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Protein

60S ribosomal protein L6-A

Gene

RPL6A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32667-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6-A
Alternative name(s):
L17
RP18
YL16
Gene namesi
Name:RPL6A
Synonyms:RPL17A, YL16A
Ordered Locus Names:YML073C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML073C.
SGDiS000004538. RPL6A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001710172 – 17660S ribosomal protein L6-AAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei12PhosphoserineCombined sources1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ02326.
PRIDEiQ02326.

PTM databases

iPTMnetiQ02326.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi35068. 73 interactors.
IntActiQ02326. 35 interactors.
MINTiMINT-1325508.

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 42Combined sources5
Turni46 – 49Combined sources4
Beta strandi51 – 57Combined sources7
Turni59 – 61Combined sources3
Beta strandi63 – 66Combined sources4
Helixi69 – 72Combined sources4
Beta strandi76 – 79Combined sources4
Helixi81 – 83Combined sources3
Beta strandi84 – 90Combined sources7
Helixi93 – 95Combined sources3
Helixi104 – 106Combined sources3
Helixi132 – 149Combined sources18
Beta strandi152 – 154Combined sources3
Helixi155 – 160Combined sources6
Turni171 – 173Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10L61-176[»]
3J6Yelectron microscopy6.10L61-176[»]
3J77electron microscopy6.20L61-176[»]
3J78electron microscopy6.30L61-176[»]
3JBSelectron microscopy2.90A1-176[»]
3JCTelectron microscopy3.08E1-176[»]
4U3MX-ray3.00L6/l62-176[»]
4U3NX-ray3.20L6/l62-176[»]
4U3UX-ray2.90L6/l62-176[»]
4U4NX-ray3.10L6/l62-176[»]
4U4OX-ray3.60L6/l62-176[»]
4U4QX-ray3.00L6/l62-176[»]
4U4RX-ray2.80L6/l62-176[»]
4U4UX-ray3.00L6/l62-176[»]
4U4YX-ray3.20L6/l62-176[»]
4U4ZX-ray3.10L6/l62-176[»]
4U50X-ray3.20L6/l62-176[»]
4U51X-ray3.20L6/l62-176[»]
4U52X-ray3.00L6/l62-176[»]
4U53X-ray3.30L6/l62-176[»]
4U55X-ray3.20L6/l62-176[»]
4U56X-ray3.45L6/l62-176[»]
4U6FX-ray3.10L6/l62-176[»]
4V6Ielectron microscopy8.80BG1-176[»]
4V7Felectron microscopy8.70G1-176[»]
4V7RX-ray4.00BF/DF1-176[»]
4V88X-ray3.00BE/DE1-176[»]
4V8Telectron microscopy8.10E1-176[»]
4V8Yelectron microscopy4.30BE2-176[»]
4V8Zelectron microscopy6.60BE2-176[»]
4V91electron microscopy3.70E1-176[»]
5APNelectron microscopy3.91E1-176[»]
5DATX-ray3.15L6/l62-176[»]
5DC3X-ray3.25L6/l62-176[»]
5FCIX-ray3.40L6/l62-176[»]
5FCJX-ray3.10L6/l62-176[»]
5FL8electron microscopy9.50E1-176[»]
5GAKelectron microscopy3.88I1-176[»]
5I4LX-ray3.10L6/l61-176[»]
5JUOelectron microscopy4.00J1-176[»]
5JUPelectron microscopy3.50J1-176[»]
5JUSelectron microscopy4.20J1-176[»]
5JUTelectron microscopy4.00J1-176[»]
5JUUelectron microscopy4.00J1-176[»]
ProteinModelPortaliQ02326.
SMRiQ02326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

HOGENOMiHOG000207317.
InParanoidiQ02326.
KOiK02934.
OMAiGKNQYPH.
OrthoDBiEOG092C5AV0.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQKAPKWY PSEDVAALKK TRKAARPQKL RASLVPGTVL ILLAGRFRGK
60 70 80 90 100
RVVYLKHLED NTLLISGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK
110 120 130 140 150
FNVEYFAKEK LTKKEKKEAN LFPEQQNKEI KAERVEDQKV VDKALIAEIK
160 170
KTPLLKQYLS ASFSLKNGDK PHMLKF
Length:176
Mass (Da):19,962
Last modified:January 23, 2007 - v2
Checksum:i2E0AB1810D3AE121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10225 Genomic DNA. Translation: BAA01077.1.
Z46373 Genomic DNA. Translation: CAA86505.1.
BK006946 Genomic DNA. Translation: DAA09824.1.
PIRiS28944.
RefSeqiNP_013638.1. NM_001182432.1.

