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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Gene

NDUFS5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Alternative name(s):
Complex I-15 kDa
Short name:
CI-15 kDa
NADH-ubiquinone oxidoreductase 15 kDa subunit
Gene namesi
Name:NDUFS5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:31970 NDUFS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001187852 – 106NADH dehydrogenase [ubiquinone] iron-sulfur protein 5Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 66PROSITE-ProRule annotation
Disulfide bondi43 ↔ 56PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ02379
PRIDEiQ02379

Expressioni

Gene expression databases

BgeeiENSBTAG00000010232

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.2 Publications

Protein-protein interaction databases

CORUMiQ02379
DIPiDIP-38809N
IntActiQ02379, 2 interactors
STRINGi9913.ENSBTAP00000013507

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35e1-106[»]
5LDWelectron microscopy4.27e2-106[»]
5LDXelectron microscopy5.60e1-106[»]
5O31electron microscopy4.13e2-106[»]
SMRiQ02379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 74CHCHPROSITE-ProRule annotationAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 43Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi56 – 66Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFS5 subunit family.Curated

Phylogenomic databases

eggNOGiKOG4110 Eukaryota
ENOG41123TD LUCA
GeneTreeiENSGT00390000002919
HOGENOMiHOG000264236
HOVERGENiHBG001646
InParanoidiQ02379
KOiK03938
OMAiFEDFYEC
OrthoDBiEOG091G1CDO
TreeFamiTF332111

Family and domain databases

InterProiView protein in InterPro
IPR019342 NADH_UbQ_OxRdtase_FeS-su5
PfamiView protein in Pfam
PF10200 Ndufs5, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFFDVQKRL GVDLDRWMTI QSAEQPHKIP SRCHAFEKEW IECAHGIGSI
60 70 80 90 100
RAEKECKIEF EDFRECLLRQ KTMKRLHAIR RQREKLIKEG KYTPPPHHSG

QEEPRS
Length:106
Mass (Da):12,668
Last modified:January 23, 2007 - v2
Checksum:i75BE02EF2C1A9144
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63220 mRNA Translation: CAA44905.1
BC102919 mRNA Translation: AAI02920.1
PIRiS28239
RefSeqiNP_788825.1, NM_176652.2
UniGeneiBt.57

Genome annotation databases

EnsembliENSBTAT00000013507; ENSBTAP00000013507; ENSBTAG00000010232
GeneIDi338057
KEGGibta:338057

Similar proteinsi

Entry informationi

Entry nameiNDUS5_BOVIN
AccessioniPrimary (citable) accession number: Q02379
Secondary accession number(s): Q3ZC47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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