Reviewed, UniProtKB/Swiss-Prot Q02383 (SEMG2_HUMAN)

Names and origin

Protein names

Recommended name:
    Semenogelin-2
Alternative name(s):
    Semenogelin II
      Short name=SGII

Gene names

Name:

SEMG2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
Subcellular location	Secreted.
Tissue specificity	Seminal vesicles, and to a much lesser extent, epididymis.
Post-translational modification	Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide. Ref.8
Sequence similarities	Belongs to the semenogelin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Repeat Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	sexual reproduction Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Ref.2 Traceable author statement. Source: ProtInc secretory granule Inferred from electronic annotation. Source: InterPro
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 582	559	Semenogelin-2		PRO_0000032359
Regions
	Repeat	70 – 129	60	3-1
	Repeat	141 – 200	60	2-1
	Repeat	201 – 260	60	2-2
	Repeat	501 – 559	59	3-2
	Region	70 – 559	490	Repeat-rich region
	Region	261 – 500	240	4 X 60 AA tandem repeats, type I
Amino acid modifications
	Glycosylation	272	1	N-linked (GlcNAc...) Probable
Natural variations
	Natural variant	43	1	Q → K: dbSNP rs2233896.		VAR_034489
	Natural variant	57	1	T → A: dbSNP rs2233897.		VAR_034490
	Natural variant	274	1	S → N: dbSNP rs2233901. Ref.3		VAR_024630
	Natural variant	279	1	H → Y: dbSNP rs2233903.		VAR_034491
	Natural variant	368	1	G → R: dbSNP rs2071650. Ref.3		VAR_024631

Sequences

	Sequence		Length	Mass (Da)
	Q02383-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: EBF63FBF3A8EC45B	FASTA	582	65,444
	10 20 30 40 50 60 MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLPSGSSQFP HGQKGQHYFG QKDQQHTKSK 70 80 90 100 110 120 GSFSIQHTYH VDINDHDWTR KSQQYDLNAL HKATKSKQHL GGSQQLLNYK QEGRDHDKSK 130 140 150 160 170 180 GHFHMIVIHH KGGQAHHGTQ NPSQDQGNSP SGKGLSSQCS NTEKRLWVHG LSKEQASASG 190 200 210 220 230 240 AQKGRTQGGS QSSYVLQTEE LVVNKQQRET KNSHQNKGHY QNVVDVREEH SSKLQTSLHP 250 260 270 280 290 300 AHQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLSQDQEHG RKAHKISYPS SRTEERQLHH 310 320 330 340 350 360 GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIHSQDQEHG HKENKISYQS SSTEERHLNC 370 380 390 400 410 420 GEKGIQKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEYG HKENKISYQS SSTEERRLNS 430 440 450 460 470 480 GEKDVQKGVS KGSISIQTEE KIHGKSQNQV TIPSQDQEHG HKENKMSYQS SSTEERRLNY 490 500 510 520 530 540 GGKSTQKDVS QSSISFQIEK LVEGKSQIQT PNPNQDQWSG QNAKGKSGQS ADSKQDLLSH 550 560 570 580 EQKGRYKQES SESHNIVITE HEVAQDDHLT QQYNEDRNPI ST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein." Lundwall A., Lilja H. Proc. Natl. Acad. Sci. U.S.A. 89:4559-4563(1992) [PubMed: 1584792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Seminal vesicle.
[2]	"Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20." Ulvsbaeck M., Lazure C., Lilja H., Spurr N.K., Rao V.V., Loeffler C., Hansmann I., Lundwall A. J. Biol. Chem. 267:18080-18084(1992) [PubMed: 1517240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen." Jensen-Seaman M.I., Li W.-H. J. Mol. Evol. 57:261-270(2003) [PubMed: 14629036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-274 AND ARG-368.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Isolation and structure determination of two peptides occurring in human seminal plasma." Schneider K., Kausler W., Tripier D., Jouvenal K., Spiteller G. Biol. Chem. Hoppe-Seyler 370:353-356(1989) [PubMed: 2757795] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[7]	"Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II." Malm J., Hellman J., Magnusson H., Laurell C.B., Lilja H. Eur. J. Biochem. 238:48-53(1996) [PubMed: 8665951] [Abstract] Cited for: CHARACTERIZATION.
[8]	"Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor." Kise H., Nishioka J., Kawamura J., Suzuki K. Eur. J. Biochem. 238:88-96(1996) [PubMed: 8665956] [Abstract] Cited for: GLYCOSYLATION.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Shackled sperm - Issue 62 of September 2005

Cross-references

Sequence databases
EMBL GenBank DDBJ	M81652 mRNA. Translation: AAA60562.1. M81651 Genomic DNA. Translation: AAA60313.1. Z47556 Genomic DNA. Translation: CAA87637.1. AY259284 Genomic DNA. Translation: AAP86625.1. AY259285 Genomic DNA. Translation: AAP86626.1. AY259286 Genomic DNA. Translation: AAP86627.1. AL049767 Genomic DNA. Translation: CAB53522.1. CH471077 Genomic DNA. Translation: EAW75870.1.
IPI	IPI00025415.
PIR	A43412.
RefSeq	NP_002999.1.
UniGene	Hs.537218
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q02383.
Proteomic databases
PeptideAtlas	Q02383.
PRIDE	Q02383.
Genome annotation databases
Ensembl	ENST00000372769; ENSP00000361855; ENSG00000124157; Homo sapiens. [Genome view]
GeneID	6407.
KEGG	hsa:6407.
UCSC	uc002xnk.1. human.
Organism-specific databases
CTD	6407.
GeneCards	GC20P043283.
H-InvDB	HIX0040567.
HGNC	HGNC:10743. SEMG2.
MIM	182141. gene.
PharmGKB	PA35665.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG100157.
HOVERGEN	Q02383.
InParanoid	Q02383.
OMA	GKSQNQV.
OrthoDB	EOG951HCS.
PhylomeDB	Q02383.
Gene expression databases
ArrayExpress	Q02383.
Bgee	Q02383.
CleanEx	HS_SEMG2.
Genevestigator	Q02383.
GermOnline	ENSG00000124157. Homo sapiens.
Family and domain databases
InterPro	IPR008836. Semenogelin. [Graphical view]
PANTHER	PTHR10547. Semenogelin. 1 hit.
Pfam	PF05474. Semenogelin. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	24896.
PMAP-CutDB	Q02383.
SOURCE	Search...

Entry information

Entry name

SEMG2_HUMAN

Accession

Primary (citable) accession number: Q02383
Secondary accession number(s): Q53ZU2, Q6X2M5, Q6X2M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	January 19, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.