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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

NDUFC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name:
CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene namesi
Name:NDUFC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 59HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionAdd BLAST27
ChainiPRO_000002004828 – 76NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialAdd BLAST49

Proteomic databases

PaxDbiQ02376.

Expressioni

Gene expression databases

BgeeiENSBTAG00000039582.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.3 Publications

Protein-protein interaction databases

CORUMiQ02376.
DIPiDIP-38817N.
IntActiQ02376. 1 interactor.
STRINGi9913.ENSBTAP00000051891.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35c1-76[»]
5LDWelectron microscopy4.27c28-76[»]
5LDXelectron microscopy5.60c28-76[»]
5LNKelectron microscopy3.90x28-76[»]
SMRiQ02376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC1 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MG. Eukaryota.
ENOG410XUGS. LUCA.
GeneTreeiENSGT00390000002565.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiQ02376.
KOiK03967.
OMAiNAKPDWL.
OrthoDBiEOG091G14QE.
TreeFamiTF338333.

Family and domain databases

InterProiView protein in InterPro
IPR026192. NDUFC1.
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiView protein in Pfam
PF15088. NADH_dh_m_C1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSALLRPF WKLLAPARFP SVSSSRSKFY IQEPPHGSPN WLKVGLTLGT
60 70
SVFLWIYLIK QHNEDVLEYK RRNGLE
Length:76
Mass (Da):8,784
Last modified:July 1, 1993 - v1
Checksum:i326286716C4394F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63214 mRNA. Translation: CAA44899.1.
BC102392 mRNA. Translation: AAI02393.1.
PIRiS28250.
RefSeqiNP_776989.1. NM_174564.2.
XP_005217593.1. XM_005217536.2.
UniGeneiBt.98783.

Genome annotation databases

EnsembliENSBTAT00000055713; ENSBTAP00000051891; ENSBTAG00000039582.
GeneIDi282289.
KEGGibta:282289.

Similar proteinsi

Entry informationi

Entry nameiNDUC1_BOVIN
AccessioniPrimary (citable) accession number: Q02376
Secondary accession number(s): Q3T0H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families