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Q02383

- SEMG2_HUMAN

UniProt

Q02383 - SEMG2_HUMAN

Protein

Semenogelin-2

Gene

SEMG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. sexual reproduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semenogelin-2
    Alternative name(s):
    Semenogelin II
    Short name:
    SGII
    Gene namesi
    Name:SEMG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:10743. SEMG2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: ProtInc
    2. nucleus Source: UniProt
    3. secretory granule Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35665.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 582559Semenogelin-2PRO_0000032359Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi272 – 2721N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ02383.
    PeptideAtlasiQ02383.
    PRIDEiQ02383.

    PTM databases

    PhosphoSiteiQ02383.

    Miscellaneous databases

    PMAP-CutDBQ02383.

    Expressioni

    Tissue specificityi

    Seminal vesicles, and to a much lesser extent, epididymis.

    Gene expression databases

    BgeeiQ02383.
    CleanExiHS_SEMG2.
    GenevestigatoriQ02383.

    Organism-specific databases

    HPAiHPA042767.
    HPA042835.

    Interactioni

    Subunit structurei

    Interacts with SERPINA5.1 Publication

    Protein-protein interaction databases

    BioGridi112307. 5 interactions.
    IntActiQ02383. 3 interactions.
    STRINGi9606.ENSP00000361855.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati70 – 129603-1Add
    BLAST
    Repeati141 – 200602-1Add
    BLAST
    Repeati201 – 260602-2Add
    BLAST
    Repeati501 – 559593-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 559490Repeat-rich regionAdd
    BLAST
    Regioni261 – 5002404 X 60 AA tandem repeats, type IAdd
    BLAST

    Sequence similaritiesi

    Belongs to the semenogelin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG87347.
    HOGENOMiHOG000263413.
    HOVERGENiHBG054194.
    InParanoidiQ02383.
    OMAiGHKENKI.
    OrthoDBiEOG7J4469.
    PhylomeDBiQ02383.
    TreeFamiTF342360.

    Family and domain databases

    InterProiIPR008836. Semenogelin.
    [Graphical view]
    PANTHERiPTHR10547. PTHR10547. 1 hit.
    PfamiPF05474. Semenogelin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02383-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLPSGSSQFP HGQKGQHYFG    50
    QKDQQHTKSK GSFSIQHTYH VDINDHDWTR KSQQYDLNAL HKATKSKQHL 100
    GGSQQLLNYK QEGRDHDKSK GHFHMIVIHH KGGQAHHGTQ NPSQDQGNSP 150
    SGKGLSSQCS NTEKRLWVHG LSKEQASASG AQKGRTQGGS QSSYVLQTEE 200
    LVVNKQQRET KNSHQNKGHY QNVVDVREEH SSKLQTSLHP AHQDRLQHGP 250
    KDIFTTQDEL LVYNKNQHQT KNLSQDQEHG RKAHKISYPS SRTEERQLHH 300
    GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIHSQDQEHG HKENKISYQS 350
    SSTEERHLNC GEKGIQKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEYG 400
    HKENKISYQS SSTEERRLNS GEKDVQKGVS KGSISIQTEE KIHGKSQNQV 450
    TIPSQDQEHG HKENKMSYQS SSTEERRLNY GGKSTQKDVS QSSISFQIEK 500
    LVEGKSQIQT PNPNQDQWSG QNAKGKSGQS ADSKQDLLSH EQKGRYKQES 550
    SESHNIVITE HEVAQDDHLT QQYNEDRNPI ST 582
    Length:582
    Mass (Da):65,444
    Last modified:July 1, 1993 - v1
    Checksum:iEBF63FBF3A8EC45B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431Q → K.
    Corresponds to variant rs2233896 [ dbSNP | Ensembl ].
    VAR_034489
    Natural varianti57 – 571T → A.
    Corresponds to variant rs2233897 [ dbSNP | Ensembl ].
    VAR_034490
    Natural varianti274 – 2741S → N.1 Publication
    Corresponds to variant rs2233901 [ dbSNP | Ensembl ].
    VAR_024630
    Natural varianti279 – 2791H → Y.
    Corresponds to variant rs2233903 [ dbSNP | Ensembl ].
    VAR_034491
    Natural varianti368 – 3681G → R.1 Publication
    Corresponds to variant rs2071650 [ dbSNP | Ensembl ].
    VAR_024631

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81652 mRNA. Translation: AAA60562.1.
    M81651 Genomic DNA. Translation: AAA60313.1.
    Z47556 Genomic DNA. Translation: CAA87637.1.
    AY259284 Genomic DNA. Translation: AAP86625.1.
    AY259285 Genomic DNA. Translation: AAP86626.1.
    AY259286 Genomic DNA. Translation: AAP86627.1.
    AL049767 Genomic DNA. Translation: CAB53522.1.
    CH471077 Genomic DNA. Translation: EAW75870.1.
    CCDSiCCDS13346.1.
    PIRiA43412.
    RefSeqiNP_002999.1. NM_003008.2.
    UniGeneiHs.537218.

