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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Gene

NDUFB9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Alternative name(s):
Complex I-B22
Short name:
CI-B22
NADH-ubiquinone oxidoreductase B22 subunit
Gene namesi
Name:NDUFB9
Synonyms:UQOR22
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 179178NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9PRO_0000174305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei85 – 851PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ02369.
PeptideAtlasiQ02369.
PRIDEiQ02369.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

IntActiQ02369. 2 interactions.
STRINGi9913.ENSBTAP00000027191.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3466. Eukaryota.
ENOG4111PES. LUCA.
GeneTreeiENSGT00390000005809.
HOGENOMiHOG000021684.
HOVERGENiHBG000418.
InParanoidiQ02369.
KOiK03965.
OMAiDYWHPSE.
OrthoDBiEOG7CNZH0.
TreeFamiTF315148.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR033034. NDUFB9.
[Graphical view]
PANTHERiPTHR12868:SF0. PTHR12868:SF0. 1 hit.
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLSSGAYL THQQKVLRLY KRALRHLESW CIHRDKYRYF ACLLRARFDE
60 70 80 90 100
HKNEKDMVKA TQLLREAEEE FWHGQHPQPY IFPESPGGTS YERYECYKVP
110 120 130 140 150
EWCLDDWHPS EKAMYPDYFA KREQWKKLRR ESWEREVKQL QEETPVGGPR
160 170
TEALPPARKQ GDLPPLWWHI VTRPRERPM
Length:179
Mass (Da):21,789
Last modified:January 23, 2007 - v2
Checksum:i6D7BFA4AAAAD7C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64836 mRNA. Translation: CAA46048.1.
BC102701 mRNA. Translation: AAI02702.1.
PIRiS28256.
RefSeqiNP_786977.1. NM_175783.4.
UniGeneiBt.3117.

Genome annotation databases

EnsembliENSBTAT00000027191; ENSBTAP00000027191; ENSBTAG00000020405.
GeneIDi327660.
KEGGibta:327660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64836 mRNA. Translation: CAA46048.1.
BC102701 mRNA. Translation: AAI02702.1.
PIRiS28256.
RefSeqiNP_786977.1. NM_175783.4.
UniGeneiBt.3117.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02369. 2 interactions.
STRINGi9913.ENSBTAP00000027191.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02369.
PeptideAtlasiQ02369.
PRIDEiQ02369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027191; ENSBTAP00000027191; ENSBTAG00000020405.
GeneIDi327660.
KEGGibta:327660.

Organism-specific databases

CTDi4715.

Phylogenomic databases

eggNOGiKOG3466. Eukaryota.
ENOG4111PES. LUCA.
GeneTreeiENSGT00390000005809.
HOGENOMiHOG000021684.
HOVERGENiHBG000418.
InParanoidiQ02369.
KOiK03965.
OMAiDYWHPSE.
OrthoDBiEOG7CNZH0.
TreeFamiTF315148.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR033034. NDUFB9.
[Graphical view]
PANTHERiPTHR12868:SF0. PTHR12868:SF0. 1 hit.
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction."
    Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M., Pilkington S.J., Runswick M.J., Skehel J.M.
    J. Mol. Biol. 226:1051-1072(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 58-84 AND 115-144.
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. "Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme."
    Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.
    Biochemistry 39:7229-7235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I.
  4. "Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization-tandem mass spectrometry, and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry."
    Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A., Robinson N.C.
    Anal. Biochem. 382:116-121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN COMPLEX I.

Entry informationi

Entry nameiNDUB9_BOVIN
AccessioniPrimary (citable) accession number: Q02369
Secondary accession number(s): Q3SZU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.