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Q02326

- RL6A_YEAST

UniProt

Q02326 - RL6A_YEAST

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Protein

60S ribosomal protein L6-A

Gene

RPL6A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: SGD
  2. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
  2. ribosomal large subunit assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32667-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6-A
Alternative name(s):
L17
RP18
YL16
Gene namesi
Name:RPL6A
Synonyms:RPL17A, YL16A
Ordered Locus Names:YML073C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

SGDiS000004538. RPL6A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 17617560S ribosomal protein L6-APRO_0000171017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei12 – 121Phosphoserine1 Publication

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ02326.
PaxDbiQ02326.
PeptideAtlasiQ02326.
PRIDEiQ02326.

Expressioni

Gene expression databases

GenevestigatoriQ02326.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi35068. 148 interactions.
IntActiQ02326. 33 interactions.
MINTiMINT-1325508.
STRINGi4932.YML073C.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW8electron microscopy6.10F1-176[»]
1VWUelectron microscopy6.10F1-176[»]
1VXVelectron microscopy6.20F1-176[»]
1VXYelectron microscopy6.30F1-176[»]
3IZSelectron microscopy-G1-176[»]
3J65electron microscopy8.70G1-176[»]
3O58X-ray4.00F1-176[»]
3O5HX-ray4.00F1-176[»]
3U5EX-ray3.00E1-176[»]
3U5IX-ray3.00E1-176[»]
4B6Aelectron microscopy8.10E1-176[»]
4BYNelectron microscopy4.30E2-176[»]
4BYUelectron microscopy6.60E2-176[»]
4CUWelectron microscopy3.70E1-176[»]
ProteinModelPortaliQ02326.
SMRiQ02326. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

eggNOGiCOG2163.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
InParanoidiQ02326.
KOiK02934.
OMAiEANFFNE.
OrthoDBiEOG7Q8D0N.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02326-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAQKAPKWY PSEDVAALKK TRKAARPQKL RASLVPGTVL ILLAGRFRGK
60 70 80 90 100
RVVYLKHLED NTLLISGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK
110 120 130 140 150
FNVEYFAKEK LTKKEKKEAN LFPEQQNKEI KAERVEDQKV VDKALIAEIK
160 170
KTPLLKQYLS ASFSLKNGDK PHMLKF
Length:176
Mass (Da):19,962
Last modified:January 23, 2007 - v2
Checksum:i2E0AB1810D3AE121
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10225 Genomic DNA. Translation: BAA01077.1.
Z46373 Genomic DNA. Translation: CAA86505.1.
BK006946 Genomic DNA. Translation: DAA09824.1.
PIRiS28944.
RefSeqiNP_013638.1. NM_001182432.1.

Genome annotation databases

EnsemblFungiiYML073C; YML073C; YML073C.
GeneIDi854902.
KEGGisce:YML073C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10225 Genomic DNA. Translation: BAA01077.1 .
Z46373 Genomic DNA. Translation: CAA86505.1 .
BK006946 Genomic DNA. Translation: DAA09824.1 .
PIRi S28944.
RefSeqi NP_013638.1. NM_001182432.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VW8 electron microscopy 6.10 F 1-176 [» ]
1VWU electron microscopy 6.10 F 1-176 [» ]
1VXV electron microscopy 6.20 F 1-176 [» ]
1VXY electron microscopy 6.30 F 1-176 [» ]
3IZS electron microscopy - G 1-176 [» ]
3J65 electron microscopy 8.70 G 1-176 [» ]
3O58 X-ray 4.00 F 1-176 [» ]
3O5H X-ray 4.00 F 1-176 [» ]
3U5E X-ray 3.00 E 1-176 [» ]
3U5I X-ray 3.00 E 1-176 [» ]
4B6A electron microscopy 8.10 E 1-176 [» ]
4BYN electron microscopy 4.30 E 2-176 [» ]
4BYU electron microscopy 6.60 E 2-176 [» ]
4CUW electron microscopy 3.70 E 1-176 [» ]
ProteinModelPortali Q02326.
SMRi Q02326. Positions 1-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35068. 148 interactions.
IntActi Q02326. 33 interactions.
MINTi MINT-1325508.
STRINGi 4932.YML073C.

Proteomic databases

MaxQBi Q02326.
PaxDbi Q02326.
PeptideAtlasi Q02326.
PRIDEi Q02326.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML073C ; YML073C ; YML073C .
GeneIDi 854902.
KEGGi sce:YML073C.

Organism-specific databases

SGDi S000004538. RPL6A.

Phylogenomic databases

eggNOGi COG2163.
GeneTreei ENSGT00390000003682.
HOGENOMi HOG000207317.
InParanoidi Q02326.
KOi K02934.
OMAi EANFFNE.
OrthoDBi EOG7Q8D0N.

Enzyme and pathway databases

BioCyci YEAST:G3O-32667-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

NextBioi 977882.

Gene expression databases

Genevestigatori Q02326.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
InterProi IPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR10715. PTHR10715. 1 hit.
Pfami PF01159. Ribosomal_L6e. 1 hit.
[Graphical view ]
SUPFAMi SSF50104. SSF50104. 1 hit.
PROSITEi PS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16."
    Hashimoto T., Suzuki K., Mizuta K., Otaka E.
    Biochim. Biophys. Acta 1132:195-198(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL6A_YEAST
AccessioniPrimary (citable) accession number: Q02326
Secondary accession number(s): D6VZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 37100 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L6 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3