    Genome annotation databases

    EnsembliENST00000372769; ENSP00000361855; ENSG00000124157.
    GeneIDi6407.
    KEGGihsa:6407.
    UCSCiuc002xnk.3. human.

    Polymorphism databases

    DMDMi401079.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Shackled sperm - Issue 62 of September 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81652 mRNA. Translation: AAA60562.1 .
    M81651 Genomic DNA. Translation: AAA60313.1 .
    Z47556 Genomic DNA. Translation: CAA87637.1 .
    AY259284 Genomic DNA. Translation: AAP86625.1 .
    AY259285 Genomic DNA. Translation: AAP86626.1 .
    AY259286 Genomic DNA. Translation: AAP86627.1 .
    AL049767 Genomic DNA. Translation: CAB53522.1 .
    CH471077 Genomic DNA. Translation: EAW75870.1 .
    CCDSi CCDS13346.1.
    PIRi A43412.
    RefSeqi NP_002999.1. NM_003008.2.
    UniGenei Hs.537218.

    3D structure databases

    ProteinModelPortali Q02383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112307. 5 interactions.
    IntActi Q02383. 3 interactions.
    STRINGi 9606.ENSP00000361855.

    PTM databases

    PhosphoSitei Q02383.

    Polymorphism databases

    DMDMi 401079.

    Proteomic databases

    PaxDbi Q02383.
    PeptideAtlasi Q02383.
    PRIDEi Q02383.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372769 ; ENSP00000361855 ; ENSG00000124157 .
    GeneIDi 6407.
    KEGGi hsa:6407.
    UCSCi uc002xnk.3. human.

    Organism-specific databases

    CTDi 6407.
    GeneCardsi GC20P043849.
    HGNCi HGNC:10743. SEMG2.
    HPAi HPA042767.
    HPA042835.
    MIMi 182141. gene.
    neXtProti NX_Q02383.
    PharmGKBi PA35665.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87347.
    HOGENOMi HOG000263413.
    HOVERGENi HBG054194.
    InParanoidi Q02383.
    OMAi GHKENKI.
    OrthoDBi EOG7J4469.
    PhylomeDBi Q02383.
    TreeFami TF342360.

    Miscellaneous databases

    GeneWikii SEMG2.
    GenomeRNAii 6407.
    NextBioi 24896.
    PMAP-CutDB Q02383.
    PROi Q02383.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02383.
    CleanExi HS_SEMG2.
    Genevestigatori Q02383.

    Family and domain databases

    InterProi IPR008836. Semenogelin.
    [Graphical view ]
    PANTHERi PTHR10547. PTHR10547. 1 hit.
    Pfami PF05474. Semenogelin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein."
      Lundwall A., Lilja H.
      Proc. Natl. Acad. Sci. U.S.A. 89:4559-4563(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Seminal vesicle.
    2. "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20."
      Ulvsbaeck M., Lazure C., Lilja H., Spurr N.K., Rao V.V., Loeffler C., Hansmann I., Lundwall A.
      J. Biol. Chem. 267:18080-18084(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen."
      Jensen-Seaman M.I., Li W.-H.
      J. Mol. Evol. 57:261-270(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-274 AND ARG-368.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Isolation and structure determination of two peptides occurring in human seminal plasma."
      Schneider K., Kausler W., Tripier D., Jouvenal K., Spiteller G.
      Biol. Chem. Hoppe-Seyler 370:353-356(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
    7. "Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II."
      Malm J., Hellman J., Magnusson H., Laurell C.B., Lilja H.
      Eur. J. Biochem. 238:48-53(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor."
      Kise H., Nishioka J., Kawamura J., Suzuki K.
      Eur. J. Biochem. 238:88-96(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION, INTERACTION WITH SERPINA5.

    Entry informationi

    Entry nameiSEMG2_HUMAN
    AccessioniPrimary (citable) accession number: Q02383
    Secondary accession number(s): Q53ZU2, Q6X2M5, Q6X2M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3