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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Gene

NDUFB7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Alternative name(s):
Complex I-B18
Short name:
CI-B18
NADH-ubiquinone oxidoreductase B18 subunit
Gene namesi
Name:NDUFB7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity
  • Mitochondrion intermembrane space By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 137136NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7PRO_0000118810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Disulfide bondi59 ↔ 90Sequence analysis
Disulfide bondi69 ↔ 80Sequence analysis
Modified residuei73 – 731PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ02368.
PRIDEiQ02368.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012634.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

IntActiQ02368. 1 interaction.
STRINGi9913.ENSBTAP00000016768.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 6911C-X9-C motif 1Add
BLAST
Motifi80 – 9011C-X9-C motif 2Add
BLAST

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFB7 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiQ02368.
KOiK03963.
OMAiREMKATW.
OrthoDBiEOG091G10SJ.
TreeFamiTF315152.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAHLARRYL GDASVEPDPL RMPTFPPDYG FPERKEREMV ATQQEMNDAQ
60 70 80 90 100
LVLQQRDYCA HYLIRFLKCK RDSFPNFLAC KHERHDWDYC EHLDYVKRMK
110 120 130
EFERERRLLQ RKKRREQREA DMAKGLGPGE VAPEVAL
Length:137
Mass (Da):16,398
Last modified:January 23, 2007 - v2
Checksum:iF75B1365E32DC573
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63210 mRNA. Translation: CAA44895.1.
BC102482 mRNA. Translation: AAI02483.1.
PIRiS28247.
RefSeqiNP_788833.1. NM_176660.2.
UniGeneiBt.64.

Genome annotation databases

EnsembliENSBTAT00000016768; ENSBTAP00000016768; ENSBTAG00000012634.
GeneIDi338065.
KEGGibta:338065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63210 mRNA. Translation: CAA44895.1.
BC102482 mRNA. Translation: AAI02483.1.
PIRiS28247.
RefSeqiNP_788833.1. NM_176660.2.
UniGeneiBt.64.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02368. 1 interaction.
STRINGi9913.ENSBTAP00000016768.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02368.
PRIDEiQ02368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016768; ENSBTAP00000016768; ENSBTAG00000012634.
GeneIDi338065.
KEGGibta:338065.

Organism-specific databases

CTDi4713.

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiQ02368.
KOiK03963.
OMAiREMKATW.
OrthoDBiEOG091G10SJ.
TreeFamiTF315152.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000012634.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB7_BOVIN
AccessioniPrimary (citable) accession number: Q02368
Secondary accession number(s): Q3T0A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.