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Q02382 (RDRP_LRVLG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable RNA-directed RNA polymerase

EC=2.7.7.48
Gene names
Name:ORF3
OrganismLeishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1) [Reference proteome]
Taxonomic identifier58103 [NCBI]
Taxonomic lineageVirusesdsRNA virusesTotiviridaeLeishmaniavirus
Virus hostLeishmania major [TaxID: 5664]

Protein attributes

Sequence length874 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase which replicates the viral genome. Catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded from the virion into the cytoplasm where they function as mRNAs for translation of viral proteins and also as substrates for encapsidation to form new virions. Once encapsidated, the positive strand is converted to dsRNA by the RNA-directed RNA polymerase. Displays ssRNA-binding activity By similarity.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the totiviridae RNA-directed RNA polymerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 874874Probable RNA-directed RNA polymerase
PRO_0000404517

Sequences

Sequence LengthMass (Da)Tools
Q02382 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A21CABDF4AA1A009

FASTA87498,321
        10         20         30         40         50         60 
MQCPNQNHML VNRAMVVAAL DSFEDARRII SGVLDLSRLT NTSVKGQHTN DTNYFSRYSN 

        70         80         90        100        110        120 
FFSQMPAIIL NQLKCCIKAQ VDDAVKMVLQ KAKKVEVSKP VEKMLTFTTL NTYLGYPEST 

       130        140        150        160        170        180 
GCVMEYTEEQ SGPIAAKLLI TLLSSTLNAM VRPKSDPNIS QNKIPRHYYQ LKVHVGAQKK 

       190        200        210        220        230        240 
VNLTAIEVIR GCQHECSVVY CEFVRYSAYF AGLYDDQVAA ILLYAVAAHN VQGFGARFCV 

       250        260        270        280        290        300 
LWALMCVRIA GFADDINIYI KHRGMSGLLP QLVEMKCLLG RGVNEIDVET EARRRLDVGS 

       310        320        330        340        350        360 
LSMQRLDENE LRAAVRLIYS EELRRPVTYP LICDFWSSRW LWAANGSHSR ALEHAHPELA 

       370        380        390        400        410        420 
TRKEGQAYRK AVMEQWQHNP MDRWDGTVYV TPSAKLEHGK TRLLLACDTL SYMWFEYALR 

       430        440        450        460        470        480 
PVERIWENSN VILDPGSMGN CGIATRINGW RNGMPGQSFF AVDYDDFNSQ HTLMSQKIVF 

       490        500        510        520        530        540 
EELFHHIGYN ASWVKTLVDS FDSMELWIKG KCAGIMAGTL MSGHRATSFI NSVLNRAYII 

       550        560        570        580        590        600 
CAGGHVPTSM HVGDDILMSC TLGHADNLIA NLNRKGVRLN ASKQVFSKTS GEFLRVAHRE 

       610        620        630        640        650        660 
HTSHGYLARV ISSAVSGNWV SDHTLNQQEA LMNAIVCCRG ILNRSLPGEK NPVVRVISRS 

       670        680        690        700        710        720 
VSKRTKIEEK TIRLLLSGRA CLKGGVVYGE QTNYIQVYRI NCRVERSEEK LPPYRHATED 

       730        740        750        760        770        780 
YLNNHLADIE VMAVRQYGSD IADIMAQASW KKSMSTEGAE DVSRLSLQRD KTLPCLHCIT 

       790        800        810        820        830        840 
EKETSLLPVR YGLFSSYPIL MMLKDRIPIK EALKLAVTIG YRPQPNSDLE LDLWGESNNS 

       850        860        870 
CAIEGVLPYN EATSLAQKLP CGGVVIQVIH NVYV 

« Hide

References

[1]"Molecular organization of Leishmania RNA virus 1."
Stuart K.D., Weeks R., Guilbride L., Myler P.J.
Proc. Natl. Acad. Sci. U.S.A. 89:8596-8600(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92355 Genomic RNA. Translation: AAB50024.1.
PIRC46171.
RefSeqNP_041191.1. NC_002063.1.

3D structure databases

ProteinModelPortalQ02382.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1446405.

Family and domain databases

InterProIPR001795. RNA-dir_pol_luteovirus.
[Graphical view]
PfamPF02123. RdRP_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_LRVLG
AccessionPrimary (citable) accession number: Q02382
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families