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Q02358

- CAPSD_LRVLG

UniProt

Q02358 - CAPSD_LRVLG

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Protein

Major capsid protein

Gene

ORF2

Organism
Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry, 35 nm in diameter, and consisting of 60 capsid proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA and the polymerase and remains intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of the virion and are extruded into the cytoplasm By similarity.By similarity
Binds and removes 5' cap structures from cellular mRNA.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein
Alternative name(s):
Major coat protein
Gene namesi
Name:ORF2
OrganismiLeishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
Taxonomic identifieri58103 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesTotiviridaeLeishmaniavirus
Virus hostiLeishmania major [TaxID: 5664]
ProteomesiUP000006721: Genome

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. T=2 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, T=2 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 741741Major capsid proteinPRO_0000404515Add
BLAST

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR008871. Totivirus_coat.
[Graphical view]
PfamiPF05518. Totivirus_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02358-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSDTPNSDKV ACGRKPMFCE IIKLANRKRL ILDTTGERVY DARINYCSTA
60 70 80 90 100
DATVQADCHI YWRLKLRRTD AVFEEYTGQG YALDTASYPQ QYADIIRGYY
110 120 130 140 150
SKHVSSALAA NTQHFVNVLA MLRHAGACIA HYCMTGKIDF DILSKKKHKN
160 170 180 190 200
KEVVTLSSAD SLSFLPHSAL YLPSALRASD PEIFNVLYLL GCACDASIAM
210 220 230 240 250
DNIANTSGAA KYAMPHYNPL QLSHALHVTI FYMLGLMDSC GYGEDAVLAL
260 270 280 290 300
TAGLHSVTTV IAHSDEGAIT RDALRELSYT QPYGTMPVPI AGYFQHINVL
310 320 330 340 350
FTTQPAWDQF AGIWDYVILA TAALVHLSDP GMTVNDVTYP TTLTTKVASV
360 370 380 390 400
DGRNSDIAAQ MMHSATRFCD IYIENLCLFW GVVANPDGNA SQALLHAFNV
410 420 430 440 450
VACGTEPNRH LEMNVMAPWY WVESSALFSD YSQFRSPISS AGYGPQSIYG
460 470 480 490 500
ARLVLAATNS LEFTGEAGDY SAYRFEWTTM RHNPLFNILN KRVGDGLANV
510 520 530 540 550
DFRLRPFNEW LLEGQPSRRS CDAVGHGTPT ATCNHKTPNR NTVDEFIWGS
560 570 580 590 600
TSCDLFHPAE LTSYTAVCVR FRNYLSEADG DVRVLNTPTR EVIEGNVVTR
610 620 630 640 650
CDGIRCLDSN KRIQHVPEVA RRYCMMARYL QARTFGALTI GDDIIRGFDK
660 670 680 690 700
VDKVVKMHKS NNRLGQMPLI DVTGLCQPMI ETSTARASMT TRIDPNRLAA
710 720 730 740
ATARIELPLA PRCTSSLIPS SDAVPEPEPH VGEPGNGSGC A
Length:741
Mass (Da):81,749
Last modified:November 1, 1996 - v1
Checksum:i894BAE24F0189F2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92355 Genomic RNA. Translation: AAB50023.1.
PIRiB46171.
RefSeqiNP_041190.1. NC_002063.1.

Genome annotation databases

GeneIDi1446404.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92355 Genomic RNA. Translation: AAB50023.1 .
PIRi B46171.
RefSeqi NP_041190.1. NC_002063.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1446404.

Family and domain databases

InterProi IPR008871. Totivirus_coat.
[Graphical view ]
Pfami PF05518. Totivirus_coat. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiCAPSD_LRVLG
AccessioniPrimary (citable) accession number: Q02358
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3