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Protein

Protein hairless

Gene

H

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Is a potent antagonist of neurogenic gene activity during sensory organ development. The expression of distinct cell fates by the trichogen (shaft) / tormogen (socket) sister cell pair depends on the level of H activity. A certain threshold level of H activity is required, below which both sister cells adopt the tormogen fate.2 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription corepressor activity Source: FlyBase

GO - Biological processi

  • imaginal disc-derived wing margin morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • intestinal stem cell homeostasis Source: FlyBase
  • lateral inhibition Source: FlyBase
  • negative regulation of Notch signaling pathway Source: FlyBase
  • Notch signaling pathway Source: FlyBase
  • regulation of cell death Source: FlyBase
  • regulation of imaginal disc-derived wing size Source: FlyBase
  • sensory organ boundary specification Source: FlyBase
  • sensory organ precursor cell fate determination Source: FlyBase
  • somatic stem cell population maintenance Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

SignaLinkiQ02308.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hairless
Gene namesi
Name:H
ORF Names:CG5460
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001169. H.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839901 – 1077Protein hairlessAdd BLAST1077

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei720Phosphoserine1 Publication1
Modified residuei723Phosphoserine1 Publication1
Modified residuei746Phosphoserine1 Publication1
Modified residuei753Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02308.
PRIDEiQ02308.

PTM databases

iPTMnetiQ02308.

Expressioni

Tissue specificityi

During embryogenesis expression is primarily in endo- and mesodermal cell layers. Ovary, embryos, larval and pupal imaginal disks.2 Publications

Developmental stagei

Expression peaks during embryogenesis and lowest during larval stages.1 Publication

Gene expression databases

BgeeiFBgn0001169.
ExpressionAtlasiQ02308. differential.
GenevisibleiQ02308. DM.

Interactioni

Protein-protein interaction databases

BioGridi67421. 63 interactors.
DIPiDIP-39152N.
IntActiQ02308. 2 interactors.
STRINGi7227.FBpp0083322.

Structurei

Secondary structure

11077
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi233 – 239Combined sources7
Beta strandi242 – 249Combined sources8
Beta strandi252 – 254Combined sources3
Beta strandi258 – 260Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E24X-ray2.14B/D232-269[»]
SMRiQ02308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi115 – 123Thr-rich9
Compositional biasi642 – 648Poly-Ser7
Compositional biasi879 – 891Poly-AlaAdd BLAST13
Compositional biasi937 – 946Poly-Ala10
Compositional biasi964 – 974Ala-richAdd BLAST11
Compositional biasi979 – 1008His/Pro-rich (PRD motif)Add BLAST30

Phylogenomic databases

eggNOGiENOG410J1GS. Eukaryota.
ENOG4111Y96. LUCA.
InParanoidiQ02308.
KOiK06064.
OMAiHYYMYPP.
OrthoDBiEOG091G0OQN.
PhylomeDBiQ02308.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q02308-1) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLNDVTSV AECNRQTTMT DEHKSNINSN SSHSSNNNNN GSSSNNDNNS
60 70 80 90 100
NDDAASSSNS KNNNTSNESS HSNNNTSSII AEAAAKFLLK NGLNGSSSTS
110 120 130 140 150
YPPLPPPLPA NLSRTTTPTT TTTPSSSSST ASNGFLPHAK TPKSSSIMAA
160 170 180 190 200
SAAVAASVVG ATASKPTIDV LGGVLDYSSL GGAATGSLPT TAVVAAAAGT
210 220 230 240 250
AKIGKGSNSG GSFDMGRTPI STHGNNSWGG YGGRLQFFKD GKFILELARS
260 270 280 290 300
KDGDKSGWVS VTRKTFRPPS AATSATVTPT SAVTTAYPKN ENSTSLSFSD
310 320 330 340 350
DNSSIQSSPW QRDQPWKQSR PRRGISKELS LFFHRPRNST LGRAALRTAA
360 370 380 390 400
RKRRRPHEPL TTSEDQQPIF ATAIKAENGD DTLKAEAAEA VEIENVAVAD
410 420 430 440 450
TTTNEIKIEK PDTIKGEDDA ERLEKEPKKA VSDDSESKEA SPGQQVEPQP
460 470 480 490 500
KDETVDVEMK MNTSEDEEPM TELPRITNAV NGDLNGDLKA SIGKPKSKPK
510 520 530 540 550
PKAKLSSIIQ KLIDSVPARL EQMSKTSAVI ASTTTSSDRI GGGLSHALTH
560 570 580 590 600
KVSPPSSATA AGRLVEYHTQ HVSPRKRILR EFEKVSLEDN GCVNNGSGGA
610 620 630 640 650
SSGGAGGKRS RAKGTSTSSP AGKASPMNLA PPQGKPSPSP GSSSSSTSPA
660 670 680 690 700
TLSTQPTRLN SSYSIHSLLG GSSGSGSSSF SSSGKKCGDH PAAIISNVHH
710 720 730 740 750
PQHSMYQPSS SSYPRALLTS PKSPDVSGSN GGGGKSPSHT GTKKRSPPYS
760 770 780 790 800
AGSPVDYGHS FYRDPYAGAG RPSTSGSASQ DLSPPRSSPA SPATTPRTVP
810 820 830 840 850
KKTASIRREF ASPSASSSSC PSPGDRSASP PERRHMQQQP HLQRSSPLHY
860 870 880 890 900
YMYPPPPQVN GNGSAGSPTS APPTSNSSAA AVAAAAAAAA AYIPSPSIYN
910 920 930 940 950
PYISTLAALR HNPLWMHHYQ TGASPLLSPH PQPGGSAAAA AAAAAARLSP
960 970 980 990 1000
QSAYHAFAYN GVGAAVAAAA AAAAFGQPAP SPHTHPHLAH PHQHPHPAAL
1010 1020 1030 1040 1050
TTHHSPAHLA TPKLTDSSTD QMSATSSHRT ASTSPSSSSA SASSSAATSG
1060 1070
ASSSAMFHTS SLRNEQSSDL PLNLSKH
Length:1,077
Mass (Da):111,100
Last modified:September 23, 2008 - v2
Checksum:iE8B846C0E2E575D4
GO
Isoform B (identifier: Q02308-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Note: No experimental confirmation available.
Show »
Length:1,059
Mass (Da):109,152
Checksum:i0825DC8015CACEF5
GO

