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Q02356

- AMPD2_RAT

UniProt

Q02356 - AMPD2_RAT

Protein

AMP deaminase 2

Gene

Ampd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle By similarity.By similarity

    Catalytic activityi

    AMP + H2O = IMP + NH3.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi364 – 3641Zinc; catalyticBy similarity
    Metal bindingi366 – 3661Zinc; catalyticBy similarity
    Binding sitei366 – 3661SubstrateBy similarity
    Metal bindingi633 – 6331Zinc; catalyticBy similarity
    Binding sitei636 – 6361SubstrateBy similarity
    Active sitei655 – 6551Proton acceptorPROSITE-ProRule annotation
    Metal bindingi710 – 7101Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. AMP deaminase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cyclic purine nucleotide metabolic process Source: UniProtKB
    2. IMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_221255. Purine salvage.
    UniPathwayiUPA00591; UER00663.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP deaminase 2 (EC:3.5.4.6)
    Alternative name(s):
    AMP deaminase isoform L
    Gene namesi
    Name:Ampd2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi2110. Ampd2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824AMP deaminase 2PRO_0000194409Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211PhosphoserineBy similarity
    Modified residuei63 – 631PhosphoserineBy similarity
    Modified residuei90 – 901PhosphotyrosineBy similarity
    Modified residuei96 – 961PhosphoserineBy similarity
    Modified residuei113 – 1131PhosphoserineBy similarity
    Modified residuei133 – 1331PhosphothreonineBy similarity
    Modified residuei135 – 1351PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ02356.
    PRIDEiQ02356.

    PTM databases

    PhosphoSiteiQ02356.

    Expressioni

    Tissue specificityi

    Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.

    Gene expression databases

    GenevestigatoriQ02356.

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02356.
    SMRiQ02356. Positions 160-807.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni435 – 4406Substrate bindingBy similarity
    Regioni711 – 7144Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1816.
    GeneTreeiENSGT00390000008190.
    HOGENOMiHOG000092200.
    HOVERGENiHBG050494.
    InParanoidiQ02356.
    KOiK01490.
    OMAiRYETLCQ.
    OrthoDBiEOG70ZZMQ.
    PhylomeDBiQ02356.
    TreeFamiTF300439.

    Family and domain databases

    InterProiIPR006650. A/AMP_deam_AS.
    IPR001365. A/AMP_deaminase_dom.
    IPR006329. AMPD.
    [Graphical view]
    PANTHERiPTHR11359. PTHR11359. 1 hit.
    PfamiPF00962. A_deaminase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001251. AMP_deaminase_met. 1 hit.
    TIGRFAMsiTIGR01429. AMP_deaminase. 1 hit.
    PROSITEiPS00485. A_DEAMINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02356-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASYPGPGKS KAKYPFKKRA SLQASAAAPE ARSGLGASPL QSARSLPGTA    50
    PCLKHFPLDL RTSMDGKCKE IAEELFSRSL AESELRSAPY EFPEESPIEQ 100
    LEERRQRLER QISQDVKLEP DILLRAKQDF LKTDSDSDLQ LYKEQGEGQG 150
    DRGLWERDVV LEREFQRVII SGEEKCGVPF TDLLDAAKSV VRALFIREKY 200
    MALSLQSFCP TTRRYLQQLA EKPLETRTYE QSPDTPVSAD APVHPPALEQ 250
    HPYEHCEPST MPGDLGLGLR MVRGVVHVYT RRDPDEHCPE VELPYPDLQE 300
    FVADVNVLMA LIINGPIKSF CYRRLQYLSS KFQMHVLLNE MKELAAQKKV 350
    PHRDFYNIRK VDTHIHASSC MNQKHLLRFI KRAMKRHLEE IVHVEQGREQ 400
    TLREVFESMN LTAYDLSVDT LDVHADRNTF HRFDKFNAKY NPIGESVLRE 450
    IFIKTDNKIS GKYFAHIIKE VMSDLEESKY QNAELRLSIY GRSRDEWDKL 500
    ARWAVNHRVH SPNVRWLVQV PRLFDVYRTK GQLANFQEML ENIFLPLFEA 550
    TVHPASHPEL HLFLEHVDGF DSVDDESKPE NHVFNLESPL PEAWVEEDNP 600
    PYAYYLYYTF ANMAMLNHLR RQRGFHTFVL RPHCGEAGPI HHLVSAFMLA 650
    ENISHGLLLR KAPVLQYLYY LAQIGIAMSP LSNNSLFLSY HRNPLPEYLS 700
    RGLMVSLSTD DPLQFHFTKE PLMEEYSIAT QVWKLSSCDM CELARNSVLM 750
    SGFSHKVKSH WLGPNYTKEG PEGNDIRRTN VPDIRVGYRY ETLCQELALI 800
    TQAVQSEMLE TIPEEVGIVM SPGP 824
    Length:824
    Mass (Da):94,787
    Last modified:March 24, 2009 - v2
    Checksum:i3076B550E17AF95C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166402 mRNA. Translation: AAI66402.1.
    M38126 Genomic DNA. Translation: AAA40728.1.
    PIRiA37056.
    RefSeqiNP_001095151.1. NM_001101681.2.
    UniGeneiRn.104557.

    Genome annotation databases

    EnsembliENSRNOT00000026051; ENSRNOP00000026051; ENSRNOG00000019240.
    GeneIDi362015.
    KEGGirno:362015.
    UCSCiRGD:2110. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166402 mRNA. Translation: AAI66402.1 .
    M38126 Genomic DNA. Translation: AAA40728.1 .
    PIRi A37056.
    RefSeqi NP_001095151.1. NM_001101681.2.
    UniGenei Rn.104557.

    3D structure databases

    ProteinModelPortali Q02356.
    SMRi Q02356. Positions 160-807.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q02356.

    Proteomic databases

    PaxDbi Q02356.
    PRIDEi Q02356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026051 ; ENSRNOP00000026051 ; ENSRNOG00000019240 .
    GeneIDi 362015.
    KEGGi rno:362015.
    UCSCi RGD:2110. rat.

    Organism-specific databases

    CTDi 271.
    RGDi 2110. Ampd2.

    Phylogenomic databases

    eggNOGi COG1816.
    GeneTreei ENSGT00390000008190.
    HOGENOMi HOG000092200.
    HOVERGENi HBG050494.
    InParanoidi Q02356.
    KOi K01490.
    OMAi RYETLCQ.
    OrthoDBi EOG70ZZMQ.
    PhylomeDBi Q02356.
    TreeFami TF300439.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00663 .
    Reactomei REACT_221255. Purine salvage.

    Miscellaneous databases

    NextBioi 678390.

    Gene expression databases

    Genevestigatori Q02356.

    Family and domain databases

    InterProi IPR006650. A/AMP_deam_AS.
    IPR001365. A/AMP_deaminase_dom.
    IPR006329. AMPD.
    [Graphical view ]
    PANTHERi PTHR11359. PTHR11359. 1 hit.
    Pfami PF00962. A_deaminase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001251. AMP_deaminase_met. 1 hit.
    TIGRFAMsi TIGR01429. AMP_deaminase. 1 hit.
    PROSITEi PS00485. A_DEAMINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    2. "Adenylate deaminase. A multigene family in humans and rats."
      Morisaki T., Sabina R.L., Holmes E.W.
      J. Biol. Chem. 265:11482-11486(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 632-719.
      Tissue: Brain.

    Entry informationi

    Entry nameiAMPD2_RAT
    AccessioniPrimary (citable) accession number: Q02356
    Secondary accession number(s): B2GUT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3