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Q02332 (PDHK2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial

Short name=Pyruvate dehydrogenase kinase
EC=2.7.11.2
Gene names
Name:pdhk-2
ORF Names:ZK370.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism By similarity.

Catalytic activity

ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the PDK/BCKDK protein kinase family.

Contains 1 histidine kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 401Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrialPRO_0000023450

Regions

Domain131 – 360230Histidine kinase
Nucleotide binding247 – 2548ATP By similarity
Nucleotide binding305 – 3062ATP By similarity
Nucleotide binding321 – 3266ATP By similarity

Sites

Binding site2861ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02332 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 00754E7999BACC12

FASTA40145,282
        10         20         30         40         50         60 
MRFSRKLLGP FVGSLAKKLD YYSQFQPSSL TIQQYLDFGR IGTSANSYTF LKNELLVRLA 

        70         80         90        100        110        120 
NIMQEFTLLP PKLLQMPSSK MVSNWYAESF EDLLLFEASD SSPEQVARFN DQLTVVLKRH 

       130        140        150        160        170        180 
AHVVETMAEG LIELRESDGV DIASEKGIQY FLDRFYINRI SIRMLQNQHL VVFGNVLPES 

       190        200        210        220        230        240 
PRHVGCIDPA CDVESVVYDA FENARFLCDR YYLTSPSMKL EMHNAVEKGK PISIVAVPSH 

       250        260        270        280        290        300 
LYHMMFELFK NAMRATVEYH GVDDDLPDIK VYVVKGQEDL SIKICDRGGG VSRTILERLY 

       310        320        330        340        350        360 
NYMYSTAPPP PRDGTQAPLA GYGYGLPLSR LYARYFLGDL FLVSMEGHGT DACIYLKAVP 

       370        380        390        400 
VEASEVLPIY STSSRRNLTM GPQVADWSHH VPGQGNRPAQ S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080164 Genomic DNA. Translation: CCD61725.1.
PIRS44666.
RefSeqNP_498928.1. NM_066527.3.
UniGeneCel.9569.

3D structure databases

ProteinModelPortalQ02332.
SMRQ02332. Positions 13-397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41429. 1 interaction.
DIPDIP-26171N.
MINTMINT-1077567.
STRING6239.ZK370.5.1.

Proteomic databases

PaxDbQ02332.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK370.5.1; ZK370.5.1; ZK370.5.
ZK370.5.2; ZK370.5.2; ZK370.5.
GeneID176226.
KEGGcel:CELE_ZK370.5.

Organism-specific databases

CTD176226.
WormBaseZK370.5; CE00397; WBGene00022719; pdhk-2.

Phylogenomic databases

eggNOGCOG0642.
HOGENOMHOG000164315.
InParanoidQ02332.
KOK00898.
OMAEDAKTIY.
PhylomeDBQ02332.

Family and domain databases

Gene3D1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProIPR018955. BCDHK/PDK_N.
IPR003594. HATPase_ATP-bd.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
PfamPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio891656.

Entry information

Entry namePDHK2_CAEEL
AccessionPrimary (citable) accession number: Q02332
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase