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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Gene

NDUFS5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Alternative name(s):
Complex I-15 kDa
Short name:
CI-15 kDa
NADH-ubiquinone oxidoreductase 15 kDa subunit
Gene namesi
Name:NDUFS5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001187852 – 106NADH dehydrogenase [ubiquinone] iron-sulfur protein 5Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 66PROSITE-ProRule annotation
Disulfide bondi43 ↔ 56PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ02379.
PRIDEiQ02379.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010232.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.2 Publications

Protein-protein interaction databases

IntActiQ02379. 2 interactors.
STRINGi9913.ENSBTAP00000013507.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35e1-106[»]
5LDWelectron microscopy4.27e2-106[»]
5LDXelectron microscopy5.60e1-106[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 74CHCHPROSITE-ProRule annotationAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 43Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi56 – 66Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFS5 subunit family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4110. Eukaryota.
ENOG41123TD. LUCA.
GeneTreeiENSGT00390000002919.
HOGENOMiHOG000264236.
HOVERGENiHBG001646.
InParanoidiQ02379.
KOiK03938.
OMAiFEDFYEC.
OrthoDBiEOG091G1CDO.
TreeFamiTF332111.

Family and domain databases

InterProiIPR019342. NADH_UbQ_OxRdtase_FeS-su5.
[Graphical view]
PfamiPF10200. Ndufs5. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFFDVQKRL GVDLDRWMTI QSAEQPHKIP SRCHAFEKEW IECAHGIGSI
60 70 80 90 100
RAEKECKIEF EDFRECLLRQ KTMKRLHAIR RQREKLIKEG KYTPPPHHSG

QEEPRS
Length:106
Mass (Da):12,668
Last modified:January 23, 2007 - v2
Checksum:i75BE02EF2C1A9144
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63220 mRNA. Translation: CAA44905.1.
BC102919 mRNA. Translation: AAI02920.1.
PIRiS28239.
RefSeqiNP_788825.1. NM_176652.2.
UniGeneiBt.57.

Genome annotation databases

EnsembliENSBTAT00000013507; ENSBTAP00000013507; ENSBTAG00000010232.
GeneIDi338057.
KEGGibta:338057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63220 mRNA. Translation: CAA44905.1.
BC102919 mRNA. Translation: AAI02920.1.
PIRiS28239.
RefSeqiNP_788825.1. NM_176652.2.
UniGeneiBt.57.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35e1-106[»]
5LDWelectron microscopy4.27e2-106[»]
5LDXelectron microscopy5.60e1-106[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02379. 2 interactors.
STRINGi9913.ENSBTAP00000013507.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02379.
PRIDEiQ02379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013507; ENSBTAP00000013507; ENSBTAG00000010232.
GeneIDi338057.
KEGGibta:338057.

Organism-specific databases

CTDi4725.

Phylogenomic databases

eggNOGiKOG4110. Eukaryota.
ENOG41123TD. LUCA.
GeneTreeiENSGT00390000002919.
HOGENOMiHOG000264236.
HOVERGENiHBG001646.
InParanoidiQ02379.
KOiK03938.
OMAiFEDFYEC.
OrthoDBiEOG091G1CDO.
TreeFamiTF332111.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000010232.

Family and domain databases

InterProiIPR019342. NADH_UbQ_OxRdtase_FeS-su5.
[Graphical view]
PfamiPF10200. Ndufs5. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUS5_BOVIN
AccessioniPrimary (citable) accession number: Q02379
Secondary accession number(s): Q3ZC47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.