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Q02358 (CAPSD_LRVLG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major capsid protein
Alternative name(s):
Major coat protein
Gene names
Name:ORF2
OrganismLeishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1) [Reference proteome]
Taxonomic identifier58103 [NCBI]
Taxonomic lineageVirusesdsRNA virusesTotiviridaeLeishmaniavirus
Virus hostLeishmania major [TaxID: 5664]

Protein attributes

Sequence length741 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry, 35 nm in diameter, and consisting of 60 capsid proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA and the polymerase and remains intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of the virion and are extruded into the cytoplasm By similarity.

Binds and removes 5' cap structures from cellular mRNA By similarity.

Subcellular location

Virion Potential.

Sequence similarities

Belongs to the totivirus major capsid protein family.

Ontologies

Keywords
   Cellular componentCapsid protein
T=2 icosahedral capsid protein
Virion
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentT=2 icosahedral viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 741741Major capsid protein
PRO_0000404515

Sequences

Sequence LengthMass (Da)Tools
Q02358 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 894BAE24F0189F2E

FASTA74181,749
        10         20         30         40         50         60 
MSDTPNSDKV ACGRKPMFCE IIKLANRKRL ILDTTGERVY DARINYCSTA DATVQADCHI 

        70         80         90        100        110        120 
YWRLKLRRTD AVFEEYTGQG YALDTASYPQ QYADIIRGYY SKHVSSALAA NTQHFVNVLA 

       130        140        150        160        170        180 
MLRHAGACIA HYCMTGKIDF DILSKKKHKN KEVVTLSSAD SLSFLPHSAL YLPSALRASD 

       190        200        210        220        230        240 
PEIFNVLYLL GCACDASIAM DNIANTSGAA KYAMPHYNPL QLSHALHVTI FYMLGLMDSC 

       250        260        270        280        290        300 
GYGEDAVLAL TAGLHSVTTV IAHSDEGAIT RDALRELSYT QPYGTMPVPI AGYFQHINVL 

       310        320        330        340        350        360 
FTTQPAWDQF AGIWDYVILA TAALVHLSDP GMTVNDVTYP TTLTTKVASV DGRNSDIAAQ 

       370        380        390        400        410        420 
MMHSATRFCD IYIENLCLFW GVVANPDGNA SQALLHAFNV VACGTEPNRH LEMNVMAPWY 

       430        440        450        460        470        480 
WVESSALFSD YSQFRSPISS AGYGPQSIYG ARLVLAATNS LEFTGEAGDY SAYRFEWTTM 

       490        500        510        520        530        540 
RHNPLFNILN KRVGDGLANV DFRLRPFNEW LLEGQPSRRS CDAVGHGTPT ATCNHKTPNR 

       550        560        570        580        590        600 
NTVDEFIWGS TSCDLFHPAE LTSYTAVCVR FRNYLSEADG DVRVLNTPTR EVIEGNVVTR 

       610        620        630        640        650        660 
CDGIRCLDSN KRIQHVPEVA RRYCMMARYL QARTFGALTI GDDIIRGFDK VDKVVKMHKS 

       670        680        690        700        710        720 
NNRLGQMPLI DVTGLCQPMI ETSTARASMT TRIDPNRLAA ATARIELPLA PRCTSSLIPS 

       730        740 
SDAVPEPEPH VGEPGNGSGC A 

« Hide

References

[1]"Molecular organization of Leishmania RNA virus 1."
Stuart K.D., Weeks R., Guilbride L., Myler P.J.
Proc. Natl. Acad. Sci. U.S.A. 89:8596-8600(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92355 Genomic RNA. Translation: AAB50023.1.
PIRB46171.
RefSeqNP_041190.1. NC_002063.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1446404.

Family and domain databases

InterProIPR008871. Totivirus_coat.
[Graphical view]
PfamPF05518. Totivirus_coat. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPSD_LRVLG
AccessionPrimary (citable) accession number: Q02358
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families