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Reviewed, UniProtKB/Swiss-Prot Q02363 (ID2_HUMAN)

Last modified June 16, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA-binding protein inhibitor ID-2
Alternative name(s):
    Inhibitor of DNA binding 2
Gene names
Name: ID2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length134 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.

Subunit structure

Heterodimer with other HLH proteins.

Subcellular location

Nucleus.

Tissue specificity

Highly expressed in early fetal tissues, including those of the central nervous system.

Developmental stage

Found in most early fetal tissues but not in the corresponding mature tissues.

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
   Cellular componentNucleus
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological processnegative regulation of transcription factor activity

Inferred from direct assay. Source: GDB

   Cellular componentnucleus

Inferred by curator. Source: GDB

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

transcription repressor activity

Inferred from direct assay. Source: GDB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TCF3P15923-12EBI-713450,EBI-769645

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 134134DNA-binding protein inhibitor ID-2
PRO_0000127240

Regions

Domain36 – 7641Helix-loop-helix motif

Experimental info

Sequence conflict681V → L in AAA58681. Ref.2
Sequence conflict981A → R in AAA58681. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q02363-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: A0D98B96396EB11E

FASTA13414,917
        10         20         30         40         50         60 
MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS 

        70         80         90        100        110        120 
KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF 

       130 
PSELMSNDSK ALCG 

« Hide

References

« Hide 'large scale' references
[1]"Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts."
Hara E., Yamaguchi T., Nojima H., Ide T., Campisi J., Okayama H., Oda K.
J. Biol. Chem. 269:2139-2145(1994) [PubMed: 8294468] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"A human Id-like helix-loop-helix protein expressed during early development."
Biggs J., Murphy E.V., Israel M.A.
Proc. Natl. Acad. Sci. U.S.A. 89:1512-1516(1992) [PubMed: 1741406] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

D13891 mRNA. Translation: BAA02990.1.
M97796 mRNA. Translation: AAA58681.1.
BC030639 mRNA. Translation: AAH30639.1.
IPIIPI00294210.
PIRA40227.
JC2007.
RefSeqNP_002157.2.
UniGeneHs.180919

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ02363. 6 interactions.

PTM databases

PhosphoSiteQ02363.

Proteomic databases

PRIDEQ02363.

Genome annotation databases

EnsemblENSG00000115738. Homo sapiens. [Contig view]
GeneID3398.
KEGGhsa:3398.

Organism-specific databases

GeneCardsGC02P008772.
H-InvDBHIX0001802.
HGNCHGNC:5361. ID2.
MIM600386. gene.
PharmGKBPA134916396.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ02363.
HOVERGENQ02363.
OMAQ02363. PVDDPLS.

Enzyme and pathway databases

Pathway_Interaction_DBhif1_tfpathway. HIF-1-alpha transcription factor network.

Gene expression databases

ArrayExpressQ02363.
BgeeQ02363.
CleanExHS_ID2.
GermOnlineENSG00000115738. Homo sapiens.

Family and domain databases

InterProIPR001092. HLH_basic.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
PROSITEPS50888. HLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio13428.
SOURCESearch...

Entry information

Entry nameID2_HUMAN
AccessionPrimary (citable) accession number: Q02363
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents