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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

Gene

NDUFB6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Alternative name(s):
Complex I-B17
Short name:
CI-B17
NADH-ubiquinone oxidoreductase B17 subunit
Gene namesi
Name:NDUFB6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 86HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001188062 – 128NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei24N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ02367.
PeptideAtlasiQ02367.
PRIDEiQ02367.

PTM databases

iPTMnetiQ02367.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005907.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.3 Publications

Protein-protein interaction databases

CORUMiQ02367.
DIPiDIP-38833N.
IntActiQ02367. 2 interactors.
STRINGi9913.ENSBTAP00000007761.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35i1-33[»]
5LDWelectron microscopy4.27i7-33[»]
5LDXelectron microscopy5.60i7-33[»]
SMRiQ02367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB6 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4633. Eukaryota.
ENOG4111RT5. LUCA.
GeneTreeiENSGT00390000007535.
HOGENOMiHOG000231724.
HOVERGENiHBG006449.
InParanoidiQ02367.
KOiK03962.
OMAiPAWIIHY.
OrthoDBiEOG091G0SHB.
TreeFamiTF328587.

Family and domain databases

InterProiView protein in InterPro
IPR019174. NADH_DH_b-subcmplx_su6.
PfamiView protein in Pfam
PF09782. NDUF_B6. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYTPEEKL RLQQLRELRR RWLKDQELSP REPVLPPQRV SPVERFWNKF
60 70 80 90 100
LQDGALWKNV IYKTYRHSIF AFTHVLIPVW IIHYYLKYHV TTKPYTIVEK
110 120
KPRIFPGDTI LETGEVIPPM KEFPDQHH
Length:128
Mass (Da):15,524
Last modified:January 23, 2007 - v2
Checksum:i2F702A1ABC5C39F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63212 mRNA. Translation: CAA44897.1.
BC102533 mRNA. Translation: AAI02534.1.
PIRiS28246.
RefSeqiNP_786981.1. NM_175787.2.
UniGeneiBt.893.

Genome annotation databases

EnsembliENSBTAT00000007761; ENSBTAP00000007761; ENSBTAG00000005907.
GeneIDi327665.
KEGGibta:327665.

Similar proteinsi

Entry informationi

Entry nameiNDUB6_BOVIN
AccessioniPrimary (citable) accession number: Q02367
Secondary accession number(s): Q3T079
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families