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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Gene

NDUFB5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Alternative name(s):
Complex I-SGDH
Short name:
CI-SGDH
NADH-ubiquinone oxidoreductase SGDH subunit
Gene namesi
Name:NDUFB5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4646MitochondrionAdd
BLAST
Chaini47 – 189143NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialPRO_0000020051Add
BLAST

Proteomic databases

PaxDbiQ02380.
PRIDEiQ02380.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

IntActiQ02380. 2 interactions.
STRINGi9913.ENSBTAP00000003197.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB5 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4632. Eukaryota.
ENOG4111HCK. LUCA.
GeneTreeiENSGT00390000009980.
HOVERGENiHBG003008.
InParanoidiQ02380.
KOiK03961.
OMAiIKPSRFQ.
OrthoDBiEOG7M98HQ.
TreeFamiTF313997.

Family and domain databases

InterProiIPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view]
PANTHERiPTHR13178. PTHR13178. 1 hit.
PfamiPF09781. NDUF_B5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMSLLHRA SVSAVAALSG RRLGTRLGFG GFLTRDFPKT VAPVRHSGDH
60 70 80 90 100
GKRLFIIKPS GFYDKRFLKL LRFYILLTGI PVAIGITLIN VFIGEAELAE
110 120 130 140 150
IPEGYVPEHW EYFKHPISRW IARTFFDGPE KNYERTMAIL QIEAEKAELR
160 170 180
LKELEVRRLM RARGDGPWFH YPTIDKELID HSPKATPDN
Length:189
Mass (Da):21,589
Last modified:July 1, 1993 - v1
Checksum:iAE3ADBA0E26DEC8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721R → T in AAW82087 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63208 mRNA. Translation: CAA44893.1.
AY911319 mRNA. Translation: AAW82087.1.
BC102690 mRNA. Translation: AAI02691.1.
PIRiS28254.
RefSeqiNP_788829.1. NM_176656.4.
UniGeneiBt.71.

Genome annotation databases

EnsembliENSBTAT00000003197; ENSBTAP00000003197; ENSBTAG00000002463.
GeneIDi338061.
KEGGibta:338061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63208 mRNA. Translation: CAA44893.1.
AY911319 mRNA. Translation: AAW82087.1.
BC102690 mRNA. Translation: AAI02691.1.
PIRiS28254.
RefSeqiNP_788829.1. NM_176656.4.
UniGeneiBt.71.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02380. 2 interactions.
STRINGi9913.ENSBTAP00000003197.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02380.
PRIDEiQ02380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003197; ENSBTAP00000003197; ENSBTAG00000002463.
GeneIDi338061.
KEGGibta:338061.

Organism-specific databases

CTDi4711.

Phylogenomic databases

eggNOGiKOG4632. Eukaryota.
ENOG4111HCK. LUCA.
GeneTreeiENSGT00390000009980.
HOVERGENiHBG003008.
InParanoidiQ02380.
KOiK03961.
OMAiIKPSRFQ.
OrthoDBiEOG7M98HQ.
TreeFamiTF313997.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Miscellaneous databases

NextBioi20812512.

Family and domain databases

InterProiIPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view]
PANTHERiPTHR13178. PTHR13178. 1 hit.
PfamiPF09781. NDUF_B5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction."
    Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M., Pilkington S.J., Runswick M.J., Skehel J.M.
    J. Mol. Biol. 226:1051-1072(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Heart.
  2. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.
  4. "Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme."
    Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.
    Biochemistry 39:7229-7235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I.
  5. "Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization-tandem mass spectrometry, and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry."
    Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A., Robinson N.C.
    Anal. Biochem. 382:116-121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN COMPLEX I.

Entry informationi

Entry nameiNDUB5_BOVIN
AccessioniPrimary (citable) accession number: Q02380
Secondary accession number(s): Q3SZV4, Q56K08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 17, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.