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Q02356

- AMPD2_RAT

UniProt

Q02356 - AMPD2_RAT

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Protein
AMP deaminase 2
Gene
Ampd2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

AMP deaminase plays a critical role in energy metabolism.

Catalytic activityi

AMP + H2O = IMP + NH3.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi364 – 3641Zinc; catalytic By similarity
Metal bindingi366 – 3661Zinc; catalytic By similarity
Binding sitei366 – 3661Substrate By similarity
Metal bindingi633 – 6331Zinc; catalytic By similarity
Binding sitei636 – 6361Substrate By similarity
Active sitei655 – 6551Proton acceptor By similarity
Metal bindingi710 – 7101Zinc; catalytic By similarity

GO - Molecular functioni

  1. AMP deaminase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_221255. Purine salvage.
UniPathwayiUPA00591; UER00663.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP deaminase 2 (EC:3.5.4.6)
Alternative name(s):
AMP deaminase isoform L
Gene namesi
Name:Ampd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi2110. Ampd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824AMP deaminase 2
PRO_0000194409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine By similarity
Modified residuei63 – 631Phosphoserine By similarity
Modified residuei90 – 901Phosphotyrosine By similarity
Modified residuei96 – 961Phosphoserine By similarity
Modified residuei113 – 1131Phosphoserine By similarity
Modified residuei133 – 1331Phosphothreonine By similarity
Modified residuei135 – 1351Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02356.
PRIDEiQ02356.

PTM databases

PhosphoSiteiQ02356.

Expressioni

Tissue specificityi

Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.

Gene expression databases

GenevestigatoriQ02356.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliQ02356.
SMRiQ02356. Positions 160-807.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni435 – 4406Substrate binding By similarity
Regioni711 – 7144Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1816.
GeneTreeiENSGT00390000008190.
HOGENOMiHOG000092200.
HOVERGENiHBG050494.
InParanoidiQ02356.
KOiK01490.
OMAiRYETLCQ.
OrthoDBiEOG70ZZMQ.
PhylomeDBiQ02356.
TreeFamiTF300439.

Family and domain databases

InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMPD.
[Graphical view]
PANTHERiPTHR11359. PTHR11359. 1 hit.
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
PIRSFiPIRSF001251. AMP_deaminase_met. 1 hit.
TIGRFAMsiTIGR01429. AMP_deaminase. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02356-1 [UniParc]FASTAAdd to Basket

« Hide

MASYPGPGKS KAKYPFKKRA SLQASAAAPE ARSGLGASPL QSARSLPGTA    50
PCLKHFPLDL RTSMDGKCKE IAEELFSRSL AESELRSAPY EFPEESPIEQ 100
LEERRQRLER QISQDVKLEP DILLRAKQDF LKTDSDSDLQ LYKEQGEGQG 150
DRGLWERDVV LEREFQRVII SGEEKCGVPF TDLLDAAKSV VRALFIREKY 200
MALSLQSFCP TTRRYLQQLA EKPLETRTYE QSPDTPVSAD APVHPPALEQ 250
HPYEHCEPST MPGDLGLGLR MVRGVVHVYT RRDPDEHCPE VELPYPDLQE 300
FVADVNVLMA LIINGPIKSF CYRRLQYLSS KFQMHVLLNE MKELAAQKKV 350
PHRDFYNIRK VDTHIHASSC MNQKHLLRFI KRAMKRHLEE IVHVEQGREQ 400
TLREVFESMN LTAYDLSVDT LDVHADRNTF HRFDKFNAKY NPIGESVLRE 450
IFIKTDNKIS GKYFAHIIKE VMSDLEESKY QNAELRLSIY GRSRDEWDKL 500
ARWAVNHRVH SPNVRWLVQV PRLFDVYRTK GQLANFQEML ENIFLPLFEA 550
TVHPASHPEL HLFLEHVDGF DSVDDESKPE NHVFNLESPL PEAWVEEDNP 600
PYAYYLYYTF ANMAMLNHLR RQRGFHTFVL RPHCGEAGPI HHLVSAFMLA 650
ENISHGLLLR KAPVLQYLYY LAQIGIAMSP LSNNSLFLSY HRNPLPEYLS 700
RGLMVSLSTD DPLQFHFTKE PLMEEYSIAT QVWKLSSCDM CELARNSVLM 750
SGFSHKVKSH WLGPNYTKEG PEGNDIRRTN VPDIRVGYRY ETLCQELALI 800
TQAVQSEMLE TIPEEVGIVM SPGP 824
Length:824
Mass (Da):94,787
Last modified:March 24, 2009 - v2
Checksum:i3076B550E17AF95C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166402 mRNA. Translation: AAI66402.1.
M38126 Genomic DNA. Translation: AAA40728.1.
PIRiA37056.
RefSeqiNP_001095151.1. NM_001101681.2.
UniGeneiRn.104557.

Genome annotation databases

EnsembliENSRNOT00000026051; ENSRNOP00000026051; ENSRNOG00000019240.
GeneIDi362015.
KEGGirno:362015.
UCSCiRGD:2110. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166402 mRNA. Translation: AAI66402.1 .
M38126 Genomic DNA. Translation: AAA40728.1 .
PIRi A37056.
RefSeqi NP_001095151.1. NM_001101681.2.
UniGenei Rn.104557.

3D structure databases

ProteinModelPortali Q02356.
SMRi Q02356. Positions 160-807.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q02356.

Proteomic databases

PaxDbi Q02356.
PRIDEi Q02356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026051 ; ENSRNOP00000026051 ; ENSRNOG00000019240 .
GeneIDi 362015.
KEGGi rno:362015.
UCSCi RGD:2110. rat.

Organism-specific databases

CTDi 271.
RGDi 2110. Ampd2.

Phylogenomic databases

eggNOGi COG1816.
GeneTreei ENSGT00390000008190.
HOGENOMi HOG000092200.
HOVERGENi HBG050494.
InParanoidi Q02356.
KOi K01490.
OMAi RYETLCQ.
OrthoDBi EOG70ZZMQ.
PhylomeDBi Q02356.
TreeFami TF300439.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00663 .
Reactomei REACT_221255. Purine salvage.

Miscellaneous databases

NextBioi 678390.

Gene expression databases

Genevestigatori Q02356.

Family and domain databases

InterProi IPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMPD.
[Graphical view ]
PANTHERi PTHR11359. PTHR11359. 1 hit.
Pfami PF00962. A_deaminase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001251. AMP_deaminase_met. 1 hit.
TIGRFAMsi TIGR01429. AMP_deaminase. 1 hit.
PROSITEi PS00485. A_DEAMINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "Adenylate deaminase. A multigene family in humans and rats."
    Morisaki T., Sabina R.L., Holmes E.W.
    J. Biol. Chem. 265:11482-11486(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 632-719.
    Tissue: Brain.

Entry informationi

Entry nameiAMPD2_RAT
AccessioniPrimary (citable) accession number: Q02356
Secondary accession number(s): B2GUT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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