Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q02326 (RL6A_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L6-A
Alternative name(s):
L17
RP18
YL16
Gene names
Name:RPL6A
Synonyms:RPL17A, YL16A
Ordered Locus Names:YML073C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.4

Subcellular location

Cytoplasm Ref.6.

Post-translational modification

N-terminally acetylated by acetyltransferase NatA. Ref.5

Miscellaneous

Present with 37100 molecules/cell in log phase SD medium.

There are 2 genes for L6 in yeast.

Sequence similarities

Belongs to the ribosomal protein L6e family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 17617560S ribosomal protein L6-A
PRO_0000171017

Amino acid modifications

Modified residue21N-acetylserine Ref.5
Modified residue121Phosphoserine Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q02326 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 2E0AB1810D3AE121

FASTA17619,962
        10         20         30         40         50         60 
MSAQKAPKWY PSEDVAALKK TRKAARPQKL RASLVPGTVL ILLAGRFRGK RVVYLKHLED 

        70         80         90        100        110        120 
NTLLISGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK FNVEYFAKEK LTKKEKKEAN 

       130        140        150        160        170 
LFPEQQNKEI KAERVEDQKV VDKALIAEIK KTPLLKQYLS ASFSLKNGDK PHMLKF 

« Hide

References

« Hide 'large scale' references
[1]"Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16."
Hashimoto T., Suzuki K., Mizuta K., Otaka E.
Biochim. Biophys. Acta 1132:195-198(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
Planta R.J., Mager W.H.
Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE, SUBUNIT.
[5]"The action of N-terminal acetyltransferases on yeast ribosomal proteins."
Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Crystal structure of the eukaryotic ribosome."
Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
[11]"The structure of the eukaryotic ribosome at 3.0 A resolution."
Ben-Shem A., Garreau de Loubresse N., Melnikov S., Jenner L., Yusupova G., Yusupov M.
Science 334:1524-1529(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10225 Genomic DNA. Translation: BAA01077.1.
Z46373 Genomic DNA. Translation: CAA86505.1.
BK006946 Genomic DNA. Translation: DAA09824.1.
PIRS28944.
RefSeqNP_013638.1. NM_001182432.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3IZSelectron microscopy-G1-176[»]
3O58X-ray4.00F1-176[»]
3O5HX-ray4.00F1-176[»]
3U5EX-ray3.00E1-176[»]
3U5IX-ray3.00E1-176[»]
4B6Aelectron microscopy8.10E1-176[»]
4BYNelectron microscopy4.30E2-176[»]
4BYUelectron microscopy6.60E2-176[»]
ProteinModelPortalQ02326.
SMRQ02326. Positions 1-176.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35068. 147 interactions.
IntActQ02326. 33 interactions.
MINTMINT-1325508.
STRING4932.YML073C.

Proteomic databases

PaxDbQ02326.
PeptideAtlasQ02326.
PRIDEQ02326.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYML073C; YML073C; YML073C.
GeneID854902.
KEGGsce:YML073C.

Organism-specific databases

SGDS000004538. RPL6A.

Phylogenomic databases

eggNOGCOG2163.
GeneTreeENSGT00390000003682.
HOGENOMHOG000207317.
KOK02934.
OMAEAEFFNE.
OrthoDBEOG7Q8D0N.

Enzyme and pathway databases

BioCycYEAST:G3O-32667-MONOMER.

Gene expression databases

GenevestigatorQ02326.

Family and domain databases

Gene3D2.30.30.30. 1 hit.
InterProIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERPTHR10715. PTHR10715. 1 hit.
PfamPF01159. Ribosomal_L6e. 1 hit.
[Graphical view]
SUPFAMSSF50104. SSF50104. 1 hit.
PROSITEPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977882.

Entry information

Entry nameRL6A_YEAST
AccessionPrimary (citable) accession number: Q02326
Secondary accession number(s): D6VZA0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references