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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

Gene

NDUFB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Alternative name(s):
Complex I-MNLL
Short name:
CI-MNLL
NADH-ubiquinone oxidoreductase MNLL subunit
Gene namesi
Name:NDUFB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 26HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188261 – 57NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1Add BLAST57

Proteomic databases

PaxDbiQ02378.
PRIDEiQ02378.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.3 Publications

Protein-protein interaction databases

CORUMiQ02378.
DIPiDIP-38823N.
IntActiQ02378. 2 interactors.
STRINGi9913.ENSBTAP00000020160.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35f1-57[»]
5LDWelectron microscopy4.27f1-57[»]
5LDXelectron microscopy5.60f1-57[»]
SMRiQ02378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB1 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2ZX. Eukaryota.
ENOG410XXU1. LUCA.
HOVERGENiHBG006501.
InParanoidiQ02378.
KOiK03957.
OMAiQDQKLTA.

Family and domain databases

InterProiView protein in InterPro
IPR012575. NADH_UbQ_OxRdtase_MNLL_su.
PANTHERiPTHR15222. PTHR15222. 1 hit.
PfamiView protein in Pfam
PF08040. NADH_oxidored. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD052001. NADH_UbQ_OxRdtase_MNLL_su. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLQVVRDH WVHVLVPMGF VFGYYLDRKN DEKLTAFRNK SLLYKRELKP

NEEVTWK
Length:57
Mass (Da):6,966
Last modified:July 1, 1993 - v1
Checksum:i56D0A3C8CB046973
GO

Sequence cautioni

The sequence CAA44908 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63223 mRNA. Translation: CAA44908.1. Different initiation.
PIRiS28251.
RefSeqiNP_787003.1. NM_175809.2.
UniGeneiBt.62532.

Genome annotation databases

GeneIDi327690.
KEGGibta:327690.

Similar proteinsi

Entry informationi

Entry nameiNDUB1_BOVIN
AccessioniPrimary (citable) accession number: Q02378
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families