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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene

NDUFS4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Alternative name(s):
Complex I-18 kDa
Short name:
CI-18 kDa
Complex I-AQDQ
Short name:
CI-AQDQ
NADH-ubiquinone oxidoreductase 18 kDa subunit
Gene namesi
Name:NDUFS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionAdd BLAST42
ChainiPRO_000002003743 – 175NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAdd BLAST133

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02375.
PeptideAtlasiQ02375.
PRIDEiQ02375.

PTM databases

iPTMnetiQ02375.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003728.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.2 Publications

Protein-protein interaction databases

IntActiQ02375. 3 interactors.
STRINGi9913.ENSBTAP00000044670.

Structurei

3D structure databases

ProteinModelPortaliQ02375.
SMRiQ02375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS4 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3389. Eukaryota.
ENOG4111TR4. LUCA.
GeneTreeiENSGT00390000013835.
HOGENOMiHOG000140414.
HOVERGENiHBG003007.
InParanoidiQ02375.
KOiK03937.
OMAiCEKNRWE.
OrthoDBiEOG091G0LT1.
TreeFamiTF105619.

Family and domain databases

InterProiIPR006885. NADH_UbQ_FeS_4_mit.
[Graphical view]
PANTHERiPTHR12219. PTHR12219. 1 hit.
PfamiPF04800. ETC_C1_NDUFA4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSMSVAL RQALWGRRVA TVAAVSVSKV STRSLSTSTW RLAQDQTRDT
60 70 80 90 100
QLITVDEKLD ITTITGVPEE HIKTRKARIF VPARNNMQSG VNNTKKWKME
110 120 130 140 150
FDTRERWENP LMGWASTADP LSNLVLTFST KEDAVAFAEK NGWSYDVEER
160 170
KVPKPKSKSY GANFSWNKRT RVSTK
Length:175
Mass (Da):19,812
Last modified:July 1, 1993 - v1
Checksum:iC77BE67FE6E5A407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63215 mRNA. Translation: CAA44900.1.
PIRiS28240.
RefSeqiNP_786994.1. NM_175800.2.
UniGeneiBt.58.

Genome annotation databases

EnsembliENSBTAT00000047463; ENSBTAP00000044670; ENSBTAG00000003728.
GeneIDi327680.
KEGGibta:327680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63215 mRNA. Translation: CAA44900.1.
PIRiS28240.
RefSeqiNP_786994.1. NM_175800.2.
UniGeneiBt.58.

3D structure databases

ProteinModelPortaliQ02375.
SMRiQ02375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02375. 3 interactors.
STRINGi9913.ENSBTAP00000044670.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

PTM databases

iPTMnetiQ02375.

Proteomic databases

PaxDbiQ02375.
PeptideAtlasiQ02375.
PRIDEiQ02375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000047463; ENSBTAP00000044670; ENSBTAG00000003728.
GeneIDi327680.
KEGGibta:327680.

Organism-specific databases

CTDi4724.

Phylogenomic databases

eggNOGiKOG3389. Eukaryota.
ENOG4111TR4. LUCA.
GeneTreeiENSGT00390000013835.
HOGENOMiHOG000140414.
HOVERGENiHBG003007.
InParanoidiQ02375.
KOiK03937.
OMAiCEKNRWE.
OrthoDBiEOG091G0LT1.
TreeFamiTF105619.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000003728.

Family and domain databases

InterProiIPR006885. NADH_UbQ_FeS_4_mit.
[Graphical view]
PANTHERiPTHR12219. PTHR12219. 1 hit.
PfamiPF04800. ETC_C1_NDUFA4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUS4_BOVIN
AccessioniPrimary (citable) accession number: Q02375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.