true1995-11-012024-03-27194ANK1_MOUSEMurine erythrocyte ankyrin cDNA: highly conserved regions of the regulatory domain.White R.A.Birkenmeier C.S.Peters L.L.Barker J.E.Lux S.E.doi:10.1007/bf002921561992Mamm. Genome3281-285NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ER1)ErythrocyteComplex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene.Birkenmeier C.S.White R.A.Peters L.L.Hall E.J.Lux S.E.Barker J.E.doi:10.1016/s0021-9258(18)98384-51993J. Biol. Chem.2689533-9540NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BR2; ER3 AND BR4)C57BL/6JCerebellumAn alternative first exon in the distal end of the erythroid ankyrin gene leads to production of a small isoform containing an NH2-terminal membrane anchor.Birkenmeier C.S.Sharp J.J.Gifford E.J.Deveau S.A.Barker J.E.doi:10.1006/geno.1998.53051998Genomics5079-88NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MU7)TISSUE SPECIFICITYSUBCELLULAR LOCATIONSkeletal muscleThe transcriptional landscape of the mammalian genome.Carninci P.Kasukawa T.Katayama S.Gough J.Frith M.C.Maeda N.Oyama R.Ravasi T.Lenhard B.Wells C.Kodzius R.Shimokawa K.Bajic V.B.Brenner S.E.Batalov S.Forrest A.R.Zavolan M.Davis M.J.Wilming L.G.Aidinis V.Allen J.E.Ambesi-Impiombato A.Apweiler R.Aturaliya R.N.Bailey T.L.Bansal M.Baxter L.Beisel K.W.Bersano T.Bono H.Chalk A.M.Chiu K.P.Choudhary V.Christoffels A.Clutterbuck D.R.Crowe M.L.Dalla E.Dalrymple B.P.de Bono B.Della Gatta G.di Bernardo D.Down T.Engstrom P.Fagiolini M.Faulkner G.Fletcher C.F.Fukushima T.Furuno M.Futaki S.Gariboldi M.Georgii-Hemming P.Gingeras T.R.Gojobori T.Green R.E.Gustincich S.Harbers M.Hayashi Y.Hensch T.K.Hirokawa N.Hill D.Huminiecki L.Iacono M.Ikeo K.Iwama A.Ishikawa T.Jakt M.Kanapin A.Katoh M.Kawasawa Y.Kelso J.Kitamura H.Kitano H.Kollias G.Krishnan S.P.Kruger A.Kummerfeld S.K.Kurochkin I.V.Lareau L.F.Lazarevic D.Lipovich L.Liu J.Liuni S.McWilliam S.Madan Babu M.Madera M.Marchionni L.Matsuda H.Matsuzawa S.Miki H.Mignone F.Miyake S.Morris K.Mottagui-Tabar S.Mulder N.Nakano N.Nakauchi H.Ng P.Nilsson R.Nishiguchi S.Nishikawa S.Nori F.Ohara O.Okazaki Y.Orlando V.Pang K.C.Pavan W.J.Pavesi G.Pesole G.Petrovsky N.Piazza S.Reed J.Reid J.F.Ring B.Z.Ringwald M.Rost B.Ruan Y.Salzberg S.L.Sandelin A.Schneider C.Schoenbach C.Sekiguchi K.Semple C.A.Seno S.Sessa L.Sheng Y.Shibata Y.Shimada H.Shimada K.Silva D.Sinclair B.Sperling S.Stupka E.Sugiura K.Sultana R.Takenaka Y.Taki K.Tammoja K.Tan S.L.Tang S.Taylor M.S.Tegner J.Teichmann S.A.Ueda H.R.van Nimwegen E.Verardo R.Wei C.L.Yagi K.Yamanishi H.Zabarovsky E.Zhu S.Zimmer A.Hide W.Bult C.Grimmond S.M.Teasdale R.D.Liu E.T.Brusic V.Quackenbush J.Wahlestedt C.Mattick J.S.Hume D.A.Kai C.Sasaki D.Tomaru Y.Fukuda S.Kanamori-Katayama M.Suzuki M.Aoki J.Arakawa T.Iida J.Imamura K.Itoh M.Kato T.Kawaji H.Kawagashira N.Kawashima T.Kojima M.Kondo S.Konno H.Nakano K.Ninomiya N.Nishio T.Okada M.Plessy C.Shibata K.Shiraki T.Suzuki S.Tagami M.Waki K.Watahiki A.Okamura-Oho Y.Suzuki H.Kawai J.Hayashizaki Y.doi:10.1126/science.11120142005Science3091559-1563NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS BR2; 5; 6 AND MU8)ForelimbInner earThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MU7)HeartLungBirkenmeier C.B.Sharp J.J.Hall E.J.Deveau S.A.Barker