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Reviewed, UniProtKB/Swiss-Prot Q02361 (FD3_DROME)

Last modified February 9, 2010. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Fork head domain-containing protein FD3
Gene names
Name: fd59A
Synonyms: FD3
ORF Names: CG3668
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Involved in development during embryogenesis. Ref.5

Subcellular location

Nucleus.

Tissue specificity

During embryogenesis, expressed in neuroblasts derived from procephalic region, ventral nervous system, thoracic sensory neurons and brain cells. Ref.5

Developmental stage

Expressed at very low levels during embryogenesis. Ref.5

Sequence similarities

Contains 1 fork-head DNA-binding domain.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Fork head domain-containing protein FD3
PRO_0000091911

Regions

DNA binding84 – 17592Fork-head

Experimental info

Sequence conflict2251E → D in AAL89942. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Q02361-1 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 208FEAF27C953F4B

FASTA45649,054
        10         20         30         40         50         60 
MHTSTDPMHT LHDSVSLSPP LIKSSRGGSS IGNGIGCSAS SRTAAADAMS MGCDDSDIEP 

        70         80         90        100        110        120 
SSMGGSGAAG GNGDGSGSSG GPLVKPPYSY IALITMAILQ SPHKKLTLSG ICDFIMSRFP 

       130        140        150        160        170        180 
YYKDKFPAWQ NSIRHNLSLN DCFIKVPREP GNPGKGNFWT LDPLAEDMFD NGSFLRRRKR 

       190        200        210        220        230        240 
YKRAPTMQRF SFPAVFGTLS PFWIRKPVPL VPVHFNVPNF NGSREFDVVH NPADVFDSAL 

       250        260        270        280        290        300 
RADKKFNFFA NAEASFYQGS QSGDKFDRLP FMNRGRGADV LDALPHSSGS GGGVGGGSES 

       310        320        330        340        350        360 
SRGSKYKSPY AFDVATVASA AGIPGHRDYA ERLSAGGGYM DLNVYNDDAD TEADAEAEGD 

       370        380        390        400        410        420 
DDSCEDKIDV ESGNEQEDSH ISDSVDSACT NRLDAPPEAL IFEASAEASD SSPRRRFDSE 

       430        440        450 
PLVLRTSKQS SAKDFRIETL IGHHLHRGGS QEETSD

« Hide

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References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
[5]"Developmentally regulated Drosophila gene family encoding the fork head domain."
Haecker U., Grossniklaus U., Gehring W.J., Jaeckle H.
Proc. Natl. Acad. Sci. U.S.A. 89:8754-8758(1992) [PubMed: 1356269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-197, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013599 Genomic DNA. Translation: AAF46917.1.
AY084204 mRNA. Translation: AAL89942.1.
BT025198 mRNA. Translation: ABF17889.1.
M96442 Genomic DNA. Translation: AAA28534.1.
PIRC46178.
RefSeqNP_523814.1.
UniGeneDm.738

3D structure databases

SMRQ02361. Positions 84-180.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-19745N.
IntActQ02361. 36 interactions.

Proteomic databases

PRIDEQ02361.

Genome annotation databases

EnsemblFBtr0071898; FBpp0071809; FBgn0004896; Drosophila melanogaster. [Genome view]
GeneID37631.
KEGGdme:Dmel_CG3668.
NMPDRfig|7227.3.peg.6937.

Organism-specific databases

CTD37631.
FlyBaseFBgn0004896. fd59A.

Phylogenomic databases

eggNOGinNOG09513.
InParanoidQ02361.
OMAQEDSHIS.
OrthoDBEOG9BP1KB.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-006104-MONOMER.

Gene expression databases

GermOnlineCG3668. Drosophila melanogaster.

Family and domain databases

InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHERPTHR11829. Fork_box_protein. 1 hit.
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio804648.

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Entry information

Entry nameFD3_DROME
AccessionPrimary (citable) accession number: Q02361
Secondary accession number(s): Q1LZ28, Q8T4G1, Q9W1Y5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 21, 2001
Last modified: February 9, 2010
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents