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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Gene

NDUFA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Alternative name(s):
Complex I-MWFE
Short name:
CI-MWFE
NADH-ubiquinone oxidoreductase MWFE subunit
Gene namesi
Name:NDUFA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188141 – 70NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1Add BLAST70

Proteomic databases

PaxDbiQ02377.
PRIDEiQ02377.

PTM databases

iPTMnetiQ02377.

Expressioni

Gene expression databases

BgeeiENSBTAG00000006033.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

CORUMiQ02377.
DIPiDIP-38822N.
IntActiQ02377. 1 interactor.
STRINGi9913.ENSBTAP00000007925.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35a1-70[»]
5LDWelectron microscopy4.27a1-70[»]
5LDXelectron microscopy5.60a1-70[»]
5LNKelectron microscopy3.90z1-70[»]
SMRiQ02377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA1 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J32W. Eukaryota.
ENOG4112BUF. LUCA.
GeneTreeiENSGT00390000007560.
HOGENOMiHOG000010206.
HOVERGENiHBG000813.
InParanoidiQ02377.
KOiK03945.
OMAiQWYLMER.
OrthoDBiEOG091G179T.
TreeFamiTF333394.

Family and domain databases

InterProiView protein in InterPro
IPR017384. NADH_Ub_cplx-1_asu_su-1.
PANTHERiPTHR17098. PTHR17098. 1 hit.
PfamiView protein in Pfam
PF15879. MWFE. 1 hit.
PIRSFiPIRSF038095. NDUA1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFEVLPGIA VMGVCLFIPG MATARIHRFS NGGKEKRVAH YPYQWYLMER
60 70
DRRVSGVNRS YVSKGLENID
Length:70
Mass (Da):8,105
Last modified:July 1, 1993 - v1
Checksum:iDC64CF71EA573324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63222 mRNA. Translation: CAA44907.1.
BC102993 mRNA. Translation: AAI02994.1.
PIRiS28252.
RefSeqiNP_786988.1. NM_175794.2.
UniGeneiBt.69.

Genome annotation databases

EnsembliENSBTAT00000007925; ENSBTAP00000007925; ENSBTAG00000006033.
GeneIDi327673.
KEGGibta:327673.

Similar proteinsi

Entry informationi

Entry nameiNDUA1_BOVIN
AccessioniPrimary (citable) accession number: Q02377
Secondary accession number(s): Q3ZC06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families