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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Gene

NDUFA6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB-KW
  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Alternative name(s):
Complex I-B14
Short name:
CI-B14
NADH-ubiquinone oxidoreductase B14 subunit
Gene namesi
Name:NDUFA6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001743012 – 128NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ02366.
PRIDEiQ02366.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009509.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

IntActiQ02366. 3 interactors.
STRINGi9913.ENSBTAP00000012512.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35W1-128[»]
5LDWelectron microscopy4.27W1-128[»]
5LDXelectron microscopy5.60W2-128[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3426. Eukaryota.
ENOG4111S2F. LUCA.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiQ02366.
KOiK03950.
OMAiEWIRAAP.
OrthoDBiEOG091G0UGT.
TreeFamiTF105625.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGLRQAA VAASTSVKPI FSRDMNEAKR RVRELYRAWY REVPNTVHLF
60 70 80 90 100
QLDISVKQGR DKVREMFKKN AHITDPRVVD LLVIKGKMEL EETIKVWKQR
110 120
THVMRFFHET EAPRPKDFLS KFYVGHDP
Length:128
Mass (Da):15,053
Last modified:January 23, 2007 - v2
Checksum:i4DB92284502488BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63211 mRNA. Translation: CAA44896.1.
BC102430 mRNA. Translation: AAI02431.1.
PIRiS28245.
RefSeqiNP_786985.1. NM_175791.2.
UniGeneiBt.63.

Genome annotation databases

EnsembliENSBTAT00000012512; ENSBTAP00000012512; ENSBTAG00000009509.
GeneIDi327670.
KEGGibta:327670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63211 mRNA. Translation: CAA44896.1.
BC102430 mRNA. Translation: AAI02431.1.
PIRiS28245.
RefSeqiNP_786985.1. NM_175791.2.
UniGeneiBt.63.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35W1-128[»]
5LDWelectron microscopy4.27W1-128[»]
5LDXelectron microscopy5.60W2-128[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02366. 3 interactors.
STRINGi9913.ENSBTAP00000012512.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02366.
PRIDEiQ02366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012512; ENSBTAP00000012512; ENSBTAG00000009509.
GeneIDi327670.
KEGGibta:327670.

Organism-specific databases

CTDi4700.

Phylogenomic databases

eggNOGiKOG3426. Eukaryota.
ENOG4111S2F. LUCA.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiQ02366.
KOiK03950.
OMAiEWIRAAP.
OrthoDBiEOG091G0UGT.
TreeFamiTF105625.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000009509.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA6_BOVIN
AccessioniPrimary (citable) accession number: Q02366
Secondary accession number(s): Q3T0E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.