Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plasminogen-like protein B

Gene

PLGLB1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen-like protein B
Alternative name(s):
Plasminogen-related protein B
Gene namesi
Name:PLGLB1
Synonyms:PLGL, PRGB
AND
Name:PLGLB2
Synonyms:PLGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:9072. PLGLB1.
HGNC:9073. PLGLB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33406.

Polymorphism and mutation databases

BioMutaiPLGLB1.
DMDMi548594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 9677Plasminogen-like protein BPRO_0000022105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 73PROSITE-ProRule annotation
Disulfide bondi53 ↔ 61PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ02325.
PeptideAtlasiQ02325.
PRIDEiQ02325.

PTM databases

iPTMnetiQ02325.
PhosphoSiteiQ02325.

Expressioni

Gene expression databases

BgeeiENSG00000125551.
CleanExiHS_PLGLB1.
ExpressionAtlasiQ02325. baseline and differential.
GenevisibleiQ02325. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352458.

Structurei

3D structure databases

ProteinModelPortaliQ02325.
SMRiQ02325. Positions 20-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 9677PANPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PAN domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000014844.
HOGENOMiHOG000115578.
HOVERGENiHBG003051.
OMAiVEDCASR.
PhylomeDBiQ02325.
TreeFamiTF344093.

Family and domain databases

InterProiIPR003609. Pan_app.
IPR016351. Plasminogen-rel.
[Graphical view]
PfamiPF00024. PAN_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002483. Plasminogen-related. 1 hit.
SMARTiSM00473. PAN_AP. 1 hit.
[Graphical view]
PROSITEiPS50948. PAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG PSLFSVTKKQ LGAGSREECA
60 70 80 90
AKCEEDKEFT CRAFQYHSKE QQCVIMAENR KSSIIIRMRD AVLFEK
Length:96
Mass (Da):10,971
Last modified:June 1, 1994 - v1
Checksum:i8D8073F529F2716D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93143 mRNA. Translation: AAB06491.1.
M86876, M86874, M86875 Genomic DNA. Translation: AAA60169.1.
AC093616 Genomic DNA. Translation: AAX82025.1.
BC005379 mRNA. Translation: AAH05379.1.
BC022294 mRNA. Translation: AAH22294.1.
BC109248 mRNA. Translation: AAI09249.1.
CCDSiCCDS1999.1.
CCDS33238.1.
PIRiJC1195.
RefSeqiNP_001027564.1. NM_001032392.2.
NP_002656.1. NM_002665.4.
UniGeneiHs.652169.
Hs.652174.

Genome annotation databases

EnsembliENST00000355705; ENSP00000347933; ENSG00000183281.
ENST00000359481; ENSP00000352458; ENSG00000125551.
ENST00000409310; ENSP00000386505; ENSG00000183281.
ENST00000409801; ENSP00000386975; ENSG00000183281.
ENST00000410086; ENSP00000386317; ENSG00000125551.
GeneIDi5342.
5343.
KEGGihsa:5342.
hsa:5343.
UCSCiuc002ssd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93143 mRNA. Translation: AAB06491.1.
M86876, M86874, M86875 Genomic DNA. Translation: AAA60169.1.
AC093616 Genomic DNA. Translation: AAX82025.1.
BC005379 mRNA. Translation: AAH05379.1.
BC022294 mRNA. Translation: AAH22294.1.
BC109248 mRNA. Translation: AAI09249.1.
CCDSiCCDS1999.1.
CCDS33238.1.
PIRiJC1195.
RefSeqiNP_001027564.1. NM_001032392.2.
NP_002656.1. NM_002665.4.
UniGeneiHs.652169.
Hs.652174.

3D structure databases

ProteinModelPortaliQ02325.
SMRiQ02325. Positions 20-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352458.

PTM databases

iPTMnetiQ02325.
PhosphoSiteiQ02325.

Polymorphism and mutation databases

BioMutaiPLGLB1.
DMDMi548594.

Proteomic databases

PaxDbiQ02325.
PeptideAtlasiQ02325.
PRIDEiQ02325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355705; ENSP00000347933; ENSG00000183281.
ENST00000359481; ENSP00000352458; ENSG00000125551.
ENST00000409310; ENSP00000386505; ENSG00000183281.
ENST00000409801; ENSP00000386975; ENSG00000183281.
ENST00000410086; ENSP00000386317; ENSG00000125551.
GeneIDi5342.
5343.
KEGGihsa:5342.
hsa:5343.
UCSCiuc002ssd.4. human.

Organism-specific databases

CTDi5342.
5343.
GeneCardsiPLGLB1.
PLGLB2.
HGNCiHGNC:9072. PLGLB1.
HGNC:9073. PLGLB2.
MIMi173340. gene.
neXtProtiNX_Q02325.
PharmGKBiPA33406.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000014844.
HOGENOMiHOG000115578.
HOVERGENiHBG003051.
OMAiVEDCASR.
PhylomeDBiQ02325.
TreeFamiTF344093.

Miscellaneous databases

GeneWikiiPLGLB2.
PROiQ02325.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125551.
CleanExiHS_PLGLB1.
ExpressionAtlasiQ02325. baseline and differential.
GenevisibleiQ02325. HS.

Family and domain databases

InterProiIPR003609. Pan_app.
IPR016351. Plasminogen-rel.
[Graphical view]
PfamiPF00024. PAN_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002483. Plasminogen-related. 1 hit.
SMARTiSM00473. PAN_AP. 1 hit.
[Graphical view]
PROSITEiPS50948. PAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLGB_HUMAN
AccessioniPrimary (citable) accession number: Q02325
Secondary accession number(s): Q580R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.