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Q02382

- RDRP_LRVLG

UniProt

Q02382 - RDRP_LRVLG

Protein

Probable RNA-directed RNA polymerase

Gene

ORF3

Organism
Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase which replicates the viral genome. Catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded from the virion into the cytoplasm where they function as mRNAs for translation of viral proteins and also as substrates for encapsidation to form new virions. Once encapsidated, the positive strand is converted to dsRNA by the RNA-directed RNA polymerase. Displays ssRNA-binding activity By similarity.By similarity

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW
    4. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable RNA-directed RNA polymerase (EC:2.7.7.48)
    Gene namesi
    Name:ORF3
    OrganismiLeishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
    Taxonomic identifieri58103 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesTotiviridaeLeishmaniavirus
    Virus hostiLeishmania major [TaxID: 5664]
    ProteomesiUP000006721: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 874874Probable RNA-directed RNA polymerasePRO_0000404517Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ02382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001795. RNA-dir_pol_luteovirus.
    [Graphical view]
    PfamiPF02123. RdRP_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02382-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQCPNQNHML VNRAMVVAAL DSFEDARRII SGVLDLSRLT NTSVKGQHTN    50
    DTNYFSRYSN FFSQMPAIIL NQLKCCIKAQ VDDAVKMVLQ KAKKVEVSKP 100
    VEKMLTFTTL NTYLGYPEST GCVMEYTEEQ SGPIAAKLLI TLLSSTLNAM 150
    VRPKSDPNIS QNKIPRHYYQ LKVHVGAQKK VNLTAIEVIR GCQHECSVVY 200
    CEFVRYSAYF AGLYDDQVAA ILLYAVAAHN VQGFGARFCV LWALMCVRIA 250
    GFADDINIYI KHRGMSGLLP QLVEMKCLLG RGVNEIDVET EARRRLDVGS 300
    LSMQRLDENE LRAAVRLIYS EELRRPVTYP LICDFWSSRW LWAANGSHSR 350
    ALEHAHPELA TRKEGQAYRK AVMEQWQHNP MDRWDGTVYV TPSAKLEHGK 400
    TRLLLACDTL SYMWFEYALR PVERIWENSN VILDPGSMGN CGIATRINGW 450
    RNGMPGQSFF AVDYDDFNSQ HTLMSQKIVF EELFHHIGYN ASWVKTLVDS 500
    FDSMELWIKG KCAGIMAGTL MSGHRATSFI NSVLNRAYII CAGGHVPTSM 550
    HVGDDILMSC TLGHADNLIA NLNRKGVRLN ASKQVFSKTS GEFLRVAHRE 600
    HTSHGYLARV ISSAVSGNWV SDHTLNQQEA LMNAIVCCRG ILNRSLPGEK 650
    NPVVRVISRS VSKRTKIEEK TIRLLLSGRA CLKGGVVYGE QTNYIQVYRI 700
    NCRVERSEEK LPPYRHATED YLNNHLADIE VMAVRQYGSD IADIMAQASW 750
    KKSMSTEGAE DVSRLSLQRD KTLPCLHCIT EKETSLLPVR YGLFSSYPIL 800
    MMLKDRIPIK EALKLAVTIG YRPQPNSDLE LDLWGESNNS CAIEGVLPYN 850
    EATSLAQKLP CGGVVIQVIH NVYV 874
    Length:874
    Mass (Da):98,321
    Last modified:November 1, 1996 - v1
    Checksum:iA21CABDF4AA1A009
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92355 Genomic RNA. Translation: AAB50024.1.
    PIRiC46171.
    RefSeqiNP_041191.1. NC_002063.1.

    Genome annotation databases

    GeneIDi1446405.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92355 Genomic RNA. Translation: AAB50024.1 .
    PIRi C46171.
    RefSeqi NP_041191.1. NC_002063.1.

    3D structure databases

    ProteinModelPortali Q02382.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1446405.

    Family and domain databases

    InterProi IPR001795. RNA-dir_pol_luteovirus.
    [Graphical view ]
    Pfami PF02123. RdRP_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_LRVLG
    AccessioniPrimary (citable) accession number: Q02382
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3