J.E.1996-10EMBL/GenBank/DDBJPARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA]Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.Yang M.Ge W.Chowdhury R.Claridge T.D.Kramer H.B.Schmierer B.McDonough M.A.Gong L.Kessler B.M.Ratcliffe P.J.Coleman M.L.Schofield C.J.doi:10.1074/jbc.m110.1935402011J. Biol. Chem.2867648-7660PROTEIN SEQUENCE OF 95-106HYDROXYLATION AT ASN-101Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle.Zhou D.Birkenmeier C.S.Williams M.W.Sharp J.J.Barker J.E.Bloch R.J.doi:10.1083/jcb.136.3.6211997J. Cell Biol.136621-631SUBCELLULAR LOCATIONComprehensive identification of phosphorylation sites in postsynaptic density preparations.Trinidad J.C.Specht C.G.Thalhammer A.Schoepfer R.Burlingame A.L.doi:10.1074/mcp.t500041-mcp2002006Mol. Cell. Proteomics5914-922PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852 AND THR-862IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]BrainLarge-scale phosphorylation analysis of mouse liver.Villen J.Beausoleil S.A.Gerber S.A.Gygi S.P.doi:10.1073/pnas.06098361042007Proc. Natl. Acad. Sci. U.S.A.1041488-1493PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-957 AND SER-1388IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]LiverLarge-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.Ballif B.A.Carey G.R.Sunyaev S.R.Gygi S.P.doi:10.1021/pr07012542008J. Proteome Res.7311-318PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1069IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L.Jedrychowski M.P.Elias J.E.Goswami T.Rad R.Beausoleil S.A.Villen J.Haas W.Sowa M.E.Gygi S.P.doi:10.1016/j.cell.2010.12.0012010Cell1431174-1189PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-777; SER-813; SER-852; THR-862; THR-957; SER-1078; SER-1386; SER-1388; THR-1396; SER-1424; SER-1473; SER-1482 AND SER-1612PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55 (ISOFORMS MU7 AND MU8)IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Brown adipose tissueKidneyPancreasSpleenTestis133 sequenced antibodies496 antibodies from 34 providersmousemousemousemouseAnk1EukaryotaInteraction between L1 and AnkyrinsNeurofascin interactionsCOPI-mediated anterograde transport2 hits in 79 CRISPR screensmouseProteinExpressed in fetal liver hematopoietic progenitor cell and 183 other cell types or tissuesbaseline and differentialDeath_ank1Ankyrin repeat-containing domainDeath Domain, FasAnkyrin_rptAnkyrin_rpt-contain_sfAnkyrin_UPADEATH-like_dom_sfDeath_domainZU5_domANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEINANKYRIN-3AnkAnk_2Ank_4DeathUPA_2ZU5ANKYRINANKDEATHZU5Ankyrin repeatDEATH domainANK_REP_REGIONANK_REPEATDEATH_DOMAINZU5MMAnkyrin-1ANK-1Erythrocyte ankyrinAnk1Ank-1Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1. Interacts with a number of integral membrane proteins and cytoskeletal proteins. Interacts (via N-terminus) with SPTB/spectrin (beta chain). Also interacts with TTN/titin. Isoform Mu17 interacts with OBSCN isoform 3/obscurin. Interacts with HIF1AN. Interacts (via ANK 1-5 repeats) with RHCE; this interaction mediates the primary membrane attachment site for ANK1. Interacts (via ANK 1-2 repeats) with AQP1 (via the N-terminal). Interacts (via ANK 1-13 repeats) with EPB42. Interacts directly with SLC4A1 (via the cytoplasmic domain); this interaction is mediated by the SLC4A1 Band 3-II and Band 3-III dimers.Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and SLC4A1/erythrocyte membrane protein band 3.The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU. ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function other than binding to spectrin (By similarity).The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion transporters. Adopts a T-shaped arrangement, in the ankyrin-1 complex, in which ANK 1-5 repeats are orthogonal to ANK 6-24 repeats, with the peptide binding groove of ANK 1-5 repeats oriented toward the membrane. The rearrangement of the ANK 1-5 repeats orients the canonical protein binding groove to directly face the membrane, to interact the membrane-embedded targets RHCE and AQP1.Regulated by phosphorylation.Acylated by palmitic acid group(s).Hydroxylated by HIF1AN at several asparagine and 1 aspartate residue within ANK repeat region; hydroxylation seems to increase the conformational stability of this region and may also modulate protein-protein interactions mediated by the ANK repeat region.Produced by alternative promoter usage.Produced by alternative splicing of isoform Er1.Incomplete sequence. Produced by alternative splicing of isoform Er1.Incomplete sequence. Produced by alternative splicing of isoform Er1.Produced by alternative splicing of isoform Er1.Produced by alternative splicing of isoform Er1.Produced by alternative promoter usage.Produced by alternative splicing of isoform Mu7.Ankyrin-120422711862ANK 14069ANK 273102ANK 3106135ANK 4139168ANK 5170197ANK 6201230ANK 7234263ANK 8267296ANK 9300329ANK 10333362ANK 11366395ANK 12399428ANK 13432461ANK 14465494ANK 15498527ANK 16531560ANK 17564593ANK 18597626ANK 19630659ANK 20663692ANK 21696725ANK 22729758ANK 23762791ZU5 19091064ZU5 210661212Death1399148389 kDa domain827Disordered812834Disordered872900UPA domain1197133155 kDa regulatory domain1387Disordered14811506Disordered15981720Disordered17441767Basic and acidic residues817Basic and acidic residues14861500Basic and acidic residues16361652Polar residues16531684Polar residues1699(3S)-3-hydroxyasparagine; by HIF1AN; partial101(3S)-3-hydroxyasparagine; by HIF1AN229Phosphoserine425(3S)-3-hydroxyasparagine; by HIF1AN427(3S)-3-hydroxyasparagine; by HIF1AN460(3S)-3-hydroxyasparagine; by HIF1AN625(3S)-3-hydroxyasparagine; by HIF1AN658(3S)-3-hydroxyaspartate; by HIF1AN691(3S)-3-hydroxyasparagine; by HIF1AN724Phosphoserine755(3S)-3-hydroxyasparagine; by HIF1AN757Phosphoserine777Phosphoserine813Phosphoserine830Phosphoserine852Phosphothreonine862Phosphothreonine957Phosphotyrosine1069Phosphoserine1078Phosphothreonine1374Phosphothreonine1376Phosphoserine1386Phosphoserine1388Phosphothreonine1396Phosphoserine1424Phosphoserine1473Phosphoserine1482Phosphoserine1519Phosphoserine1529Phosphoserine1612Phosphoserine1660Phosphoserine1675Phosphoserine1685In isoform Mu7 and isoform Mu8.1707In isoform Br2.MAERPRRSGSDPA5In isoform 5 and isoform 6.MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKK4In isoform Br2 and isoform 6.GTAHISIMGIn isoform 5.15101664In isoform Br2.1665In isoform Mu7 and isoform Mu8.MWTFITQLLVTLVLLGFFLVSCQNVMHIVKGSLCFVLKHIHQELDKELGESEGLSDDEETISTRVVRRRVFLK17081780In isoform Br4.VIVEGPLADPGDLEADIESFMKLTKV1831In isoform Er3 and isoform Mu8.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