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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Gene

NDUFA6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB-KW
  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Alternative name(s):
Complex I-B14
Short name:
CI-B14
NADH-ubiquinone oxidoreductase B14 subunit
Gene namesi
Name:NDUFA6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 128127NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6PRO_0000174301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ02366.
PRIDEiQ02366.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009509.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

IntActiQ02366. 3 interactions.
STRINGi9913.ENSBTAP00000012512.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3426. Eukaryota.
ENOG4111S2F. LUCA.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiQ02366.
KOiK03950.
OMAiEWIRAAP.
OrthoDBiEOG091G0UGT.
TreeFamiTF105625.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGLRQAA VAASTSVKPI FSRDMNEAKR RVRELYRAWY REVPNTVHLF
60 70 80 90 100
QLDISVKQGR DKVREMFKKN AHITDPRVVD LLVIKGKMEL EETIKVWKQR
110 120
THVMRFFHET EAPRPKDFLS KFYVGHDP
Length:128
Mass (Da):15,053
Last modified:January 23, 2007 - v2
Checksum:i4DB92284502488BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63211 mRNA. Translation: CAA44896.1.
BC102430 mRNA. Translation: AAI02431.1.
PIRiS28245.
RefSeqiNP_786985.1. NM_175791.2.
UniGeneiBt.63.

Genome annotation databases

EnsembliENSBTAT00000012512; ENSBTAP00000012512; ENSBTAG00000009509.
GeneIDi327670.
KEGGibta:327670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63211 mRNA. Translation: CAA44896.1.
BC102430 mRNA. Translation: AAI02431.1.
PIRiS28245.
RefSeqiNP_786985.1. NM_175791.2.
UniGeneiBt.63.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02366. 3 interactions.
STRINGi9913.ENSBTAP00000012512.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02366.
PRIDEiQ02366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012512; ENSBTAP00000012512; ENSBTAG00000009509.
GeneIDi327670.
KEGGibta:327670.

Organism-specific databases

CTDi4700.

Phylogenomic databases

eggNOGiKOG3426. Eukaryota.
ENOG4111S2F. LUCA.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiQ02366.
KOiK03950.
OMAiEWIRAAP.
OrthoDBiEOG091G0UGT.
TreeFamiTF105625.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000009509.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA6_BOVIN
AccessioniPrimary (citable) accession number: Q02366
Secondary accession number(s): Q3T0E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.