYSSAEYRLK EKFVMRKIQI
510 520 530 540 550
CDKEDACEYR HAFELVSKDE NSVIFAAKSA EEKNNWMAAL ISLHYRSTLD
560 570 580 590 600
RMLDSVLLKE ENEQPLRLPS PDMYRFVVTD SEENIVFEDN LQSRSGIPII
610 620 630 640 650
KGGTVVKLIE RLTYHMYADP NFVRTFLTTY RSFCKPQELL NLLIERFEIP
660 670 680 690 700
EPEPTEADKL ALEKGEQPIS ADLKRFRKEY VQPVQLRVLN VFRHWVEHHY
710 720 730 740 750
YDFERDLELL ERLESFISSV RGKAMKKWVE SIAKIIKRKK QAQANGISHN
760 770 780 790 800
ITFESSPPPV EWHISRTGQF ETFDLMTLHP IEIARQLTLL ESDLYRKVQP
810 820 830 840 850
SELVGSVWTK EDKEINSPNL LKMIRHTTNL TLWFEKCIVE AENFEERVAV
860 870 880 890 900
LSRIVEILQV FQDLNNFNGV LEIVSAVNSV SVYRLDHTFE ALQERKRRIL
910 920 930 940 950
DDAVELSQDH FKKYLVKLKS INPPCVPFFG IYLTNILKTE EGNSDFLKRK
960 970 980 990 1000
GKDLINFSKR RKVAEITGEI QQYQNQPYCL RTEPEMRRFF ENLNPMGILS
1010 1020 1030 1040 1050
EKEFTDYLFN KSLEIEPRNC KQPPRFPRKS TFSLKSPGIR PNAGRHGSTS
1060 1070 1080 1090 1100
GTLRGHPTPL EREPYKISFS RIAETELEST VSAPTSPNTP STPPVSASSD
1110 1120 1130 1140 1150
HSVFLDVDLN SSCGSNTIFA PVLLPHSKTF FSSCGSLHKL SEEPLIPPPL
1160 1170 1180 1190 1200
PPRKKFDHDA LNSKGAVKSD DDPPAIPPRQ PPPPKVKPRV PVLMGTFDGP
1210 1220 1230 1240 1250
VPSPPPPPPR DPLPDTPPPV PLRPPEHFIN CPFNLQPPPL GHPHRDPDWL
1260 1270 1280 1290 1300
RDVSTCPNSP STPPTTPSPR IPRSCHLLSS SHSSLAHLPA PPVPPRQNSS
1310 1320 1330
PLLPKLPPKT YKRELSHPPL YRLPLLENAE TPQ
Length:1,333
Mass (Da):153,127
Last modified:January 9, 2007 - v2
Checksum:i5F687E3CFFCF7F1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358Missing in CAA77732 (PubMed:1631150).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133949 Genomic DNA. No translation available.
AC141560 Genomic DNA. No translation available.
AC153658 Genomic DNA. No translation available.
Z11664 mRNA. Translation: CAA77732.1.
PIRiS25714.
RefSeqiXP_006515698.1. XM_006515635.1.
UniGeneiMm.3770.

Genome annotation databases

EnsembliENSMUST00000183277; ENSMUSP00000138793; ENSMUSG00000034801.
GeneIDi20663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133949 Genomic DNA. No translation available.
AC141560 Genomic DNA. No translation available.
AC153658 Genomic DNA. No translation available.
Z11664 mRNA. Translation: CAA77732.1.
PIRiS25714.
RefSeqiXP_006515698.1. XM_006515635.1.
UniGeneiMm.3770.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GBRNMR-B1300-1314[»]
ProteinModelPortaliQ02384.
SMRiQ02384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02384. 5 interactors.
MINTiMINT-1348606.
STRINGi10090.ENSMUSP00000044866.

PTM databases

iPTMnetiQ02384.
PhosphoSitePlusiQ02384.

Proteomic databases

MaxQBiQ02384.
PaxDbiQ02384.
PeptideAtlasiQ02384.
PRIDEiQ02384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000183277; ENSMUSP00000138793; ENSMUSG00000034801.
GeneIDi20663.

Organism-specific databases

CTDi6655.
MGIiMGI:98355. Sos2.

Phylogenomic databases

eggNOGiKOG3417. Eukaryota.
ENOG410XR96. LUCA.
GeneTreeiENSGT00860000133664.
HOGENOMiHOG000013040.
HOVERGENiHBG017831.
InParanoidiQ02384.
OMAiVAICADQ.
OrthoDBiEOG091G04UL.
PhylomeDBiQ02384.
TreeFamiTF317296.

Enzyme and pathway databases

ReactomeiR-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-416482. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSiSos2. mouse.
EvolutionaryTraceiQ02384.
PROiQ02384.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034801.
CleanExiMM_SOS2.
ExpressionAtlasiQ02384. baseline and differential.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOS2_MOUSE
AccessioniPrimary (citable) accession number: Q02384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.