Q02358 (CAPSD_LRVLG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major capsid protein

Alternative name(s):
Major coat protein

Gene names

Name:

ORF2

Organism

Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1) [Reference proteome]

Taxonomic identifier

58103 [NCBI]

Taxonomic lineage

Viruses › dsRNA viruses › Totiviridae › Leishmaniavirus

Virus host

Leishmania major [TaxID: 5664]

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry, 35 nm in diameter, and consisting of 60 capsid proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA and the polymerase and remains intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of the virion and are extruded into the cytoplasm By similarity. Binds and removes 5' cap structures from cellular mRNA By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the totivirus major capsid protein family.

Ontologies

Keywords
Cellular component	Virion
Molecular function	Capsid protein T=2 icosahedral capsid protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	T=2 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 741	741	Major capsid protein		PRO_0000404515

Sequences

	Sequence		Length	Mass (Da)
	Q02358 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 894BAE24F0189F2E	FASTA	741	81,749
	10 20 30 40 50 60 MSDTPNSDKV ACGRKPMFCE IIKLANRKRL ILDTTGERVY DARINYCSTA DATVQADCHI 70 80 90 100 110 120 YWRLKLRRTD AVFEEYTGQG YALDTASYPQ QYADIIRGYY SKHVSSALAA NTQHFVNVLA 130 140 150 160 170 180 MLRHAGACIA HYCMTGKIDF DILSKKKHKN KEVVTLSSAD SLSFLPHSAL YLPSALRASD 190 200 210 220 230 240 PEIFNVLYLL GCACDASIAM DNIANTSGAA KYAMPHYNPL QLSHALHVTI FYMLGLMDSC 250 260 270 280 290 300 GYGEDAVLAL TAGLHSVTTV IAHSDEGAIT RDALRELSYT QPYGTMPVPI AGYFQHINVL 310 320 330 340 350 360 FTTQPAWDQF AGIWDYVILA TAALVHLSDP GMTVNDVTYP TTLTTKVASV DGRNSDIAAQ 370 380 390 400 410 420 MMHSATRFCD IYIENLCLFW GVVANPDGNA SQALLHAFNV VACGTEPNRH LEMNVMAPWY 430 440 450 460 470 480 WVESSALFSD YSQFRSPISS AGYGPQSIYG ARLVLAATNS LEFTGEAGDY SAYRFEWTTM 490 500 510 520 530 540 RHNPLFNILN KRVGDGLANV DFRLRPFNEW LLEGQPSRRS CDAVGHGTPT ATCNHKTPNR 550 560 570 580 590 600 NTVDEFIWGS TSCDLFHPAE LTSYTAVCVR FRNYLSEADG DVRVLNTPTR EVIEGNVVTR 610 620 630 640 650 660 CDGIRCLDSN KRIQHVPEVA RRYCMMARYL QARTFGALTI GDDIIRGFDK VDKVVKMHKS 670 680 690 700 710 720 NNRLGQMPLI DVTGLCQPMI ETSTARASMT TRIDPNRLAA ATARIELPLA PRCTSSLIPS 730 740 SDAVPEPEPH VGEPGNGSGC A

References

[1]	"Molecular organization of Leishmania RNA virus 1." Stuart K.D., Weeks R., Guilbride L., Myler P.J. Proc. Natl. Acad. Sci. U.S.A. 89:8596-8600(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M92355 Genomic RNA. Translation: AAB50023.1.
PIR	B46171.
RefSeq	NP_041190.1. NC_002063.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1446404.
Family and domain databases
InterPro	IPR008871. Totivirus_coat. [Graphical view]
Pfam	PF05518. Totivirus_coat. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAPSD_LRVLG

Accession

Primary (citable) accession number: Q02358

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 8, 2011
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program