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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Gene

NDUFB7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Alternative name(s):
Complex I-B18
Short name:
CI-B18
NADH-ubiquinone oxidoreductase B18 subunit
Gene namesi
Name:NDUFB7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity
  • Mitochondrion intermembrane space By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001188102 – 137NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Disulfide bondi59 ↔ 90PROSITE-ProRule annotation
Disulfide bondi69 ↔ 80PROSITE-ProRule annotation
Modified residuei73PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ02368.
PRIDEiQ02368.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012634.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

IntActiQ02368. 1 interactor.
STRINGi9913.ENSBTAP00000016768.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35o58-115[»]
5LDWelectron microscopy4.27o2-137[»]
5LDXelectron microscopy5.60o58-115[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 98CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 69Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi80 – 90Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFB7 subunit family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiQ02368.
KOiK03963.
OMAiREMKATW.
OrthoDBiEOG091G10SJ.
TreeFamiTF315152.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAHLARRYL GDASVEPDPL RMPTFPPDYG FPERKEREMV ATQQEMNDAQ
60 70 80 90 100
LVLQQRDYCA HYLIRFLKCK RDSFPNFLAC KHERHDWDYC EHLDYVKRMK
110 120 130
EFERERRLLQ RKKRREQREA DMAKGLGPGE VAPEVAL
Length:137
Mass (Da):16,398
Last modified:January 23, 2007 - v2
Checksum:iF75B1365E32DC573
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63210 mRNA. Translation: CAA44895.1.
BC102482 mRNA. Translation: AAI02483.1.
PIRiS28247.
RefSeqiNP_788833.1. NM_176660.2.
UniGeneiBt.64.

Genome annotation databases

EnsembliENSBTAT00000016768; ENSBTAP00000016768; ENSBTAG00000012634.
GeneIDi338065.
KEGGibta:338065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63210 mRNA. Translation: CAA44895.1.
BC102482 mRNA. Translation: AAI02483.1.
PIRiS28247.
RefSeqiNP_788833.1. NM_176660.2.
UniGeneiBt.64.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35o58-115[»]
5LDWelectron microscopy4.27o2-137[»]
5LDXelectron microscopy5.60o58-115[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02368. 1 interactor.
STRINGi9913.ENSBTAP00000016768.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02368.
PRIDEiQ02368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016768; ENSBTAP00000016768; ENSBTAG00000012634.
GeneIDi338065.
KEGGibta:338065.

Organism-specific databases

CTDi4713.

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiQ02368.
KOiK03963.
OMAiREMKATW.
OrthoDBiEOG091G10SJ.
TreeFamiTF315152.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000012634.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB7_BOVIN
AccessioniPrimary (citable) accession number: Q02368
Secondary accession number(s): Q3T0A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.