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Q02382

- RDRP_LRVLG

UniProt

Q02382 - RDRP_LRVLG

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Protein

Probable RNA-directed RNA polymerase

Gene

ORF3

Organism
Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which replicates the viral genome. Catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded from the virion into the cytoplasm where they function as mRNAs for translation of viral proteins and also as substrates for encapsidation to form new virions. Once encapsidated, the positive strand is converted to dsRNA by the RNA-directed RNA polymerase. Displays ssRNA-binding activity (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-directed RNA polymerase (EC:2.7.7.48)
Gene namesi
Name:ORF3
OrganismiLeishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
Taxonomic identifieri58103 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesTotiviridaeLeishmaniavirus
Virus hostiLeishmania major [TaxID: 5664]
ProteomesiUP000006721: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Probable RNA-directed RNA polymerasePRO_0000404517Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ02382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001795. RNA-dir_pol_luteovirus.
[Graphical view]
PfamiPF02123. RdRP_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02382-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MQCPNQNHML VNRAMVVAAL DSFEDARRII SGVLDLSRLT NTSVKGQHTN
60 70 80 90 100
DTNYFSRYSN FFSQMPAIIL NQLKCCIKAQ VDDAVKMVLQ KAKKVEVSKP
110 120 130 140 150
VEKMLTFTTL NTYLGYPEST GCVMEYTEEQ SGPIAAKLLI TLLSSTLNAM
160 170 180 190 200
VRPKSDPNIS QNKIPRHYYQ LKVHVGAQKK VNLTAIEVIR GCQHECSVVY
210 220 230 240 250
CEFVRYSAYF AGLYDDQVAA ILLYAVAAHN VQGFGARFCV LWALMCVRIA
260 270 280 290 300
GFADDINIYI KHRGMSGLLP QLVEMKCLLG RGVNEIDVET EARRRLDVGS
310 320 330 340 350
LSMQRLDENE LRAAVRLIYS EELRRPVTYP LICDFWSSRW LWAANGSHSR
360 370 380 390 400
ALEHAHPELA TRKEGQAYRK AVMEQWQHNP MDRWDGTVYV TPSAKLEHGK
410 420 430 440 450
TRLLLACDTL SYMWFEYALR PVERIWENSN VILDPGSMGN CGIATRINGW
460 470 480 490 500
RNGMPGQSFF AVDYDDFNSQ HTLMSQKIVF EELFHHIGYN ASWVKTLVDS
510 520 530 540 550
FDSMELWIKG KCAGIMAGTL MSGHRATSFI NSVLNRAYII CAGGHVPTSM
560 570 580 590 600
HVGDDILMSC TLGHADNLIA NLNRKGVRLN ASKQVFSKTS GEFLRVAHRE
610 620 630 640 650
HTSHGYLARV ISSAVSGNWV SDHTLNQQEA LMNAIVCCRG ILNRSLPGEK
660 670 680 690 700
NPVVRVISRS VSKRTKIEEK TIRLLLSGRA CLKGGVVYGE QTNYIQVYRI
710 720 730 740 750
NCRVERSEEK LPPYRHATED YLNNHLADIE VMAVRQYGSD IADIMAQASW
760 770 780 790 800
KKSMSTEGAE DVSRLSLQRD KTLPCLHCIT EKETSLLPVR YGLFSSYPIL
810 820 830 840 850
MMLKDRIPIK EALKLAVTIG YRPQPNSDLE LDLWGESNNS CAIEGVLPYN
860 870
EATSLAQKLP CGGVVIQVIH NVYV
Length:874
Mass (Da):98,321
Last modified:November 1, 1996 - v1
Checksum:iA21CABDF4AA1A009
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92355 Genomic RNA. Translation: AAB50024.1.
PIRiC46171.
RefSeqiNP_041191.1. NC_002063.1.

Genome annotation databases

GeneIDi1446405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92355 Genomic RNA. Translation: AAB50024.1 .
PIRi C46171.
RefSeqi NP_041191.1. NC_002063.1.

3D structure databases

ProteinModelPortali Q02382.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1446405.

Family and domain databases

InterProi IPR001795. RNA-dir_pol_luteovirus.
[Graphical view ]
Pfami PF02123. RdRP_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_LRVLG
AccessioniPrimary (citable) accession number: Q02382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3