Reviewed, UniProtKB/Swiss-Prot Q02363 (ID2_HUMAN)

Names and origin

Protein names

Recommended name:
    DNA-binding protein inhibitor ID-2
Alternative name(s):
    Inhibitor of DNA binding 2

Gene names

Name:

ID2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.
Subunit structure	Heterodimer with other HLH proteins.
Subcellular location	Nucleus.
Tissue specificity	Highly expressed in early fetal tissues, including those of the central nervous system.
Developmental stage	Found in most early fetal tissues but not in the corresponding mature tissues.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	negative regulation of transcription factor activity Inferred from direct assay. Source: GDB
Cellular component	nucleus Inferred by curator. Source: GDB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct transcription repressor activity Inferred from direct assay. Source: GDB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TCF3	P15923-1	2	EBI-713450,EBI-769645

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	DNA-binding protein inhibitor ID-2		PRO_0000127240
Regions
	Domain	36 – 76	41	Helix-loop-helix motif
Experimental info
	Sequence conflict	68	1	V → L in AAA58681. Ref.2
	Sequence conflict	98	1	A → R in AAA58681. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q02363-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: A0D98B96396EB11E	FASTA	134	14,917
	10 20 30 40 50 60 MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS 70 80 90 100 110 120 KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF 130 PSELMSNDSK ALCG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts." Hara E., Yamaguchi T., Nojima H., Ide T., Campisi J., Okayama H., Oda K. J. Biol. Chem. 269:2139-2145(1994) [PubMed: 8294468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"A human Id-like helix-loop-helix protein expressed during early development." Biggs J., Murphy E.V., Israel M.A. Proc. Natl. Acad. Sci. U.S.A. 89:1512-1516(1992) [PubMed: 1741406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D13891 mRNA. Translation: BAA02990.1. M97796 mRNA. Translation: AAA58681.1. BC030639 mRNA. Translation: AAH30639.1.
IPI	IPI00294210.
PIR	A40227. JC2007.
RefSeq	NP_002157.2.
UniGene	Hs.180919
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q02363. 6 interactions.
PTM databases
PhosphoSite	Q02363.
Proteomic databases
PRIDE	Q02363.
Genome annotation databases
Ensembl	ENSG00000115738. Homo sapiens. [Contig view]
GeneID	3398.
KEGG	hsa:3398.
Organism-specific databases
GeneCards	GC02P008772.
H-InvDB	HIX0001802.
HGNC	HGNC:5361. ID2.
MIM	600386. gene.
PharmGKB	PA134916396.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q02363.
HOVERGEN	Q02363.
OMA	Q02363. PVDDPLS.
Enzyme and pathway databases
Pathway_Interaction_DB	hif1_tfpathway. HIF-1-alpha transcription factor network.
Gene expression databases
ArrayExpress	Q02363.
Bgee	Q02363.
CleanEx	HS_ID2.
GermOnline	ENSG00000115738. Homo sapiens.
Family and domain databases
InterPro	IPR001092. HLH_basic. [Graphical view]
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	13428.
SOURCE	Search...

Entry information

Entry name

ID2_HUMAN

Accession

Primary (citable) accession number: Q02363

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)