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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Gene

NDUFA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Alternative name(s):
Complex I-MWFE
Short name:
CI-MWFE
NADH-ubiquinone oxidoreductase MWFE subunit
Gene namesi
Name:NDUFA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1PRO_0000118814Add
BLAST

Proteomic databases

PaxDbiQ02377.
PRIDEiQ02377.

PTM databases

iPTMnetiQ02377.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

IntActiQ02377. 1 interaction.
STRINGi9913.ENSBTAP00000007925.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J32W. Eukaryota.
ENOG4112BUF. LUCA.
GeneTreeiENSGT00390000007560.
HOGENOMiHOG000010206.
HOVERGENiHBG000813.
InParanoidiQ02377.
KOiK03945.
OMAiWYLMERD.
OrthoDBiEOG7NGQFC.
TreeFamiTF333394.

Family and domain databases

InterProiIPR017384. NADH_Ub_cplx-1_asu_su-1.
[Graphical view]
PANTHERiPTHR17098. PTHR17098. 1 hit.
PfamiPF15879. MWFE. 1 hit.
[Graphical view]
PIRSFiPIRSF038095. NDUA1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFEVLPGIA VMGVCLFIPG MATARIHRFS NGGKEKRVAH YPYQWYLMER
60 70
DRRVSGVNRS YVSKGLENID
Length:70
Mass (Da):8,105
Last modified:July 1, 1993 - v1
Checksum:iDC64CF71EA573324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63222 mRNA. Translation: CAA44907.1.
BC102993 mRNA. Translation: AAI02994.1.
PIRiS28252.
RefSeqiNP_786988.1. NM_175794.2.
UniGeneiBt.69.

Genome annotation databases

EnsembliENSBTAT00000007925; ENSBTAP00000007925; ENSBTAG00000006033.
GeneIDi327673.
KEGGibta:327673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63222 mRNA. Translation: CAA44907.1.
BC102993 mRNA. Translation: AAI02994.1.
PIRiS28252.
RefSeqiNP_786988.1. NM_175794.2.
UniGeneiBt.69.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02377. 1 interaction.
STRINGi9913.ENSBTAP00000007925.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

PTM databases

iPTMnetiQ02377.

Proteomic databases

PaxDbiQ02377.
PRIDEiQ02377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007925; ENSBTAP00000007925; ENSBTAG00000006033.
GeneIDi327673.
KEGGibta:327673.

Organism-specific databases

CTDi4694.

Phylogenomic databases

eggNOGiENOG410J32W. Eukaryota.
ENOG4112BUF. LUCA.
GeneTreeiENSGT00390000007560.
HOGENOMiHOG000010206.
HOVERGENiHBG000813.
InParanoidiQ02377.
KOiK03945.
OMAiWYLMERD.
OrthoDBiEOG7NGQFC.
TreeFamiTF333394.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Family and domain databases

InterProiIPR017384. NADH_Ub_cplx-1_asu_su-1.
[Graphical view]
PANTHERiPTHR17098. PTHR17098. 1 hit.
PfamiPF15879. MWFE. 1 hit.
[Graphical view]
PIRSFiPIRSF038095. NDUA1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction."
    Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M., Pilkington S.J., Runswick M.J., Skehel J.M.
    J. Mol. Biol. 226:1051-1072(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-23.
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  3. "Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization-tandem mass spectrometry, and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry."
    Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A., Robinson N.C.
    Anal. Biochem. 382:116-121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN COMPLEX I.

Entry informationi

Entry nameiNDUA1_BOVIN
AccessioniPrimary (citable) accession number: Q02377
Secondary accession number(s): Q3ZC06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.