Sequence cautioni

The sequence AAA28607 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK93230 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8T → S in AAT94449 (Ref. 5) Curated1
Sequence conflicti680F → S in CAA47664 (PubMed:1419850).Curated1
Sequence conflicti914L → P in AAT94449 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069521 – 18Missing in isoform B. CuratedAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95192 mRNA. Translation: AAA28607.1. Different initiation.
X67239 mRNA. Translation: CAA47664.1.
AE014297 Genomic DNA. Translation: AAF55790.1.
AE014297 Genomic DNA. Translation: AAF55791.1.
AE014297 Genomic DNA. Translation: AAN14357.1.
AE014297 Genomic DNA. Translation: AAN14358.1.
BT015220 mRNA. Translation: AAT94449.1.
AY051806 mRNA. Translation: AAK93230.1. Different initiation.
PIRiA44067.
RefSeqiNP_524418.2. NM_079694.3. [Q02308-2]
NP_732533.1. NM_169907.2. [Q02308-1]
NP_732534.1. NM_169908.2. [Q02308-1]
NP_732535.1. NM_169909.2. [Q02308-2]
UniGeneiDm.7139.

Genome annotation databases

EnsemblMetazoaiFBtr0083914; FBpp0083322; FBgn0001169. [Q02308-1]
FBtr0083916; FBpp0083324; FBgn0001169. [Q02308-1]
GeneIDi42445.
KEGGidme:Dmel_CG5460.
UCSCiCG5460-RA. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95192 mRNA. Translation: AAA28607.1. Different initiation.
X67239 mRNA. Translation: CAA47664.1.
AE014297 Genomic DNA. Translation: AAF55790.1.
AE014297 Genomic DNA. Translation: AAF55791.1.
AE014297 Genomic DNA. Translation: AAN14357.1.
AE014297 Genomic DNA. Translation: AAN14358.1.
BT015220 mRNA. Translation: AAT94449.1.
AY051806 mRNA. Translation: AAK93230.1. Different initiation.
PIRiA44067.
RefSeqiNP_524418.2. NM_079694.3. [Q02308-2]
NP_732533.1. NM_169907.2. [Q02308-1]
NP_732534.1. NM_169908.2. [Q02308-1]
NP_732535.1. NM_169909.2. [Q02308-2]
UniGeneiDm.7139.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E24X-ray2.14B/D232-269[»]
SMRiQ02308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67421. 63 interactors.
DIPiDIP-39152N.
IntActiQ02308. 2 interactors.
STRINGi7227.FBpp0083322.

PTM databases

iPTMnetiQ02308.

Proteomic databases

PaxDbiQ02308.
PRIDEiQ02308.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083914; FBpp0083322; FBgn0001169. [Q02308-1]
FBtr0083916; FBpp0083324; FBgn0001169. [Q02308-1]
GeneIDi42445.
KEGGidme:Dmel_CG5460.
UCSCiCG5460-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0001169. H.

Phylogenomic databases

eggNOGiENOG410J1GS. Eukaryota.
ENOG4111Y96. LUCA.
InParanoidiQ02308.
KOiK06064.
OMAiHYYMYPP.
OrthoDBiEOG091G0OQN.
PhylomeDBiQ02308.

Enzyme and pathway databases

SignaLinkiQ02308.

Miscellaneous databases

GenomeRNAii42445.
PROiPR:Q02308.

Gene expression databases

BgeeiFBgn0001169.
ExpressionAtlasiQ02308. differential.
GenevisibleiQ02308. DM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiHLES_DROME
AccessioniPrimary (citable) accession number: Q02308
Secondary accession number(s): A4V358
, A4V359, Q6AWM8, Q960W5, Q9VDK0, Q9VDK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 23, 2008
Last modified: April 12, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.