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Protein

AMP deaminase 2

Gene

Ampd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity).By similarity

Catalytic activityi

AMP + H2O = IMP + NH3.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from AMP.
Proteins known to be involved in this subpathway in this organism are:
  1. AMP deaminase 1 (Ampd1), AMP deaminase 2 (Ampd2), AMP deaminase 3 (Ampd3)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from AMP, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi364Zinc; catalyticBy similarity1
Metal bindingi366Zinc; catalyticBy similarity1
Binding sitei366SubstrateBy similarity1
Metal bindingi633Zinc; catalyticBy similarity1
Binding sitei636SubstrateBy similarity1
Active sitei655Proton acceptorPROSITE-ProRule annotation1
Metal bindingi710Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-74217. Purine salvage.
UniPathwayiUPA00591; UER00663.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP deaminase 2 (EC:3.5.4.6)
Alternative name(s):
AMP deaminase isoform L
Gene namesi
Name:Ampd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2110. Ampd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001944091 – 824AMP deaminase 2Add BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Modified residuei44Omega-N-methylarginineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei90PhosphotyrosineBy similarity1
Modified residuei96PhosphoserineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei133PhosphothreonineBy similarity1
Modified residuei135PhosphoserineCombined sources1
Modified residuei137PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ02356.
PRIDEiQ02356.

PTM databases

iPTMnetiQ02356.
PhosphoSitePlusiQ02356.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019240.
ExpressionAtlasiQ02356. differential.
GenevisibleiQ02356. RN.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026051.

Chemistry databases

BindingDBiQ02356.

Structurei

3D structure databases

ProteinModelPortaliQ02356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni435 – 440Substrate bindingBy similarity6
Regioni711 – 714Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1096. Eukaryota.
COG1816. LUCA.
GeneTreeiENSGT00390000008190.
HOGENOMiHOG000092200.
HOVERGENiHBG050494.
InParanoidiQ02356.
KOiK01490.
OMAiRCFLHQS.
OrthoDBiEOG091G01OU.
PhylomeDBiQ02356.
TreeFamiTF300439.

Family and domain databases

CDDicd01319. AMPD. 1 hit.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMPD.
IPR029749. AMPD2.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11359. PTHR11359. 1 hit.
PTHR11359:SF3. PTHR11359:SF3. 1 hit.
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
PIRSFiPIRSF001251. AMP_deaminase_met. 1 hit.
SUPFAMiSSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01429. AMP_deaminase. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYPGPGKS KAKYPFKKRA SLQASAAAPE ARSGLGASPL QSARSLPGTA
60 70 80 90 100
PCLKHFPLDL RTSMDGKCKE IAEELFSRSL AESELRSAPY EFPEESPIEQ
110 120 130 140 150
LEERRQRLER QISQDVKLEP DILLRAKQDF LKTDSDSDLQ LYKEQGEGQG
160 170 180 190 200
DRGLWERDVV LEREFQRVII SGEEKCGVPF TDLLDAAKSV VRALFIREKY
210 220 230 240 250
MALSLQSFCP TTRRYLQQLA EKPLETRTYE QSPDTPVSAD APVHPPALEQ
260 270 280 290 300
HPYEHCEPST MPGDLGLGLR MVRGVVHVYT RRDPDEHCPE VELPYPDLQE
310 320 330 340 350
FVADVNVLMA LIINGPIKSF CYRRLQYLSS KFQMHVLLNE MKELAAQKKV
360 370 380 390 400
PHRDFYNIRK VDTHIHASSC MNQKHLLRFI KRAMKRHLEE IVHVEQGREQ
410 420 430 440 450
TLREVFESMN LTAYDLSVDT LDVHADRNTF HRFDKFNAKY NPIGESVLRE
460 470 480 490 500
IFIKTDNKIS GKYFAHIIKE VMSDLEESKY QNAELRLSIY GRSRDEWDKL
510 520 530 540 550
ARWAVNHRVH SPNVRWLVQV PRLFDVYRTK GQLANFQEML ENIFLPLFEA
560 570 580 590 600
TVHPASHPEL HLFLEHVDGF DSVDDESKPE NHVFNLESPL PEAWVEEDNP
610 620 630 640 650
PYAYYLYYTF ANMAMLNHLR RQRGFHTFVL RPHCGEAGPI HHLVSAFMLA
660 670 680 690 700
ENISHGLLLR KAPVLQYLYY LAQIGIAMSP LSNNSLFLSY HRNPLPEYLS
710 720 730 740 750
RGLMVSLSTD DPLQFHFTKE PLMEEYSIAT QVWKLSSCDM CELARNSVLM
760 770 780 790 800
SGFSHKVKSH WLGPNYTKEG PEGNDIRRTN VPDIRVGYRY ETLCQELALI
810 820
TQAVQSEMLE TIPEEVGIVM SPGP
Length:824
Mass (Da):94,787
Last modified:March 24, 2009 - v2
Checksum:i3076B550E17AF95C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166402 mRNA. Translation: AAI66402.1.
M38126 Genomic DNA. Translation: AAA40728.1.
PIRiA37056.
RefSeqiNP_001095151.1. NM_001101681.2.
UniGeneiRn.104557.

Genome annotation databases

EnsembliENSRNOT00000026051; ENSRNOP00000026051; ENSRNOG00000019240.
GeneIDi362015.
KEGGirno:362015.
UCSCiRGD:2110. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166402 mRNA. Translation: AAI66402.1.
M38126 Genomic DNA. Translation: AAA40728.1.
PIRiA37056.
RefSeqiNP_001095151.1. NM_001101681.2.
UniGeneiRn.104557.

3D structure databases

ProteinModelPortaliQ02356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026051.

Chemistry databases

BindingDBiQ02356.

PTM databases

iPTMnetiQ02356.
PhosphoSitePlusiQ02356.

Proteomic databases

PaxDbiQ02356.
PRIDEiQ02356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026051; ENSRNOP00000026051; ENSRNOG00000019240.
GeneIDi362015.
KEGGirno:362015.
UCSCiRGD:2110. rat.

Organism-specific databases

CTDi271.
RGDi2110. Ampd2.

Phylogenomic databases

eggNOGiKOG1096. Eukaryota.
COG1816. LUCA.
GeneTreeiENSGT00390000008190.
HOGENOMiHOG000092200.
HOVERGENiHBG050494.
InParanoidiQ02356.
KOiK01490.
OMAiRCFLHQS.
OrthoDBiEOG091G01OU.
PhylomeDBiQ02356.
TreeFamiTF300439.

Enzyme and pathway databases

UniPathwayiUPA00591; UER00663.
ReactomeiR-RNO-74217. Purine salvage.

Miscellaneous databases

PROiQ02356.

Gene expression databases

BgeeiENSRNOG00000019240.
ExpressionAtlasiQ02356. differential.
GenevisibleiQ02356. RN.

Family and domain databases

CDDicd01319. AMPD. 1 hit.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMPD.
IPR029749. AMPD2.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11359. PTHR11359. 1 hit.
PTHR11359:SF3. PTHR11359:SF3. 1 hit.
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
PIRSFiPIRSF001251. AMP_deaminase_met. 1 hit.
SUPFAMiSSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01429. AMP_deaminase. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMPD2_RAT
AccessioniPrimary (citable) accession number: Q02356
Secondary accession number(s): B2GUT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.