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Q02326

- RL6A_YEAST

UniProt

Q02326 - RL6A_YEAST

Protein

60S ribosomal protein L6-A

Gene

RPL6A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA binding Source: SGD
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. ribosomal large subunit assembly Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32667-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L6-A
    Alternative name(s):
    L17
    RP18
    YL16
    Gene namesi
    Name:RPL6A
    Synonyms:RPL17A, YL16A
    Ordered Locus Names:YML073C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    SGDiS000004538. RPL6A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 17617560S ribosomal protein L6-APRO_0000171017Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei12 – 121Phosphoserine1 Publication

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatA.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ02326.
    PaxDbiQ02326.
    PeptideAtlasiQ02326.
    PRIDEiQ02326.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02326.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi35068. 147 interactions.
    IntActiQ02326. 33 interactions.
    MINTiMINT-1325508.
    STRINGi4932.YML073C.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW8electron microscopy6.10F1-176[»]
    1VWUelectron microscopy6.10F1-176[»]
    3IZSelectron microscopy-G1-176[»]
    3J65electron microscopy8.70G1-176[»]
    3O58X-ray4.00F1-176[»]
    3O5HX-ray4.00F1-176[»]
    3U5EX-ray3.00E1-176[»]
    3U5IX-ray3.00E1-176[»]
    4B6Aelectron microscopy8.10E1-176[»]
    4BYNelectron microscopy4.30E2-176[»]
    4BYUelectron microscopy6.60E2-176[»]
    4CUWelectron microscopy3.70E1-176[»]
    ProteinModelPortaliQ02326.
    SMRiQ02326. Positions 1-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L6e family.Curated

    Phylogenomic databases

    eggNOGiCOG2163.
    GeneTreeiENSGT00390000003682.
    HOGENOMiHOG000207317.
    KOiK02934.
    OMAiEANFFNE.
    OrthoDBiEOG7Q8D0N.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    InterProiIPR000915. 60S_ribosomal_L6E.
    IPR014722. Rib_L2_dom2.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR10715. PTHR10715. 1 hit.
    PfamiPF01159. Ribosomal_L6e. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02326-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAQKAPKWY PSEDVAALKK TRKAARPQKL RASLVPGTVL ILLAGRFRGK    50
    RVVYLKHLED NTLLISGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK 100
    FNVEYFAKEK LTKKEKKEAN LFPEQQNKEI KAERVEDQKV VDKALIAEIK 150
    KTPLLKQYLS ASFSLKNGDK PHMLKF 176
    Length:176
    Mass (Da):19,962
    Last modified:January 23, 2007 - v2
    Checksum:i2E0AB1810D3AE121
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10225 Genomic DNA. Translation: BAA01077.1.
    Z46373 Genomic DNA. Translation: CAA86505.1.
    BK006946 Genomic DNA. Translation: DAA09824.1.
    PIRiS28944.
    RefSeqiNP_013638.1. NM_001182432.1.

    Genome annotation databases

    EnsemblFungiiYML073C; YML073C; YML073C.
    GeneIDi854902.
    KEGGisce:YML073C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10225 Genomic DNA. Translation: BAA01077.1 .
    Z46373 Genomic DNA. Translation: CAA86505.1 .
    BK006946 Genomic DNA. Translation: DAA09824.1 .
    PIRi S28944.
    RefSeqi NP_013638.1. NM_001182432.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW8 electron microscopy 6.10 F 1-176 [» ]
    1VWU electron microscopy 6.10 F 1-176 [» ]
    3IZS electron microscopy - G 1-176 [» ]
    3J65 electron microscopy 8.70 G 1-176 [» ]
    3O58 X-ray 4.00 F 1-176 [» ]
    3O5H X-ray 4.00 F 1-176 [» ]
    3U5E X-ray 3.00 E 1-176 [» ]
    3U5I X-ray 3.00 E 1-176 [» ]
    4B6A electron microscopy 8.10 E 1-176 [» ]
    4BYN electron microscopy 4.30 E 2-176 [» ]
    4BYU electron microscopy 6.60 E 2-176 [» ]
    4CUW electron microscopy 3.70 E 1-176 [» ]
    ProteinModelPortali Q02326.
    SMRi Q02326. Positions 1-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35068. 147 interactions.
    IntActi Q02326. 33 interactions.
    MINTi MINT-1325508.
    STRINGi 4932.YML073C.

    Proteomic databases

    MaxQBi Q02326.
    PaxDbi Q02326.
    PeptideAtlasi Q02326.
    PRIDEi Q02326.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML073C ; YML073C ; YML073C .
    GeneIDi 854902.
    KEGGi sce:YML073C.

    Organism-specific databases

    SGDi S000004538. RPL6A.

    Phylogenomic databases

    eggNOGi COG2163.
    GeneTreei ENSGT00390000003682.
    HOGENOMi HOG000207317.
    KOi K02934.
    OMAi EANFFNE.
    OrthoDBi EOG7Q8D0N.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32667-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 977882.

    Gene expression databases

    Genevestigatori Q02326.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    InterProi IPR000915. 60S_ribosomal_L6E.
    IPR014722. Rib_L2_dom2.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR10715. PTHR10715. 1 hit.
    Pfami PF01159. Ribosomal_L6e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    PROSITEi PS01170. RIBOSOMAL_L6E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16."
      Hashimoto T., Suzuki K., Mizuta K., Otaka E.
      Biochim. Biophys. Acta 1132:195-198(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    11. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL6A_YEAST
    AccessioniPrimary (citable) accession number: Q02326
    Secondary accession number(s): D6VZA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 37100 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L6 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3