Genome annotation databases

EnsemblFungiiYML073C; YML073C; YML073C.
GeneIDi854902.
KEGGisce:YML073C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10225 Genomic DNA. Translation: BAA01077.1.
Z46373 Genomic DNA. Translation: CAA86505.1.
BK006946 Genomic DNA. Translation: DAA09824.1.
PIRiS28944.
RefSeqiNP_013638.1. NM_001182432.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10L61-176[»]
3J6Yelectron microscopy6.10L61-176[»]
3J77electron microscopy6.20L61-176[»]
3J78electron microscopy6.30L61-176[»]
3JBSelectron microscopy2.90A1-176[»]
3JCTelectron microscopy3.08E1-176[»]
4U3MX-ray3.00L6/l62-176[»]
4U3NX-ray3.20L6/l62-176[»]
4U3UX-ray2.90L6/l62-176[»]
4U4NX-ray3.10L6/l62-176[»]
4U4OX-ray3.60L6/l62-176[»]
4U4QX-ray3.00L6/l62-176[»]
4U4RX-ray2.80L6/l62-176[»]
4U4UX-ray3.00L6/l62-176[»]
4U4YX-ray3.20L6/l62-176[»]
4U4ZX-ray3.10L6/l62-176[»]
4U50X-ray3.20L6/l62-176[»]
4U51X-ray3.20L6/l62-176[»]
4U52X-ray3.00L6/l62-176[»]
4U53X-ray3.30L6/l62-176[»]
4U55X-ray3.20L6/l62-176[»]
4U56X-ray3.45L6/l62-176[»]
4U6FX-ray3.10L6/l62-176[»]
4V6Ielectron microscopy8.80BG1-176[»]
4V7Felectron microscopy8.70G1-176[»]
4V7RX-ray4.00BF/DF1-176[»]
4V88X-ray3.00BE/DE1-176[»]
4V8Telectron microscopy8.10E1-176[»]
4V8Yelectron microscopy4.30BE2-176[»]
4V8Zelectron microscopy6.60BE2-176[»]
4V91electron microscopy3.70E1-176[»]
5APNelectron microscopy3.91E1-176[»]
5DATX-ray3.15L6/l62-176[»]
5DC3X-ray3.25L6/l62-176[»]
5FCIX-ray3.40L6/l62-176[»]
5FCJX-ray3.10L6/l62-176[»]
5FL8electron microscopy9.50E1-176[»]
5GAKelectron microscopy3.88I1-176[»]
5I4LX-ray3.10L6/l61-176[»]
5JUOelectron microscopy4.00J1-176[»]
5JUPelectron microscopy3.50J1-176[»]
5JUSelectron microscopy4.20J1-176[»]
5JUTelectron microscopy4.00J1-176[»]
5JUUelectron microscopy4.00J1-176[»]
ProteinModelPortaliQ02326.
SMRiQ02326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35068. 73 interactors.
IntActiQ02326. 35 interactors.
MINTiMINT-1325508.

PTM databases

iPTMnetiQ02326.

Proteomic databases

MaxQBiQ02326.
PRIDEiQ02326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML073C; YML073C; YML073C.
GeneIDi854902.
KEGGisce:YML073C.

Organism-specific databases

EuPathDBiFungiDB:YML073C.
SGDiS000004538. RPL6A.

Phylogenomic databases

HOGENOMiHOG000207317.
InParanoidiQ02326.
KOiK02934.
OMAiGKNQYPH.
OrthoDBiEOG092C5AV0.

Enzyme and pathway databases

BioCyciYEAST:G3O-32667-MONOMER.

Miscellaneous databases

PROiQ02326.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL6A_YEAST
AccessioniPrimary (citable) accession number: Q02326
Secondary accession number(s): D6VZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 37100 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L6 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.