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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Gene

NDUFA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Alternative name(s):
Complex I-MWFE
Short name:
CI-MWFE
NADH-ubiquinone oxidoreductase MWFE subunit
Gene namesi
Name:NDUFA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:31944 NDUFA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188141 – 70NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1Add BLAST70

Proteomic databases

PaxDbiQ02377
PRIDEiQ02377

PTM databases

iPTMnetiQ02377

Expressioni

Gene expression databases

BgeeiENSBTAG00000006033

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

CORUMiQ02377
DIPiDIP-38822N
IntActiQ02377, 1 interactor
STRINGi9913.ENSBTAP00000007925

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35a1-70[»]
5LDWelectron microscopy4.27a1-70[»]
5LDXelectron microscopy5.60a1-70[»]
5LNKelectron microscopy3.90z1-70[»]
5O31electron microscopy4.13a1-70[»]
SMRiQ02377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA1 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J32W Eukaryota
ENOG4112BUF LUCA
GeneTreeiENSGT00390000007560
HOGENOMiHOG000010206
HOVERGENiHBG000813
InParanoidiQ02377
KOiK03945
OMAiQWYLMER
OrthoDBiEOG091G179T
TreeFamiTF333394

Family and domain databases

InterProiView protein in InterPro
IPR017384 NADH_Ub_cplx-1_asu_su-1
PANTHERiPTHR17098 PTHR17098, 1 hit
PfamiView protein in Pfam
PF15879 MWFE, 1 hit
PIRSFiPIRSF038095 NDUA1, 1 hit

Sequencei

Sequence statusi: Complete.

Q02377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFEVLPGIA VMGVCLFIPG MATARIHRFS NGGKEKRVAH YPYQWYLMER
60 70
DRRVSGVNRS YVSKGLENID
Length:70
Mass (Da):8,105
Last modified:July 1, 1993 - v1
Checksum:iDC64CF71EA573324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63222 mRNA Translation: CAA44907.1
BC102993 mRNA Translation: AAI02994.1
PIRiS28252
RefSeqiNP_786988.1, NM_175794.2
UniGeneiBt.69

Genome annotation databases

EnsembliENSBTAT00000007925; ENSBTAP00000007925; ENSBTAG00000006033
GeneIDi327673
KEGGibta:327673

Similar proteinsi

Entry informationi

Entry nameiNDUA1_BOVIN
AccessioniPrimary (citable) accession number: Q02377
Secondary accession number(s): Q3ZC06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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