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Q02383 (SEMG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Semenogelin-2
Alternative name(s):
Semenogelin II
Short name=SGII
Gene names
Name:SEMG2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.

Subunit structure

Interacts with SERPINA5. Ref.8

Subcellular location

Secreted.

Tissue specificity

Seminal vesicles, and to a much lesser extent, epididymis.

Post-translational modification

Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide. Ref.8

Sequence similarities

Belongs to the semenogelin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processsexual reproduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Traceable author statement Ref.2. Source: ProtInc

nucleus

Inferred from direct assay PubMed 21630459. Source: UniProt

secretory granule

Inferred from electronic annotation. Source: InterPro

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 582559Semenogelin-2
PRO_0000032359

Regions

Repeat70 – 129603-1
Repeat141 – 200602-1
Repeat201 – 260602-2
Repeat501 – 559593-2
Region70 – 559490Repeat-rich region
Region261 – 5002404 X 60 AA tandem repeats, type I

Amino acid modifications

Glycosylation2721N-linked (GlcNAc...) Probable

Natural variations

Natural variant431Q → K.
Corresponds to variant rs2233896 [ dbSNP | Ensembl ].
VAR_034489
Natural variant571T → A.
Corresponds to variant rs2233897 [ dbSNP | Ensembl ].
VAR_034490
Natural variant2741S → N. Ref.3
Corresponds to variant rs2233901 [ dbSNP | Ensembl ].
VAR_024630
Natural variant2791H → Y.
Corresponds to variant rs2233903 [ dbSNP | Ensembl ].
VAR_034491
Natural variant3681G → R. Ref.3
Corresponds to variant rs2071650 [ dbSNP | Ensembl ].
VAR_024631

Sequences

Sequence LengthMass (Da)Tools
Q02383 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: EBF63FBF3A8EC45B

FASTA58265,444
        10         20         30         40         50         60 
MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLPSGSSQFP HGQKGQHYFG QKDQQHTKSK 

        70         80         90        100        110        120 
GSFSIQHTYH VDINDHDWTR KSQQYDLNAL HKATKSKQHL GGSQQLLNYK QEGRDHDKSK 

       130        140        150        160        170        180 
GHFHMIVIHH KGGQAHHGTQ NPSQDQGNSP SGKGLSSQCS NTEKRLWVHG LSKEQASASG 

       190        200        210        220        230        240 
AQKGRTQGGS QSSYVLQTEE LVVNKQQRET KNSHQNKGHY QNVVDVREEH SSKLQTSLHP 

       250        260        270        280        290        300 
AHQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLSQDQEHG RKAHKISYPS SRTEERQLHH 

       310        320        330        340        350        360 
GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIHSQDQEHG HKENKISYQS SSTEERHLNC 

       370        380        390        400        410        420 
GEKGIQKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEYG HKENKISYQS SSTEERRLNS 

       430        440        450        460        470        480 
GEKDVQKGVS KGSISIQTEE KIHGKSQNQV TIPSQDQEHG HKENKMSYQS SSTEERRLNY 

       490        500        510        520        530        540 
GGKSTQKDVS QSSISFQIEK LVEGKSQIQT PNPNQDQWSG QNAKGKSGQS ADSKQDLLSH 

       550        560        570        580 
EQKGRYKQES SESHNIVITE HEVAQDDHLT QQYNEDRNPI ST 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein."
Lundwall A., Lilja H.
Proc. Natl. Acad. Sci. U.S.A. 89:4559-4563(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Seminal vesicle.
[2]"Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20."
Ulvsbaeck M., Lazure C., Lilja H., Spurr N.K., Rao V.V., Loeffler C., Hansmann I., Lundwall A.
J. Biol. Chem. 267:18080-18084(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen."
Jensen-Seaman M.I., Li W.-H.
J. Mol. Evol. 57:261-270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-274 AND ARG-368.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Isolation and structure determination of two peptides occurring in human seminal plasma."
Schneider K., Kausler W., Tripier D., Jouvenal K., Spiteller G.
Biol. Chem. Hoppe-Seyler 370:353-356(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
[7]"Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II."
Malm J., Hellman J., Magnusson H., Laurell C.B., Lilja H.
Eur. J. Biochem. 238:48-53(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor."
Kise H., Nishioka J., Kawamura J., Suzuki K.
Eur. J. Biochem. 238:88-96(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION, INTERACTION WITH SERPINA5.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Shackled sperm - Issue 62 of September 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81652 mRNA. Translation: AAA60562.1.
M81651 Genomic DNA. Translation: AAA60313.1.
Z47556 Genomic DNA. Translation: CAA87637.1.
AY259284 Genomic DNA. Translation: AAP86625.1.
AY259285 Genomic DNA. Translation: AAP86626.1.
AY259286 Genomic DNA. Translation: AAP86627.1.
AL049767 Genomic DNA. Translation: CAB53522.1.
CH471077 Genomic DNA. Translation: EAW75870.1.
CCDSCCDS13346.1.
PIRA43412.
RefSeqNP_002999.1. NM_003008.2.
UniGeneHs.537218.

3D structure databases

ProteinModelPortalQ02383.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112307. 5 interactions.
IntActQ02383. 3 interactions.
STRING9606.ENSP00000361855.

PTM databases

PhosphoSiteQ02383.

Polymorphism databases

DMDM401079.

Proteomic databases

PaxDbQ02383.
PeptideAtlasQ02383.
PRIDEQ02383.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372769; ENSP00000361855; ENSG00000124157.
GeneID6407.
KEGGhsa:6407.
UCSCuc002xnk.3. human.

Organism-specific databases

CTD6407.
GeneCardsGC20P043849.
HGNCHGNC:10743. SEMG2.
HPAHPA042767.
HPA042835.
MIM182141. gene.
neXtProtNX_Q02383.
PharmGKBPA35665.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87347.
HOGENOMHOG000263413.
HOVERGENHBG054194.
InParanoidQ02383.
OMAGHKENKI.
OrthoDBEOG7J4469.
PhylomeDBQ02383.
TreeFamTF342360.

Gene expression databases

BgeeQ02383.
CleanExHS_SEMG2.
GenevestigatorQ02383.

Family and domain databases

InterProIPR008836. Semenogelin.
[Graphical view]
PANTHERPTHR10547. PTHR10547. 1 hit.
PfamPF05474. Semenogelin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSEMG2.
GenomeRNAi6407.
NextBio24896.
PMAP-CutDBQ02383.
PROQ02383.
SOURCESearch...

Entry information

Entry nameSEMG2_HUMAN
AccessionPrimary (citable) accession number: Q02383
Secondary accession number(s): Q53ZU2, Q6X2M5, Q6X2M6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM