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Q02382

- RDRP_LRVLG

UniProt

Q02382 - RDRP_LRVLG

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Protein

Probable RNA-directed RNA polymerase

Gene
ORF3
Organism
Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which replicates the viral genome. Catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded from the virion into the cytoplasm where they function as mRNAs for translation of viral proteins and also as substrates for encapsidation to form new virions. Once encapsidated, the positive strand is converted to dsRNA by the RNA-directed RNA polymerase. Displays ssRNA-binding activity By similarity.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-directed RNA polymerase (EC:2.7.7.48)
Gene namesi
Name:ORF3
OrganismiLeishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
Taxonomic identifieri58103 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesTotiviridaeLeishmaniavirus
Virus hostiLeishmania major [TaxID: 5664]
ProteomesiUP000006721: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Probable RNA-directed RNA polymerasePRO_0000404517Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ02382.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001795. RNA-dir_pol_luteovirus.
[Graphical view]
PfamiPF02123. RdRP_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02382-1 [UniParc]FASTAAdd to Basket

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MQCPNQNHML VNRAMVVAAL DSFEDARRII SGVLDLSRLT NTSVKGQHTN    50
DTNYFSRYSN FFSQMPAIIL NQLKCCIKAQ VDDAVKMVLQ KAKKVEVSKP 100
VEKMLTFTTL NTYLGYPEST GCVMEYTEEQ SGPIAAKLLI TLLSSTLNAM 150
VRPKSDPNIS QNKIPRHYYQ LKVHVGAQKK VNLTAIEVIR GCQHECSVVY 200
CEFVRYSAYF AGLYDDQVAA ILLYAVAAHN VQGFGARFCV LWALMCVRIA 250
GFADDINIYI KHRGMSGLLP QLVEMKCLLG RGVNEIDVET EARRRLDVGS 300
LSMQRLDENE LRAAVRLIYS EELRRPVTYP LICDFWSSRW LWAANGSHSR 350
ALEHAHPELA TRKEGQAYRK AVMEQWQHNP MDRWDGTVYV TPSAKLEHGK 400
TRLLLACDTL SYMWFEYALR PVERIWENSN VILDPGSMGN CGIATRINGW 450
RNGMPGQSFF AVDYDDFNSQ HTLMSQKIVF EELFHHIGYN ASWVKTLVDS 500
FDSMELWIKG KCAGIMAGTL MSGHRATSFI NSVLNRAYII CAGGHVPTSM 550
HVGDDILMSC TLGHADNLIA NLNRKGVRLN ASKQVFSKTS GEFLRVAHRE 600
HTSHGYLARV ISSAVSGNWV SDHTLNQQEA LMNAIVCCRG ILNRSLPGEK 650
NPVVRVISRS VSKRTKIEEK TIRLLLSGRA CLKGGVVYGE QTNYIQVYRI 700
NCRVERSEEK LPPYRHATED YLNNHLADIE VMAVRQYGSD IADIMAQASW 750
KKSMSTEGAE DVSRLSLQRD KTLPCLHCIT EKETSLLPVR YGLFSSYPIL 800
MMLKDRIPIK EALKLAVTIG YRPQPNSDLE LDLWGESNNS CAIEGVLPYN 850
EATSLAQKLP CGGVVIQVIH NVYV 874
Length:874
Mass (Da):98,321
Last modified:November 1, 1996 - v1
Checksum:iA21CABDF4AA1A009
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92355 Genomic RNA. Translation: AAB50024.1.
PIRiC46171.
RefSeqiNP_041191.1. NC_002063.1.

Genome annotation databases

GeneIDi1446405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92355 Genomic RNA. Translation: AAB50024.1 .
PIRi C46171.
RefSeqi NP_041191.1. NC_002063.1.

3D structure databases

ProteinModelPortali Q02382.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1446405.

Family and domain databases

InterProi IPR001795. RNA-dir_pol_luteovirus.
[Graphical view ]
Pfami PF02123. RdRP_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_LRVLG
AccessioniPrimary (citable) accession number: Q02382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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