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Q02346

- MYOD1_RAT

UniProt

Q02346 - MYOD1_RAT

Protein

Myoblast determination protein 1

Gene

Myod1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins By similarity.By similarity

    GO - Molecular functioni

    1. chromatin DNA binding Source: UniProtKB
    2. core promoter binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to estradiol stimulus Source: UniProtKB
    2. histone H3 acetylation Source: UniProtKB
    3. histone H4 acetylation Source: UniProtKB
    4. myoblast differentiation Source: UniProtKB
    5. myoblast fate determination Source: UniProtKB
    6. positive regulation of skeletal muscle tissue regeneration Source: UniProtKB
    7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    8. regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
    9. skeletal muscle tissue development Source: UniProtKB
    10. striated muscle cell differentiation Source: UniProtKB
    11. transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Myogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myoblast determination protein 1
    Gene namesi
    Name:Myod1
    Synonyms:Myod
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi631429. Myod1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Myoblast determination protein 1PRO_0000127363Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki1 – 1Peptide (Met-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei104 – 1041N6-methyllysine; by EHMT2By similarity

    Post-translational modificationi

    Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation By similarity.By similarity
    Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function By similarity.By similarity
    Ubiquitinated on the N-terminus; which is required for proteasomal degradation.By similarity
    Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.By similarity

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ02346.

    PTM databases

    PhosphoSiteiQ02346.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02346.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5. Interacts with CHD2. Interacts with TSC22D3 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ02346.
    SMRiQ02346. Positions 102-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 16052bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG292792.
    HOGENOMiHOG000234800.
    HOVERGENiHBG006429.
    InParanoidiQ02346.
    KOiK09064.
    PhylomeDBiQ02346.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR002546. Basic.
    IPR011598. bHLH_dom.
    IPR022032. Myf5.
    [Graphical view]
    PfamiPF01586. Basic. 1 hit.
    PF00010. HLH. 1 hit.
    PF12232. Myf5. 1 hit.
    [Graphical view]
    SMARTiSM00520. BASIC. 1 hit.
    SM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02346-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLSPPLRD TDLLGPDGSL CSFATRDDFY DDPCFDSPDL RFFEDLDPRL    50
    VHVGALLKPE EHAHFPTTVH PGPGAREDEH VRAPSGHHQA GRCLLWACKA 100
    CKRKTTNADR RKAATMRERR RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL 150
    RNAIRYIEGL QALLRDQDAA PPGAAAFYAP GPLPPGRGSE HYSGDSDASS 200
    PRSNCSDGMM DYSGPPSGPR RQNGYDAAYY SEASSEPRPG KSAAVSSLDC 250
    LSSIVERIST DSPAAPSLLL PDAPPESPPG PPEETSSSDA EQGTQTPSPD 300
    STPQCPAGSK PNPIYQVL 318
    Length:318
    Mass (Da):34,359
    Last modified:July 1, 1993 - v1
    Checksum:iFC43E46BB1287F5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84176 Genomic DNA. Translation: AAA41661.1.
    PIRiJC1171.
    RefSeqiNP_788268.1. NM_176079.1.
    UniGeneiRn.9493.

    Genome annotation databases

    GeneIDi337868.
    KEGGirno:337868.
    UCSCiRGD:631429. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84176 Genomic DNA. Translation: AAA41661.1 .
    PIRi JC1171.
    RefSeqi NP_788268.1. NM_176079.1.
    UniGenei Rn.9493.

    3D structure databases

    ProteinModelPortali Q02346.
    SMRi Q02346. Positions 102-166.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q02346.

    Proteomic databases

    PaxDbi Q02346.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 337868.
    KEGGi rno:337868.
    UCSCi RGD:631429. rat.

    Organism-specific databases

    CTDi 4654.
    RGDi 631429. Myod1.

    Phylogenomic databases

    eggNOGi NOG292792.
    HOGENOMi HOG000234800.
    HOVERGENi HBG006429.
    InParanoidi Q02346.
    KOi K09064.
    PhylomeDBi Q02346.

    Miscellaneous databases

    NextBioi 672553.
    PROi Q02346.

    Gene expression databases

    Genevestigatori Q02346.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR002546. Basic.
    IPR011598. bHLH_dom.
    IPR022032. Myf5.
    [Graphical view ]
    Pfami PF01586. Basic. 1 hit.
    PF00010. HLH. 1 hit.
    PF12232. Myf5. 1 hit.
    [Graphical view ]
    SMARTi SM00520. BASIC. 1 hit.
    SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMYOD1_RAT
    AccessioniPrimary (citable) accession number: Q02346
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3