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Reviewed, UniProtKB/Swiss-Prot Q02383 (SEMG2_HUMAN)

Last modified January 19, 2010. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Semenogelin-2
Alternative name(s):
    Semenogelin II
      Short name=SGII
Gene names
Name: SEMG2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.

Subcellular location

Secreted.

Tissue specificity

Seminal vesicles, and to a much lesser extent, epididymis.

Post-translational modification

Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide. Ref.8

Sequence similarities

Belongs to the semenogelin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processsexual reproduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular space Ref.2

Traceable author statement. Source: ProtInc

secretory granule

Inferred from electronic annotation. Source: InterPro

   Molecular functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 582559Semenogelin-2
PRO_0000032359

Regions

Repeat70 – 129603-1
Repeat141 – 200602-1
Repeat201 – 260602-2
Repeat501 – 559593-2
Region70 – 559490Repeat-rich region
Region261 – 5002404 X 60 AA tandem repeats, type I

Amino acid modifications

Glycosylation2721N-linked (GlcNAc...) Probable

Natural variations

Natural variant431Q → K: dbSNP rs2233896.
VAR_034489
Natural variant571T → A: dbSNP rs2233897.
VAR_034490
Natural variant2741S → N: dbSNP rs2233901. Ref.3
VAR_024630
Natural variant2791H → Y: dbSNP rs2233903.
VAR_034491
Natural variant3681G → R: dbSNP rs2071650. Ref.3
VAR_024631

Sequences

Sequence LengthMass (Da)Tools
Q02383-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: EBF63FBF3A8EC45B

FASTA58265,444
        10         20         30         40         50         60 
MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLPSGSSQFP HGQKGQHYFG QKDQQHTKSK 

        70         80         90        100        110        120 
GSFSIQHTYH VDINDHDWTR KSQQYDLNAL HKATKSKQHL GGSQQLLNYK QEGRDHDKSK 

       130        140        150        160        170        180 
GHFHMIVIHH KGGQAHHGTQ NPSQDQGNSP SGKGLSSQCS NTEKRLWVHG LSKEQASASG 

       190        200        210        220        230        240 
AQKGRTQGGS QSSYVLQTEE LVVNKQQRET KNSHQNKGHY QNVVDVREEH SSKLQTSLHP 

       250        260        270        280        290        300 
AHQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLSQDQEHG RKAHKISYPS SRTEERQLHH 

       310        320        330        340        350        360 
GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIHSQDQEHG HKENKISYQS SSTEERHLNC 

       370        380        390        400        410        420 
GEKGIQKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEYG HKENKISYQS SSTEERRLNS 

       430        440        450        460        470        480 
GEKDVQKGVS KGSISIQTEE KIHGKSQNQV TIPSQDQEHG HKENKMSYQS SSTEERRLNY 

       490        500        510        520        530        540 
GGKSTQKDVS QSSISFQIEK LVEGKSQIQT PNPNQDQWSG QNAKGKSGQS ADSKQDLLSH 

       550        560        570        580 
EQKGRYKQES SESHNIVITE HEVAQDDHLT QQYNEDRNPI ST 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein."
Lundwall A., Lilja H.
Proc. Natl. Acad. Sci. U.S.A. 89:4559-4563(1992) [PubMed: 1584792] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Seminal vesicle.
[2]"Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20."
Ulvsbaeck M., Lazure C., Lilja H., Spurr N.K., Rao V.V., Loeffler C., Hansmann I., Lundwall A.
J. Biol. Chem. 267:18080-18084(1992) [PubMed: 1517240] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen."
Jensen-Seaman M.I., Li W.-H.
J. Mol. Evol. 57:261-270(2003) [PubMed: 14629036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-274 AND ARG-368.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Isolation and structure determination of two peptides occurring in human seminal plasma."
Schneider K., Kausler W., Tripier D., Jouvenal K., Spiteller G.
Biol. Chem. Hoppe-Seyler 370:353-356(1989) [PubMed: 2757795] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
[7]"Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II."
Malm J., Hellman J., Magnusson H., Laurell C.B., Lilja H.
Eur. J. Biochem. 238:48-53(1996) [PubMed: 8665951] [Abstract]
Cited for: CHARACTERIZATION.
[8]"Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor."
Kise H., Nishioka J., Kawamura J., Suzuki K.
Eur. J. Biochem. 238:88-96(1996) [PubMed: 8665956] [Abstract]
Cited for: GLYCOSYLATION.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Shackled sperm - Issue 62 of September 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81652 mRNA. Translation: AAA60562.1.
M81651 Genomic DNA. Translation: AAA60313.1.
Z47556 Genomic DNA. Translation: CAA87637.1.
AY259284 Genomic DNA. Translation: AAP86625.1.
AY259285 Genomic DNA. Translation: AAP86626.1.
AY259286 Genomic DNA. Translation: AAP86627.1.
AL049767 Genomic DNA. Translation: CAB53522.1.
CH471077 Genomic DNA. Translation: EAW75870.1.
IPIIPI00025415.
PIRA43412.
RefSeqNP_002999.1.
UniGeneHs.537218

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ02383.

Proteomic databases

PeptideAtlasQ02383.
PRIDEQ02383.

Genome annotation databases

EnsemblENST00000372769; ENSP00000361855; ENSG00000124157; Homo sapiens. [Genome view]
GeneID6407.
KEGGhsa:6407.
UCSCuc002xnk.1. human.

Organism-specific databases

CTD6407.
GeneCardsGC20P043283.
H-InvDBHIX0040567.
HGNCHGNC:10743. SEMG2.
MIM182141. gene.
PharmGKBPA35665.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG100157.
HOVERGENQ02383.
InParanoidQ02383.
OMAGKSQNQV.
OrthoDBEOG951HCS.
PhylomeDBQ02383.

Gene expression databases

ArrayExpressQ02383.
BgeeQ02383.
CleanExHS_SEMG2.
GenevestigatorQ02383.
GermOnlineENSG00000124157. Homo sapiens.

Family and domain databases

InterProIPR008836. Semenogelin.
[Graphical view]
PANTHERPTHR10547. Semenogelin. 1 hit.
PfamPF05474. Semenogelin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio24896.
PMAP-CutDBQ02383.
SOURCESearch...

Entry information

Entry nameSEMG2_HUMAN
AccessionPrimary (citable) accession number: Q02383
Secondary accession number(s): Q53ZU2, Q6X2M5, Q6X2M6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: January 19, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents